Chapter 1 Folate‐Mediated One‐Carbon Metabolism

The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth

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Posttranscriptional Regulation of Mammalian Methionine Synthase by B12

Gulati, S. L., Brody, L. C., & Banerjee, R. V. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0696 · Cited by 39

Structural Insights into the Avian AICAR Transformylase Mechanism

Wolan, D. W., Greasley, S. E., Beardsley, G. P., & Wilson, I. A. (2002) · Biochemistry · doi:10.1021/bi020505x · Cited by 39

Subcellular Distribution of some Folic Acid-Linked Enzymes in Rat Liver

Brown, S. S., Neal, G. E., & Williams, D. C. (1965) · Biochemical Journal · doi:10.1042/bj0970034c · Cited by 39

NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase: Detection of the mRNA in normal murine tissues and transcriptional regulation of the gene in cell lines

Peri, K. G., & MacKenzie, R. E. (1993) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(93)90066-m · Cited by 38

Stereochemistry and mechanism of hydrogen transfer between NADPH and methylenetetrahydrofolate in the reaction catalyzed by methylenetetrahydrofolate reductase from pig liver

Sumner, J. S., & Matthews, R. G. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00044a001 · Cited by 38

Introns are Essential for Growth-Regulated Expression of the Mouse Thymidylate Synthase Gene

Ash, J. D., Ke, Y., Korb, M., & Johnson, L. F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.3.1565 · Cited by 37

Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme

Cohen, L., & MacKenzie, R. E. (1978) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(78)90065-7 · Cited by 37

Identification of a novel single nucleotide polymorphism in the first tandem repeat sequence of the thymidylate synthase 2R allele

Lincz, L. F., Scorgie, F. E., Garg, M. B., & Ackland, S. P. (2007) · International Journal of Cancer · doi:10.1002/ijc.22568 · Cited by 37

Methenyltetrahydrofolate Cyclohydrolase Is Rate Limiting for the Enzymatic Conversion of 10-Formyltetrahydrofolate to 5,10-Methylenetetrahydrofolate in Bifunctional Dehydrogenase-Cyclohydrolase Enzymes

Pawelek, P. D., & MacKenzie, R. E. (1998) · Biochemistry · doi:10.1021/bi971906t · Cited by 36

Formation and utilization of formyl phosphate by N10-formyltetrahydrofolate synthetase: evidence for formyl phosphate as an intermediate in the reaction

Mejillano, M. R., Jahansouz, H., Matsunaga, T. O., Kenyon, G. L., & Himes, R. H. (1989) · Biochemistry · doi:10.1021/bi00438a034 · Cited by 36

A Ferritin-responsive Internal Ribosome Entry Site Regulates Folate Metabolism

Woeller, C. F., Fox, J. T., Perry, C. A., & Stover, P. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706264200 · Cited by 36

Splicing Signals Are Required for S-Phase Regulation of the Mouse Thymidylate Synthase Gene

Ke, Y., Ash, J. D., & Johnson, L. F. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.376 · Cited by 36

Human AICAR Transformylase: Role of the 4-Carboxamide of AICAR in Binding and Catalysis

Wall, M., Shim, J. H., & Benkovic, S. J. (2000) · Biochemistry · doi:10.1021/bi0007268 · Cited by 35

Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate

Tatum, C. M., Benkovic, P. A., Benkovic, S. J., Potts, R. C., Schleicher, E. D., & Floss, H. G. (1977) · Biochemistry · doi:10.1021/bi00625a010 · Cited by 35

Regulation of expression of the ADE3 gene for yeast C1-tetrahydrofolate synthase, a trifunctional enzyme involved in one-carbon metabolism.

Appling, D. R., & Rabinowitz, J. C. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)71236-6 · Cited by 35

Prognostic significance of folate metabolism polymorphisms for lung cancer

Matakidou, A., Galta, R. E., Rudd, M. F., Webb, E. L., Bridle, H. L., Eisen, T. G., & Houlston, R. S. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603830 · Cited by 33

Kinetic relationships between the various activities of the formyl-methenyl-methylenetetrahydrofolate synthetase

Folena-Wasserman, G., Benkovic, P. A., Young, M., & Benkovic, S. J. (1983) · Biochemistry · doi:10.1021/bi00274a002 · Cited by 33

Mammalian Mitochondrial Initiation Factor 2 Supports Yeast Mitochondrial Translation without Formylated Initiator tRNA

Tibbetts, A. S., Oesterlin, L. K., Chan, S. Y., Kramer, G., Hardesty, B., & Appling, D. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304962200 · Cited by 32

Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia

Okamura-Ikeda, K., Hosaka, H., Yoshimura, M., Yamashita, E., Toma, S., Nakagawa, A., Fujiwara, K., Motokawa, Y., & Taniguchi, H. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.06.056 · Cited by 32

Mammalian Glycinamide Ribonucleotide Transformylase

Caperelli, C. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83698-5 · Cited by 32

Cyclization of 5‐amino‐1‐β‐d‐ribofuranosylimidazole‐4‐carboxamide (AICA‐riboside): A review

