The DOI matches its Crossref record; 51 of the 54 references it cites were found in a registry or an index.
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Open accessAbstract
We previously showed that leptin inhibits bone formation by an undefined mechanism. Here, we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks differ, and that the peripheral mediators of leptin antiosteogenic function appear to be neuronal. Neuropeptides mediating leptin anorexigenic function do not affect bone formation. Leptin deficiency results in low sympathetic tone, and genetic or pharmacological ablation of adrenergic signaling leads to a leptin-resistant high bone mass. beta-adrenergic receptors on osteoblasts regulate their proliferation, and a beta-adrenergic agonist decreases bone mass in leptin-deficient and wild-type mice while a beta-adrenergic antagonist increases bone mass in wild-type and ovariectomized mice. None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis.
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“leptin deficiency lowers sympathetic tone, leading to higher bone mass, while β-adrenergic blockade or leptin replacement during disuse mitigates bone loss by boosting osteoblast activity, curbing osteoclast function, and maintaining leptin levels to preserve bone density and formation rates [80,81]”
From Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies (2026) · cites this paper as [80]
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Cites
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Gan, D., Qin, L., & Xiao, G. (2026) · Research · doi:10.34133/research.1319 · Cited by 1
“…deficiency lowers sympathetic tone, leading to higher bone mass, while β -adrenergic blockade or leptin replacement during disuse mitigates bone loss by boosting osteoblast activity, curbing osteoclast function, and maintaining leptin levels to preserve bone density and formation rates [ 80 , 81 ].”
Metadata
- Authors
- Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Baylor College of Medicine (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 111
- Issue
- 3
- Pages
- 305-317
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2147510409
- Cited by
- 1,735
- References
- 54
- Citations by year
- 2026: 50 · 2025: 58 · 2024: 61 · 2023: 49 · 2022: 55 · 2021: 57 · 2020: 69 · 2019: 70 · 2018: 66 · 2017: 68 · 2016: 66 · 2015: 81 · 2014: 86 · 2013: 71 · 2012: 105
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-54480, R01DK058883, R01DK054480, DK58883)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24054)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- leptin, bone formation, sympathetic nervous system, beta-adrenergic receptors, osteoblast proliferation, leptin resistance, leptin deficiency, hypothalamic neurons, osteoporosis, bone mass, ovariectomy
- MeSH terms
- Adrenergic beta-Antagonists, Animals, Cells, Cultured, Hypothalamus, Mice, Inbred C57BL, Neuropeptides, Obesity, Oligopeptides, Osteoblasts, Osteogenesis, Pyrrolidonecarboxylic Acid, Receptors, Adrenergic, beta, Sympathetic Nervous System, Receptors, Corticotropin, Leptin, Receptor, Melanocortin, Type 4, Mice, Receptors, Leptin
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