Mechanisms of Dopaminergic and Serotonergic Neurotransmission in Tourette Syndrome: Clues from an In Vivo Neurochemistry Study with PET
Open accessAbstract
Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by motor and phonic tics. Obsessive-compulsive disorder (OCD) is often concomitant with TS. Dysfunctional tonic and phasic dopamine (DA) and serotonin (5-HT) metabolism may play a role in the pathophysiology of TS. We simultaneously measured the density, affinity, and brain distribution of dopamine D2 receptors (D2-R's), dopamine transporter binding potential (BP), and amphetamine-induced dopamine release (DA(rel)) in 14 adults with TS and 10 normal adult controls. We also measured the brain distribution and BP of serotonin 5-HT2A receptors (5-HT2AR), and serotonin transporter (SERT) BP, in 11 subjects with TS and 10 normal control subjects. As compared with controls, DA rel was significantly increased in the ventral striatum among subjects with TS. Adults with TS+OCD exhibited a significant D(2)-R increase in left ventral striatum. SERT BP in midbrain and caudate/putamen was significantly increased in adults with TS (TS+OCD and TS-OCD). In three subjects with TS+OCD, in whom D2-R, 5-HT2AR, and SERT were measured within a 12-month period, there was a weakly significant elevation of DA rel and 5-HT2A BP, when compared with TS-OCD subjects and normal controls. The current study confirms, with a larger sample size and higher resolution PET scanning, our earlier report that elevated DA rel is a primary defect in TS. The finding of decreased SERT BP, and the possible elevation in 5-HT2AR in individuals with TS who had increased DA rel, suggest a condition of increased phasic DA rel modulated by low 5-HT in concomitant OCD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The identification of an underlying DA deficit leading to dysfunction in TS has proven to be elusive.
“however the identification of an underlying DA deficit leading to dysfunction in TS has proven to be elusive [619].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [619]
A phasic DA imbalance, similar to that seen in schizophrenia, may help to explain the pathophysiology of TS.
“Available evidence suggests that a phasic DA imbalance, similar to that seen in schizophrenia, may help to explain the pathophysiology of TS [619,620].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [619]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 114,103 · see citing works
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090 · see citing works
(1976) · Medical Entomology and Zoology · Cited by 8,899 · see citing works
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110054008 · Cited by 2,799 · see citing works
The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency
Kim, S. W., Dysken, M. W., Pheley, A. M., & Hoover, K. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90039-6 · Cited by 2,361 · see citing works
The yale global tic severity scale: initial testing of a clinician-rated scale of tic severity
LECKMAN, J. F., RIDDLE, M. A., HARDIN, M. T., ORT, S. I., SWARTZ, K. L., STEVENSON, J., & COHEN, D. J. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198907000-00015 · Cited by 2,146 · see citing works
Simplified Reference Tissue Model for PET Receptor Studies
Lammertsma, A. A., & Hume, S. P. (1996) · NeuroImage · doi:10.1006/nimg.1996.0066 · Cited by 2,025 · see citing works
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831 · see citing works
Self-citationDistribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Logan, J., Fowler, J. S., Volkow, N. D., Wang, G., Ding, Y., & Alexoff, D. L. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00008 · Cited by 1,515 · see citing works
Logan, J., Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., HITZEMANN, R. J., Bendriem, B., Gatley, S. J., et al. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.127 · Cited by 1,481 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Increased dopamine transmission in schizophrenia: relationship to illness phases.
Laruelle, M., Abi-Dargham, A., Gil, R. B., Kegeles, L., & Innis, R. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00067-0 · Cited by 744 · see citing works
ATTENTION-DEFICIT HYPERACTIVITY DISORDER IN ADULTS
Wender, P. H. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70039-3 · Cited by 728 · see citing works
Ichise, M., Liow, J., Lu, J., Takano, A., Modell, K. J., Toyama, H., Suhara, T., Suzuki, K., Innis, R. B., & Carson, R. E. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000085441.37552.ca · Cited by 651 · see citing works
McDougle, C. J., Epperson, C. N., Pelton, G. H., Wasylink, S., & Price, L. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.794 · Cited by 571 · see citing works
Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569 · see citing works
Biochemical aspects of Parkinson's disease
Hornykiewicz, O. (1998) · Neurology · doi:10.1212/wnl.51.2_suppl_2.s2 · Cited by 563 · see citing works
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
Laruelle, M., & Abi-Dargham, A. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300405 · Cited by 464 · see citing works
Farde, L., Eriksson, L. I., Blomquist, G., & Halldin, C. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.98 · Cited by 448 · see citing works
Volumetric MRI changes in basal ganglia of children with Tourette's syndrome
