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Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Open accessAbstract
Neural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This germinal region, which continually generates new neurons destined for the olfactory bulb, is composed of four cell types: migrating neuroblasts, immature precursors, astrocytes, and ependymal cells. Here we show that SVZ astrocytes, and not ependymal cells, remain labeled with proliferation markers after long survivals in adult mice. After elimination of immature precursors and neuroblasts by an antimitotic treatment, SVZ astrocytes divide to generate immature precursors and neuroblasts. Furthermore, in untreated mice, SVZ astrocytes specifically infected with a retrovirus give rise to new neurons in the olfactory bulb. Finally, we show that SVZ astrocytes give rise to cells that grow into multipotent neurospheres in vitro. We conclude that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain.
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“Radial glial cells, stem cell precursors, and astrocytes - all reported to express GFAP (reviewed in ref.26) - are found in the dentate gyrus2,27,28.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [28]
In the citing paper
“After this period of symmetric divisions, these progenitor cells — also known as radial glia — divide asymmetrically, generating postmitotic excitatory neurons that will migrate to their final location in the cerebral cortex by using the basal process of the radial glial cell as a scaffold55–58.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [58]
In the citing paper
“Adult V-SVZ NSCs are radial cells with many hallmarks of astrocytes (Doetsch et al., 1999).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Doetsch et al., 1999
In the citing paper
“Upon activation, they give rise to transit amplifying cells (TACs), which in turn generate neuroblasts (NBs) that migrate to the olfactory bulb (Doetsch et al., 1999).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Doetsch et al., 1999
Citations
Cites
Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
The Fine Structure of the Nervous System.
Tennyson, V. M. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480240094019 · Cited by 1,946
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05046.1997 · Cited by 1,909
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875
Luskin, M. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90281-u · Cited by 1,803
(1991) · Medical Entomology and Zoology · Cited by 1,512
Altman, J. (1969) · The Journal of Comparative Neurology · doi:10.1002/cne.901370404 · Cited by 1,489
Cited by
Sorted by citations
Items 101–200 of 1,026
Schüller, U., Heine, V., Mao, J., Kho, A., Dillon, A. K., Han, Y.-G., Huillard, E., Sun, T., Ligon, A., Qian, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.005 · Cited by 656
Purification of a pluripotent neural stem cell from the adult mouse brain
Rietze, R. L., Valcanis, H., Brooker, G. J. F., Thomas, T., Voss, A. K., & Bartlett, P. F. (2001) · Nature · doi:10.1038/35089085 · Cited by 665
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
Ferri, L., Cavallaro, M., Braida, D., Cristofano, A. D., Canta, A., Vezzani, A., Ottolenghi, S., Pandolfi, P. P., Sala, M., Debiasi, S., et al. (2004) · Development · doi:10.1242/dev.01204 · Cited by 688
Regeneration of a germinal layer in the adult mammalian brain
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11619 · Cited by 662
hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo
Zhuo, L., Theis, M., Álvarez-Maya, I., Brenner, M., Willecke, K., & Messing, A. (2001) · genesis · doi:10.1002/gene.10008 · Cited by 661
Nunes, M. C., Roy, N. S., Keyoung, H. M., Goodman, R. R., McKhann, G. M., Jiang, L., Kang, J., Nedergaard, M., & Goldman, S. A. (2003) · Nature Medicine · doi:10.1038/nm837 · Cited by 659
Epidermal growth factor receptor and Ink4a/Arf
Bachoo, R. M., Maher, E. A., Ligon, K. L., Sharpless, N. E., Chan, S., You, M. J., Tang, Y., DeFrances, J., Stover, E. H., Weissleder, R., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00046-6 · Cited by 659
Taupin, P. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.08.002 · Cited by 645
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells
Lehtinen, M. K., Zappaterra, M. W., Chen, X., Yang, Y. J., Hill, A. D., Lun, M., Maynard, T., Gonzalez, D., Kim, S., Ye, P., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.023 · Cited by 648
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634
Heterogeneity of astrocytic form and function.
Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638
Neural induction, the default model and embryonic stem cells
Muñoz-Sanjuán, I., & Brivanlou, A. H. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn786 · Cited by 645
Functional significance of adult neurogenesis
Kempermann, G., Wiskott, L., & Gage, F. H. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.001 · Cited by 646
The glial identity of neural stem cells
Doetsch, F. (2003) · Nature Neuroscience · doi:10.1038/nn1144 · Cited by 724
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus
Seri, B., García‐Verdugo, J. M., Collado-Morente, L., McEwen, B. S., & Álvarez-Buylla, A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20288 · Cited by 650
Noctor, S. C., Flint, A. C., Weissman, T. A., Wong, W. S., Clinton, B. K., & Kriegstein, A. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03161.2002 · Cited by 647
Nestin expression ? a property of multi-lineage progenitor cells?
