MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

Functional rafts in cell membranes

Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757

Targeting multidrug resistance in cancer

Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Böttcher, A., Diederich, W., Drobnik, W., Barlage, S., Büchler, C., Porsch-Özcürümez, M., et al. (1999) · Nature Genetics · doi:10.1038/11914 · Cited by 1,512

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Starqardt macular dystrophy

Allikmets, R., Singh, N., Sun, H., Shroyer, N. F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-236 · Cited by 1,435

The human ATP-binding cassette (ABC) transporter superfamily

Dean, M., Hamon, Y., & Chimini, G. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31588-1 · Cited by 1,302

Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies.

Li, W., Zhang, H., Assaraf, Y. G., Zhao, K., Xu, X., Xie, J., Yang, D.-H., & Chen, Z.-S. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.05.001 · Cited by 673

Organization of vesicular trafficking in epithelia

Rodriguez-Boulan, E., Kreitzer, G., & Müsch, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1593 · Cited by 574

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

Mitra, P., Oskeritzian, C. A., Payne, S. G., Beaven, M. A., Milstien, S., & Spiegel, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603734103 · Cited by 407

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

Sun, H., Molday, R. S., & Nathans, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8269 · Cited by 353

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

Eloranta, J. J., & Kullak-Ublick, G. A. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.019 · Cited by 260

Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments

Sun, H., & Nathans, J. (1997) · Nature Genetics · doi:10.1038/ng0997-15 · Cited by 251

Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors: Analysis of p-glycoprotein substrates and inhibitors

Wang, R. B., Kuo, C. L., Lien, L. L., & Lien, E. J. (2003) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2003.00487.x · Cited by 225

Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance

Prasad, R., & Goffeau, A. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150111 · Cited by 221

Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

Zhu, H.-J., Wang, J.-S., Markowitz, J. S., Donovan, J. L., Gibson, B. B., Gefroh, H. A., & DeVane, C. L. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.098541 · Cited by 192

The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration

Molday, R. S., Zhong, M., & Quazi, F. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.02.004 · Cited by 182

N-Retinylidene-phosphatidylethanolamine Is the Preferred Retinoid Substrate for the Photoreceptor-specific ABC Transporter ABCA4 (ABCR)

Beharry, S., Zhong, M., & Molday, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405216200 · Cited by 174

Apical/Basolateral Surface Expression of Drug Transporters and its Role in Vectorial Drug Transport

Ito, K., Suzuki, H., Horie, T., & Sugiyama, Y. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-6810-2 · Cited by 174

One hundred years of membrane permeability: does Overton still rule?

Al-Awqati, Q. (1999) · Nature Cell Biology · doi:10.1038/70230 · Cited by 128

Transport of fatty acids and metabolites across the peroxisomal membrane

Hettema, E. H., & Tabak, H. F. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00045-7 · Cited by 126

Bile Formation and Secretion

Boyer, J. L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00519.x · Cited by 124

Transport of Activated Fatty Acids by the Peroxisomal ATP‐binding‐cassette Transporter Pxa2 in a Semi‐Intact Yeast Cell System

Verleur, N., Hettema, E. H., Van Roermund, C. W. T., Tabak, H. F., & Wanders, R. J. A. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00657.x · Cited by 117

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids

Cao, W., Kayama, H., Chen, M. L., Delmas, A., Sun, A., Kim, S. Y., Rangarajan, E. S., McKevitt, K., Beck, A. P., Jackson, C. B., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.012 · Cited by 102

Essential role of phosphatidylserine externalization in apoptosing cell phagocytosis by macrophages

Shiratsuchi, A., Osada, S., Kanazawa, S., & Nakanishi, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8663 · Cited by 86

Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration

Molday, R. S., & Zhang, K. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.07.002 · Cited by 82

Deciphering the plasma membrane hallmarks of apoptotic cells: Phosphatidylserine transverse redistribution and calcium entry

Martínez, M. C., & Freyssinet, J.-M. (2001) · BMC Cell Biology · doi:10.1186/1471-2121-2-20 · Cited by 54

Balancing cholesterol in the brain: from synthesis to disposal

Qian, L., Chai, A. B., Gelissen, I. C., & Brown, A. J. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00015 · Cited by 31

Ether lipid transfer across the blood-brain and placental barriers does not improve by inactivation of the most abundant ABC transporters.

Dorninger, F., Vaz, F. M., Waterham, H. R., Klinken, J. B. V., Zeitler, G., Forss-Petter, S., Berger, J., & Wiesinger, C. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.08.006 · Cited by 12