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Cited by 79Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatments

Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome

STEEVES, T, FOX, S·2008·Progress in Brain Research
DOI 10.1016/s0079-6123(08)00924-2
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Abstract

Tourette syndrome (TS) is a heritable neuropsychiatric disorder that presents in childhood with a constellation of motor and non-motor symptoms. The defining feature of the disorder is the presence of brief, stereotyped, motor or vocal behaviours called tics. Although tics are themselves voluntary, they are typically performed secondary to involuntary sensory symptoms or irresistible urges. TS is therefore said to be a disorder of human volition that likely represents a general failure of inhibition. It shares many features with obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD) and impulse control disorder with which it is also commonly associated. Much of the anatomic substrate for TS probably lies in the circuits that connect multiple areas of cortex with the basal ganglia and thalamus to subserve motivation, inhibition of behaviour, planning of motor acts and detection of threats. To date, pathological studies of TS have been very few and the number of subjects evaluated too small to reliably elucidate the nature and significance of several reported abnormalities. However, evidence derived from both pharmacological trials and selected functional imaging studies suggests that disturbances of the dopaminergic and serotonergic neurotransmitter systems play a key role in the pathogenesis of TS. At the same time, multiple studies have demonstrated reciprocal interactions between the serotonin and dopamine systems of the brain. This information, when placed in the context of the observed functional imaging abnormalities, may generate further insights into the pathophysiology of TS.

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Authors
STEEVES, T., & FOX, S.
Affiliations
University of Toronto (CA)
Corresponding author
FOX, S
ORCID
FOX, S
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2008
Volume
172
Pages
495-513
ISSN
0079-6123 (ISSN-L)
DOI
10.1016/s0079-6123(08)00924-2
OpenAlex
W1564685812
Cited by
79
References
154
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 13 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 10 · 2014: 6 · 2013: 2 · 2012: 10
FWCI
21.64
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Tourette syndrome, tics, serotonin-dopamine interaction, basal ganglia, thalamus, impulse control disorders, pathophysiology, pharmacotherapy
MeSH terms
Basal Ganglia, Clinical Trials as Topic, Dopamine, Tourette Syndrome, Humans, Synaptic Transmission, Obsessive-Compulsive Disorder, Serotonin, Serotonin Antagonists, Receptors, Dopamine D2, Dopamine Antagonists

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