The translational biology of remyelination: past, present, and future
Abstract
Amongst neurological diseases, multiple sclerosis (MS) presents an attractive target for regenerative medicine. This is because the primary pathology, the loss of myelin‐forming oligodendrocytes, can be followed by a spontaneous and efficient regenerative process called remyelination. While cell transplantation approaches have been explored as a means of replacing lost oligodendrocytes, more recently therapeutic approaches that target the endogenous regenerative process have been favored. This is in large part due to our increasing understanding of (1) the cell types within the adult brain that are able to generate new oligodendrocytes, (2) the mechanisms and pathways by which this achieved, and (3) an emerging awareness of the reasons why remyelination efficiency eventually fails. Here we review some of these advances and also highlight areas where questions remain to be answered in both the biology and translational potential of this important regenerative process. GLIA 2014;62:1905–1915
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Functional recovery in MS patients will likely hinge on therapies that promote myelin regeneration.
“Functional recovery in MS patients will likely hinge on the therapies that promote myelin regeneration (Deshmukh et al., 2013; Franklin and Gallo, 2014).”
From miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS (2017) · cites this paper as Franklin and Gallo, 2014
A failure in myelin repair after oligodendrocyte damage contributes to persistence of demyelination in multiple sclerosis and leukodystrophies.
“A failure in myelin repair after OL damage contributes to persistence of demyelination in debilitating diseases such as multiple sclerosis (MS) and leukodystrophies (Franklin and Gallo, 2014).”
From miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS (2017) · cites this paper as Franklin and Gallo, 2014
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Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
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“…MS research is directed towards the development of individual MS therapies and the establishment of new regenerative agents that support repair mechanisms (Lucchinetti et al., 1997; Stangel and Hartung, 2002; Huang et al., 2011; Zhang et al., 2011; Hagemeier et al., 2012; Franklin and Gallo, 2014).”
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miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS
Wang, H., Moyano, A. L., Ma, Z., Deng, Y., Lin, Y., Zhao, C., Zhang, L., Jiang, M., He, X., Ma, Z., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.03.001 · Cited by 174 · see citing works
- Authors
- Franklin, R. J. M., & Gallo, V.
- Affiliations
- Wellcome Trust‐MRC Cambridge Stem Cell Institute and Department of Veterinary Medicine University of Cambridge Cambridge CB3 0ES United Kingdom
- Center for Neuroscience Research, Children's National Medical Center Washington DC
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2014-01-20
- Volume
- 62
- Issue
- 11
- Pages
- 1905-1915
- ISSN
- 0894-1491
- 1098-1136
- Cited by
- 153
- References
- 16
- Language
- en
- Funders
- NIH (R01NS045702, R01NS056427)
- National Multiple Sclerosis Society (RG 4019)
- UK Multiple Sclerosis Society
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