Abnormal grey matter in victims of rape with PTSD in mainland China: a voxel - based morphometry study
Abstract
Sui SG, Wu MX, King ME, Zhang Y, Ling L, Xu JM, Weng XC, Duan L, Shan BC, Li LJ. Abnormal grey matter in victims of rape with PTSD in Mainland China: a voxel-based morphometry study. Objective: This study examined changes in brain grey matter in victims of rape (VoR) with and without post-traumatic stress disorder (PTSD). Previous research has focused on PTSD caused by various traumatic events, such as war and disaster, among others. Although considerable research has focused on rape-related PTSD, limited studies have been carried out in the context of Mainland China. Methods: The study included 11 VoR with PTSD, 8 VoR without PTSD and 12 healthy comparison (HC) subjects. We used voxel-based morphometry to explore changes in brain grey-matter density (GMD) by applying statistical parametric mapping to high-resolution magnetic resonance images. Results: Compared with HC, VoR with PTSD showed significant GMD reductions in the bilateral medial frontal cortex, left middle frontal cortex, middle temporal gyrus and fusiform cortex and significant GMD increases in the right posterior cingulate cortex, postcentral cortex, bilateral precentral cortex and inferior parietal lobule. Compared to VoR without PTSD, VoR with PTSD showed significant GMD reductions in the right uncus, left middle temporal gyrus, and the fusiform cortex, and increases in the left precentral cortex, inferior parietal lobule and right post-central cortex. Conclusion: The findings of abnormal GMD in VoR with PTSD support the hypothesis that PTSD is associated with widespread anatomical changes in the brain. The medial frontal cortex, precentral cortex, posterior cingulate cortex, post-central cortex and inferior parietal lobule may play important roles in the neuropathology of PTSD.
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Other studies, including one meta-analysis, failed to identify amygdala volumetric abnormalities associated with PTSD.
“Other studies including one meta-analysis failed to identify amygdala volumetric abnormalities associated with PTSD (Fennema-Notestine et al., 2002;Herringa et al., 2012;Sui et al., 2010).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Sui et al., 2010
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Gray Matter Correlates of Posttraumatic Stress Disorder: A Quantitative Meta-Analysis
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- Authors
- Sui, S. G., Wu, M. X., King, M. E., Zhang, Y., Ling, L., Xu, J. M., Weng, X. C., Duan, L., Shan, B. C., & Li, L. J.
- Affiliations
- Central South University (CN)
- ShenZhen People’s Hospital (CN)
- University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Li, Ling Jiang
- Venue
- Acta Neuropsychiatrica
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-06
- Volume
- 22
- Issue
- 3
- Pages
- 118-126
- ISSN
- 0924-2708 (ISSN-L)
- 1601-5215
- OpenAlex
- W2084717653
- Cited by
- 36
- References
- 10
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Neuropsychiatrica (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Gender Studies › Sexual Assault and Victimization Studies
- Keywords
- rape, post-traumatic stress disorder, gray matter density, brain structural changes, medial frontal cortex, posterior cingulate cortex, fusiform cortex, middle temporal gyrus, inferior parietal lobule, precentral cortex, postcentral cortex
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