Cited by 3,898Neurogenesis and neuroplasticity mechanismsCongenital heart defects researchDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

Open access

Doetsch, Fiona, Caillé, Isabelle, Lim, Daniel A., García-Verdugo, Jose Manuel, Alvarez-Buylla, Arturo·1999·Cell

DOI 10.1016/s0092-8674(00)80783-7

Open this paper in CoChat — free account Open PDF

Abstract

Neural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This germinal region, which continually generates new neurons destined for the olfactory bulb, is composed of four cell types: migrating neuroblasts, immature precursors, astrocytes, and ependymal cells. Here we show that SVZ astrocytes, and not ependymal cells, remain labeled with proliferation markers after long survivals in adult mice. After elimination of immature precursors and neuroblasts by an antimitotic treatment, SVZ astrocytes divide to generate immature precursors and neuroblasts. Furthermore, in untreated mice, SVZ astrocytes specifically infected with a retrovirus give rise to new neurons in the olfactory bulb. Finally, we show that SVZ astrocytes give rise to cells that grow into multipotent neurospheres in vitro. We conclude that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(00)80783-7

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System
Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331
A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
The Fine Structure of the Nervous System.
Tennyson, V. M. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480240094019 · Cited by 1,946
Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05046.1997 · Cited by 1,909
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875
Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
Luskin, M. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90281-u · Cited by 1,803
Untitled work
(1991) · Medical Entomology and Zoology · Cited by 1,512
Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
Altman, J. (1969) · The Journal of Comparative Neurology · doi:10.1002/cne.901370404 · Cited by 1,489

