Cited by 594Posttraumatic Stress Disorder ResearchMemory and Neural MechanismsMemory Processes and Influences

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The functional neuroanatomy of PTSD: a critical review

Liberzon, Israel, Sripada, Chandra Sekhar·2007·Progress in Brain Research

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Abstract

Neuroimaging provides an opportunity to understand core processes that mediate the experience of emotions in healthy individuals as well as dysregulation of these processes in conditions such as posttraumatic stress disorder (PTSD). The first decade of neuroimaging research produced symptom provocation, cognitive activation, and functional connectivity studies that highlighted the role of the medial prefrontal cortex (mPFC), amygdala, sublenticular extended amygdala (SLEA), and hippocampus, in mediating symptom formation in PTSD. There is a growing realization that a number of other psychological processes are relevant to PTSD, and they are emerging as a new focus of neuroimaging research. These include fear conditioning, habituation, and extinction; cognitive-emotional interactions; and self-related and social emotional processing. Neuroimaging findings are reviewed that suggest that the mPFC is implicated in a number of these processes. It is proposed that the mPFC plays a role in the "contextualization" of stimuli, and dysregulation of contextualization processes might play a key role in the generation of PTSD symptoms.

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Authors: Liberzon, I., & Sripada, C. S.
Affiliations: University of Michigan (US)
Corresponding author: Liberzon, Israel
ORCID: Liberzon, Israel
Sripada, Chandra Sekhar
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2007
Volume: 167
Pages: 151-169
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(07)67011-3
OpenAlex: W1564331199
Cited by: 594
References: 71
Citations by year: 2026: 11 · 2025: 17 · 2024: 17 · 2023: 20 · 2022: 21 · 2021: 33 · 2020: 45 · 2019: 24 · 2018: 42 · 2017: 37 · 2016: 46 · 2015: 37 · 2014: 46 · 2013: 42 · 2012: 43
FWCI: 91.41
Type: book chapter
Language: en
Open access: closed
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: post-traumatic stress disorder, functional neuroanatomy, medial prefrontal cortex, amygdala, hippocampus, fear conditioning, habituation, extinction, cognitive-emotional interaction, social-emotional processing, contextualization, emotional dysregulation
MeSH terms: Animals, Cognition, Humans, Magnetic Resonance Imaging, Stress Disorders, Post-Traumatic, Prefrontal Cortex

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