The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor
Open accessAbstract
Signals from CD4+ T cells induce two opposite fates in B cells: clonal proliferation of B cells that bind specifically to foreign antigens and clonal deletion of equivalent B cells that bind self-antigens. This B cell fate decision is determined by the concerted action of two surface proteins on activated T cells, CD40-and Fas-ligands (CD40L and FasL), whose effects are switched by signals from the B cell antigen receptor (BCR). Foreign antigens that stimulate the BCR acutely cause CD40L and FasL to promote clonal proliferation. CD40L and FasL trigger deletion, however, when the BCRs become desensitized by chronic stimulation with self-antigens or when BCRs have not bound an antigen. The need for both Fas and CD40L to correctly regulate self-reactive B cell fate may explain the severe autoantibody disorders in Fas- or CD40L-deficient children.
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Cites
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Self-citationFas(CD95)/FasL interactions required for programmed cell death after T-cell activation
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Cited by
Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,647
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,539
Self-citationLymphocyte-Mediated Cytotoxicity
Russell, J. H., & Ley, T. J. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100201.131730 · Cited by 1,122
The many roles of FAS receptor signaling in the immune system
Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968
FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis
Krueger, A., Baumann, S., Krammer, P. H., & Kirchhoff, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8247-8254.2001 · Cited by 549
Metadata
- Authors
- Rathmell, J. C., Townsend, S. E., Xu, J. C., Flavell, R. A., & Goodnow, C. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1996-10
- Volume
- 87
- Issue
- 2
- Pages
- 319-329
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2016808992
- Cited by
- 408
- References
- 59
- FWCI
- 16.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor. https://app.cochat.ai/papers/10.1016/s0092-8674(00)81349-5
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- Rathmell, J. C., Townsend, S. E., Xu, J. C., Flavell, R. A., & Goodnow, C. C. (1996). Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor. Cell. https://doi.org/10.1016/s0092-8674(00)81349-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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