Singer, H. S., Reiss, A. L., Brown, J. E., Aylward, E., Shih, B., Chee, E., Harris, E. L., Reader, M. J., Chase, G. A., Bryan, R. N., et al. (1993) · Neurology · doi:10.1212/wnl.43.5.950 · Cited by 370 · see citing works
Self-citationStrategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis
Ichise, M., Toyama, H., Innis, R. B., & Carson, R. E. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000038000.34930.4e · Cited by 358 · see citing works
Elevated dopa decarboxylase activity in living brain of patients with psychosis
Reith, J., Benkelfat, C., Sherwin, A., Yasuhara, Y., Kuwabara, H., Andermann, F., Bachneff, S., Cumming, P., Diksic, M., & Dyve, S. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11651 · Cited by 342 · see citing works
Self-citationContemporary assessment and pharmacotherapy of Tourette syndrome
Scahill, L., Erenberg, G., Berlin, C. M., Budman, C., Coffey, B. J., Jankovic, J., Kiessling, L., King, R. A., Kurlan, R., Lang, A., et al. (2006) · NeuroRX · doi:10.1016/j.nurx.2006.01.009 · Cited by 300 · see citing works
Transient changes in mesolimbic dopamine and their association with ‘reward’
Wightman, R. M., & Robinson, D. L. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01005.x · Cited by 280 · see citing works
Lodge, D. J., & Grace, A. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300963 · Cited by 280 · see citing works
Self-citationAbnormal dopamine uptake sites in postmortem striatum from patients with tourette's syndrome
Singer, H. S., Hahn, I., & Moran, T. H. (1991) · Annals of Neurology · doi:10.1002/ana.410300408 · Cited by 273 · see citing works
Self-citationGrace, A. A. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)01066-t · Cited by 272 · see citing works
Self-citationElevated Intrasynaptic Dopamine Release in Tourette’s Syndrome Measured by PET
Singer, H. S., Szymanski, S., Giuliano, J., Yokoi, F., Dogan, A. S., Brasic, J. R., Zhou, Y., Grace, A. A., & Wong, D. F. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1329 · Cited by 259 · see citing works
Self-citationAttention-deficit hyperactivity disorder in adults
Feifel, D. (1996) · Postgraduate Medicine · doi:10.3810/pgm.1996.09.78 · Cited by 258 · see citing works
West, A. R., & Grace, A. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00294.2002 · Cited by 252 · see citing works
Self-citation[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder
Malison, R. T., McDougle, C. J., van Dyck, C. H., Scahill, L. D., Baldwin, R. M., Seibyl, J. P., Price, L. H., Leckman, J. F., & Innis, R. B. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1359 · Cited by 223 · see citing works
Porras, G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00333-5 · Cited by 222 · see citing works
McCann, U. D., Szabó, Z. R., Seckin, E., Rosenblatt, P., Mathews, W. B., Ravert, H. T., Dannals, R. F., & Ricaurte, G. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300736 · Cited by 204 · see citing works
Cognitive-behavioral therapy and treatment for late-life depression.
Bruun, R. D., & Budman, C. L. (1996) · PubMed · Cited by 201 · see citing works
Baumann, B., Danos, P., Krell, D., Diekmann, S., Leschinger, A., Stauch, R., Wurthmann, C., Bernstein, H.-G., & Bogerts, B. (1999) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.11.1.71 · Cited by 198 · see citing works
Biogenic amine metabolism in tourette syndrome
Butler, I. J., Koslow, S. H., Seifert, W. E., Caprioli, R. M., & Singer, H. S. (1979) · Annals of Neurology · doi:10.1002/ana.410060109 · Cited by 185 · see citing works
Self-citationCortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia
Grace, A. A. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245228 · Cited by 185 · see citing works
Self-citationDopaminergic dysfunction in tourette syndrome
Singer, H. S., Butler, I. J., Tune, L. E., Seifert, W. E., & Coyle, J. T. (1982) · Annals of Neurology · doi:10.1002/ana.410120408 · Cited by 180 · see citing works
Self-citationWong, D. F., YUNG, B. C. K., Dannals, R. F., Shaya, E. K., Ravert, H. T., Chen, C. A., Chan, B., Folio, T., Scheffel, U., Ricaurte, G. A., et al. (1993) · Synapse · doi:10.1002/syn.890150205 · Cited by 174 · see citing works
Self-citationAssessment of Spatial Normalization of PET Ligand Images Using Ligand-Specific Templates
Meyer, J. H., Gunn, R. N., Myers, R., & Grasby, P. M. (1999) · NeuroImage · doi:10.1006/nimg.1999.0431 · Cited by 172 · see citing works
The phasic reward signal of primate dopamine neurons
Schultz, W. (1997) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60841-8 · Cited by 169 · see citing works
Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro
O’Donnell, P., & Grace, A. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)90263-1 · Cited by 169 · see citing works
Self-citationNicotine, Brain Nicotinic Receptors, and Neuropsychiatric Disorders
Mihailescu, S., & Drucker-Colı́n, R. (2000) · Archives of Medical Research · doi:10.1016/s0188-4409(99)00087-9 · Cited by 162 · see citing works
Increased ventral striatal monoaminergic innervation in Tourette syndrome
Albin, R. L., Koeppe, R. A., Bohnen, N. I., Nichols, T. E., Meyer, P., Wernette, K., Minoshima, S., Kilbourn, M. R., & Frey, K. A. (2003) · Neurology · doi:10.1212/01.wnl.0000076181.39162.fc · Cited by 150 · see citing works
Hecker, J. E., & Thorpe, G. L. (2015) · Psychology Press eBooks · doi:10.4324/9781315665122-22 · Cited by 143 · see citing works
