Cited by 52Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

No change in striatal dopamine re-uptake site density in psychotropic drug naive and in currently treated Tourette’s disorder patients: a [123I]-β-CIT SPECT-study

Stamenkovic, Mara, Schindler, Shird Dieter, Asenbaum, Susanne, Neumeister, Alexander, Willeit, Mathäus, Willinger, Ulrike, de Zwaan, Martina, Riederer, Franz +2 more·2001·European Neuropsychopharmacology

Abstract

Background There is evidence that Tourette's disorder (TD) is associated with abnormalities in the dopaminergic system involving the dopamine transporter (DAT). Data from [(123)I]-beta-CIT single photon emission computed tomography (SPECT) studies and postmortem findings concerning DAT densities in TD patients are not conclusive. The objective of our study was to measure DAT densities with [(123)I]-beta-CIT binding in TD patients who were either psychotropic drug naive or currently treated with antipsychotics (AP) and healthy controls.Method Altogether 20 TD patients were investigated. A total of 15 patients were psychotropic drug naive and five were currently treated with AP. Ten psychotropic drug naive patients were compared with ten age and sex matched healthy subjects. Five currently treated patients were compared with five age and sex matched psychotropic drug naive TD patients. The investigation was carried out using [(123)I]-beta-CIT (2-beta-carbomethoxy-3-beta(4-iodophenyl)-tropane and SPECT. Regions of interest (ROI) were drawn over the striatum and the cerebellum.Results The DAT densities measured by the striatal/cerebellar (S/C) binding ratio did not differ between drug naive TD patients and the controls. The difference between currently AP treated and psychotropic drug naive TD patients did not reach the level of significance. There was no correlation between the ratio and severity of tics and illness.Conclusion Our study with psychotropic drug naive TD patients contributed to clarify the inconsistent results concerning the DAT.

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Crossref · 10.1016/s0924-977x(00)00134-6

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Authors
Stamenkovic, M., Schindler, S. D., Asenbaum, S., Neumeister, A., Willeit, M., Willinger, U., de Zwaan, M., Riederer, F., Aschauer, H. N., & Kasper, S.
Affiliations
University of Vienna (AT)
Corresponding author
Stamenkovic, Mara
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2001-02
Volume
11
Issue
1
Pages
69-74
ISSN
0924-977X (ISSN-L)
OpenAlex
W2048277075
Cited by
52
References
21
Citations by year
2026: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 4
FWCI
4.88
Type
journal article
Language
en
Open access
closed
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
Tourette syndrome, dopamine transporter, striatum, [123I]beta-CIT, antipsychotic drugs, dopaminergic system, tics
MeSH terms
Adult, Basal Ganglia, Cocaine, Dopamine, Female, Tourette Syndrome, Humans, Male, Middle Aged, Psychotropic Drugs, Tomography, Emission-Computed, Single-Photon

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