Wiese, C., Rolletschek, A., Kania, G., Błyszczuk, P., Tarasov, K. V., Tarasova, Y. S., Wersto, R. P., Boheler, K. R., & Wobus, A. M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4144-6 · Cited by 616
A niche for adult neural stem cells
Doetsch, F. K. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.08.012 · Cited by 641
Neuronal fate determinants of adult olfactory bulb neurogenesis
Hack, M., Saghatelyan, A., de Chevigny, A., Pfeifer, A., Ashery-Padan, R., Lledo, P., & Götz, M. (2005) · Nature Neuroscience · doi:10.1038/nn1479 · Cited by 648
Emerging roles of Wnts in the adult nervous system
Inestrosa, N. C., & Arenas, E. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2755 · Cited by 622
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
Palma, V., Lim, D. A., Dahmane, N., Sánchez‐Gómez, P., Brionne, T. C., Herzberg, C. D., Gitton, Y., Carleton, A., Álvarez-Buylla, A., & Altaba, A. R. I. (2004) · Development · doi:10.1242/dev.01567 · Cited by 610
The Role of Notch in Promoting Glial and Neural Stem Cell Fates
Gaiano, N., & Fishell, G. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.030702.130823 · Cited by 598
Vallières, L., Campbell, I. L., Gage, F. H., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00486.2002 · Cited by 608
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 610
Evidence for neurogenesis in the adult mammalian substantia nigra
Zhao, M., Momma, S., Delfani, K., Carlén, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisén, J., & Janson, A. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1131955100 · Cited by 605
SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells.
Kim, J., Lo, L., Dormand, E., & Anderson, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00163-6 · Cited by 584
Grandel, H., Kaslin, J., Ganz, J., Wenzel, I., & Brand, M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.03.040 · Cited by 598
Müller glia are a potential source of neural regeneration in the postnatal chicken retina
Fischer, A. J., & Reh, T. A. (2001) · Nature Neuroscience · doi:10.1038/85090 · Cited by 579
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578
Neural Stem Cells: Generating and Regenerating the Brain
Gage, F. H., & Temple, S. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.037 · Cited by 595
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
Self-citationVertical silicon nanowires as a universal platform for delivering biomolecules into living cells
Shalek, A. K., Robinson, J. T., Karp, E. S., Lee, J. S., Ahn, D., Yoon, M., Sutton, A., Jorgolli, M., Gertner, R. S., Gujral, T. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909350107 · Cited by 563
In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus
Roy, N. S., Wang, S., Jiang, L., Kang, J., Benraiss, A., Harrison‐Restelli, C., Fraser, R. A. R., Couldwell, W. T., Kawaguchi, A., Okano, H., et al. (2000) · Nature Medicine · doi:10.1038/73119 · Cited by 559
Quiñones‐Hinojosa, A., Sanai, N., Soriano‐Navarro, M., González-Pérez, Ó., Mirzadeh, Z., Gil‐Perotín, S., Romero-Rodriguez, R., Berger, M. S., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20798 · Cited by 555
Zhu, Y., Guignard, F., Zhao, D., Liu, L., Burns, D. K., Mason, R. P., Messing, A., & Parada, L. F. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.07.004 · Cited by 553
The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord
Deneen, B., Ho, R., Lukaszewicz, A., Hochstim, C. J., Gronostajski, R. M., & Anderson, D. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.019 · Cited by 514
Crane, G. M., Mosher, J. T., Bixby, S., Joseph, N. M., Iwashita, T., & Morrison, S. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00827-9 · Cited by 543
Jackson, E., García-Verdugo, J., Gil-Perotín, S., Roy, M., Quiñones-Hinojosa, A., Vandenberg, S., & Álvarez-Buylla, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.012 · Cited by 587
H3K4me3 breadth is linked to cell identity and transcriptional consistency
Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.027 · Cited by 536
Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells
Chen, J., McKay, R. M., & Parada, L. F. (2012) · Cell · doi:10.1016/j.cell.2012.03.009 · Cited by 549
Adult neurogenesis and neural stem cells of the central nervous system in mammals
Taupin, P., & Gage, F. H. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10378 · Cited by 538
Alsalameh, S., Amin, R. J., Gemba, T., & Lotz, M. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20269 · Cited by 525
Maslov, A. Y., Barone, T. A., Plunkett, R. J., & Pruitt, S. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-03.2004 · Cited by 522
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521
Musashi1: An Evolutionally Conserved Marker for CNS Progenitor Cells Including Neural Stem Cells
Kaneko, Y., Sakakibara, S., Imai, T., Suzuki, A., Nakamura, Y., Sawamoto, K., Ogawa, Y., Toyama, Y., Miyata, T., & Okano, H. (2000) · Developmental Neuroscience · doi:10.1159/000017435 · Cited by 519
Wang, D. D., & Bordey, A. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.015 · Cited by 538
Seaberg, R. M., & van der Kooy, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01784.2002 · Cited by 523
The stem cell potential of glia: lessons from reactive gliosis
Robel, S., Berninger, B., & Götz, M. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2978 · Cited by 536
Stenman, J. M., Toresson, H., & Campbell, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00167.2003 · Cited by 518
The Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 531
Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors
Imayoshi, I., Isomura, A., Harima, Y., Kawaguchi, K., Kori, H., Miyachi, H., Fujiwara, T., Ishidate, F., & Kageyama, R. (2013) · Science · doi:10.1126/science.1242366 · Cited by 509
Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors.
