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RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson Disease–Related Copper Transporter, Is Required for Ethylene Signaling in Arabidopsis
Open accessAbstract
Ethylene is an important regulator of plant growth. We identified an Arabidopsis mutant, responsive-to-antagonist1 (ran1), that shows ethylene phenotypes in response to treatment with trans-cyclooctene, a potent receptor antagonist. Genetic epistasis studies revealed an early requirement for RAN1 in the ethylene pathway. RAN1 was cloned and found to encode a protein with similarity to copper-transporting P-type ATPases, including the human Menkes/Wilson proteins and yeast Ccc2p. Expression of RAN1 complemented the defects of a ccc2delta mutant, demonstrating its function as a copper transporter. Transgenic CaMV 35S::RAN1 plants showed constitutive expression of ethylene responses, due to cosuppression of RAN1. These results provide an in planta demonstration that ethylene signaling requires copper and reveal that RAN1 acts by delivering copper to create functional hormone receptors.
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A permease-oxidase complex involved in high-affinity iron uptake in yeast.
Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D., & Dancis, A. (1996) · Science · doi:10.1126/science.271.5255.1552 · Cited by 683
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Molecular mechanisms of plant metal tolerance and homeostasis
Clemens, S. (2001) · Planta · doi:10.1007/s004250000458 · Cited by 1,417
EIN2, a Bifunctional Transducer of Ethylene and Stress Responses in Arabidopsis
Alonso, J. M., Hirayama, T., Roman, G., Nourizadeh, S., & Ecker, J. R. (1999) · Science · doi:10.1126/science.284.5423.2148 · Cited by 1,312
Self-citationA long way ahead: understanding and engineering plant metal accumulation
Clemens, S., Palmgren, M. G., & Krämer, U. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02295-1 · Cited by 1,265
Metallochaperones, an Intracellular Shuttle Service for Metal Ions
O'Halloran, T. V., & Culotta, V. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000006200 · Cited by 806
Iron Transport and Signaling in Plants
Curie, C., & Briat, J.-F. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.135018 · Cited by 570
Metadata
- Authors
- Hirayama, T., Kieber, J. J., Hirayama, N., Kogan, M., Guzman, P., Nourizadeh, S., Alonso, J. M., Dailey, W. P., Dancis, A., & Ecker, J. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 97
- Issue
- 3
- Pages
- 383-393
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2054708511
- Cited by
- 429
- References
- 1
- FWCI
- 24.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Hirayama, T., Kieber, J. J., Hirayama, N., Kogan, M., Guzman, P., Nourizadeh, S., Alonso, J. M., Dailey, W. P., Dancis, A., & Ecker, J. R. (1999). RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson Disease–Related Copper Transporter, Is Required for Ethylene Signaling in Arabidopsis. Cell. https://doi.org/10.1016/s0092-8674(00)80747-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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