Yamazaki, A., & Okutsu, M. (1978) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.5570150301 · Cited by 32

Synergistic Activation of the TATA-less Mouse Thymidylate Synthase Promoter by the Ets Transcription Factor GABP and Sp1

Rudge, T. L., & Johnson, L. F. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5451 · Cited by 31

Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells

Nakshatri, H., Bouillet, P., Bhat‐Nakshatri, P., & Chambon, P. (1996) · Gene · doi:10.1016/0378-1119(96)00391-5 · Cited by 30

Observations on the monovalent cation requirements of formyltetrahydrofolate synthetase

Welch, W. H., Irwin, C. L., & Himes, R. H. (1968) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(68)90443-9 · Cited by 30

The Two Monofunctional Domains of Octameric Formiminotransferase-Cyclodeaminase Exist as Dimers

Murley, L. L., & MacKenzie, R. E. (1995) · Biochemistry · doi:10.1021/bi00033a006 · Cited by 29

Metabolism of Formiminoglycine

Uyeda, K., & Rabinowitz, J. C. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97492-2 · Cited by 29

Translational regulation of human methionine synthase by upstream open reading frames

Çöl, B., Oltean, S., & Banerjee, R. V. (2007) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2007.06.003 · Cited by 28

MTR 2756 A > G polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population

Burzynski, M., Duriagin, S., Mostowska, M., Wudarski, M., Chwalinska-Sadowska, H., & Jagodziński, P. P. (2007) · Lupus · doi:10.1177/0961203307077988 · Cited by 28

Formyltetrahydrofolate Synthetase

Joyce, B. K., & Himes, R. H. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96403-3 · Cited by 28

Coordinate inhibition of DNA synthesis and thymidylate synthase activity following DNA damage and repair

Boorstein, R. J., & Pardee, A. B. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91536-x · Cited by 27

Lack of association between the C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene and venous thromboembolism in Northwestern Greece.

Zalavras, C. G., Giotopoulou, S., Dokou, E., Mitsis, M., Ioannou, H. V., Tzolou, A., Kolaitis, N. A., & Vartholomatos, G. (2002) · PubMed · Cited by 27

Studies on the mechanism of formyltetrahydrofolate synthetase. The Peptococcus aerogenes enzyme

McGuire, J. J., & Rabinowitz, J. C. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38113-9 · Cited by 26

TREATMENT OF TETANUS

Lassen, H. C. A., & Henriksen, E. (1956) · The Lancet · doi:10.1016/s0140-6736(56)91564-1 · Cited by 26

Folate Activation and Catalysis in Methylenetetrahydrofolate Reductase from Escherichia coli: Roles for Aspartate 120 and Glutamate 28

Trimmer, E. E., Ballou, D. P., Ludwig, M. L., & Matthews, R. G. (2001) · Biochemistry · doi:10.1021/bi002790v · Cited by 24

Regulation of mouse thymidylate synthaswe gene expression in growth-stimulsated cells: upstream S phase control elements are indistinguishable from the essential promoter elements

Ash, J. D., Liao, W., Ke, Y., & Johnson, L. F. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.22.4649 · Cited by 24

Inhibition of 5,10-methenyltetrahydrofolate synthetase

Field, M. S., Szebenyi, D. M. E., Perry, C. A., & Stover, P. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.12.023 · Cited by 22

Mechanism for the Coupling of ATP Hydrolysis to the Conversion of 5-Formyltetrahydrofolate to 5,10-Methenyltetrahydrofolate

Huang, T. H., & Schirch, V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22296 · Cited by 22

THE CONVERSION OF UROCANIC ACID TO FORMAMIDINOGLUTARIC ACID

Miller, A., & Waelsch, H. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70719-9 · Cited by 21

5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors

Szabados, E., Hindmarsh, E. J., Phillips, L., Duggleby, R. G., & Christopherson, R. I. (1994) · Biochemistry · doi:10.1021/bi00251a036 · Cited by 20

Mitochondrial Methionyl-tRNAfMet Formyltransferase from Saccharomyces cerevisiae: Gene Disruption and tRNA Substrate Specificity

Vial, L., Gomez, P., Panvert, M., Schmitt, E., Blanquet, S., & Méchulam, Y. (2003) · Biochemistry · doi:10.1021/bi026901x · Cited by 20

Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid

Erba, E., Sen, S., Sessa, C., Vikhanskaya, F., & D’Incalci, M. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.40 · Cited by 20

Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development

Howard, K. M., Muga, S. J., Zhang, L., Thigpen, A. E., & Appling, D. R. (2003) · Gene · doi:10.1016/s0378-1119(03)00796-0 · Cited by 18

Site-directed mutagenesis of a potential catalytic and formyl phosphate binding site and substrate inhibition of N10-formyltetrahydrofolate synthetase

Leaphart, A. B., Spencer, H. T., & Lovell, C. R. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00552-0 · Cited by 18

The effect of nitrous oxide-induced inactivation of vitamin B12 on the activity of formyl-methenyl-methylenetetrahydrofolate synthetase, methylene-tetrahydrofolate reductase and form iminotetrahydrofolate transferase