Ehrin, E., Farde, L., de Paulis, T., Eriksson, L., Greitz, T. V. B., Johnström, P., Litton, J., Nilsson, J., Sedvall, G., Stone‐Elander, S., et al. (1985) · The International Journal of Applied Radiation and Isotopes · doi:10.1016/0020-708x(85)90083-3 · Cited by 140 · see citing works
Zhou, Y., Endres, C. J., Brašić, J. R., Huang, S., & Wong, D. F. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00017-x · Cited by 135 · see citing works
Self-citationSzabó, Z. R., McCann, U. D., Wilson, A. A., Scheffel, U., Owonikoko, T. K., Mathews, W. B., Ravert, H. T., Hilton, J., Dannals, R. F., & Ricaurte, G. A. (2002) · PubMed · Cited by 134 · see citing works
Schmidt, C. J., Sullivan, C. K., & Fedayal, G. M. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62041382.x · Cited by 132 · see citing works
High Presynaptic Dopaminergic Activity in Children With Tourette's Disorder
Monique Ernst, D., Zametkin, A. J., Jons, P. H., Matochik, J. A., Pascualvaca, D. M., & Cohen, R. M. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199901000-00024 · Cited by 125 · see citing works
D2-like dopamine receptor density in Tourette syndrome measured by PET.
Wong, D., Singer, H. S., Brandt, J., Shaya, E. K., Chen, C. A., Brown, J. E., Kimball, A. W., GJEDDE, A. H., Dannals, R. F., Ravert, H. T., et al. (1997) · PubMed · Cited by 120 · see citing works
Self-citationElevated brain serotonin transporter availability in patients with obsessive-compulsive disorder
Pogarell, O. M., Hamann, C., Pöpperl, G., Juckel, G., Choukèr, M., Zaudig, M., Riedel, M. J., Möller, H., Hegerl, U., & Tatsch, K. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00183-5 · Cited by 113 · see citing works
Heinz, A., Knable, M. B., Wolf, S. S., Jones, D. W., Gorey, J. G., Hyde, T. M., & Weinberger, D. R. (1998) · Neurology · doi:10.1212/wnl.51.4.1069 · Cited by 95 · see citing works
Karachi, C., François, C., Parain, K., Bardinet, É., Tandé, D., Hirsch, É. C., & Yelnik, J. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10312 · Cited by 94 · see citing works
Simpson, H. B., Lombardo, I., Slifstein, M., Huang, Y. H., Hwang, D., Abi‐Dargham, A., Liebowitz, M. R., & Laruelle, M. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00544-4 · Cited by 94 · see citing works
Blood serotonin and tryptophan in Tourette syndrome
Comings, D. E. (1990) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320360410 · Cited by 87 · see citing works
Risperidone augmentation in refractory obsessive—compulsive disorder: an open-label study
Pfanner, C., Marazziti, D., Dell’Osso, L., Presta, S., Gemignani, A., Milanfranchi, A., & Cassano, G. B. (2000) · International Clinical Psychopharmacology · doi:10.1097/00004850-200015050-00007 · Cited by 83 · see citing works
Dopamine in manic depressive illness
Silverstone, T. (1985) · Journal of Affective Disorders · doi:10.1016/0165-0327(85)90020-5 · Cited by 77 · see citing works
Serotonin transporter binding in Tourette Syndrome
Müller‐Vahl, K., Meyer, G.-J., Knapp, W. H., Emrich, H. M., Gielow, P., Brücke, T., & Berding, G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.031 · Cited by 77 · see citing works
Reduced serotonin transporter?availability in obsessive?compulsive disorder (OCD)
Stengler‐Wenzke, K., M�ller, U., Angermeyer, M. C., Sabri, O., & Hesse, S. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0489-y · Cited by 76 · see citing works
Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome
Haugbøl, S., Pinborg, L. H., Regeur, L., Hansen, E. S., Bolwig, T. G., Nielsen, F. Å., Svarer, C., Skovgaard, L. T., & Knudsen, G. M. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706006559 · Cited by 75 · see citing works
Improved Parametric Image Generation Using Spatial-Temporal Analysis of Dynamic PET Studies
Zhou, Y., Huang, S., Bergsneider, M., & Wong, D. F. (2002) · NeuroImage · doi:10.1006/nimg.2001.1021 · Cited by 65 · see citing works
Self-citationMecamylamine in Tourette's Syndrome: A Two-Year Retrospective Case Study
Silver, A. A., Shytle, R. D., & Sanberg, P. R. (2000) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2000.10.59 · Cited by 61 · see citing works
Shytle, R. D., Silver, A. A., & Sanberg, P. R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00945-8 · Cited by 41 · see citing works
Quantification in positron emission tomography for research in pharmacology and drug development
Cunningham, V. J., Gunn, R. N., & Matthews, J. C. (2004) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000134330.38536.bc · Cited by 34 · see citing works
Leckman, J. F., Anderson, G. M., Cohen, D. J., Ort, S., Harcherik, D. F., Hoder, E. L., & Shaywitz, B. A. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90435-1 · Cited by 33 · see citing works
Singer, H. S. (2001) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-001-0016-8 · Cited by 26 · see citing works
Self-citationWeizman, A., Mandel, A., Barber, Y., Weitz, R., Cohen, A., Mester, R., & Rehavi, M. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90280-d · Cited by 23 · see citing works
as Serotonin Transporter Radioligands Under Various Experimental Conditions
Szabó, Z. R., McCann, U. D., Wilson, A. A., Scheffel, U., Owonikoko, T. K., Mathews, W. B., Ravert, H. T., Hilton, J., Dannals, R. F., & Ricaurte, G. A. (2002) · Cited by 18 · see citing works
Serotoninergic agents in the treatment of Gilles de la Tourette's syndrome.