Show all 77 references

Sorted by citations

Items 501–600 of 1,026

In vivo neurogenesis in the adult brain: regulation and functional implications
Fuchs, E., & Gould, E. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00130.x · Cited by 215
The Role of Astrocytes and Complement System in Neural Plasticity
Pekny, M., Wilhelmsson, U., Bogestål, Y. R., & Pekna, M. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82005-8 · Cited by 180
IGF‐I stimulates neurogenesis in the hypothalamus of adult rats
Pérez‐Martín, M., Cifuentes, M., Grondona, J. M., López-Ávalos, M. D., Gómez‐Pinedo, U., García‐Verdugo, J. M., & Fernández‐Llebrez, P. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07220.x · Cited by 181
Astrocytes and Stroke: Networking for Survival?
Anderson, M. F., Blomstrand, F., Blomstrand, C., Eriksson, P. S., & Nilsson, M. (2003) · Neurochemical Research · doi:10.1023/a:1022385402197 · Cited by 173
Endothelial Cells Support Survival, Proliferation, and Neuronal Differentiation of Transplanted Adult Ischemia-Induced Neural Stem/Progenitor Cells After Cerebral Infarction
Nakagomi, N., Nakagomi, T., Kubo, S., Nakano‐Doi, A., Saino, O., Takata, M., Yoshikawa, H., Stern, D. M., Matsuyama, T., & Taguchi, A. (2009) · Stem Cells · doi:10.1002/stem.161 · Cited by 172
Entrapment of Migrating Hippocampal Neural Cells in Three-Dimensional Peptide Nanofiber Scaffold
Semino, C. E., Kasahara, J., Hayashi, Y., & Zhang, S. (2004) · Tissue Engineering · doi:10.1089/107632704323061997 · Cited by 173
Hippocampal plasticity during the progression of Alzheimer’s disease
Mufson, E. J., Mahady, L. J., Waters, D., Counts, S., Perez, S. E., DeKosky, S. T., Ginsberg, S. D., Ikonomović, M. D., Scheff, S. W., & Binder, L. I. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.006 · Cited by 184
GFAP‐expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes
Liu, X., Bolteus, A. J., Balkin, D. M., Henschel, O., & Bordey, A. (2006) · Glia · doi:10.1002/glia.20392 · Cited by 172
In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells
Li, H., & Chen, G. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.004 · Cited by 176
Adult neurogenesis in the mammalian dentate gyrus
Abbott, L. C., & Nigussie, F. (2019) · Anatomia Histologia Embryologia · doi:10.1111/ahe.12496 · Cited by 183
Neuronal replacement in adult brain
Nottebohm, F. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00750-5 · Cited by 172
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesisPreprint
Calvo, C.-F., Fontaine, R. H., Soueid, J., Tammela, T., Makinen, T., Alfaro-Cervello, C., Bonnaud, F., Miguez, A., Benhaim, L., Xu, Y., et al. (2011) · Genes & Development · doi:10.1101/gad.615311 · Cited by 175
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons
Balordi, F., & Fishell, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1040-07.2007 · Cited by 185
Roles of Eph receptors and ephrins in the normal and damaged adult CNS
Goldshmit, Y., McLenachan, S., & Turnley, A. M. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.006 · Cited by 171
Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer
Dirks, P. B. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.6792 · Cited by 170
De novo Induction of Genetically Engineered Brain Tumors in Mice Using Plasmid DNA
Wiesner, S. M., Decker, S. A., Larson, J. D., Ericson, K., Forster, C. L., Gallardo, J. L., Long, C., Demorest, Z. L., Zamora, E. A., Low, W. C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1800 · Cited by 170
Adenovirally Expressed Noggin and Brain-Derived Neurotrophic Factor Cooperate to Induce New Medium Spiny Neurons from Resident Progenitor Cells in the Adult Striatal Ventricular Zone
Chmielnicki, E., Benraiss, A., Economides, A. N., & Goldman, S. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1554-03.2004 · Cited by 171
NMDA and AMPA/Kainate Glutamate Receptors Modulate Dentate Neurogenesis and CA3 Synapsin-I in Normal and Ischemic Hippocampus
Bernabeu, R., & Sharp, F. R. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200012000-00006 · Cited by 171
OPHTHALMIC INVOLVEMENT IN THE FETAL ALCOHOL SYNDROME: CLINICAL AND ANIMAL MODEL STUDIES
Strömland, K. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.1.2 · Cited by 171
The Road We Travelled: Discovery, Choreography, and Significance of Brain Replaceable Neurons
Nottebohm, F. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1298.027 · Cited by 170
Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor
Lemkine, G. F., Raji, A., Alfama, G., Turque, N., Hassani, Z., Alegria-Prévot, O., Samarut, J., Levi, G., & DEMENEIX, B. A. (2005) · The FASEB Journal · doi:10.1096/fj.04-2916fje · Cited by 170
Neurospheres: Insights into neural stem cell biology
Campos, L. S. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20333 · Cited by 172
Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
del Pulgar, T. G., CEBALLOS, M. L. D., Guzmán, M., & Velasco, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205797200 · Cited by 173
Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor
González-Pérez, Ó., & Álvarez-Buylla, A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.01.001 · Cited by 176
Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model
Yoo, S., Kim, S., Lee, S., Lee, H.-S., Kim, H.-S., Lee, Y., & Suh‐Kim, H. (2008) · Experimental & Molecular Medicine · doi:10.3858/emm.2008.40.4.387 · Cited by 167
Gene expression in human neural stem cells: effects of leukemia inhibitory factor
Wright, L. S., Li, J., Caldwell, M. A., Wallace, K., Johnson, J. A., & Svendsen, C. N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01826.x · Cited by 168
From Neural Stem Cells to Myelinating Oligodendrocytes
Rogister, B., Ben‐Hur, T., & Dubois-Dalcq, M. E. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0790 · Cited by 168
Development of a flexible and specific gene delivery system for production of murine tumor models
Fisher, G. H., Oršulić, S., Holland, E. C., Hively, W. P., Li, Y., Lewis, B. C., Williams, B. O., & VARMUS, H. E. (1999) · Oncogene · doi:10.1038/sj.onc.1203087 · Cited by 165
Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration
Torella, D., Ellison, G. M., Méndez‐Ferrer, S., Ibáñez, B., & Nadal‐Ginard, B. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0409 · Cited by 167
Intrastriatal Transforming Growth Factor α Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons
Cooper, O., & Ole Isacson, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2344-04.2004 · Cited by 167
Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors
Consiglio, A., Gritti, A., Dolcetta, D., Follenzi, A., Bordignon, C., Gage, F. H., Vescovi, A. L., & Naldini, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404180101 · Cited by 172
GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches
Young, S. Z., & Bordey, A. (2009) · Physiology · doi:10.1152/physiol.00002.2009 · Cited by 169
Blood vessels form a migratory scaffold in the rostral migratory stream
Whitman, M. C., Fan, W., Rela, L., Rodriguez‐Gil, D. J., & Greer, C. A. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22093 · Cited by 181
Roles of the mammalian subventricular zone in brain development
Brazel, C. Y., Romanko, M. J., Rothstein, R. P., & Levison, S. W. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00002-9 · Cited by 171
Grafted Lineage-Restricted Precursors Differentiate Exclusively into Neurons in the Adult Spinal Cord
Han, S. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7995 · Cited by 165
Glycoprotein 130 Signaling RegulatesNotch1Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells
Chojnacki, A. K., Shimazaki, T., Gregg, C., Weinmaster, G., & Weiss, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01730.2003 · Cited by 164
Mosaic Removal of Hedgehog Signaling in the Adult SVZ Reveals That the Residual Wild-Type Stem Cells Have a Limited Capacity for Self-Renewal
Balordi, F., & Fishell, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4531-07.2007 · Cited by 165
Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia
Jurisch‐Yaksi, N., Yaksi, E., & Kızıl, Ç. (2020) · Glia · doi:10.1002/glia.23849 · Cited by 174
Expression of the ecto‐ATPase NTPDase2 in the germinal zones of the developing and adult rat brain
Braun, N., Sévigny, J., Mishra, S. K., Robson, S. C., Barth, S., Gerstberger, R., Hammer, K., & Zimmermann, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02567.x · Cited by 165
Distinct Populations of Forebrain Neural Stem and Progenitor Cells Can Be Isolated Using Side-Population Analysis
Kim, M. K., & Morshead, C. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10703.2003 · Cited by 165
The effect of neurodegenerative diseases on the subventricular zone
Curtis, M. A., Faull, R. L. M., & Eriksson, P. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2216 · Cited by 165
p75 Neurotrophin Receptor Expression Defines a Population of BDNF-Responsive Neurogenic Precursor Cells