Nieto, M., Schuurmans, C., Britz, O., & Guillemot, F. (2001) · Neuron · doi:10.1016/s0896-6273(01)00214-8 · Cited by 553
Local generation of glia is a major astrocyte source in postnatal cortex
Ge, W.-P., Miyawaki, A., Gage, F. H., Jan, Y. N., & Jan, L. Y. (2012) · Nature · doi:10.1038/nature10959 · Cited by 507
Dietrich, J., Han, R., Yang, Y. M., Mayer‐Pröschel, M., & Noble, M. (2006) · Journal of Biology · doi:10.1186/jbiol50 · Cited by 520
Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis
Lagace, D. C., Whitman, M. C., Noonan, M. A., Ables, J. L., DeCarolis, N. A., Arguello, A. A., Donovan, M. H., Fischer, S. J., Farnbauch, L. A., Beech, R. D., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3812-07.2007 · Cited by 502
Ligon, K. L., Huillard, E., Mehta, S. V., Kesari, S., Liu, H., Alberta, J. A., Bachoo, R. M., Kane, M., Louis, D. N., DePinho, R. A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.009 · Cited by 524
Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons
Heinrich, C., Blum, R., Gascón, S., Masserdotti, G., Tripathi, P., Sánchez, R., Tiedt, S., Schroeder, T., Götz, M., & Berninger, B. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000373 · Cited by 465
Belachew, S. M., Chittajallu, R., Aguirre, A. A., Yuan, X. Q., Kirby, M., Anderson, S. M., & Gallo, V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210110 · Cited by 498
Embryonic origin of postnatal neural stem cells
Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A. (2015) · Cell · doi:10.1016/j.cell.2015.05.041 · Cited by 488
Skeletal myogenic potential of human and mouse neural stem cells
Galli, R., Borello, U., Gritti, A., Minasi, M. G., Bjornson, C. R. R., Coletta, M., Mora, M., Angelis, M. G. C. D., Fiocco, R., Cossu, G., et al. (2000) · Nature Neuroscience · doi:10.1038/79924 · Cited by 483
Filippov, V., Kronenberg, G., Pivneva, T. A., Reuter, K., Steiner, B., Wang, L.-P., Yamaguchi, M., Kettenmann, H., & Kempermann, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00060-5 · Cited by 483
Conover, J. C., Doetsch, F. K., García‐Verdugo, J. M., Gale, N. W., Yancopoulos, G. D., & Álvarez-Buylla, A. (2000) · Nature Neuroscience · doi:10.1038/80606 · Cited by 482
Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal
Aguirre, A. A., Rubio, M. E., & Gallo, V. (2010) · Nature · doi:10.1038/nature09347 · Cited by 482
Hochgerner, H., Zeisel, A., Lönnerberg, P., & Linnarsson, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0056-2 · Cited by 482
Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq
Gokce, O., Stanley, G. M., Treutlein, B., Neff, N. F., Camp, J. G., Malenka, R. C., Rothwell, P. E., Fuccillo, M. V., Südhof, T. C., & Quake, S. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.059 · Cited by 430
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
Dahmane, N., Sánchez‐Gómez, P., Gitton, Y., Palma, V., Sun, T., Beyna, M., Weiner, H. L., & Altaba, A. R. I. (2001) · Development · doi:10.1242/dev.128.24.5201 · Cited by 479
Picard-Riéra, N., Decker, L., Delarasse, C., Goude, K., Nait‐Oumesmar, B., Liblau, R., Pham-Dinh, D., & Evercooren, A. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192314199 · Cited by 469
Contribution of olfactory neural stem cells to tissue maintenance and regeneration
Leung, C. T., Coulombe, P. A., & Reed, R. R. (2007) · Nature Neuroscience · doi:10.1038/nn1882 · Cited by 466
Regulation of adult neurogenesis by antidepressant treatment
Duman, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00358-x · Cited by 463
Woodbury, D., Reynolds, K., & Black, I. B. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10365 · Cited by 460
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, S., Akagi, T., Kageyama, R., Akita, J., Mandai, M., Honda, Y., & Takahashi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402129101 · Cited by 454
Migration and differentiation of neural precursor cells can be directed by microglia
Aarum, J., Sandberg, K., Haeberlein, S. L. B., & Persson, M. A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237050100 · Cited by 450
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Carlén, M., Meletis, K., Göritz, C., Darsalia, V., Evergren, E., Tanigaki, K., Amendola, M., Barnabé‐Heider, F., Yeung, M. S. Y., Naldini, L., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2268 · Cited by 463
Pigment epithelium–derived factor is a niche signal for neural stem cell renewal
Ramírez‐Castillejo, C., Sánchez‐Sánchez, F., Andreu-Agulló, C., Ferrón, S. R., Aroca‐Aguilar, J., Sánchez‐Gómez, P., Mira, H., Escribano, J., & Fariñas, I. (2006) · Nature Neuroscience · doi:10.1038/nn1657 · Cited by 446
The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential
Lie, D. C., Dziewczapolski, G., Willhoite, A. R., Kaspar, B. K., Shults, C. W., & Gage, F. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06639.2002 · Cited by 452
Liu, X., Wang, Q., Haydar, T. F., & Bordey, A. (2005) · Nature Neuroscience · doi:10.1038/nn1522 · Cited by 446
Günther, H. S., Schmidt, N. O., PHILLIPS, H. S., Kemming, D., Kharbanda, S., Soriano, R. H., Modrusan, Z. D., Meissner, H., Westphal, M., & Lamszus, K. (2007) · Oncogene · doi:10.1038/sj.onc.1210949 · Cited by 443
Calderón‐Garcidueñas, L., Franco-Lira, M., Henríquez-Roldán, C. F., Brizuela, N. O., González-Maciel, A., Reynoso-Robles, R., Villarreal‐Calderon, R., Herritt, L., Brooks, D. M., Keefe, S., et al. (2009) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2009.02.117 · Cited by 433
Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398
Roles of TGF-β family signaling in stem cell renewal and differentiation
Watabe, T., & Miyazono, K. (2008) · Cell Research · doi:10.1038/cr.2008.323 · Cited by 446
Origin and function of olfactory bulb interneuron diversity
Lledo, P., Merkle, F. T., & Álvarez-Buylla, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.05.006 · Cited by 440
Glial specification in the vertebrate neural tube
Rowitch, D. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1389 · Cited by 432
Induced neuronal differentiation of human embryonic stem cells
Schuldiner, M., Eiges, R., Eden, A., Yanuka, O., Itskovitz‐Eldor, J., Goldstein, R. S., & Benvenisty, N. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02776-7 · Cited by 425
The generation, migration, and differentiation of olfactory neurons in the adult primate brain
Kornack, D. R., & RAKIC, P. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081074998 · Cited by 437
The neuropoietic cytokine family in development, plasticity, disease and injury
Bauer, Š., Kerr, B. J., & Patterson, P. H. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2054 · Cited by 412
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar, T. F., Wang, F., Schwartz, M. L., & RAKIC, P. T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05764.2000 · Cited by 418
Multipotent Neural Stem Cells Reside into the Rostral Extension and Olfactory Bulb of Adult Rodents
Gritti, A., Bonfanti, L., Doetsch, F. K., Caillé, I., Álvarez-Buylla, A., Lim, D. A., Galli, R., García‐Verdugo, J. M., Herrera, D. G., & Vescovi, A. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00437.2002 · Cited by 415
Identification of neural stem cells in the adult vertebrate brain
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Metadata
- Authors
- Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A.
- Affiliations
- Rockefeller University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 97
- Issue
- 6
- Pages
- 703-716
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165867905
- Cited by
- 3,898
- References
- 77
- Citations by year
- 2026: 31 · 2025: 71 · 2024: 54 · 2023: 79 · 2022: 94 · 2021: 110 · 2020: 105 · 2019: 113 · 2018: 110 · 2017: 134 · 2016: 135 · 2015: 177 · 2014: 154 · 2013: 180 · 2012: 243
- FWCI
- 26.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM 07739, T32GM007739)
- National Institute of Neurological Disorders and Stroke (NS-28478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- subventricular zone, astrocytes, neural stem cells, adult neurogenesis, olfactory bulb, neuroblast migration, ependymal cells, retroviral labeling, neurospheres, stem cell self-renewal
- MeSH terms
- Animals, Astrocytes, Brain, Cerebral Ventricles, Chick Embryo, Glial Fibrillary Acidic Protein, Male, Olfactory Bulb, Regeneration, Stem Cells, Mice
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