Silvestri, R., Raffaele, M., De Domenico, P., Tisano, A., Laganà, A., & Di Perri, R. (1994) · PubMed · Cited by 9 · see citing works
Wong, D., Sølling, T., Yokoi, F., & Gjedde, A. (1998) · Elsevier eBooks · doi:10.1016/b978-012161340-2/50071-8 · Cited by 9 · see citing works
Self-citationModelling Metabolite and Tracer Kinetics
GJEDDE, A. H. (2003) · Springer eBooks · doi:10.1007/978-3-642-55539-8_7 · Cited by 8 · see citing works
Self-citationPsychophysiological Aspects of Tourette's Syndrome
Murray, J. B. (1997) · The Journal of Psychology · doi:10.1080/00223989709603843 · Cited by 8 · see citing works
GJEDDE, A. H., & Wong, D. F. (1998) · NeuroImage · doi:10.1016/s1053-8119(18)31913-x · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- First MB, Spitzer RL, Gibbon M, Williams JBW (1994). Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). American Psychiatric Press: Washington, DC.
Cited by
Sorted by citations
Gilles de la Tourette syndrome
Robertson, M. M., Eapen, V., Singer, H. S., Martino, D., Scharf, J. M., Paschou, P., Roessner, V., Woods, D. W., Hariz, M. I., Mathews, C. A., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.97 · Cited by 364 · see citing works
Self-citationDichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Deep Brain Stimulation for Tourette-Syndrome: A Systematic Review and Meta-Analysis
Baldermann, J. C., Schüller, T., Huys, D., Becker, I., Timmermann, L., Jessen, F., Visser-Vandewalle, V. E. R. M., & Kuhn, J. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.11.005 · Cited by 258 · see citing works
Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
Castellan-Baldan, L., Williams, K. A., Gallezot, J., Pogorelov, V. M., Rapanelli, M., Crowley, M. J., Anderson, G. M., Loring, E. C., Gorczyca, R. R., Billingslea, E., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.10.052 · Cited by 255 · see citing works
Nikolaus, S., Antke, C., Beu, M., & Müller, H.-W. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.2.119 · Cited by 243 · see citing works
European clinical guidelines for Tourette Syndrome and other tic disorders. Part I: assessment
Cath, D., Hedderly, T., Ludolph, A., Stern, J., Murphy, T., Hartmann, A., Czernecki, V., Robertson, M. M., Martino, D., Münchau, A., et al. (2011) · European Child and Adolescent Psychiatry · doi:10.1007/s00787-011-0164-6 · Cited by 213 · see citing works
Neurobiology of Tourette Syndrome: Current Status and Need for Further Investigation: Table 1.