Perry, J. R., Deacon, R., Lumb, M. J., & Chanarin, I. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(80)80012-x · Cited by 18

Transcriptional regulation of murine NADP+‐dependent methylenetetrahydrofolate dehydrogenase‐cyclohydrolase‐synthetase

Peri, K. G., & MacKenzie, R. E. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81354-b · Cited by 17

Heteroallelic missense mutations of the galactosamine-6-sulfate sulfatase (GALNS) gene in a mild form of Morquio disease (MPS IVA)

Cole, D. E. C., Fukuda, S., Gordon, B. A., Rip, J. W., LeCouteur, A. N., Rupar, C. A., Tomatsu, S., Ogawa, T., Sukegawa, K., & Orii, T. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960628)63:4 · Cited by 17

Formyltetrahydrofolate synthetase-catalyzed formation of ATP from carbamyl phosphate and ADP. Evidence for a formyl phosphate intermediate in the enzyme's catalytic mechanism.

Buttlaire, D. H., Himes, R. H., & Reed, G. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33370-7 · Cited by 16

Tyrosine 146 of Thymidylate Synthase Assists Proton Abstraction from the 5-Position of 2‘-Deoxyuridine 5‘-Monophosphate

Liu, Y., Barrett, J. E., Schultz, P. G., & Santi, D. V. (1998) · Biochemistry · doi:10.1021/bi9822877 · Cited by 15

Nuclear Expression of Thymidylate Synthase in Colorectal Cancer Cell Lines and Clinical Samples

Bissoon-Haqqani, S., Moyana, T. N., Jonker, D. J., Maroun, J. A., & Birnboim, H. C. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6642.2005 · Cited by 15

Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-κB sensitivity

Pickell, L., Tran, P. V., Leclerc, D., Hiscott, J. B., & Rozen, R. R. (2005) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2005.09.002 · Cited by 14

Evaluation of the Catalytic Mechanism of AICAR Transformylase by pH-Dependent Kinetics, Mutagenesis, and Quantum Chemical Calculations

Shim, J. H., Wall, M., Benkovic, S. J., Díaz, N., Suárez, D., & Merz, K. M. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010014k · Cited by 14

Structural and functional characterization of a 5,10‐methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087)

Chen, S., Yakunin, A. F., Proudfoot, M., Kim, R., & Kim, S. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20591 · Cited by 13

Cytosolic biosynthesis of GTP and ATP in normal rat pancreatic islets

Meredith, M., Rabaglia, M. E., & Metz, S. A. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)00235-7 · Cited by 13

A Noncatalytic Tetrahydrofolate Tight Binding Site Is on the Small Domain of 10-Formyltetrahydrofolate Dehydrogenase

Fu, T.-F., Maras, B., Barra, D., & Schirch, V. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1262 · Cited by 12

Function of yeast cytoplasmic C1-tetrahydrofolate synthase.

Song, J. M., & Rabinowitz, J. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2636 · Cited by 12

Evidence of Folic Acid and Folate in the Prevention of Neural Tube Defects

Scott, J. M. (2001) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000059465 · Cited by 11

How does folic acid prevent neural tube defects?

Scott, J. M. (1998) · Nature Medicine · doi:10.1038/nm0898-895 · Cited by 11

Evidence that 5-Formyltetrahydropteroylglutamate has a Metabolic Role in One-Carbon Metabolism

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18Oxygen incorporation into inorganic phosphate in the reaction catalyzed byN5,10‐methenyltetrahydrofolate synthetase

Kounga, K., VanderVelde, D. G., & Himes, R. H. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00396-q · Cited by 8

A quantum chemical study of the water-assisted mechanism in one-carbon unit transfer reaction catalyzed by glycinamide ribonucleotide transformylase

Qiao, Q. A., Cai, Z. T., Feng, D. C., & Jiang, Y. (2004) · Biophysical Chemistry · doi:10.1016/j.bpc.2004.03.003 · Cited by 8

Nitrous oxide exposure reduces hepatic C1-tetrahydrofolate synthase expression in rats

Barlowe, C. K., & Appling, D. R. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80039-1 · Cited by 6

Solvent oxygen is not incorporated into N10‐formyltetrahydrofolate in the reaction catalyzed by N10‐formyltetrahydrofolate synthetase

Song, S., Jahansouz, H., & Himes, R. H. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80502-l · Cited by 4

Mitochondria are the powerhouses of immunity

Mills, E. L., Kelly, B., & O'Neill, L. A. J. (2017) · Nature Immunology · doi:10.1038/ni.3704 · Cited by 1,161

Biomarkers of Nutrition for Development—Folate Review

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Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

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ESPEN micronutrient guideline

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Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

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The association-dissociation of formyltetrahydrofolate synthetase and its relation to monovalent cation activation of catalytic activity

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One-Carbon Metabolism in Health and Disease

Ducker, G. S., & Rabinowitz, J. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.009 · Cited by 2,239

The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular Function

Xiu, Y., & Field, M. S. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa153 · Cited by 75

In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units.

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Compartmentation of folate‐mediated one‐carbon metabolism in eukaryotes

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