The role of vagal visceral afferents in the control of nociception
Abstract
We have shown that activity in subdiaphragmatic vagal afferents modulates mechanical hyperalgesic behavior in the rat. Subdiaphragmatic vagotomy decreases paw-withdrawal threshold to mechanical stimulation (baseline and after intradermal injection of bradykinin), thus enhancing mechanical hyperalgesic behavior. Most of this decrease is generated by an endocrine signal released by the adrenal medullae because denervation or removal of the adrenal medullae prevents or reverses these changes. This novel mechanism may imply that: (a) the brain is able to regulate sensitivity of nociceptors all over the body by a neuroendocrine mechanisms, (b) sensitivity of nociceptors can be influenced by changes in parts of the body which are remote from the location of the sensitized nociceptors and (c) circulating catecholamines can influence nociceptors in a way which is different from those reported so far (see Jänig and McLachlan, 1994; Jänig, 1996a; Jänig et al., 1996).
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The celiac branch of the vagus nerve innervates the small intestine.
“The celiac branch of the vagus nerve innervates the small intestine, and a prominent role of afferents of this branch in the modulation of experimental knee-joint inflammation and pain sensitivity has been reported.74”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [74]
A prominent role of afferents of the celiac branch of the vagus nerve in the modulation of experimental knee-joint inflammation and pain sensitivity has been reported.
“The celiac branch of the vagus nerve innervates the small intestine, and a prominent role of afferents of this branch in the modulation of experimental knee-joint inflammation and pain sensitivity has been reported.74”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [74]
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- Authors
- Jänig, W., Khasar, S. G., Miao, F. J.-P., & Levine, J. D.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- National Institutes of Health (US)
- Corresponding author
- Jänig, W.
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2000
- Volume
- 122
- Pages
- 273-287
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W2908175543
- Cited by
- 70
- References
- 61
- Citations by year
- 2024: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 2
- FWCI
- 17.65
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR32634)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- nociception, mechanical hyperalgesia, subdiaphragmatic vagotomy, bradykinin, adrenal medulla, catecholamines, neuroendocrine regulation, brain-gut interaction
- MeSH terms
- Animals, Brain, Neural Pathways, Pain, Vagus Nerve, Visceral Afferents
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