Felling, R. J., & Singer, H. S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0150-11.2011 · Cited by 227 · see citing works
Self-citationPerani, D., Garibotto, V., Gorini, A., Moresco, R. M., Henin, M., Panzacchi, A., Matarrese, M., Carpinelli, A., Bellodi, L., & Fazio, F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.233 · Cited by 219 · see citing works
Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder
Attwells, S., Setiawan, E., Wilson, A. A., Rusjan, P., Mizrahi, R., Miler, L., Xu, C., Richter, M. A., Kahn, A., Kish, S. J., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.1567 · Cited by 209 · see citing works
Neurobiological Substrates of Tourette's Disorder
Leckman, J. F., Bloch, M. H., Smith, M. E., Larabi, D. I., & Hampson, M. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0118 · Cited by 198 · see citing works
Neuromodulation in Tourette syndrome: dopamine and beyond
Buse, J., Schoenefeld, K., Münchau, A., & Roessner, V. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.004 · Cited by 185 · see citing works
Enomoto, T., Tse, M. T., & Floresco, S. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.038 · Cited by 179 · see citing works
Widespread abnormality of the γ-aminobutyric acid-ergic system in Tourette syndrome
Lerner, A., Bagic, A. I., Simmons, J. M., Mari, Z. K., Bonne, O. B., Xu, B., Kazuba, D. M., Herscovitch, P., Carson, R. E., Murphy, D. L., et al. (2012) · Brain · doi:10.1093/brain/aws104 · Cited by 179 · see citing works
European clinical guidelines for Tourette Syndrome and other tic disorders
Roessner, V., Rothenberger, A., Rickards, H. E., & Hoekstra, P. J. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0165-5 · Cited by 171 · see citing works
Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder
Denys, D. A. J. P., de Vries, F., Cath, D. C., Figee, M., Vulink, N. C. C., Veltman, D. J., van der Doef, T. F., Boellaard, R., Westenberg, H. G. M., van Balkom, A. J. L. M., et al. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.05.012 · Cited by 167 · see citing works
Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders
van Velzen, L. S., Vriend, C., de Wit, S. J., & van den Heuvel, O. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00419 · Cited by 159 · see citing works
Pharmacological modulation of subliminal learning in Parkinson's and Tourette's syndromes
Palminteri, S., Lebreton, M. P., Worbe, Y., Grabli, D., Hartmann, A., & Pessiglione, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904035106 · Cited by 147 · see citing works
Dopaminergic Disturbances in Tourette Syndrome: An Integrative Account
Maia, T. V., & Conceição, V. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.1172 · Cited by 138 · see citing works
Ryan, B. C., Young, N. B., Crawley, J. N., Bodfish, J. W., & Moy, S. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.031 · Cited by 135 · see citing works
Nikolaus, S., Antke, C., & Müller, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.009 · Cited by 125 · see citing works
Singer, H. S. (2019) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000752 · Cited by 122 · see citing works
Self-citationNeurocomputational models of motor and cognitive deficits in Parkinson’s disease
Wiecki, T. V., & Frank, M. J. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)83014-6 · Cited by 108 · see citing works
Shprecher, D., & Kurlan, R. (2008) · Movement Disorders · doi:10.1002/mds.22378 · Cited by 110 · see citing works
Caligiore, D., Mannella, F., Arbib, M. A., & Baldassarre, G. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005395 · Cited by 111 · see citing works
Extrastriatal dopaminergic dysfunction in tourette syndrome
Steeves, T. D. L., Ko, J. H., Kideckel, D. M., Rusjan, P., Houle, S., Sandor, P., Lang, A. E., & Strafella, A. P. (2009) · Annals of Neurology · doi:10.1002/ana.21809 · Cited by 103 · see citing works
Deep brain stimulation for psychiatric disorders: where we are now
Cleary, D. R., Ozpinar, A., Raslan, A. M. T., & Ko, A. L. (2015) · Neurosurgical FOCUS · doi:10.3171/2015.3.focus1546 · Cited by 99 · see citing works
Simonyan, K., Berman, B., Herscovitch, P., & Hallett, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0407-13.2013 · Cited by 89 · see citing works
Palminteri, S., Lebreton, M., Worbe, Y., Hartmann, A., Lehéricy, S., Vidailhet, M., Grabli, D., & Pessiglione, M. (2011) · Brain · doi:10.1093/brain/awr147 · Cited by 90 · see citing works
Hoffmann, M. W. (2013) · ISRN Neurology · doi:10.1155/2013/892459 · Cited by 90 · see citing works
Dopamine regulation of human speech and bird song: A critical review
Simonyan, K., Horwitz, B., & Jarvis, E. D. (2012) · Brain and Language · doi:10.1016/j.bandl.2011.12.009 · Cited by 84 · see citing works
Vermeire, S. T., Audenaert, K., Meester, R. H. D., Vandermeulen, E., Waelbers, T., Spiegeleer, B. M. J. D., Eersels, J. L. H., Dobbeleir, A. A., & Peremans, K. Y. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.06.006 · Cited by 86 · see citing works
Motor control, habits, complex motor stereotypies, and Tourette syndrome
Singer, H. S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12281 · Cited by 85 · see citing works
