The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Meiotic Pachytene Arrest in MLH1-Deficient Mice
Open accessAbstract
Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary nonpolyposis colon cancer. To understand the role of MLH1 in normal growth and development, we generated mice that have a null mutation of this gene. Mice homozygous for this mutation show a replication error phenotype, and extracts of these cells are deficient in mismatch repair activity. Homozygous mutant males show normal mating behavior but have no detectable mature sperm. Examination of meiosis in these males reveals that the cells enter meiotic prophase and arrest at pachytene. Homozygous mutant females have normal estrous cycles and reproductive and mating behavior but are infertile. The phenotypes of the mlh1 mutant mice are distinct from those deficient in msh2 and pms2. The different phenotypes of the three types of mutant mice suggest that these three genes may have independent functions in mammalian meiosis.
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Cites
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Cited by
Microsatellite Instability in Colorectal Cancer
Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456
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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
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Meiotic Chromosomes: Integrating Structure and Function
Zickler, D., & Kleckner, N. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,255
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
Harfe, B. D., & Jinks-Robertson, S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.359 · Cited by 608
Metadata
- Authors
- Edelmann, W., Cohen, P. E., Kane, M., Lau, K., Morrow, B., Bennett, S., Umar, A., Kunkel, T., Cattoretti, G., Chaganti, R., Pollard, J. W., Kolodner, R. D., & Kucherlapati, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 85
- Issue
- 7
- Pages
- 1125-1134
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2133492775
- Cited by
- 554
- References
- 53
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Edelmann, W., Cohen, P. E., Kane, M., Lau, K., Morrow, B., Bennett, S., Umar, A., Kunkel, T., Cattoretti, G., Chaganti, R., Pollard, J. W., Kolodner, R. D., & Kucherlapati, R. (1996). Meiotic Pachytene Arrest in MLH1-Deficient Mice. Cell. https://doi.org/10.1016/s0092-8674(00)81312-4
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