Young, K. M., Merson, T. D., Sotthibundhu, A., Coulson, E. J., & Bartlett, P. F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0654-07.2007 · Cited by 163
Oligodendrocyte and astrocyte development in rodents: An in situ and immunohistological analysis during embryonic development
Liu, Y., Wu, Y., Lee, J. C., Xue, H., Pevny, L., Kaprielian, Z., & Rao, M. S. (2002) · Glia · doi:10.1002/glia.10111 · Cited by 169
Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain
Fasano, C. A., Phoenix, T. N., Kokovay, E., Lowry, N., Elkabetz, Y., Dimos, J. T., Lemischka, I. R., Studer, L., & Temple, S. (2009) · Genes & Development · doi:10.1101/gad.1743709 · Cited by 146
Toward modeling the bone marrow niche using scaffold-based 3D culture systems
Maggio, N. D., Piccinini, E., Jaworski, M., Trumpp, A., Wendt, D. J., & Martín, I. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.041 · Cited by 166
Coxsackievirus B3 and the Neonatal CNS
Feuer, R., Mena, I., Pagarigan, R. R., Harkins, S., Hassett, D. E., & Whitton, J. L. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63496-7 · Cited by 163
Neurogenesis in Alzheimer’s disease
Rodriguez, J. J., & Verkhratsky, A. (2011) · Journal of Anatomy · doi:10.1111/j.1469-7580.2011.01343.x · Cited by 174
Alexander Disease-Associated Glial Fibrillary Acidic Protein Mutations in Mice Induce Rosenthal Fiber Formation and a White Matter Stress Response
Hagemann, T. L., Connor, J. X., & Messing, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3260-06.2006 · Cited by 167
Chain formation and glial tube assembly in the shift from neonatal to adult subventricular zone of the rodent forebrain
Peretto, P., Giachino, C., Aimar, P., Fasolo, A., & Bonfanti, L. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20576 · Cited by 162
Repairing brain after stroke: A review on post-ischemic neurogenesis
WILTROUT, C., Lang, B. T., Yan, Y., Dempsey, R. J., & Vemuganti, R. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.011 · Cited by 164
Cell of origin of glioma: biological and clinical implications
Llaguno, S. R. A., & Parada, L. F. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.354 · Cited by 176
Polydendrocytes: NG2 Cells with Many Roles in Development and Repair of the CNS
Nishiyama, A. (2007) · The Neuroscientist · doi:10.1177/1073858406295586 · Cited by 166
Emerging roles for TGF‐β1 in nervous system development
Gomes, F. C. A., Sousa, V. D. O., & Romão, L. F. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.04.001 · Cited by 161
Dorsal Radial Glia Generate Olfactory Bulb Interneurons in the Postnatal Murine Brain
Ventura, R. E., & Goldman, J. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0399-07.2007 · Cited by 161
Defining glial cells during CNS development
Zhang, S. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097593 · Cited by 161
Neural Stem Cells: Historical Perspective and Future Prospects
Breunig, J. J., Haydar, T. F., & RAKIC, P. T. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.005 · Cited by 167
Scaffolds for 3D in vitro culture of neural lineage cells
Murphy, A. R., Laslett, A. L., O’Brien, C., & Cameron, N. R. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.02.046 · Cited by 160
A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma
Barnes, J. M., Kaushik, S., Bainer, R. O., Sa, J. K., Woods, E. C., Kai, F., Przybyla, L., Lee, M., Lee, H. W., Tung, J. C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0183-3 · Cited by 169
Suicide neurobiology
Ernst, C., Mechawar, N., & Turecki, G. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.09.001 · Cited by 166
Human Cytomegalovirus Inhibits Neuronal Differentiation and Induces Apoptosis in Human Neural Precursor Cells
Odeberg, J., Wolmer‐Solberg, N., Falci, S. P., Westgren, M., Seiger, Å., & Söderberg‐Nauclér, C. (2006) · Journal of Virology · doi:10.1128/jvi.00676-06 · Cited by 160
Neurogenesis and Neuronal Regeneration in the Adult Reptilian Brain
Font, E., Desfilis, E., Pérez-Cañellas, M., & García‐Verdugo, J. M. (2001) · Brain Behavior and Evolution · doi:10.1159/000057570 · Cited by 160
Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain
Englund, U., Björklund, A., & Wictorin, K. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00330-3 · Cited by 160
Increased Proliferation of Neural Progenitor Cells but Reduced Survival of Newborn Cells in the Contralateral Hippocampus after Focal Cerebral Ischemia in Rats
高沢健一郎, Kitagawa, K., Yagita, Y., Sasaki, T., Tanaka, S., Matsushita, K., Ohstuki, T., Miyata, T., Okano, H., Hori, M., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200203000-00007 · Cited by 159
