CHILDHOOD MALTREATMENT PREDICTS REDUCED INHIBITION-RELATED ACTIVITY IN THE ROSTRAL ANTERIOR CINGULATE IN PTSD, BUT NOT TRAUMA-EXPOSED CONTROLS: Research Article: Childhood Maltreatment, Inhibition, and PTSD
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BACKGROUND: A deficit in the ability to inhibit fear has been proposed as a biomarker of posttraumatic stress disorder (PTSD). Previous research indicates that individuals with PTSD show reduced inhibition-related activation in rostral anterior cingulate cortex (rACC). The goal of the current study was to investigate differential influences of an early environmental risk factor for PTSD-childhood maltreatment-on inhibition-related brain function in individuals with PTSD versus trauma-exposed controls. METHODS: Individuals with PTSD (n = 37) and trauma-exposed controls (n = 53) were recruited from the primary care waiting rooms of an urban public hospital in Atlanta, GA. Participants completed an inhibition task during fMRI, and reported childhood and adult traumatic experiences. The groups were matched for adult and child trauma load. RESULTS: We observed an interaction between childhood maltreatment severity and PTSD status in the rACC (P < .05, corrected), such that maltreatment was negatively associated with inhibition-related rACC activation in the PTSD group, but did not influence rACC activation in the TC group. Rostral ACC activation was associated with inhibition-related task performance in the TC group but not the PTSD group, suggesting a possible contribution to stress resilience. CONCLUSIONS: Findings highlight individual differences in neural function following childhood trauma, and point to inhibition-related activation in rostral ACC as a risk factor for PTSD.
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A follow-up study with a larger sample size suggested that the effects of vmPFC/rACC on behavioral inhibition are moderated by childhood maltreatment effects in participants with PTSD.
“A follow-up study with a larger sample size suggested that the effects of vmPFC/rACC on behavioral inhibition are moderated by childhood maltreatment effects in participants with PTSD [175].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [175]
The Abstract Results report that childhood maltreatment was associated with reduced inhibition-related rACC activation in participants with PTSD, but not in trauma-exposed controls. They do not establish that maltreatment moderated an effect of vmPFC/rACC activity on behavioral inhibition: rACC activation was associated with task performance in controls, not in the PTSD group. The paper describes this as following earlier work, but the supplied passages do not establish the relative sample size. (LLM, conf=0.86)
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- Authors
- Stevens, J. S., Ely, T. D., Sawamura, T., Guzman, D., Bradley, B., Ressler, K. J., & Jovanovic, T.
- Affiliations
- Emory University (US)
- Harvard University (US)
- Department of Psychiatry and Behavioral Sciences; Emory University School of Medicine; Atlanta Georgia
- Corresponding author
- Stevens, Jennifer S.
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2016-04-08
- Volume
- 33
- Issue
- 7
- Pages
- 614-622
- ISSN
- 1091-4269 (ISSN-L)
- PMC
- PMC4930398
- OpenAlex
- W2340972133
- Cited by
- 40
- References
- 75
- Citations by year
- 2026: 4 · 2025: 3 · 2023: 1 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 2
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Mental Health (MH098212, F32MH101976, and MH071537;)
- NIH National Centers for Research Resources (M01RR00039)
- NIH (UL1TR000454)
- Howard Hughes Medical Institute
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- child abuse, post-traumatic stress disorder, rostral anterior cingulate cortex, inhibition, fear inhibition, stress resilience, neural markers, inhibitory control
- MeSH terms
- Adolescent, Adult, Black or African American, Child, Child Abuse, Female, Georgia, Gyrus Cinguli, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Middle Aged, Severity of Illness Index, Stress Disorders, Post-Traumatic, Stress, Psychological, Urban Population, Young Adult
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