Cited by 273Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Abnormal dopamine uptake sites in postmortem striatum from patients with tourette's syndrome

Singer, Harvey S., Hahn, In‐Hei, Moran, Timothy H.·1991·Annals of Neurology

Abstract

The dopamine hypothesis for Tourette's syndrome proposes that the disorder is pathologically related either to an excessive amount of dopamine or to supersensitive receptors. To evaluate these proposals, pre‐ and postsynaptic markers of dopamine metabolism were measured in postmortem striatum from three adults with the diagnosis of Tourette's syndrome. Neuronal dopamine uptake carrier sites ([3 H]mazindol binding) were significantly increased in number over control values by 37% in the caudate and by 50% in the putamen. High‐pressure liquid chromatographic assays of dopamine and its primary metabolites, homovanillic acid and 3,4‐dihydroxyphenylacetic acid, showed normal findings. D1 and D2 subtypes of dopaminergic receptors ([3 H]SCH 23390 and [3 H]spiperone binding, respectively) showed only slight alterations, presumably due to treatment with neuroleptics. The concentration of adenosine 3′,5′‐ monophosphate (cyclic AMP) in putamen was reduced by 23%. Our data support earlier proposals of a dopaminergic abnormality in TS, but suggest that the mechanism involves a significant alteration of uptake sites. We spéculate that increases in carrier site binding indicate an enhanced dopamine innervation within the striatum.

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Crossref · 10.1002/ana.410300408

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Authors
Singer, H. S., Hahn, I., & Moran, T. H.
Affiliations
Johns Hopkins University (US)
Corresponding author
Singer, Harvey S.
Venue
Annals of Neurology
Publisher
Wiley
Published
1991-10
Volume
30
Issue
4
Pages
558-562
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2074018083
Cited by
273
References
31
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 9 · 2012: 8
FWCI
16.14
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01ns027327-01)
  • National Institute of Neurological Disorders and Stroke (NS 27327)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
Tourette syndrome, dopamine uptake, striatum, caudate nucleus, putamen, dopamine hypothesis, dopamine receptors, dopamine D1 receptor, dopamine D2 receptor, dopamine metabolism, homovanillic acid, cyclic AMP, antipsychotic drugs, postmortem brain
MeSH terms
Adult, Caudate Nucleus, Chromatography, High Pressure Liquid, Corpus Striatum, Dopamine, Female, Tourette Syndrome, Homovanillic Acid, Humans, Kinetics, Male, Middle Aged, Putamen, Radioligand Assay, Receptors, Dopamine, 3,4-Dihydroxyphenylacetic Acid, Receptors, Dopamine D1, Receptors, Dopamine D2, In Vitro Techniques

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