CoChat
Sign Up
Cited by 88Pharmacological Effects and Toxicity StudiesGrowth Hormone and Insulin-like Growth FactorsPrenatal Substance Exposure Effects

Structural–functional relationships in experimentally induced brain damage

Open access
Patricia M. Rodier·1988·Progress in brain research
DOI 10.1016/s0079-6123(08)60514-2
Open this paper in CoChat — free account

Abstract

The purpose of this chapter is to introduce some of the themes of neuroteratology by tracing its historical connections to the study of somatic malformations. This is most easily done by discussing studies of general teratogens, that is, ones which affect all cells. Antimitotic agents are a classic example of teratogens with general effects. The availability of antisera to growth hormone, growth hormone releasing factor (GHRF) and somatostatin, the fact that the feedback loops of this system do not automatically adjust hormone levels to normal, and the fact that the target tissue includes most or all parts of the body. The pattern of growth in the absence of growth hormone is distinctive. In the mouse and rat, growthhormone-deficient animals begin to diverge from normal animals after about two weeks of postnatal life, as seen in mutants such as the dwarf mouse, which lacks somatotropes. One teratological syndrome that appears to exhibit this pattern of growth is fetal alcohol syndrome (FAS).

Integrity signals

Registry

Crossref · 10.1016/s0079-6123(08)60514-2

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Nicotine exposure in rats during the second postnatal week disrupted auditory cortex glutamate synapses, linked to long-term auditory processing and learning deficits.

    “Exposure of rats to nicotine in the second postnatal week, corresponding to the third trimester of human fetal brain development,(147) disrupted the development of glutamate synapses in the auditory cortex, which has been associated with long-term deficits in auditory processing and learning.”

    From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [147]

Cites

Flagged first, then by citations

1 of the 52 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Rodier, P. M.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Patricia M. Rodier
Venue
Progress in brain research
Publisher
Elsevier
Published
1988
Volume
73
Pages
335-348
ISSN
0079-6123 (ISSN-L)
DOI
10.1016/s0079-6123(08)60514-2
OpenAlex
W1842749771
Cited by
88
References
52
Citations by year
2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 2 · 2012: 1
FWCI
4.27
Type
book chapter
Language
en
Open access
Licence
Locations
  • Progress in brain research (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS 24287)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
teratogens, brain malformations, antimitotic agents, growth hormone deficiency, growth hormone-releasing hormone, somatostatin, somatotrophs, fetal alcohol syndrome, structural-functional correlation
MeSH terms
Animals, Mental Disorders, Brain, Embryonic and Fetal Development, Teratogens

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review