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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Open accessAbstract
OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest that Olig1(-/-)2(-/-) pMN progenitors instead generate V2 interneurons and then astrocytes. This apparent conversion likely reflects independent roles for OLIG1/2 in specifying motoneuron and oligodendrocyte fates. Olig genes therefore couple neuronal and glial subtype specification, unlike proneural bHLH factors that control the neuron versus glia decision. Our results suggest that in the spinal cord, Olig and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendrocytes, the three fundamental cell types of the central nervous system.
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“Cell type-specific transcription factor expression is important for cell fate determination and cell differentiation (e.g., Neu-roD for specification of neuron cell fate, Olig2 for specification of oligodendrocyte fate, and GM98/Myrf for oligodendrocyte differentiation; Lee et al., 1995;Zhou and Anderson, 2002;Emery et al., 2009).”
From An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014) · cites this paper as Zhou and Anderson, 2002
Citations
Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089 · cited 5×
“Anderson1,2,3 Division of Biology 216-76 2 Howard Hughes Medical Institute California Institute of Technology V3 interneurons are generated from the p0, p1, p2, and Pasadena, California 91125 p3 domains, respectively (Briscoe et al., 2000; Jessell, 2000).”
BackgroundInfluentialLu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,087
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
Kanda, T., Sullivan, K., & Wahl, G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70156-3 · Cited by 1,040
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997
Lu, Q. R., Yuk, D.-I., Alberta, J., Zhu, Z.-M., Pawlitzky, I., Chan, J., McMahon, A., Stiles, C., & Rowitch, D. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80897-1 · Cited by 883 · cited 1×
“In heterozygotes, Olig2-hGFP -derived precursors gave is restricted to oligodendrocyte precursors (Lu et al., 2000; Zhou et al., 2000), nearly all OLIG2-positive cells rise to Islet1/2 (cid:2) motoneurons (Figure 3A, yellow cells) but not Chx10 (cid:2) V2 interneurons (Figure 3B).”
Identification of neurogenin, a vertebrate neuronal determination gene.
Ma, Q.-F., Kintner, C., & Anderson, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81321-5 · Cited by 874 · cited 1×
“These data sug-sophila proneural genes, such as the Neurogenins gest that Olig genes couple neuronal and glial subtype (Ngns) (Gradwohl et al., 1996; Ma et al., 1996; McCor-specification. mick et al., 1996) and Mash1 (Johnson et al., 1990 .”
BackgroundSelf-citationHomeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T., Rubenstein, J., & Ericson, J. (1999) · Nature · doi:10.1038/19315 · Cited by 807
Zhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789 · cited 13×
“In heterozygotes, Olig2-hGFP -derived precursors gave is restricted to oligodendrocyte precursors (Lu et al., 2000; Zhou et al., 2000), nearly all OLIG2-positive cells rise to Islet1/2 (cid:2) motoneurons (Figure 3A, yellow cells) but not Chx10 (cid:2) V2 interneurons (Figure 3B).”
InfluentialSelf-citationIshibashi, M., Ang, S., Shiota, K., Nakanishi, S., Kageyama, R., & Guillemot, F. (1995) · Genes & Development · doi:10.1101/gad.9.24.3136 · Cited by 767
Pfaff, S. L., Mendelsohn, M. M., Stewart, C. L., Edlund, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80985-x · Cited by 766
Glial Cell Diversification in the Rat Optic Nerve
RAFF, M. C. (1989) · Science · doi:10.1126/science.2648568 · Cited by 715 · cited 1×
“…of distinct neuronal subtypes, initiates motoneurondifferentiation and cellcycle arrest, in addition to subtypes of astroglia and perhaps of oligo-in part by promoting expression of Ngn2 (Mizuguchi et dendroglia as well (Raff, 1989; Woodruff et al., 2001). al., 2001; Novitch et al., 2001).”
Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.
Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M. Z., Zubiaga, A., Hua, X., Fan, G., & Greenberg, M. E. (2001) · Cell · doi:10.1016/s0092-8674(01)00224-0 · Cited by 681
Zhou, Q., Choi, G. B., & Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00414-7 · Cited by 625 · cited 5×
“In recent years, a great factor appears to function in both cases as a transcripdeal has been learned about the transcriptional control tional repressor (Novitch et al., 2001; Zhou et al., 2001).”
BackgroundMethodInfluentialSelf-citationNovitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615 · cited 1×
“…of distinct neuronal subtypes, initiates motoneurondifferentiation and cellcycle arrest, in addition to subtypes of astroglia and perhaps of oligo-in part by promoting expression of Ngn2 (Mizuguchi et dendroglia as well (Raff, 1989; Woodruff et al., 2001). al., 2001; Novitch et al., 2001).”
Luskin, M. B. (1988) · Neuron · doi:10.1016/0896-6273(88)90163-8 · Cited by 577
Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors.
Nieto, M., Schuurmans, C., Britz, O., & Guillemot, F. (2001) · Neuron · doi:10.1016/s0896-6273(01)00214-8 · Cited by 553
rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells.
Furukawa, T., Mukherjee, S., Bao, Z., Morrow, E. M., & Cepko, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81171-x · Cited by 545
Basic helix-loop-helix genes in neural development.
Lee, J. E. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80115-8 · Cited by 541 · cited 1×
“Richard Lu, Charles Stiles, and David Rowitch for a single cell type, such as muscle or neuron (Weintraub, communicating unpublished results and Tom Jessell for advice, 1993; Lee, 1997).”
BackgroundTwo rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors
Johnson, J. E. B., Birren, S. J., & Anderson, D. J. (1990) · Nature · doi:10.1038/346858a0 · Cited by 520 · cited 1×
“These data sug-sophila proneural genes, such as the Neurogenins gest that Olig genes couple neuronal and glial subtype (Ngns) (Gradwohl et al., 1996; Ma et al., 1996; McCor-specification. mick et al., 1996) and Mash1 (Johnson et al., 1990 .”
BackgroundSelf-citationMizuguchi, R., Sugimori, M., Takebayashi, H., Kosako, H., Nagao, M., Yoshida, S., Nabeshima, Y., Shimamura, K., & Nakafuku, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00413-5 · Cited by 471
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.
Sharma, K., Sheng, H. Z., Lettieri, K., Li, H., Karavanov, A., Potter, S., Westphal, H., & Pfaff, S. (1998) · Cell · doi:10.1016/s0092-8674(00)81704-3 · Cited by 461
Parras, C., Schuurmans, C., Scardigli, R., Kim, J., Anderson, D. J., & Guillemot, F. (2002) · Genes & Development · doi:10.1101/gad.940902 · Cited by 434
Self-citationMuhr, J., Andersson, E., Persson, M., Jessell, T., & Ericson, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00283-5 · Cited by 412
Takebayashi, H., Yoshida, S., Sugimori, M., Kosako, H., Kominami, R., Nakafuku, M., & Nabeshima, Y. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00466-4 · Cited by 409
Lin, J. H., Saito, T., Anderson, D. J., Lance-Jones, C. C., Jessell, T. M., & Arber, S. (1998) · Cell · doi:10.1016/s0092-8674(00)81770-5 · Cited by 334
Self-citationTomita, K., Moriyoshi, K., Nakanishi, S., Guillemot, F., & Kageyama, R. (2000) · EMBO Journal · doi:10.1093/emboj/19.20.5460 · Cited by 331
Stem Cells and Pattern Formation in the Nervous System
Anderson, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00260-4 · Cited by 300 · cited 1×
“ture (reviewed in Gage, 2000; Anderson, 2001).”
Self-citationVallstedt, A., Muhr, J., Pattyn, A., Pierani, A., Mendelsohn, M., Sander, M., Jessell, T., & Ericson, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00412-3 · Cited by 288
Kania, A., Johnson, R. L., & Jessell, T. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00022-2 · Cited by 279
Gradwohl, G., Fode, C., & Guillemot, F. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0297 · Cited by 264 · cited 1×
“These data sug-sophila proneural genes, such as the Neurogenins gest that Olig genes couple neuronal and glial subtype (Ngns) (Gradwohl et al., 1996; Ma et al., 1996; McCor-specification. mick et al., 1996) and Mash1 (Johnson et al., 1990 .”
BackgroundLineage, arrangement, and death of clonally related motoneurons in chick spinal cord
Leber, S., Breedlove, S., & Sanes, J. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-07-02451.1990 · Cited by 262
Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord.
Scardigli, R., Schuurmans, C., Gradwohl, G., & Guillemot, F. (2001) · Neuron · doi:10.1016/s0896-6273(01)00358-0 · Cited by 253
Miller, R. H. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80036-1 · Cited by 224
McCormick, M., Tamimi, R. M., Snider, L. D., Asakura, A., Bergstrom, D. A., & Tapscott, S. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5792 · Cited by 160
Richardson, W., Pringle, N., Yu, W.-P., & Hall, A. (1997) · Developmental Neuroscience · doi:10.1159/000111186 · Cited by 158
Sun, T., Echelard, Y., Lu, R. Q., Yuk, D.-I., Kaing, S., Stiles, C., & Rowitch, D. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00441-9 · Cited by 148
Chisholm, A. D. (n.d.) · doi:10.1016/b978-0-12-374984-0.00211-4 · Cited by 129
Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives
Woodruff, R., Tekki-Kessaris, N., Stiles, C., Rowitch, D., & Richardson, W. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00083-6 · Cited by 124 · cited 2×
“This basic triad comprises many hun- minative role in patterning the pMN domain and also dreds or even thousands of distinct neuronal subtypes, initiates motoneuron differentiation and cell cycle arrest, in addition to subtypes of astroglia and perhaps of oligo- in part by promoting expression of Ngn2 (Mizuguchi et de…”
BackgroundLu, Q. R., Cai, L., Rowitch, D., Cepko, C. L., & Stiles, C. (2001) · Nature Neuroscience · doi:10.1038/nn718 · Cited by 122
Pax6 influences the time and site of origin of glial precursors in the ventral neural tube.
Sun, T., Pringle, N., Hardy, A. P., Richardson, W., & Smith, H. (1998) · Molecular and cellular neurosciences · doi:10.1006/mcne.1998.0711 · Cited by 121
The Basic Helix-Loop-Helix Gene hesr2 Promotes Gliogenesis in Mouse Retina
Satow, T., Bae, S.-K., Inoue, T., Inoue, C., Miyoshi, G., Tomita, K., Bessho, Y., Hashimoto, N., & Kageyama, R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01265.2001 · Cited by 110
Dorsal spinal cord neuroepithelium generates astrocytes but not oligodendrocytes.
Pringle, N., Guthrie, S., Lumsden, A., & Richardson, W. (1998) · Neuron · doi:10.1016/s0896-6273(00)80470-5 · Cited by 106 · cited 1×
“Astrocytes are thought to arise from multiple levels along the dorso-ventral axis of the spinal cord (Pringle et al., 1998).”
BackgroundAubourg, P. R., & Dubois-Dalcq, M. E. (2000) · Glia · doi:10.1002/(sici)1098-1136(20000115)29:2 · Cited by 42
Alternative repair pathways for UV-induced DNA damage
Yasui, A., & McCready, S. J. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199804)20:4
Research works printed but not linked: 7
- Briscoe, 2000, A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube, Cell, 101, 435, 10.1016/S0092-8674(00)80853-3 · DOI
- Dubreuil, 2000, The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity, Development, 127, 5191, 10.1242/dev.127.23.5191 · DOI
- Farah, 2000, Generation of neurons by transient expression of neural bHLH proteins in mammalian cells, Development, 127, 693, 10.1242/dev.127.4.693 · DOI
- Hall, 1996, Spinal cord oligodendrocytes develop from ventrally derived progenitor cells that express PDGF alpha-receptors, Development, 122, 4085, 10.1242/dev.122.12.4085 · DOI
- Hojo, 2000, Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina, Development, 127, 2515, 10.1242/dev.127.12.2515 · DOI
- Lo, 2002, Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells, Development, in press
- Vetter, 2001, A turn of the helix, Neuron, 29, 559, 10.1016/S0896-6273(01)00231-8 · DOI
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Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
“…expression is important for cell fate determination and cell differentiation (e.g., NeuroD for specification of neuron cell fate, Olig2 for specification of oligodendrocyte fate, and GM98/Myrf for oligodendrocyte differentiation; Lee et al., 1995; Zhou and Anderson, 2002; Emery et al., 2009).”
BackgroundDirected differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792
“Each of these transcription factors has an essential role in the specification of spinal MN identity (Ericson et al., 1997; Sander et al., 2000; Vallstedt et al., 2001; Novitch et al., 2001; Mizuguchi et al., 2001; Zhou and Anderson, 2002; Lu et al., 2002).”
BackgroundProneural genes and the specification of neural cell types
Bertrand, N., Castro, D. S., & Guillemot, F. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn874 · Cited by 1,572
Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195
Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,087
Metadata
- Authors
- Zhou, Q., & Anderson, D. J.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Anderson, David J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 109
- Issue
- 1
- Pages
- 61-73
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2125920059
- Cited by
- 1,059
- References
- 70
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 29 · 2023: 27 · 2022: 45 · 2021: 46 · 2020: 26 · 2019: 36 · 2018: 36 · 2017: 36 · 2016: 33 · 2015: 41 · 2014: 52 · 2013: 48 · 2012: 52
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01-NS23476, R01NS023476)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Olig2, Olig1, bHLH transcription factors, motor neurons, oligodendrocytes, astrocytes, proneural genes, lineage tracing
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Astrocytes, Cell Differentiation, DNA-Binding Proteins, Female, Interneurons, Male, Motor Neurons, Mutation, Nerve Tissue Proteins, Neuroglia, Neurons, Oligodendroglia, Rhombencephalon, Spinal Cord, Stem Cells, Transcription Factors, Helix-Loop-Helix Motifs, Mice, Knockout, Homeodomain Proteins, Cell Lineage, Mice, Basic Helix-Loop-Helix Proteins
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