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A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Open accessAbstract
A mouse gene, mper1, having all the properties expected of a circadian clock gene, was reported recently. This gene is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN). mper1 maintains this pattern of circadian expression in constant darkness and can be entrained to a new light/dark cycle. Here we report the isolation of a second mammalian gene, mper2, which also has these properties and greater homology to Drosophila period. Expression of mper1 and mper2 is overlapping but asynchronous by 4 hr. mper1, unlike period and mper2, is expressed rapidly after exposure to light at CT22. It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment.
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“Light exposure during the night phase shifts the clock transcription-translations cycle by rapidly inducing expression of Per1 or Per2, depending on whether the light occurs during the early or late night42–44.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [42]
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Metadata
- Authors
- Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Lee, Cheng Chi
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 91
- Issue
- 7
- Pages
- 1055-1064
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2151468131
- Cited by
- 879
- References
- 46
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 16 · 2021: 27 · 2020: 17 · 2019: 20 · 2018: 16 · 2017: 27 · 2016: 27 · 2015: 22 · 2014: 29 · 2013: 28 · 2012: 26
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- mPer1, mPer2, clock genes, light entrainment, suprachiasmatic nucleus, light response, circadian pacemaker
- MeSH terms
- Amino Acid Sequence, Animals, Circadian Rhythm, Light, Male, Mice, Inbred C57BL, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Gene Expression, DNA, Complementary, Cell Cycle Proteins, Mice, Period Circadian Proteins
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