Chapter 1 Folate‐Mediated One‐Carbon Metabolism

Homocysteine and Cardiovascular Disease

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Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J., & Rozen, R. R. (1996) · Circulation · doi:10.1161/01.cir.93.1.7 · Cited by 1,380

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

Blount, B. C., Mack, M. M., Wehr, C. M., MacGregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B., & Ames, B. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3290 · Cited by 1,139

Folate and Carcinogenesis: An Integrated Scheme

Choi, S., & Mason, J. B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.129 · Cited by 954

MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease

Klerk, M., Verhoef, P., Clarke, R., Blom, H. J., Kok, F. J., & Schouten, E. G. (2002) · JAMA · doi:10.1001/jama.288.16.2023 · Cited by 932

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

van der Put, N. M. J., Trijbels, F. J. M., van den Heuvel, L. P., Blom, H. J., Steegers‐Theunissen, R. P. M., Eskes, T. K. A. B., Mariman, E. C. M., den Heyer, M., Frosst, P. D., & Rozen, R. R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91743-8 · Cited by 862

THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

Carreras, C. W., & Santi, D. V. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003445 · Cited by 789

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Ma, J., Stampfer, M. J., Giovannucci, E. L., Artigas, C., Hunter, D. J., Fuchs, C. S., Willett, W. C., Selhub, J., Hennekens, C. H., & Rozen, R. R. (1997) · PubMed · Cited by 774

DNA methylation: The nuts and bolts of repression

Miranda, T. B., & Jones, P. A. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21224 · Cited by 701

Mitochondria are the powerhouses of immunity

Mills, E. L., Kelly, B., & O'Neill, L. A. J. (2017) · Nature Immunology · doi:10.1038/ni.3704 · Cited by 1,161

Biomarkers of Nutrition for Development—Folate Review

Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., et al. (2015) · Journal of Nutrition · doi:10.3945/jn.114.206599 · Cited by 1,170

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

Tibbetts, A. S., & Appling, D. R. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104810 · Cited by 692

ESPEN micronutrient guideline

Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615

Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

Gonen, N., & Assaraf, Y. G. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.07.002 · Cited by 444

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.007 · Cited by 429

Mitochondrial translation requires folate-dependent tRNA methylation

Morscher, R. J., Ducker, G. S., Li, H., Mayer, J., Gitai, Z., Sperl, W., & Rabinowitz, J. D. (2018) · Nature · doi:10.1038/nature25460 · Cited by 281

One-Carbon Metabolism–Genome Interactions in Folate-Associated Pathologies ,

Stover, P. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.113670 · Cited by 276

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

Joubert, B. R., den Dekker, H. T., Felix, J. F., Bohlin, J., Ligthart, S., Beckett, E., Tiemeier, H. W., van Meurs, J. B. J., Uitterlinden, A. G., Albert Hofman, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10577 · Cited by 268

The many roles of glutamate in metabolism

Walker, M. C., & van der Donk, W. A. (2015) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-015-1665-y · Cited by 259

Betaine chemistry, roles, and potential use in liver disease

Day, C. R., & Kempson, S. A. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.02.001 · Cited by 233

The Intestinal Absorption of Folates

Visentin, M., Diop-Bove, N., Zhao, R., & Goldman, I. D. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153251 · Cited by 223

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

Anderson, D. D., & Stover, P. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005839 · Cited by 199

The epigenetics of autoimmunity

Meda, F., Folci, M., Baccarelli, A., & Selmi, C. F. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.78 · Cited by 198

Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

Anderson, D. D., Quintero, C. M., & Stover, P. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103623108 · Cited by 186

β-Lactoglobulin/Folic Acid Complexes: Formation, Characterization, and Biological Implication

Liang, L., & Subirade, M. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp101096r · Cited by 182

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

Shuvalov, O., Petukhov, A., Daks, A., Fedorova, O., Vasileva, E., & Barlev, N. A. (2017) · Oncotarget · doi:10.18632/oncotarget.15053 · Cited by 168

Molecular Basis of Alcohol-Related Gastric and Colon Cancer

Na, H., & Lee, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061116 · Cited by 160

Safety of folic acid

Field, M. S., & Stover, P. J. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13499 · Cited by 160

Folic acid‐induced animal model of kidney disease

Yan, L. (2021) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12194 · Cited by 144

Folic Acid and the Prevention of Birth Defects: 30 Years of Opportunity and Controversies

Crider, K. S., Qi, Y., Yeung, L. F., Mai, C. T., Zauche, L. H., Wang, A., Daniels, K., & Williams, J. L. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-043020-091647 · Cited by 161

Trafficking of Intracellular Folates

Stover, P. J., & Field, M. S. (2011) · Advances in Nutrition · doi:10.3945/an.111.000596 · Cited by 135

One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health

Kalhan, S. C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.006 · Cited by 137

Recent Developments in Folate Nutrition

Naderi, N., & House, J. D. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.12.006 · Cited by 131

Possible Roles for Folic Acid in the Regulation of Trophoblast Invasion and Placental Development in Normal Early Human Pregnancy1

Williams, P. J., Bulmer, J. N., Innes, B. A., & Pipkin, F. B. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.110.088351 · Cited by 127

Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid

Aparicio‐Trejo, O. E., Reyes-Fermín, L. M., Briones‐Herrera, A., Tapia, E., León‐Contreras, J. C., Hernández‐Pando, R., Sánchez‐Lozada, L. G., & Pedraza‐Chaverrí, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.005 · Cited by 125

Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

Anderson, D. D., Woeller, C. F., Chiang, E. I., Shane, B., & Stover, P. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333120 · Cited by 124

The complexity of the serine glycine one-carbon pathway in cancer

Reina‐Campos, M., Díaz-Meco, M. T., & Moscat, J. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201907022 · Cited by 125

Folate metabolic pathways in Leishmania

Vickers, T. J., & Beverley, S. M. (2011) · Essays in Biochemistry · doi:10.1042/bse0510063 · Cited by 122

Fluorescent probes for imaging formaldehyde in biological systems

Bruemmer, K. J., Brewer, T. F., & Chang, C. J. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.04.010 · Cited by 122

Copper- or manganese-doped ZnS quantum dots as fluorescent probes for detecting folic acid in aqueous media

Geszke-Moritz, M., Clavier, G. M., Lulek, J., & Schneider, R. (2011) · Journal of Luminescence · doi:10.1016/j.jlumin.2011.12.014 · Cited by 121

More than just a gut instinct–the potential interplay between a baby's nutrition, its gut microbiome, and the epigenome

Mischke, M., & Plösch, T. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00551.2012 · Cited by 120

Folates: Chemistry, analysis, occurrence, biofortification and bioavailability

Saini, R. K., Nile, S. H., & Keum, Y. (2016) · Food Research International · doi:10.1016/j.foodres.2016.07.013 · Cited by 123

ALDH1L2 Is the Mitochondrial Homolog of 10-Formyltetrahydrofolate Dehydrogenase

Krupenko, N. I., Dubard, M. E., Strickland, K. C., Moxley, K. M., Oleinik, N. V., & Krupenko, S. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.128843 · Cited by 114

Mechanisms of quantitative disease resistance in plants

French, E., Kim, B.-S., & Iyer‐Pascuzzi, A. S. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.05.015 · Cited by 113

Cell cycle regulation of folate‐mediated one‐carbon metabolism

Lan, X., Field, M. S., & Stover, P. J. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1426 · Cited by 113

Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host–microbiota interactions

Romoli, O., Schönbeck, J. C., Hapfelmeier, S., & Gendrin, M. (2021) · Nature Communications · doi:10.1038/s41467-021-21195-3 · Cited by 107

Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies

Stover, P. J. (2011) · Lifestyle Genomics · doi:10.1159/000334586 · Cited by 109

Emerging therapeutic targets for treatment of leishmaniasis

Sundar, S., & Singh, B. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1472241 · Cited by 109

The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

Zhao, H., French, J. B., Ye, F., & Benkovic, S. J. (2013) · Chemical Communications · doi:10.1039/c3cc41437j · Cited by 105

The metabolic basis for developmental disorders due to defective folate transport

Desai, A., Sequeira, J. M., & Quadros, E. V. (2016) · Biochimie · doi:10.1016/j.biochi.2016.02.012 · Cited by 98

Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?

Obeid, R., Holzgreve, W., & Pietrzik, K. F. (2013) · Journal of Perinatal Medicine · doi:10.1515/jpm-2012-0256 · Cited by 96

Methylenetetrahydrofolate Reductase: Biochemical Characterization and Medical Significance

Trimmer, E. E. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319140008 · Cited by 94

The toxic side of one-carbon metabolism and epigenetics

Morellato, A. E., Umansky, C., & Pontel, L. B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101850 · Cited by 95

Folic Acid Protects against Lipopolysaccharide-Induced Preterm Delivery and Intrauterine Growth Restriction through Its Anti-Inflammatory Effect in Mice

Zhao, M., Chen, Y., Dong, X.-T., Zhou, J. F., Chen, X., Wang, H., Wu, S., Xia, M., Zhang, C., & Xu, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082713 · Cited by 96

Relationship between Maternal Vitamin D Levels and Adverse Outcomes

Zhang, H., Wang, S., Tuo, L., Zhai, Q., Cui, J., Chen, D., & Xu, D. (2022) · Nutrients · doi:10.3390/nu14204230 · Cited by 90

Evidence for the Role of Mitochondrial DNA Release in the Inflammatory Response in Neurological Disorders

Moya, G. E., Rivera, P. D., & Dittenhafer‐Reed, K. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137030 · Cited by 90

Nuclear Folate Metabolism

Field, M. S., Kamynina, E., Chon, J., & Stover, P. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034441 · Cited by 85

Rice Intake and Emerging Concerns on Arsenic in Rice: a Review of the Human Evidence and Methodologic Challenges

Karagas, M. R., Punshon, T., Davis, M. M., Bulka, C. M., Slaughter, F. A., Karalis, D., Argos, M., & Ahsan, H. (2019) · Current Environmental Health Reports · doi:10.1007/s40572-019-00249-1 · Cited by 85

Folate metabolism in human malaria parasites—75 years on

Müller, I. B., & Hyde, J. E. (2013) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2013.02.008 · Cited by 82

Targeting nuclear thymidylate biosynthesis

Chon, J., Stover, P. J., & Field, M. S. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.005 · Cited by 83

Effect of in ovo feeding of folic acid on the folate metabolism, immune function and epigenetic modification of immune effector molecules of broiler

Li, S., LiHui, Z., Liu, Y., Shen, J., Liu, L., Yao, J., & Yang, X. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004511 · Cited by 86

PHGDH: a novel therapeutic target in cancer

Lee, C. M., Hwang, Y., Kim, M., Park, Y.-C., Kim, H., & Fang, S. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01268-1 · Cited by 88

Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer

Raz, S., Stark, M., & Assaraf, Y. G. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.06.004 · Cited by 80

ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A

Oleinik, N. V., Krupenko, N. I., & Krupenko, S. A. (2010) · Oncogene · doi:10.1038/onc.2010.356 · Cited by 80

Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protect de Novo Thymidylate Biosynthesis during Folate Deficiency

Field, M. S., Kamynina, E., Agunloye, O. C., Liebenthal, R. P., Lamarre, S. G., Brosnan, M. E., Brosnan, J. T., & Stover, P. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.599589 · Cited by 77

One-Carbon Metabolism, Spermatogenesis, and Male Infertility

Singh, K., & Jaiswal, D. (2012) · Reproductive Sciences · doi:10.1177/1933719112459232 · Cited by 76

Metabolic characterization of asthenozoospermia using nontargeted seminal plasma metabolomics

Zhang, X., Diao, R., Zhu, X., Li, Z., & Cai, Z. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.09.001 · Cited by 75

Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes

MacFarlane, A. J., Strom, A., & Scott, F. W. (2009) · Mammalian Genome · doi:10.1007/s00335-009-9213-6 · Cited by 78

Methionine synthase supports tumour tetrahydrofolate pools

Ghergurovich, J. M., Xu, X., Wang, J. Z., Yang, L., Ryseck, R.-P., Wang, L., & Rabinowitz, J. D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00465-w · Cited by 86

The clinical presentation of cobalamin‐related disorders: From acquired deficiencies to inborn errors of absorption and intracellular pathways

Huemer, M., & Baumgartner, M. R. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12012 · Cited by 75

Folate Stress Induces Apoptosis via p53-dependent de Novo Ceramide Synthesis and Up-regulation of Ceramide Synthase 6

Hoeferlin, L. A., Fekry, B., Öğretmen, B., Krupenko, S. A., & Krupenko, N. I. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.461798 · Cited by 72

Molecular mechanisms underlying the potentially adverse effects of folate

Strickland, K. C., Krupenko, N. I., & Krupenko, S. A. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0561 · Cited by 70

Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid

Aparicio‐Trejo, O. E., Avila-Rojas, S. H., Tapia, E., Rojas‐Morales, P., León‐Contreras, J. C., Martínez‐Klimova, E., Hernández‐Pando, R., Sánchez‐Lozada, L. G., & Pedraza‐Chaverrí, J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.016 · Cited by 70

Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential

Zhao, L. N., Björklund, M., Caldez, M. J., Zheng, J., & Kaldis, P. (2021) · Oncogene · doi:10.1038/s41388-021-01695-8 · Cited by 70

A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

Berardis, D. D., Orsolini, L., Serroni, N., Girinelli, G., Iasevoli, F., Tomasetti, C., de Bartolomeis, A., Mazza, M., Valchera, A., Fornaro, M., et al. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150821103825 · Cited by 74

Nanomaterials for sensing of formaldehyde in air: Principles, applications, and performance evaluation

Kukkar, D., Vellingiri, K., Kaur, R., Bhardwaj, S. K., Deep, A., & Kim, K. (2018) · Nano Research · doi:10.1007/s12274-018-2207-5 · Cited by 71

Mito-Nuclear Communication by Mitochondrial Metabolites and Its Regulation by B-Vitamins

Janssen, J. J. E., Grefte, S., Keijer, J., & de Boer, V. C. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00078 · Cited by 70

Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis

Field, M. S., Kamynina, E., Watkins, D., Rosenblatt, D. S., & Stover, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414555112 · Cited by 63

Is the Measurement of Serum Formate Concentration Useful in the Diagnostics of Acute Methanol Poisoning? A Prospective Study of 38 Patients

Zakharov, S., Kurcová, I., Navrátil, T., Šálek, T., Komarc, M., & Pelclová, D. (2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12338 · Cited by 63

Maximizing the Therapeutic Window of an Antimicrobial Drug by Imparting Mitochondrial Sequestration in Human Cells

Pereira, M. P., & Kelley, S. O. (2011) · Journal of the American Chemical Society · doi:10.1021/ja110246u · Cited by 63

ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer

Krupenko, S. A., & Krupenko, N. I. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-98788-0_10 · Cited by 63

One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

Corbin, J. M., & Ruiz-Echevarría, M. J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081208 · Cited by 67

Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer’s Disease

Troesch, B., Weber, P., & Mohajeri, M. H. (2016) · Nutrients · doi:10.3390/nu8120803 · Cited by 63

Development of chemically defined media supporting high cell density growth of Ketogulonicigenium vulgare and Bacillus megaterium

Zhang, J., Zhou, J., Liu, J., Chen, K., Liu, L., & Chen, J. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.10.124 · Cited by 61

Folate and folate receptor alpha antagonists mechanism of action in ovarian cancer

Walters, C. L., Arend, R. C., Armstrong, D. K., Naumann, R. W., & Alvarez, R. D. (2013) · Gynecologic Oncology · doi:10.1016/j.ygyno.2013.07.080 · Cited by 60

Brain structure, working memory and response inhibition in childhood leukemia survivors

van der Plas, E., Schachar, R. J., Hitzler, J., Crosbie, J., Guger, S. L., Spiegler, B. J., Ito, S., & Nieman, B. J. (2017) · Brain and Behavior · doi:10.1002/brb3.621 · Cited by 59

Subinhibitory Concentrations of Trimethoprim and Sulfamethoxazole Prevent Biofilm Formation by Acinetobacter baumannii through Inhibition of Csu Pilus Expression

Moon, K. H., Weber, B. S., & Feldman, M. F. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00778-17 · Cited by 59

Folate nutrition and blood–brain barrier dysfunction

Stover, P. J., Durga, J., & Field, M. S. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.01.006 · Cited by 59

Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin -Mediated Intestinal Cancer Risk

MacFarlane, A. J., Perry, C. A., McEntee, M. F., Lin, D. M., & Stover, P. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1886 · Cited by 57

Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population

Zinck, J. W. R., de Groh, M., & MacFarlane, A. J. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.107219 · Cited by 57

Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice

Beaudin, A. E., Abarinov, E. V., Malysheva, O., Perry, C. A., Caudill, M. A., & Stover, P. J. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.020305 · Cited by 54

Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment

Burda, P., Küster, A., Hjalmarson, O., Suormala, T., Bürer, C., Lutz, S., Roussey, G., Christa, L., Asin-Cayuela, J., Kollberg, G., et al. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9810-3 · Cited by 53

Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice

Swayne, B. G., Kawata, A., Behan, N. A., Williams, A., Wade, M. G., MacFarlane, A. J., & Yauk, C. L. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.07.002 · Cited by 56

Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression

Krupenko, S. A., & Krupenko, N. I. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.013 · Cited by 51

Differential proteomic analysis by SWATH-MS unravels the most dominant mechanisms underlying yeast adaptation to non-optimal temperatures under anaerobic conditions

Pinheiro, T., Lip, K. Y. F., García‐Ríos, E., Querol, A., Teixeira, J. A., van Gulik, W. M., Guillamón, J. M., & Domingues, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-77846-w · Cited by 50

Rho GTPases RhoA and Rac1 Mediate Effects of Dietary Folate on Metastatic Potential of A549 Cancer Cells through the Control of Cofilin Phosphorylation

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