The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain
Mudò, G., Bonomo, A., Di Liberto, V., Frinchi, M., Fuxe, K., & Belluardo, N. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0207-z · Cited by 158
Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton
Roelofs, R. F., Fischer, D. F., Houtman, S. H., Sluijs, J. A., Haren, W. V., van Leeuwen, F. W., & Hol, E. M. (2005) · Glia · doi:10.1002/glia.20243 · Cited by 158
Endogenous and exogenous ciliary neurotrophic factor enhances forebrain neurogenesis in adult mice
Emsley, J. G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00129-8 · Cited by 167
Endogenous Neurogenesis in the Human Brain following Cerebral Infarction
Minger, S. L., Ekonomou, A., Carta, E., Chinoy, A., Perry, R. H., & Ballard, C. G. (2006) · Regenerative Medicine · doi:10.2217/17460751.2.1.69 · Cited by 158
Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury
Wang, Y., Cooke, M. J., Morshead, C. M., & Shoichet, M. S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.031 · Cited by 156
Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy
Zhang, R. L., Zhang, Z. G., & Chopp, M. (2005) · The Neuroscientist · doi:10.1177/1073858405278865 · Cited by 160
Neurogenic Radial Glial Cells in Reptile, Rodent and Human: from Mitosis to Migration
Weissman, T. A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.550 · Cited by 158
1,25-Dihydroxyvitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation
Shirazi, H. A., Rasouli, J., Ćirić, B., Rostami, A. M., & Zhang, G. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.02.004 · Cited by 164
LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1
Capela, A., & Temple, S. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.12.030 · Cited by 160
Adult Neurogenesis and Neuronal Regeneration in the Central Nervous System of Teleost Fish
Zupanc, G. K. H. (2001) · Brain Behavior and Evolution · doi:10.1159/000057569 · Cited by 157
The translational biology of remyelination: past, present, and future
Franklin, R. J. M., & Gallo, V. (2014) · Glia · doi:10.1002/glia.22622 · Cited by 162
Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis
Maekawa, M., Takashima, N., Arai, Y., Nomura, T., Inokuchi, K., Yuasa, S., & Osumi, N. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00893.x · Cited by 163
Cells in the astroglial lineage are neural stem cells
Ihrie, R. A., & Álvarez-Buylla, A. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0461-z · Cited by 157
Glutamate enhances survival and proliferation of neural progenitors derived from the subventricular zone
Brazel, C. Y., Nuñez, J. L., Yang, Z., & Levison, S. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.038 · Cited by 156
TGF-β family signaling in stem cells
Sakaki‐Yumoto, M., Katsuno, Y., & Derynck, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.008 · Cited by 163
Comparative aspects of adult neural stem cell activity in vertebrates
Grandel, H., & Brand, M. (2012) · Development Genes and Evolution · doi:10.1007/s00427-012-0425-5 · Cited by 166
Genetic ablation and restoration of the olfactory topographic map.
Gogos, J., Osborne, J., Nemes, A., Mendelsohn, M., & Axel, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00164-1 · Cited by 147
Ischemic stroke and neurogenesis in the subventricular zone
Zhang, R. L., Zhang, Z. G., & Chopp, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.027 · Cited by 166
Cajal's contributions to glia research
García‐Marín, V., García-López, P., & Freire, M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.008 · Cited by 175
Adult neurogenesis in Parkinson’s disease
Marxreiter, F., Regensburger, M., & Winkler, J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1062-x · Cited by 162
Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch‐DSL signaling system during brain development
Irvin, D. K., Zurcher, S. D., Nguyen, T., Weinmaster, G., & Kornblum, H. I. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1059 · Cited by 155
Prolactin Prevents Chronic Stress-Induced Decrease of Adult Hippocampal Neurogenesis and Promotes Neuronal Fate
Torner, L., Karg, S., Blume, A., Kandasamy, M., Kuhn, H. G., Winkler, J., Aigner, L., & Neumann, I. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3178-08.2009 · Cited by 157
Endogenous neural stem cell responses to stroke and spinal cord injury
Grégoire, C., Goldenstein, B., Floriddia, E. M., Barnabé‐Heider, F., & Fernandes, K. J. L. (2015) · Glia · doi:10.1002/glia.22851 · Cited by 156
Asymmetric cell division of stem and progenitor cells during homeostasis and cancer
Gómez‐López, S., Lerner, R. G., & Petritsch, C. K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1386-1 · Cited by 159
Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood
Bouab, M., Paliouras, G. N., Aumont, A., Forest-Bérard, K., & Fernandes, K. J. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.032 · Cited by 153
Brain aromatase: New lessons from non-mammalian model systems
Forlano, P. M., Schlinger, B. A., & Bass, A. H. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.05.002 · Cited by 151
Characterization of the subventricular zone of the adult human brain: evidence for the involvement of Bcl-2
Bernier, P. J., Vinet, J., Cossette, M., & Parent, A. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00102-4 · Cited by 153
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells
Sakaguchi, M., Shingo, T., Shimazaki, T., Okano, H. J., Shiwa, M., Ishibashi, S., Oguro, H., Ninomiya, M., Kadoya, T., Horie, H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508793103 · Cited by 153
Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex
Suzuki, M., Wright, L. S., Marwah, P., Lardy, H. A., & Svendsen, C. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307325101 · Cited by 152
Autocrine/Paracrine Activation of the GABAAReceptor Inhibits the Proliferation of Neurogenic Polysialylated Neural Cell Adhesion Molecule-Positive (PSA-NCAM+) Precursor Cells from Postnatal Striatum
Nguyen, L., Malgrange, B., Breuskin, I., Bettendorff, L., Moonen, G., Belachew, S. M., & Rigo, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03278.2003 · Cited by 152
The neural stem cell niche
Conover, J. C., & Notti, R. Q. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0503-6 · Cited by 158
Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease
Cova, L., Armentero, M., Zennaro, E., Calzarossa, C., Bossolasco, P., Busca, G. A., Deliliers, G. L., Polli, E. E., Nappi, G., Silani, V., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.041 · Cited by 152
Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
Jha, M. K., Kim, J.-H., Song, G. J., Lee, W., Lee, I. K., Lee, H., An, S. S. A., Kim, S., & Suk, K. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.12.003 · Cited by 156
Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
Ferrón, S., Mira, H., Franco, S., Cano-Jaimez, M., Bellmunt, E., Ramírez, C., Fariñas, I., & Blasco, M. A. (2004) · Development · doi:10.1242/dev.01215 · Cited by 152
The Chromatin Remodeler CHD7 Regulates Adult Neurogenesis via Activation of SoxC Transcription Factors
Feng, W., Khan, M. A., Bellvís, P., Zhu, Z., Bernhardt, O., Herold‐Mende, C. C., & Liu, H. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.002 · Cited by 154
The human subventricular zone: A source of new cells and a potential source of brain tumors
Quiñones‐Hinojosa, A., & Chaichana, K. L. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.016 · Cited by 149
Axonal Control of the Adult Neural Stem Cell Niche
Tong, C. K., Chen, J., Cebrián‐Silla, A., Mirzadeh, Z., Obernier, K., Guinto, C. D., Tecott, L. H., García‐Verdugo, J. M., Kriegstein, A. R., & Álvarez-Buylla, A. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.014 · Cited by 148

Authors: Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A.
Affiliations: Rockefeller University (US)
ORCID: Doetsch, Fiona
Caillé, Isabelle
Lim, Daniel A.
Venue: Cell
Publisher: Elsevier BV
Published: 1999-06
Volume: 97
Issue: 6
Pages: 703-716
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)80783-7
OpenAlex: W2165867905
Cited by: 3,898
References: 77
Citations by year: 2026: 31 · 2025: 71 · 2024: 54 · 2023: 79 · 2022: 94 · 2021: 110 · 2020: 105 · 2019: 113 · 2018: 110 · 2017: 134 · 2016: 135 · 2015: 177 · 2014: 154 · 2013: 180 · 2012: 243
FWCI: 26.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5160 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 07739, T32GM007739)
National Institute of Neurological Disorders and Stroke (NS-28478)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: subventricular zone, astrocytes, neural stem cells, adult neurogenesis, olfactory bulb, neuroblast migration, ependymal cells, retroviral labeling, neurospheres, stem cell self-renewal
MeSH terms: Animals, Astrocytes, Brain, Cerebral Ventricles, Chick Embryo, Glial Fibrillary Acidic Protein, Male, Olfactory Bulb, Regeneration, Stem Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks