Cited by 3,898Neurogenesis and neuroplasticity mechanismsCongenital heart defects researchDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

Open access

Doetsch, Fiona, Caillé, Isabelle, Lim, Daniel A., García-Verdugo, Jose Manuel, Alvarez-Buylla, Arturo·1999·Cell

DOI 10.1016/s0092-8674(00)80783-7

Open this paper in CoChat — free account Open PDF

Abstract

Neural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This germinal region, which continually generates new neurons destined for the olfactory bulb, is composed of four cell types: migrating neuroblasts, immature precursors, astrocytes, and ependymal cells. Here we show that SVZ astrocytes, and not ependymal cells, remain labeled with proliferation markers after long survivals in adult mice. After elimination of immature precursors and neuroblasts by an antimitotic treatment, SVZ astrocytes divide to generate immature precursors and neuroblasts. Furthermore, in untreated mice, SVZ astrocytes specifically infected with a retrovirus give rise to new neurons in the olfactory bulb. Finally, we show that SVZ astrocytes give rise to cells that grow into multipotent neurospheres in vitro. We conclude that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(00)80783-7

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System
Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331
A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
The Fine Structure of the Nervous System.
Tennyson, V. M. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480240094019 · Cited by 1,946
Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
Doetsch, F. K., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05046.1997 · Cited by 1,909
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875
Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
Luskin, M. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90281-u · Cited by 1,803
Untitled work
(1991) · Medical Entomology and Zoology · Cited by 1,512
Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
Altman, J. (1969) · The Journal of Comparative Neurology · doi:10.1002/cne.901370404 · Cited by 1,489

Show all 77 references

Sorted by citations

Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Mammalian neural stem cells.
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
Gronthos, S., Mankani, M. H., Brahim, J. S., Robey, P. G., & Shi, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240309797 · Cited by 4,580
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
“These findings raise the persistentquestionofwhetherthemajorityofadultastrocytesare terminally differentiated or may, under the right circumstances, be able to divide or even revert to stem-cell-like behavior ( Doetsch et al., 1999 ).”
Background
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
Kim, C. F. B., Jackson, E. L., Woolfenden, A. E., Lawrence, S., Babar, I., Vogel, S., Crowley, D. G., Bronson, R. T., & Jacks, T. (2005) · Cell · doi:10.1016/j.cell.2005.03.032 · Cited by 2,229
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life
Morrison, S. J., & Spradling, A. C. (2008) · Cell · doi:10.1016/j.cell.2008.01.038 · Cited by 2,026
Direct isolation of human central nervous system stem cells
Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V., Tsukamoto, A. S., Gage, F. H., & Weissman, I. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14720 · Cited by 1,829
Spatial and temporal expression of short, long/medium or both opsins in human fetal cones
Xiao (2000) · doi:10.1002/1096-9861(20001002)425:4
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,891
Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow
Mezey, É., Chandross, K. J., Harta, G., Maki, R. A., & McKercher, S. R. (2000) · Science · doi:10.1126/science.290.5497.1779 · Cited by 1,814
Out of Eden: Stem Cells and Their Niches
Watt, F. M., & Hogan, A. B. L. M. (2000) · Science · doi:10.1126/science.287.5457.1427 · Cited by 1,754
Physiology of Astroglia
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Álvarez‐Dolado, M., Pardal, R., García‐Verdugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., & Álvarez-Buylla, A. (2003) · Nature · doi:10.1038/nature02069 · Cited by 1,617
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,601
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
The development of neural stem cells
Temple, S. (2001) · Nature · doi:10.1038/35102174 · Cited by 1,479
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473
Neurogenesis in Adult Subventricular Zone
Álvarez-Buylla, A., & García‐Verdugo, J. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00629.2002 · Cited by 1,502
Milestones of neuronal development in the adult hippocampus
Kempermann, G., Jessberger, S., Steiner, B., & Kronenberg, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.013 · Cited by 1,460
Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors
Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S.-I., Hatano, O., Kawahara, N., Tamura, A., Kirino, T., & Nakafuku, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00862-0 · Cited by 1,418
Asymmetric and symmetric stem-cell divisions in development and cancer
Morrison, S. J., & Kimble, J. E. (2006) · Nature · doi:10.1038/nature04956 · Cited by 1,457
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P., Alonso, M., & Grubb, M. S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1867 · Cited by 1,425
For the Long Run
Álvarez-Buylla, A., & Lim, D. A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00111-4 · Cited by 1,348
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
Sanai, N., Tramontin, A. D., Quiñones‐Hinojosa, A., Barbaro, N. M., Gupta, N. M., Kunwar, S., Lawton, M. T., McDermott, M. W., Parsa, A. T., García‐Verdugo, J. M., et al. (2004) · Nature · doi:10.1038/nature02301 · Cited by 1,350
Plasticity of Adult Stem Cells
Wagers, A. J., & Weissman, I. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00208-9 · Cited by 1,268
STEM CELL NICHE: Structure and Function
Li, L., & Xie, T. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131525 · Cited by 1,268
Noggin Antagonizes BMP Signaling to Create a Niche for Adult Neurogenesis
Lim, D. A., Tramontin, A. D., Trevejo, J., Herrera, D. G., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2000) · Neuron · doi:10.1016/s0896-6273(00)00148-3 · Cited by 1,114
GFAP in health and disease
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080
Neurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., & Kageyama, R. (2008) · Nature Neuroscience · doi:10.1038/nn.2185 · Cited by 1,054
Generalized Potential of Adult Neural Stem Cells
Clarke, D. L., Johansson, C. B., Wilbertz, J. H., Veress, B., Nilsson, E. D., Karlström, H., Lendahl, U., & Frisén, J. (2000) · Science · doi:10.1126/science.288.5471.1660 · Cited by 1,057
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Doetsch, F. K., Petreanu, L., Caillé, I., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01133-9 · Cited by 1,048
The Evolving Concept of a Stem Cell
Blau, H. M., Brazelton, T. R., & Weimann, J. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00409-3 · Cited by 1,044
A specialized vascular niche for adult neural stem cells
Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., Garcia-Verdugo, J. M., & Doetsch, F. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.025 · Cited by 1,033
Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions
Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.-M., Goderie, S. K., Roysam, B., & Temple, S. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.026 · Cited by 1,027
Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens
Pollard, S. M., Yoshikawa, K., Clarke, I. D., Danovi, D., Stricker, S., Russell, R., Bayani, J., Head, R., Lee, M., Bernstein, M., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.03.014 · Cited by 1,025
Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., & Ferriero, D. M. (2002) · Annals of Neurology · doi:10.1002/ana.10393 · Cited by 1,020
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015
A unified hypothesis on the lineage of neural stem cells
Álvarez-Buylla, A., García‐Verdugo, J. M., & Tramontin, A. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067582 · Cited by 1,018
Human cortical glial tumors contain neural stem‐like cells expressing astroglial and neuronal markers in vitro
Ignatova, T. N., Kukekov, V. G., Laywell, E. D., Suslov, O. N., Vrionis, F. D., & Steindler, D. A. (2002) · Glia · doi:10.1002/glia.10094 · Cited by 992
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 1,019
Brain tumour stem cells
Vescovi, A. L., Galli, R., & Reynolds, B. A. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1889 · Cited by 1,015
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972
Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
Kondo, T., Setoguchi, T., & Taga, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307618100 · Cited by 993
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157
Origin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972
Doublecortin expression levels in adult brain reflect neurogenesis
Couillard‐Després, S., Winner, B., Schaubeck, S., Aigner, R., Vroemen, M., Weidner, N., Bogdahn, U., Winkler, J., Kuhn, H. G., & Aigner, L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03813.x · Cited by 990
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 1,001
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
Dopamine depletion impairs precursor cell proliferation in Parkinson disease
Höglinger, G. U., Rizk, P., Mp, M., Duyckaerts, C. J., Oertel, W. H., Caillé, I., & Hirsch, É. C. (2004) · Nature Neuroscience · doi:10.1038/nn1265 · Cited by 974
Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS
Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F., & Gage, F. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08487.1999 · Cited by 909
Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells
Kondo, T., & RAFF, M. C. (2000) · Science · doi:10.1126/science.289.5485.1754 · Cited by 880
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell
Conti, L., Pollard, S. M., Gorba, T., Reitano, E., Toselli, M., Biella, G. R., Sun, Y., Sanzone, S., Ying, Q., Cattaneo, E. F., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030283 · Cited by 876
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
Bonaguidi, M. A., Wheeler, M. A., Shapiro, J. S., Stadel, R. P., Sun, G. J., Ming, G.-L., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.024 · Cited by 831
Radial glia give rise to adult neural stem cells in the subventricular zone
Merkle, F. T., Tramontin, A. D., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407893101 · Cited by 849
Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells
Pastrana, É., Silva-Vargas, V., & Doetsch, F. K. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.04.007 · Cited by 856
Mosaic Organization of Neural Stem Cells in the Adult Brain
Merkle, F. T., Mirzadeh, Z., & Álvarez-Buylla, A. (2007) · Science · doi:10.1126/science.1144914 · Cited by 821
No place like home: anatomy and function of the stem cell niche
Jones, D. L., & Wagers, A. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2319 · Cited by 830
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
Lai, K., Kaspar, B. K., Gage, F. H., & Schaffer, D. V. (2002) · Nature Neuroscience · doi:10.1038/nn983 · Cited by 820
Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.
Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M. Z., Zubiaga, A., Hua, X., Fan, G., & Greenberg, M. E. (2001) · Cell · doi:10.1016/s0092-8674(01)00224-0 · Cited by 681
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
“Under homeostatic conditions, microglia phagocytose IPCs that have undergone apoptosis (Sierra et al., 2010), while activated microglia reduce neurogenesis (Ekdahl et al., 2003).”
Background
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709002105 · Cited by 789
Stem Cells
Fuchs, E. V., & Segre, J. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81691-8 · Cited by 762
Astrocytes: a central element in neurological diseases
Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 793
Characterization of CNS Precursor Subtypes and Radial Glia
Hartfuss, E., Galli, R., Heins, N., & Götz, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9962 · Cited by 755
Neuronal or Glial Progeny
Malatesta, P., Hack, M. A., Hartfuss, E., Kettenmann, H., Klinkert, W. E. F., Kirchhoff, F., & Götz, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00116-8 · Cited by 771
The therapeutic potential of neural stem cells
Martino, G., & Pluchino, S. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1908 · Cited by 738
Stem Cells and Cancer
Valk-Lingbeek, M. E., Bruggeman, S. W. M., & van Lohuizen, M. (2004) · Cell · doi:10.1016/j.cell.2004.08.005 · Cited by 743
SOX2, a Persistent Marker for Multipotential Neural Stem Cells Derived from Embryonic Stem Cells, the Embryo or the Adult
Ellis, P., Fagan, B. M., Magness, S. T., Hutton, S. R., Taranova, O., Hayashi, S., McMahon, A. P., Rao, M. S., & Pevny, L. (2004) · Developmental Neuroscience · doi:10.1159/000082134 · Cited by 756
Reactive Astrocytes in Neural Repair and Protection
Sofroniew, M. V. (2005) · The Neuroscientist · doi:10.1177/1073858405278321 · Cited by 759
In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain
Wichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722
Cancer stem cells in nervous system tumors
Singh, S. K., Clarke, I. D., Hide, T., & Dirks, P. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207946 · Cited by 569
Lineage Tracing
Kretzschmar, K., & Watt, F. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.002 · Cited by 756
Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain
Gaiano, N., Nye, J. S., & Fishell, G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81172-1 · Cited by 727
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell, E. D., RAKIC, P. T., Kukekov, V. G., Holland, E. C., & Steindler, D. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250471697 · Cited by 722
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack, D. R., & RAKIC, P. T. (2001) · Science · doi:10.1126/science.1065467 · Cited by 748
Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin
Shingo, T., Gregg, C., Enwere, E. K., Fujikawa, H., Hassam, R., Geary, C. L., Cross, J. C., & Weiss, S. (2003) · Science · doi:10.1126/science.1076647 · Cited by 711
Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains
Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4987-09.2010 · Cited by 716
Adult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis
Spassky, N., Merkle, F. T., Flames, N., Tramontin, A. D., García-Verdugo, J. M., & Alvarez-Buylla, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1108-04.2005 · Cited by 717
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum
Yamashita, T., Ninomiya, M., Hernandez-Acosta, P., García‐Verdugo, J. M., Sunabori, T., Sakaguchi, M., Adachi, K., Kojima, T., Hirota, Y., Kawase, T., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0149-06.2006 · Cited by 720
Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
Rola, R., Raber, J., Rizk‐Jackson, A., Otsuka, S., VandenBerg, S. R., Morhardt, D. R., & Fike, J. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.005 · Cited by 726
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
Machold, R. P., Hayashi, S., Rutlin, M. L., Muzumdar, M. D., Nery, S. V., Corbin, J. G., Gritli-Linde, A., Dellovade, T., Porter, J. A., Rubin, L. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00561-0 · Cited by 710
Neural stem and progenitor cells in nestin‐GFP transgenic mice
Mignone, J., Kukekov, V. G., Chiang, A., Steindler, D. A., & Enikolopov, G. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.10964 · Cited by 707
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
Alcantara Llaguno, S., Chen, J., Kwon, C.-H., Jackson, E. L., Li, Y., Burns, D. K., Alvarez-Buylla, A., & Parada, L. F. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.006 · Cited by 694
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
Ahn, S., & Joyner, A. L. (2005) · Nature · doi:10.1038/nature03994 · Cited by 713
Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
Liu, C., Sage, J. C., Miller, M. R., Verhaak, R. G. W., Hippenmeyer, S., Vogel, H. S., Foreman, O., Bronson, R. T., Nishiyama, A., Luo, L., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.014 · Cited by 720
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cellsPreprint
Hitoshi, S., Alexson, T. O., Tropepe, V., Donoviel, D. B., Elia, A., Nye, J. S., Conlon, R. A., Mak, T. W., Bernstein, A., & van der Kooy, D. (2002) · Genes & Development · doi:10.1101/gad.975202 · Cited by 690
Development and functions of the choroid plexus–cerebrospinal fluid system
Lun, M. P., Monuki, E. S., & Lehtinen, M. K. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3921 · Cited by 719
Maturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of Olfaction
Petreanu, L., & Álvarez-Buylla, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06106.2002 · Cited by 680
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
Krichevsky, A. M., Sonntag, K.-C., Isacson, O., & Kosik, K. S. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0441 · Cited by 692
The oligodendrocyte precursor cell in health and disease
Levine, J. M., Reynolds, R., & Fawcett, J. W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01691-x · Cited by 673
LeX/ssea-1 Is Expressed by Adult Mouse CNS Stem Cells, Identifying Them as Nonependymal
Capela, A., & Temple, S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00835-8 · Cited by 671
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Meletis, K., Barnabé‐Heider, F., Carlén, M., Evergren, E., Tomilin, N. V., Shupliakov, O., & Frisén, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060182 · Cited by 685
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma
Schüller, U., Heine, V., Mao, J., Kho, A., Dillon, A. K., Han, Y.-G., Huillard, E., Sun, T., Ligon, A., Qian, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.005 · Cited by 656

Authors: Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A.
Affiliations: Rockefeller University (US)
ORCID: Doetsch, Fiona
Caillé, Isabelle
Lim, Daniel A.
Venue: Cell
Publisher: Elsevier BV
Published: 1999-06
Volume: 97
Issue: 6
Pages: 703-716
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)80783-7
OpenAlex: W2165867905
Cited by: 3,898
References: 77
Citations by year: 2026: 31 · 2025: 71 · 2024: 54 · 2023: 79 · 2022: 94 · 2021: 110 · 2020: 105 · 2019: 113 · 2018: 110 · 2017: 134 · 2016: 135 · 2015: 177 · 2014: 154 · 2013: 180 · 2012: 243
FWCI: 26.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5160 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 07739, T32GM007739)
National Institute of Neurological Disorders and Stroke (NS-28478)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: subventricular zone, astrocytes, neural stem cells, adult neurogenesis, olfactory bulb, neuroblast migration, ependymal cells, retroviral labeling, neurospheres, stem cell self-renewal
MeSH terms: Animals, Astrocytes, Brain, Cerebral Ventricles, Chick Embryo, Glial Fibrillary Acidic Protein, Male, Olfactory Bulb, Regeneration, Stem Cells, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks