The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice
Open accessAbstract
Mice lacking functional IL-7 or IL-7R alpha genes are severely deficient in developing thymocytes, T cells, and B cells. IL-7 and IL-7 receptor functions are believed to result in lymphoid cell proliferation and cell maturation, implying signal transduction pathways directly involved in mitogenesis and elaboration of developmentally specific new gene programs. Here, we show that enforced expression of the bcl-2 gene in T-lymphoid cells (by crossing in the Emu-bcl-2 transgene) in IL-7R alpha-deficient mice results in a significant restoration of thymic positive selection and T cell numbers and function. We propose cell survival signals to be the principal function of IL-7R engagement in thymic and T cell development.
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Cites
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Vaux, D. L., Cory, S., & Adams, J. M. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,219
Veis, D. J., Sorenson, C. M., Shutter, J. R., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80065-m · Cited by 1,628
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
Peschon, J. J., Morrissey, P. J., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B. C., Park, L. S., Ziegler, S. F., Williams, D. E., Ware, C. B., et al. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.5.1955 · Cited by 1,555
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.
von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E., & Murray, R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.4.1519 · Cited by 1,428
Self-citationMolecular thanatopsis: a discourse on the BCL2 family and cell death
Yang, E., & Korsmeyer, S. (1996) · Blood · doi:10.1182/blood.v88.2.386.bloodjournal882386 · Cited by 1,332
Noguchi, M. (1993) · Cell · doi:10.1016/0092-8674(93)90167-o · Cited by 1,320
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., & Korsmeyer, S. J. (1991) · Cell · doi:10.1016/0092-8674(91)90361-2 · Cited by 1,194
Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor
Noguchi, M., Nakamura, Y., Russell, S. M., Ziegler, S. F., Tsang, M., Cao, X., & Leonard, W. J. (1993) · Science · doi:10.1126/science.8266077 · Cited by 1,109
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
Strasser, A., Harris, A. W., & Cory, S. (1991) · Cell · doi:10.1016/0092-8674(91)90362-3 · Cited by 1,054
Cited by
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Self-citationIdentification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
Self-citationMetabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
IL-7 is critical for homeostatic proliferation and survival of naïve T cells
Tan, J. T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K. I., & Surh, C. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161126098 · Cited by 965
Self-citationRodig, S. J., Meraz, M. A., White, J. M., Lampe, P. A., Riley, J. K., Arthur, C. D., King, K. L., Sheehan, K. C. F., Yin, L., Pennica, D., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81166-6 · Cited by 853
Metadata
- Authors
- Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., & Weissman, I. L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 89
- Issue
- 7
- Pages
- 1033-1041
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2065388713
- Cited by
- 593
- References
- 68
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice. https://app.cochat.ai/papers/10.1016/s0092-8674(00)80291-3
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- Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., & Weissman, I. L. (1997). Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice. Cell. https://doi.org/10.1016/s0092-8674(00)80291-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
