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BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex
Open accessAbstract
Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear. We examined the maturation and plasticity of the visual cortex in transgenic mice in which the postnatal rise of brain-derived neurotrophic factor (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation and inhibition was accelerated. Furthermore, the age-dependent decline of cortical long-term potentiation induced by white matter stimulation, a form of synaptic plasticity sensitive to cortical inhibition, occurred earlier. Finally, transgenic mice showed a precocious development of visual acuity and an earlier termination of the critical period for ocular dominance plasticity. We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity.
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In the citing paper
“Interestingly, postsynaptic BDNF release has recently been implicated in the rapid local regulation of P r (Jakawich et al. 2010), and BDNF is clearly important for the development and regulation of inhibitory synaptic transmission (Huang et al. 1999).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Huang et al. 1999
In the citing paper
“The postnatal maturation of GABA-mediated inhibition and cortical interneurons is crucial for controlling the timing of critical period plasticity in rodent primary visual cortex (17,18).”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [18]
In the citing paper
“Increased GAD67 was not only detected in the somata of PV interneurons but also in their presynaptic terminals (or puncta), forming a ring-like structure (Fig. 1 D-F) (18).”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [18]
In the citing paper
“A precocious increase of GABA transmission in V1 and precocious maturation of PV cells trigger an earlier onset (18,41), whereas an accelerated rise of PNNs results in an earlier closure of the critical period (27).”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [18]
In the citing paper
“An accelerated maturation of the PV network has been shown to trigger an early onset of the critical period (18,59).”
From MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex (2015) · cites this paper as [18]
In the citing paper
“Conversely, acceleration of interneuron circuit development by overexpressing brain-derived neurotrophic factor (BDNF) closes the critical period early (463, 507).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [507]
In the citing paper
“the maturation of inhibitory circuits, in particular mediated by PVBCs, is necessary for the expression of this early competitive plasticity”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [507]
In the citing paper
“Acceleration of PV-cell maturation by over-expressing non-cell-autonomous factors, such as brain-derived neurotrophic factor (BDNF) or orthodenticle homeobox 2 (Otx2), induces precocious plasticity (Huang et al., 1999; Sugiyama et al., 2008).”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Huang et al., 1999
In the citing paper
“which is activated by brain derived neurotrophic factor (BDNF), which itself is known to induce maturation of PV+ interneurons (Huang et al., 1999; Rutherford et al., 1997).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Huang et al., 1999
Citations
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“…Porciatti,§ Bernardo Morales,‡ Mark F. Bear,*‖ Lamberto Maffei,§ and Susumu Tonegawa*†# *Howard Hughes Medical Institute influenced by neuronal activity (Isackson et al., 1991;†Center for Learning and Memory Castren et al., 1992; Patterson et al., 1992; Blochl andDepartment of Biology and…”
BackgroundEffects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo
Cohen-Cory, S., & Fraser, S. E. (1995) · Nature · doi:10.1038/378192a0 · Cited by 580
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“However, the enhanced strength of inhibition in juvenile BDNFenced by visual experience such as dark rearing and monocular deprivation (Castren et al., 1992; Bozzi et al., transgenic mice was well correlated with changes in GAD65 staining, which showed an accelerated matura-1995).”
BackgroundBlockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns
Cabelli, R. J., Shelton, D. L., Segal, R. A., & Shatz, C. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80348-7 · Cited by 306
The effect of dark rearing on the time course of the critical period in cat visual cortex
Mower, G. D. (1991) · Developmental Brain Research · doi:10.1016/0165-3806(91)90001-y · Cited by 220
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Metadata
- Authors
- Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Scuola Normale Superiore (IT)
- Corresponding author
- Tonegawa, Susumu
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 98
- Issue
- 6
- Pages
- 739-755
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2149858533
- Cited by
- 1,198
- References
- 10
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 37 · 2023: 36 · 2022: 44 · 2021: 44 · 2020: 58 · 2019: 40 · 2018: 56 · 2017: 55 · 2016: 60 · 2015: 53 · 2014: 49 · 2013: 62 · 2012: 42
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Scuola Normale Superiore di Pisa (submittedVersion)
- Funders
- National Eye Institute (R01EY12124-01, R01EY012124)
- National Institute of Neurological Disorders and Stroke (NS-32925, R01NS032925)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, visual cortex maturation, critical period, ocular dominance plasticity, cortical inhibition, GABAergic innervation, long-term potentiation, white matter stimulation, visual acuity development, postnatal development, transgenic mice
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Base Sequence, Cerebral Cortex, Evoked Potentials, Interneurons, Mice, Transgenic, Molecular Sequence Data, Neural Inhibition, Neuronal Plasticity, Parvalbumins, Perception, Recombinant Proteins, Time Factors, Tissue Distribution, Visual Acuity, Visual Cortex, Prosencephalon, Long-Term Potentiation, Pyramidal Cells, Receptors, GABA, Transgenes, Brain-Derived Neurotrophic Factor, Mice
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