Missing Pieces in the NF-κB Puzzle

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J.-I., & Chen, Z. J. (2001) · Nature · doi:10.1038/35085597 · Cited by 2,125

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., & Chen, Z. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00126-4 · Cited by 1,872

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,814

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

Hoeflich, K. P., Luo, J., Rubie, E. A., Tsao, M., Jin, O., & Woodgett, J. R. (2000) · Nature · doi:10.1038/35017574 · Cited by 1,401

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Fitzgerald, K. A., Pålsson‐McDermott, E. M., Bowie, A., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E. K., Dunne, A., Gray, P., Harte, M. T., et al. (2001) · Nature · doi:10.1038/35092578 · Cited by 1,258

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183

Identification and Characterization of an IκB Kinase

Régnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., & Rothe, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80344-x · Cited by 1,176

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

Sha, W. C., Liou, H.-C., TUOMANEN, E. I., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90415-8 · Cited by 1,158

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

Baeuerle, P. A., & Baltimore, D. (1988) · Cell · doi:10.1016/0092-8674(88)90382-0 · Cited by 1,130

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

Sun, S., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993) · Science · doi:10.1126/science.8096091 · Cited by 1,108

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

Kelliher, M. A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B. Z., & Leder, P. (1998) · Immunity · doi:10.1016/s1074-7613(00)80535-x · Cited by 1,102

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

Yamaoka, S., Courtois, G., Chable-Bessia, C., Whiteside, S. T., Weil, R., Agou, F., Kirk, H., Kay, R. J., & Israël, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81466-x · Cited by 1,077

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

Schiemann, B. J., Gommerman, J. L., Vora, K. A., Cachero, T. G., Shulga‐Morskaya, S., Dobles, M., Frew, E. M., & Scott, M. L. (2001) · Science · doi:10.1126/science.1061964 · Cited by 1,070

Series Introduction: The transcription factor NF-κB and human disease

Baldwin, A. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11891 · Cited by 990

TIRAP: an adapter molecule in the Toll signaling pathway

Horng, T., Barton, G. M., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni0901-835 · Cited by 970

Modulation of Akt kinase activity by binding to Hsp90

Sato, S., Fujita, N., & Tsuruo, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170276797 · Cited by 967

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

Uren (2000) · Molecular Cell · Cited by 965

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

Li, Q., Antwerp, D. V., Mercurio, F., Lee, K., & Verma, I. M. (1999) · Science · doi:10.1126/science.284.5412.321 · Cited by 963

The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

Zhong, H., May, M. J., Jimi, E., & Ghosh, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00477-x · Cited by 951

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

Li, Z., Chu, W., Hu, Y., Delhase, M., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1839 · Cited by 927

NF-κB signaling pathways in mammalian and insect innate immunityPreprint

Silverman, N. S., & Maniatis, T. (2001) · Genes & Development · doi:10.1101/gad.909001 · Cited by 904

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

Sun, Z., Arendt, C., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., Gandhi, L., Annes, J. P., Petrzilka, D., Kupfer, A., Schwartzberg, P. L., et al. (2000) · Nature · doi:10.1038/35006090 · Cited by 894

BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

Thompson, J. S., Bixler, S. A., Qian, F., Vora, K. A., Scott, M. L., Cachero, T. G., Hession, C. A., Schneider, P., Sizing, I., Mullen, C., et al. (2001) · Science · doi:10.1126/science.1061965 · Cited by 890

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

Delhase, M., Hayakawa, M., Chen, Y., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.309 · Cited by 852

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

Xiao, G., Harhaj, E. W., & Sun, S. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00187-3 · Cited by 836

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

Zhong, H., Suyang, H., Erdjument‐Bromage, H., Tempst, P., & Ghosh, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80222-6 · Cited by 828

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.316 · Cited by 822

Structure of an IκBα/NF-κB Complex

Jacobs, M. D., & Harrison, S. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81698-0 · Cited by 822

CREB-binding protein/p300 are transcriptional coactivators of p65

Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 820

TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway

Dumitru, C. D., Ceci, J. D., Tsatsanis, C., Kontoyiannis, D. L., Stamatakis, K., Lin, J., Patriotis, C., Jenkins, N. A., Copeland, N. G., Kollias, G. A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00210-5 · Cited by 810

Toll-like receptor–mediated NF-κB activation: a phylogenetically conserved paradigm in innate immunity

Zhang, G., & Ghosh, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11837 · Cited by 781

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

Madrid, L. V., Mayo, M. W., Reuther, J. Y., & Baldwin, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101103200 · Cited by 777

The Toll-receptor family and control of innate immunity.

Kopp, E., & Medzhitov, R. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80003-x · Cited by 734

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

Fütterer, A., Mink, K., Luz, A., Kosco‐Vilbois, M. H., & Pfeffer, K. (1998) · Immunity · doi:10.1016/s1074-7613(00)80588-9 · Cited by 732

The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression

Ashburner, B. P., Westerheide, S. D., & Baldwin, A. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.7065-7077.2001 · Cited by 732

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.Preprint

Köntgen, F., Grumont, R. J., Strasser, A., Metcalf, D., Li, R., Tarlinton, D. M., & Gerondakis, S. (1995) · Genes & Development · doi:10.1101/gad.9.16.1965 · Cited by 727

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

Ito, K., Barnes, P. J., & Adcock, I. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6891-6903.2000 · Cited by 723

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D., & Nabel, G. J. (1997) · Science · doi:10.1126/science.275.5299.523 · Cited by 720

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

Ossareh‐Nazari, B., Bachelerie, F., & Dargemont, C. (1997) · Science · doi:10.1126/science.278.5335.141 · Cited by 713

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

May, M. J., D’Acquisto, F., Madge, L. A., Glöckner, J., Pober, J. S., & Ghosh, S. (2000) · Science · doi:10.1126/science.289.5484.1550 · Cited by 678

Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

Chen, F. E., Huang, D.-B., Chen, Y., & Ghosh, G. (1998) · Nature · doi:10.1038/34956 · Cited by 628

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

Brown, K., Park, S., KANNO, T., Franzoso, G., & Siebenlist, U. K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2532 · Cited by 621

An exceptionally well-preserved theropod dinosaur from the Yixian Formation of China

Chen, P., Dong, Z.-M., & Zhen, S. (1998) · Nature · doi:10.1038/34356 · Cited by 606

Limb and Skin Abnormalities in Mice Lacking IKKα

Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 606

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

Huxford, T., Huang, D.-B., Malek, S., & Ghosh, G. (1998) · Cell · doi:10.1016/s0092-8674(00)81699-2 · Cited by 587

Structure of NF-κB p50 homodimer bound to a κB site

Ghosh, G., Duyne, G. D. V., Ghosh, S., & Sigler, P. B. (1995) · Nature · doi:10.1038/373303a0 · Cited by 570

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

Tanaka, M., Fuentes, M. E., Yamaguchi, T., Durnin, M., Dalrymple, S. A., Hardy, K. L., & Goeddel, D. V. (1999) · Immunity · doi:10.1016/s1074-7613(00)80042-4 · Cited by 569

The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus

Rothwarf, D., & Karin, M. (1999) · Science's STKE · doi:10.1126/stke.1999.5.re1 · Cited by 553

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

Ngo, V. N., Körner, H., Gunn, M. D., Schmidt, K. N., Riminton, S., Cooper, M. D., Browning, J. L., Sedgwick, J. D., & Cyster, J. G. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.403 · Cited by 552

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

Ruland, J., Duncan, G. S., Elia, A., Barrantes, I. D. B., Nguyen, L. T., Plyte, S., Millar, D. G., Bouchard, D., Wakeham, A. C., Ohashi, P. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00189-1 · Cited by 545

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

Madrid, L. V., Wang, C.-Y., Guttridge, D. C., Schottelius, A. J. G., Baldwin, A. S., & Mayo, M. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1626-1638.2000 · Cited by 540

Structure of the NF-κB p50 homodimer bound to DNA

Müller, C. W., Rey, F. A., Sodeoka, M., Verdine, G. L., & Harrison, S. C. (1995) · Nature · doi:10.1038/373311a0 · Cited by 536

Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells

Ledebur, H. C., & Parks, T. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.933 · Cited by 536

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

Lei, L., Cao, Z., & Goeddel, D. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3792 · Cited by 536

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518

IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development

Cao, Y., Bonizzi, G., Seagroves, T. N., Greten, F. R., Johnson, R. S., Schmidt, E. V., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00599-2 · Cited by 479

Severe liver degeneration and lack of NF-κ B activation in NEMO/IKKγ-deficient mice

Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes & Development · doi:10.1101/gad.14.7.854 · Cited by 479

IKK1-deficient mice exhibit abnormal development of skin and skeletonPreprint

Li, Q., Lu, Q., Hwang, J. Y., Büscher, D., Lee, K., Izpisúa‐Belmonte, J. C., & Verma, I. M. (1999) · Genes & Development · doi:10.1101/gad.13.10.1322 · Cited by 470

Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II

Wang, D., Westerheide, S. D., Ostrander, J. H., & Baldwin, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001358200 · Cited by 454

Recruitment of the IKK Signalosome to the p55 TNF Receptor

Zhang, S. Q., Kovalenko, A., Cantarella, G., & Wallach, D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80183-1 · Cited by 454

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

Shinkura, R., Kitada, K., Matsuda, F., Tashiro, K., Ikuta, K., Suzuki, M., Kogishi, K., Serikawa, T., & Honjo, T. (1999) · Nature Genetics · doi:10.1038/8780 · Cited by 451

Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

Zandi, E., Chen, Y., & Karin, M. (1998) · Science · doi:10.1126/science.281.5381.1360 · Cited by 451

NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti

Schmidt‐Supprian, M., Bloch, W., Courtois, G., Addicks, K., Israël, A., Rajewsky, K., & Pasparakis, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80263-4 · Cited by 437

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

Merika, M., Williams, A. J., Chen, G., Collins, T., & Thanos, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80028-3 · Cited by 435

Autoregulation of I kappa B alpha activity.

Chiao, P. J., Miyamoto, S., & Verma, I. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.28 · Cited by 434

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

Devin, A., Cook, A., Lin, Y., Rodriguez, Y., Kelliher, M. A., & Liu, Z.-G. (2000) · Immunity · doi:10.1016/s1074-7613(00)80194-6 · Cited by 433

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

Arenzana‐Seisdedos, F., Thompson, J., Rodríguez, M. S., Bachelerie, F., Thomas, D., & Hay, R. T. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2689 · Cited by 433

Transcriptional Activation by NF-κB Requires Multiple Coactivators

Sheppard, K.-A., Rose, D. W., Haque, Z. K., Kurokawa, R., McInerney, E. M., Westin, S. K., Thanos, D., Rosenfeld, M. G., Glass, C. K., & Collins, T. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6367 · Cited by 430

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

Franzoso, G., Carlson, L. M., Poljak, L., Shores, E. W., Epstein, S. L., Leonardi, A., Grinberg, A., Tran, T., Scharton‐Kersten, T., Anver, M. R., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.2.147 · Cited by 425

Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway

Lucas, P. C., Yonezumi, M., Inohara, N., McAllister‐Lucas, L. M., Abazeed, M. E., Chen, F. F., Yamaoka, S., Seto, M., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009984200 · Cited by 417

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

Li, Y., Wu, L., Wesche, H., Arthur, C. D., White, J. M., Goeddel, D. V., & Schreiber, R. D. (2001) · Science · doi:10.1126/science.1058453 · Cited by 408

Regulatory functions of ubiquitination in the immune system

Ben‐Neriah, Y. (2002) · Nature Immunology · doi:10.1038/ni0102-20 · Cited by 403

TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90

Chen, G., Cao, P., & Goeddel, D. V. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00450-1 · Cited by 399

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

Arenzana‐Seisdedos, F., Turpin, P., Rodríguez, M. S., Thomas, D., Hay, R. T., Virelizier, J., & Dargemont, C. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.3.369 · Cited by 399

The essential role of MEKK3 in TNF-induced NF-κB activation

Yang, J., Lin, Y., Guo, Z., Cheng, J., Huang, J. H., Deng, L., Liao, W. S. ‐., Chen, Z. J., Liu, Z. G., & Su, B. (2001) · Nature Immunology · doi:10.1038/89769 · Cited by 396

I kappa B epsilon, a novel member of the IκB family, controls RelA and cRel NF‐κB activity

Whiteside, S. T., Epinat, J.-C., Rice, N. R., & Israël, A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.6.1413 · Cited by 396

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

Caamaño, J., Rizzo, C. A., Durham, S. K., Barton, D. S., Raventós-Suárez, C., Snapper, C. M., & Bravo, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.2.185 · Cited by 395

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

Makris, C., Godfrey, V., Krähn‐Senftleben, G., Takahashi, T., Roberts, J. L., Schwarz, T., Feng, L., Johnson, R. S., & Karin, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80262-2 · Cited by 393

Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

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