Self-citationPiedad, J. C. P., Rickards, H. E., & Cavanna, A. E. (2012) · Neurosurgery · doi:10.1227/neu.0b013e3182535a00 · Cited by 81 · see citing works
Role of the sensorimotor cortex in tourette syndrome using multimodal imaging
Tinaz, S., Belluscio, B. A., Malone, P., van der Veen, J. W. C., Hallett, M., & Horovitz, S. G. (2014) · Human Brain Mapping · doi:10.1002/hbm.22588 · Cited by 79 · see citing works
STEEVES, T., & FOX, S. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00924-2 · Cited by 79 · see citing works
Tourette syndrome and other tic disorders
Singer, H. S. (2011) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52014-2.00046-x · Cited by 78 · see citing works
Self-citationTourette Syndrome and comorbid ADHD: Current pharmacological treatment options
Rizzo, R., Gulisano, M., Calì, P. V., & Curatolo, P. (2013) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2013.01.005 · Cited by 76 · see citing works
Tourette syndrome: a disorder of the social decision-making network
Albin, R. L. (2017) · Brain · doi:10.1093/brain/awx204 · Cited by 77 · see citing works
Immunological Dysfunction in Tourette Syndrome and Related Disorders
Hsu, C., Wong, L., & Lee, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020853 · Cited by 76 · see citing works
Glutamatergic modulatory therapy for Tourette syndrome
Singer, H. S., Morris, C. M., & Grados, M. A. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.11.028 · Cited by 74 · see citing works
Self-citationMutations in ASH1L confer susceptibility to Tourette syndrome
Liu, S., Tian, M., He, F., Li, J., Xie, H. B., Liu, W., Zhang, Y., Zhang, R., Yi, M., Che, F., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0560-8 · Cited by 72 · see citing works
A Bayesian Account of the Sensory-Motor Interactions Underlying Symptoms of Tourette Syndrome
Rae, C. L., Critchley, H., & Seth, A. K. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00029 · Cited by 69 · see citing works
Hashemiyoon, R., Kuhn, J., & Visser-Vandewalle, V. (2016) · Brain Topography · doi:10.1007/s10548-016-0525-z · Cited by 66 · see citing works
Pharmacological animal models of Tourette syndrome
Bronfeld, M., Israelashvili, M., & Bar‐Gad, I. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.09.010 · Cited by 66 · see citing works
Reinforcement Learning and Gilles de la Tourette Syndrome
Worbe, Y. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.137 · Cited by 59 · see citing works
Genetic Susceptibility and Neurotransmitters in Tourette Syndrome
Paschou, P., Fernandez, T., Sharp, F., Heiman, G., & Hoekstra, P. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00006-8 · Cited by 52 · see citing works
Liao, J.-F., Cheng, Y.-F., Li, S.-W., Lee, W., Hsu, C.-C., Wu, C.-C., Jeng, O.-J., Wang, S. Z., & Tsai, Y.-C. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.07.027 · Cited by 60 · see citing works
Rominger, A., Cumming, P. D., Xiong, G., Koller, G., Böning, G., Wulff, M., Zwergal, A., Förster, S., Reilhac, A., Munk, O. L., et al. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00355.x · Cited by 59 · see citing works
Rapanelli, M., Frick, L. R., Pogorelov, V. M., Ota, K. T., Abbasi, E., Ohtsu, H., & Pittenger, C. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.10.007 · Cited by 57 · see citing works
Functional neuroimaging in Tourette syndrome
Rickards, H. E. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.07.024 · Cited by 58 · see citing works
Update on the role of antipsychotics in the treatment of Tourette syndrome
Huys, D., Huys, D., Hardenacke, Poppe, Baskin, & Bartsch (2012) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s12990 · Cited by 58 · see citing works
Moya, P. R., Wendland, J. R., Rubenstein, L. M., Timpano, K. R., Heiman, G. A., Tischfield, J. A., King, R. A., Andrews, A. M., Ramamoorthy, S., McMahon, F. J., et al. (2013) · Movement Disorders · doi:10.1002/mds.25460 · Cited by 57 · see citing works
Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation
Korchounov, A., Meyer, M. F., & Krasnianski, M. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0454-z · Cited by 57 · see citing works
Pittenger, C., Adams, T. G., Gallezot, J., Crowley, M. J., Nabulsi, N., Ropchan, J., Gao, H., Kichuk, S. A., Simpson, R., Billingslea, E., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.021 · Cited by 54 · see citing works
Striatal [ 11 C]dihydrotetrabenazine and [ 11 C]methylphenidate binding in Tourette syndrome
Albin, R. L., Koeppe, R. A., Wernette, K., Zhuang, W., Nichols, T. E., Kilbourn, M. R., & Frey, K. A. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a187dd · Cited by 57 · see citing works
Xu, M., Li, L., Ohtsu, H., & Pittenger, C. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.067 · Cited by 55 · see citing works
Animal models of tic disorders: A translational perspective
Godar, S. C., Mosher, L. J., Giovanni, G. D., & Bortolato, M. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.09.008 · Cited by 54 · see citing works
Kim, J. P., Min, H.-K. P., Knight, E. J., Duffy, P. S., Abulseoud, O. A., Marsh, M. P., Kelsey, K. M., Blaha, C. D., Bennet, K. E., Frye, M. A., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.024 · Cited by 53 · see citing works
A Review and Update on Tourette Syndrome: Where Is the Field Headed?
Gunduz, A., & Okun, M. S. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0633-x · Cited by 53 · see citing works
Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome
Suppa, A., Belvisi, D., Bologna, M., Marsili, L., Berardelli, I., Moretti, G., Pasquini, M., Fabbrini, G., & Berardelli, A. (2011) · Movement Disorders · doi:10.1002/mds.23706 · Cited by 49 · see citing works
Harris, M. K., Shneyder, N., Borazanci, A., Korniychuk, E., Kelley, R. E., & Minagar, A. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2008.09.002 · Cited by 50 · see citing works
A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome
Dehning, S., Müller, N., Matz, J., Bender, A., Kerle, I. A., Benninghoff, J., Musil, R., Spellmann, I., Bondy, B., Möller, H., et al. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833511ce · Cited by 49 · see citing works
Microfabricated Probes for Studying Brain Chemistry: A Review
Ngernsutivorakul, T., White, T. S., & Kennedy, R. T. (2018) · ChemPhysChem · doi:10.1002/cphc.201701180 · Cited by 48 · see citing works
Grados, M. A., Huselid, R., & Duque, L. (2018) · Brain Sciences · doi:10.3390/brainsci8070129 · Cited by 49 · see citing works
Systematic review of co-occurring OCD and TD: Evidence for a tic-related OCD subtype?
Kloft, L., Steinel, T., & Kathmann, N. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.021 · Cited by 47 · see citing works
Modeling tics in rodents: Conceptual challenges and paths forward
Bortolato, M., & Pittenger, C. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.02.007 · Cited by 46 · see citing works
Autistic Spectrum Disorders as Functional Disconnection Syndrome
Melillo, R. J., & Leisman, G. (2009) · Reviews in the Neurosciences · doi:10.1515/revneuro.2009.20.2.111 · Cited by 45 · see citing works
In Vivo Evidence of Deep Brain Stimulation-Induced Dopaminergic Modulation in Tourette's Syndrome
Kuhn, J., Janouschek, H., Raptis, M., Rex, S., Lenartz, D., Neuner, I., Mottaghy, F. M., Schneider, F. W., Schaefer, W. M., Sturm, V., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.035 · Cited by 45 · see citing works
Lee, W., Huang, H.-L., Wong, L., Weng, W., Vasylenko, T., Jong, Y., Lin, W., & Ho, S. (2017) · SLEEP · doi:10.1093/sleep/zsw072 · Cited by 45 · see citing works
Hienert, M., Gryglewski, G., Stamenkovic, M., Kasper, S. F., & Lanzenberger, R. R. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0202-y · Cited by 43 · see citing works
Wang, S. (2012) · BioScience Trends · doi:10.5582/bst.2012.v6.4.212 · Cited by 44 · see citing works
Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene
Müller‐Vahl, K., Loeber, G., Kotsiari, A., Müller-Engling, L., & Frieling, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.11.004 · Cited by 44 · see citing works
Öz, M., Libby, T. A., Kivell, B. M., Jaligam, V., Ramamoorthy, S., & Shippenberg, T. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06828.x · Cited by 42 · see citing works
The Neurochemistry of Tourette Syndrome
Singer, H. S. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796267.003.0013 · Cited by 41 · see citing works
Self-citationA reusable neurotransmitter aptasensor for the sensitive detection of serotonin
Geng, X., Zhang, M., Long, H., Hu, Z., Zhao, B., Feng, L., & Du, J. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.11.010 · Cited by 41 · see citing works
Loss of Specificity in Basal Ganglia Related Movement Disorders
Bronfeld, M., & Bar‐Gad, I. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00038 · Cited by 39 · see citing works
Pittenger, C. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2016_127 · Cited by 37 · see citing works
Testini, P., Min, H.-K. P., Bashir, A., & Lee, K. H. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00193 · Cited by 38 · see citing works
Molecular imaging of autism spectrum disorder
Hwang, B. J., Mohamed, M. A., & Brašić, J. R. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1397606 · Cited by 37 · see citing works
Self-citationMotor Symptoms of Schizophrenia: Is Tardive Dyskinesia a Symptom or Side Effect? A Modern Treatment
Lerner, V., & Miodownik, C. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0202-6 · Cited by 36 · see citing works
A Review of the Current Treatment of Tourette Syndrome
Seideman, M. F., & Seideman, T. A. (2020) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-25.5.401 · Cited by 40 · see citing works
Nikolaus, S., Müller, H., & Hautzel, H. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0014 · Cited by 35 · see citing works
Nondopaminergic Neurotransmission in the Pathophysiology of Tourette Syndrome
Udvardi, P. T., Nespoli, E., Rizzo, F. R., Hengerer, B., & Ludolph, A. G. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00004-4 · Cited by 35 · see citing works
Nikolaus, S., Mamlins, E., Hautzel, H., & Müller, H.-W. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0037 · Cited by 35 · see citing works
The Potential of Cannabinoid-Based Treatments in Tourette Syndrome
Artukoglu, B. B., & Bloch, M. H. (2019) · CNS Drugs · doi:10.1007/s40263-019-00627-1 · Cited by 37 · see citing works
Li, H., Wang, Y., Zhao, C., Liu, J., Zhang, L., & Li, A. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001885 · Cited by 35 · see citing works
Cognitive impulsivity in Parkinson's disease patients: Assessment and pathophysiology
Robert, G., Drapier, D., Vérin, M., Millet, B., Azulay, J., & Blin, O. J. (2009) · Movement Disorders · doi:10.1002/mds.22836 · Cited by 35 · see citing works
Bortolato, M., Frau, R., Godar, S. C., Mosher, L. J., Paba, S., Marrosu, F., & Devoto, P. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12066 · Cited by 31 · see citing works
Neurobehavioral aspects, pathophysiology, and management of Tourette syndrome
Shprecher, D., Schrock, L. E., & Himle, M. B. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000119 · Cited by 30 · see citing works
Kreiss, D. S., & Deurwaerdère, P. D. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.05.007 · Cited by 28 · see citing works
Functional Imaging of Dopaminergic Neurotransmission in Tourette Syndrome
Segura, B., & Strafella, A. P. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00003-2 · Cited by 28 · see citing works
The Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome
Ferrão, Y. A., de Alvarenga, P. G., Hounie, A. G., de Mathis, M. A., do Rosário, M. C., & Miguel, E. C. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199796267.003.0003 · Cited by 28 · see citing works
Finasteride inhibited brain dopaminergic system and open‐field behaviors in adolescent male rats
Li, L., Kang, Y., Ji, X., Li, Y., Li, S., Zhang, X., Cui, H., & Shi, G. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12781 · Cited by 28 · see citing works
Update and recent progress in the neurobiology of Tourette syndrome
Szejko, N. (2022) · International review of movement disorders · doi:10.1016/bs.irmvd.2021.11.003 · Cited by 27 · see citing works
Replicating predictive serum correlates of greater translocator protein distribution volume in brain
Attwells, S., Setiawan, E., Wilson, A. A., Rusjan, P., Miler, L., Xu, C., Hutton, C., Husain, M. I., Kish, S. J., Vasdev, N., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0561-y · Cited by 27 · see citing works
Li, A., Li, J., Li, Z., Shu-zhen, W., Qi, F., Zhao, L., & Lv, H. (2010) · Neurology India · doi:10.4103/0028-3886.68663 · Cited by 27 · see citing works
Antipsychotic-Associated Symptoms of Tourette Syndrome: A Systematic Review
Kim, D. D., Barr, A. M., Chung, Y., Yuen, J. W. Y., Etminan, M., Carleton, B., White, R. F., Honer, W. G., & Procyshyn, R. M. (2018) · CNS Drugs · doi:10.1007/s40263-018-0559-8 · Cited by 27 · see citing works
Histaminergic modulation in Tourette syndrome
Cox, J. H., Seri, S., & Cavanna, A. E. (2015) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2016.1128819 · Cited by 26 · see citing works
Serotonin transporter binding is increased in Tourette syndrome with Obsessive Compulsive Disorder
Müller‐Vahl, K., Szejko, N., Wilke, F., Jakubovski, E., Geworski, L., Bengel, F. M., & Berding, G. (2019) · Scientific Reports · doi:10.1038/s41598-018-37710-4 · Cited by 26 · see citing works
Gastrodin - A potential drug used for the treatment of Tourette Syndrome
Wang, Y., Zhao, L., & Li, A. (2021) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2021.01.005 · Cited by 26 · see citing works
- Authors
- Wong, D. F., Brašić, J. R., Singer, H. S., Schretlen, D. J., Kuwabara, H., Zhou, Y., Nandi, A., Maris, M. A., Alexander, M., Ye, W., Rousset, O., Kumar, A., Szabo, Z., Gjedde, A., & Grace, A. A.
- Affiliations
- Johns Hopkins University (US)
- Aarhus University (DK)
- University of Pittsburgh (US)
- Corresponding author
- Wong, Dean F
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2007-11-07
- Volume
- 33
- Issue
- 6
- Pages
- 1239-1251
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3696501
- OpenAlex
- W1982522250
- Cited by
- 253
- References
- 75
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 9 · 2023: 6 · 2022: 20 · 2021: 12 · 2020: 16 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 11 · 2015: 20 · 2014: 18 · 2013: 21 · 2012: 12
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- National Institute on Alcohol Abuse and Alcoholism (R01AA12839, R01AA012839)
- National Institute of Mental Health (R01MH078175)
- National Institute on Drug Abuse (K24 DA00412, K24DA000412)
- National Institute of Neurological Disorders and Stroke (NS-38927, R01NS038927)
- UCB Pharma
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Tourette syndrome, obsessive-compulsive disorder, dopamine release, serotonin transporter, dopamine D2 receptor, 5-HT2A receptor, dopamine transporter, ventral striatum, phasic dopamine release, neurotransmitter metabolism, phonic tics, motor tics
- MeSH terms
- Adult, Amphetamine, Brain Mapping, Dopamine, Female, Tourette Syndrome, Humans, Magnetic Resonance Imaging, Male, Models, Theoretical, Synaptic Transmission, Neuropsychological Tests, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Serotonin, Dopamine Agents, Receptors, Dopamine D2, Raclopride, Positron-Emission Tomography, Dopamine Plasma Membrane Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
