The DOI matches its Crossref record; 51 of the 54 references it cites were found in a registry or an index.
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Open accessAbstract
We previously showed that leptin inhibits bone formation by an undefined mechanism. Here, we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks differ, and that the peripheral mediators of leptin antiosteogenic function appear to be neuronal. Neuropeptides mediating leptin anorexigenic function do not affect bone formation. Leptin deficiency results in low sympathetic tone, and genetic or pharmacological ablation of adrenergic signaling leads to a leptin-resistant high bone mass. beta-adrenergic receptors on osteoblasts regulate their proliferation, and a beta-adrenergic agonist decreases bone mass in leptin-deficient and wild-type mice while a beta-adrenergic antagonist increases bone mass in wild-type and ovariectomized mice. None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“leptin deficiency lowers sympathetic tone, leading to higher bone mass, while β-adrenergic blockade or leptin replacement during disuse mitigates bone loss by boosting osteoblast activity, curbing osteoclast function, and maintaining leptin levels to preserve bone density and formation rates [80,81]”
From Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies (2026) · cites this paper as [80]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. S. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,715
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Self-citationRole of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Research works printed but not linked: 1
- Tremollieres, 1993, Vertebral postmenopausal bone loss is reduced in overweight women, J. Clin. Endocrinol. Metab., 77, 683
Cited by
Sorted by citations
Items 101–200 of 1,001
Regulation of bone remodeling by the central and peripheral nervous system
Elefteriou, F. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.016 · Cited by 229
Self-citationWhat's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health
Scheller, E. L., & Rosen, C. J. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12327 · Cited by 230
Rejnmark, L., Vestergaard, P., & Mosekilde, L. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000203845.26690.cb · Cited by 229
Leptin and the sympathetic connection of fat to bone
Hamrick, M. W., & Ferrari, S. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0487-9 · Cited by 223
Epigenetics: linking genotype and phenotype in development and evolution
(2012) · Choice Reviews Online · doi:10.5860/choice.49-2642 · Cited by 220
The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism
Ducy, P. F. (2011) · Diabetologia · doi:10.1007/s00125-011-2155-z · Cited by 219
Self-citationOsteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation
Matsuoka, K., Park, K.-A., Ito, M., Ikeda, K., & Takeshita, S. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2187 · Cited by 225
Cytokines and the pathogenesis of non-alcoholic steatohepatitis
Diehl, A. M., Li, Z. P., Lin, H., & Yang, S. (2005) · Gut · doi:10.1136/gut.2003.024935 · Cited by 217
Effects of Leptin on the Skeleton
Reid, I. R., Baldock, P. A., & Cornish, J. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00226 · Cited by 215
Serotonin Regulates Osteoclast Differentiation Through Its Transporter
Battaglino, R. A., Fu, J., Späte, U., Ersoy, U., Joe, M., Sedaghat, L., & Stashenko, P. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040606 · Cited by 219
Stearoyl-CoA desaturase: rogue or innocent bystander?
Hodson, L., & Fielding, B. A. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.08.002 · Cited by 220
Crosstalk between Bone and Nerves within Bone
Wan, Q., Qin, W., Ma, Y., Shen, M., Li, J., Zhang, Z., Chen, J., Tay, F. R., Niu, L., & Jiao, K. (2021) · Advanced Science · doi:10.1002/advs.202003390 · Cited by 217
The two faces of serotonin in bone biology
Ducy, P. F., & Karsenty, G. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006123 · Cited by 224
Self-citationDimitri, P., Bishop, N. J., Walsh, J., & Eastell, R. (2011) · Bone · doi:10.1016/j.bone.2011.05.011 · Cited by 217
Regulation of energy metabolism by the skeleton: osteocalcin and beyond
Ferron, M., & Lacombe, J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.022 · Cited by 211
Kondo, H., Nifuji, A., Takeda, S., Ezura, Y., Rittling, S. R., Denhardt, D. T., Nakashima, K., Karsenty, G., & Noda, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504179200 · Cited by 209
Self-citationKontogianni, M. D., Dafni, U. G., Routsias, J. G., & Skopouli, F. N. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040107 · Cited by 209
Adipose Tissue Stimulates Bone Growth in Prepubertal Children
Clark, E., Ness, A., & Tobias, J. H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0332 · Cited by 208
Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
Rahmouni, K., Sigmund, C. D., Haynes, W. G., & Mark, A. L. (2008) · Diabetes · doi:10.2337/db08-0822 · Cited by 215
Nerves in Bone: Evolving Concepts in Pain and Anabolism
Brazill, J. M., Beeve, A. T., Craft, C. S., Ivanusic, J. J., & Scheller, E. L. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3822 · Cited by 218
Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women
Syed, F., Oursler, M., Hefferanm, T. E., Peterson, J., Riggs, B., & Khosla, S. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0574-6 · Cited by 207
Central control of bone remodeling by neuromedin U
Sato, S., Hanada, R., Kimura, A., Abe, T., Μatsumoto, T., Iwasaki, M., Inose, H., Ida, T., Mieda, M., Takeuchi, Y., et al. (2007) · Nature Medicine · doi:10.1038/nm1640 · Cited by 208
Self-citationTsuji, K., Maeda, T., Kawane, T., Matsunuma, A., & Horiuchi, N. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.65 · Cited by 208
Bone remodelling: its local regulation and the emergence of bone fragility
Martin, T. J., & Seeman, E. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.07.006 · Cited by 211
Novel Role of Y1 Receptors in the Coordinated Regulation of Bone and Energy Homeostasis
Baldock, P. A. J., Allison, S. J., Lundberg, P., Lee, N. J., Slack, K., Lin, E.-J. D., Enriquez, R. F., McDonald, M. M., Zhang, L., During, M. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700644200 · Cited by 200
Guo, Z., Jiang, H., Xu, X. Z. S., Duan, W., & Mattson, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703753200 · Cited by 202
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
Tam, J., Trembovler, V., Marzo, V. D., Petrosino, S., Leo, G., Alexandrovich, A., Regev, E., Casap, N., Shteyer, A., Ledent, C. A., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7957com · Cited by 203
Campbell, J. P., Karolak, M. R., Ma, Y., Perrien, D. S., Masood-Campbell, S. K., Penner, N. L., Munoz, S. A., Zijlstra, A., Yang, X., Sterling, J. A. R., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001363 · Cited by 203
Self-citationSignaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Soltanoff, C. S., Yang, S., Chen, W., & Li, Y. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i1.10 · Cited by 201
The Effect of Periodontal Treatment on Serum Leptin, Interleukin‐6, and C‐Reactive Protein
Shimada, Y., Komatsu, Y., 池澤, 育., 田井, 秀., Sugita, N., & Yoshie, H. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.090741 · Cited by 193
Bone and muscle loss after spinal cord injury: organ interactions
Qin, W., Bauman, W. A., & Cardozo, C. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05806.x · Cited by 194
Neurovascular coupling in bone regeneration
Qin, Q., Lee, S., Patel, N., Walden, K., Gomez-Salazar, M. A., Lévi, B., & James, A. W. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00899-6 · Cited by 199
Antidepressant medications and osteoporosis
Rizzoli, R., Cooper, C. C., Reginster, J., Abrahamsen, B., Adachi, J. D., Brandi, M. L., Bruyère, O., Compston, J. E., Ducy, P. F., Ferrari, S., et al. (2012) · Bone · doi:10.1016/j.bone.2012.05.018 · Cited by 192
Self-citationGenetic determination of the cellular basis of the sympathetic regulation of bone mass accrual
Kajimura, D., Hinoi, E., Ferron, M., Kode, A., Riley, K. J., Zhou, B., Guo, X.-D. E., & Karsenty, G. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102608 · Cited by 187
Self-citationMisra, M., Miller, K. K., Cord, J., Prabhakaran, R., Herzog, D. B., Goldstein, M. A., Katzman, D. K., & Klibanski, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2855 · Cited by 186
Interleukin-6: An osteotropic factor influencing bone formation?
Franchimont, N., Wertz, S., & Malaise, M. (2005) · Bone · doi:10.1016/j.bone.2005.06.002 · Cited by 208
Adipokines: New Therapeutic Target for Osteoarthritis?
Xie, C., & Chen, Q. (2019) · Current Rheumatology Reports · doi:10.1007/s11926-019-0868-z · Cited by 187
Genetic Disorders of the Skeleton: A Developmental Approach
Kornak, U., & Mundlos, S. (2003) · The American Journal of Human Genetics · doi:10.1086/377110 · Cited by 183
Decreased Bone Formation and Osteopenia in Mice Lacking α-Calcitonin Gene-Related Peptide
Schinke, T., Liese, S., Priemel, M., Haberland, M., Schilling, A. F., Catala-Lehnen, P., Blicharski, D., Rueger, J. M., Gagel, R. F., Emeson, R. B., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040915 · Cited by 177
Leptin receptor signaling: pathways to leptin resistance
Wauman, J. (2011) · Frontiers in bioscience · doi:10.2741/3885 · Cited by 182
The skeleton as an endocrine organ
DiGirolamo, D. J., Clemens, T. L., & Kousteni, S. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.157 · Cited by 183
Capsaicin-Sensitive Sensory Neurons Contribute to the Maintenance of Trabecular Bone Integrity
Offley, S. C., Guo, T., Wei, T., Clark, J. D., Vogel, H. S., Lindsey, D. P., Jacobs, C. R., Yao, W., Lane, N. E., & Kingery, W. S. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041108 · Cited by 175
Activation of Renin-Angiotensin System Induces Osteoporosis Independently of Hypertension
Asaba, Y., Ito, M., Fumoto, T., Watanabe, K., Fukuhara, R., Takeshita, S., Nimura, Y., Ishida, J., Fukamizu, A., & Ikeda, K. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081006 · Cited by 173
Heterotopic ossification after central nervous system trauma
Sullivan, M. P., Torres, S. J., Mehta, S. D., & Ahn, J. (2013) · Bone and Joint Research · doi:10.1302/2046-3758.23.2000152 · Cited by 173
Souza, M. J. D., & Williams, N. I. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh033 · Cited by 180
Sienkiewicz, E., Magkos, F., Aronis, K. N., Brinkoetter, M., Chamberland, J. P., Chou, S., Arampatzi, K. M., Gao, C., Koniaris, A., & Mantzoros, C. S. (2011) · Metabolism · doi:10.1016/j.metabol.2011.05.016 · Cited by 166
Mediation of the Acute Stress Response by the Skeleton
Berger, J. M., Singh, P. P., Khrimian, L., Morgan, D. A., Chowdhury, S., Arteaga‐Solis, E., Horváth, T. L., Domingos, A. I., Marsland, A. L., Yadav, V. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.012 · Cited by 173
Self-citationMuscle‐bone crosstalk and potential therapies for sarco‐osteoporosis
Li, G., Zhang, L., Wang, D., AIQudsy, L., Jiang, J. X., Xu, H., & Shang, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28946 · Cited by 166
Control of Bone Remodeling by the Peripheral Sympathetic Nervous System
Elefteriou, F., Campbell, P. J., & Ma, Y. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9752-4 · Cited by 169
Self-citationBaldock, P. A., Lee, N. J., Driessler, F., Lin, S., Allison, S., Stehrer, B., Lin, E.-J. D., Zhang, L., Enriquez, R. F., Wong, I. P. L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008415 · Cited by 164
Impairment of Peripheral Circadian Clocks Precedes Metabolic Abnormalities in ob/ob Mice
Ando, H., Kumazaki, M., Motosugi, Y., Ushijima, K., Maekawa, T., Ishikawa, E., & Fujimura, A. (2011) · Endocrinology · doi:10.1210/en.2010-1068 · Cited by 166
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Regulation of apoptosis in osteoclasts and osteoblastic cells
Xing, L., & Boyce, B. F. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.072 · Cited by 171
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Cannabinoid receptors and the regulation of bone mass
Bab, I., & Zimmer, A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707593 · Cited by 162
Mizokami, A., Yasutake, Y., Gao, J., Matsuda, M., Takahashi, I., Takeuchi, H., & Hirata, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057375 · Cited by 160
The Bone-Adipose Axis in Obesity and Weight Loss
Gómez‐Ambrosi, J., Rodrı́guez, A., Catalán, V., & Frühbeck, G. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9548-1 · Cited by 160
Bartell, S. M., Rayalam, S., Ambati, S., Gaddam, D. R., Hartzell, D. L., Hamrick, M. W., She, J., Della‐Fera, M. A., & Baile, C. A. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.406 · Cited by 158
β-Blocker Use, BMD, and Fractures in the Study of Osteoporotic Fractures
Reid, I. R., Gamble, G. D., Grey, A. B., Black, D. M., Ensrud, K. E., Browner, W. S., & Bauer, D. C. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041202 · Cited by 156
Coordination of hypothalamic and pituitary T3 production regulates TSH expression
Fonseca, T. L., Correa-Medina, M., Campos, M. P. O., Wittmann, G., Werneck-de-Castro, J. P., Arrojo e Drigo, R., Mora-Garzon, M., Ueta, C. B., Caicedo, A., Fekete, C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci61231 · Cited by 155
Vickers, M. H., Gluckman, P. D., Coveny, A. H., Hofman, P. L., Cutfield, W. S., Gertler, A., Breier, B. H., & Harris, M. A. (2008) · Endocrinology · doi:10.1210/en.2007-0981 · Cited by 155
Lessons from animal models of NASH
Diehl, A. M. (2005) · Hepatology Research · doi:10.1016/j.hepres.2005.09.022 · Cited by 152
Muscle-bone interactions: From experimental models to the clinic? A critical update
Laurent, M. R., Dubois, V., Claessens, F., Verschueren, S., Vanderschueren, D., Gielen, E., & Jardí, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.017 · Cited by 156
Lerner, U. H. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500202 · Cited by 147
Fat targets for skeletal health
Kawai, M., Devlin, M. J., & Rosen, C. J. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.102 · Cited by 147
Regulation of Adipocyte Formation by GLP-1/GLP-1R Signaling
Challa, T. D., Beaton, N., Arnold, M., Rudofsky, G., Langhans, W., & Wolfrum, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310342 · Cited by 149
Rossi, F., Siniscalco, D., Luongo, L., PETROCELLIS, L. D., Bellini, G., Petrosino, S., Torella, M., Santoro, C., Nobili, B., Perrotta, S., et al. (2008) · Bone · doi:10.1016/j.bone.2008.10.056 · Cited by 149
Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats
Vikulina, T., Fan, X., Yamaguchi, M., Roser-Page, S., Zayzafoon, M., Guidot, D., Ofotokun, I., & Weitzmann, M. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1003020107 · Cited by 145
Lundberg, P., Allison, S. J., Lee, N. J., Baldock, P. A. J., Brouard, N., Rost, S., Enriquez, R. F., Sainsbury, A., Lamghari, M., Simmons, P. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609629200 · Cited by 143
The Central Regulation of Bone Mass, The First Link between Bone Remodeling and Energy Metabolism
Karsenty, G., & Oury, F. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1030 · Cited by 144
Self-citationSensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones
Hu, B., Lv, X., Chen, H., Xue, P., Gao, B., Wang, X., Zhen, G., Crane, J. L., Pan, D., Liu, S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci131554 · Cited by 144
Self-citationBonnet, N., Gadois, C., McCloskey, E. V., Lemineur, G., Lespessailles, É., Courteix, D., & Benhamou, C. L. (2007) · Bone · doi:10.1016/j.bone.2007.01.006 · Cited by 143
Stefanakis, K., Kokkorakis, M., & Mantzoros, C. S. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156057 · Cited by 142
Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies
Hamerman, D. (2005) · QJM · doi:10.1093/qjmed/hci077 · Cited by 146
Spinal Cord Injury-Induced Osteoporosis: Pathogenesis and Emerging Therapies
Battaglino, R. A., Lazzari, A. A., Garshick, E., & Morse, L. R. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0117-0 · Cited by 147
Understanding the local actions of lipids in bone physiology
During, A., Penel, G., & Hardouin, P. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.06.002 · Cited by 145
Cawthorn, W. P., Scheller, E. L., Parlee, S. D., Pham, H. A., Learman, B. S., Redshaw, C., Sulston, R. J., Burr, A. A., Das, A. K., Simon, B. R., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1477 · Cited by 141
Endocannabinoids and the Regulation of Bone Metabolism
Bab, I., Ofek, O., Tam, J., Rehnelt, J., & Zimmer, A. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01675.x · Cited by 142
Molecular bases of the sympathetic regulation of bone mass
Takeda, S., & Karsenty, G. (2008) · Bone · doi:10.1016/j.bone.2008.01.005 · Cited by 140
Self-citationSeverity of obstructive airway disease and risk of osteoporotic fracture
de Vries, F., van Staa, T. P., Bracke, M., Cooper, C. C., Leufkens, H. G. M., & Lammers, J. J. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00058204 · Cited by 136
Is obesity in women protective against osteoporosis?
Migliaccio, S., Greco, E. A., Fornari, F., Donini, L. M., & Lenzi (2011) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s11920 · Cited by 143
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo
Shi, Y., Yadav, V. K., Suda, N., Liu, X. S., Guo, X.-D. E., Myers, M. G., & Karsenty, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808701106 · Cited by 139
Self-citationThe multiple faces of autoimmune-mediated bone loss
Schett, G. A., & David, J. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.190 · Cited by 135
Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling
Baker, J. G., Hill, S. J., & Summers, R. J. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.02.010 · Cited by 134
Ablation of the Sam68 RNA Binding Protein Protects Mice from Age-Related Bone Loss
Richard, S., Torabi, N., Franco, G. V., Tremblay, G. A., Chen, T., Vogel, G., Morel, M., Cléroux, P., Forget-Richard, A., Komarova, S., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010074 · Cited by 133
Sympathetic β1-adrenergic signaling contributes to regulation of human bone metabolism
Khosla, S., Drake, M. T., Volkman, T. L., Thicke, B. S., Achenbach, S. J., Atkinson, E. J., Joyner, M. J., Rosen, C. J., Monroe, D. G., & Farr, J. N. (2018) · Journal of Clinical Investigation · doi:10.1172/jci122151 · Cited by 132
Biology Without Walls: The Novel Endocrinology of Bone
Karsenty, G., & Oury, F. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153233 · Cited by 142
Self-citationBrain-immune interactions and disease susceptibility
Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 134
Leptin Promotes Cell Proliferation and Survival of Trophoblastic Cells1
Magariños, M. P., Sánchez‐Margalet, V., Kotler, M. L., Calvo, J. C., & Varone, C. L. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.106.051391 · Cited by 131
Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells
Bliziotes, M. M., Eshleman, A. J., Burt‐Pichat, B., Zhang, X.-W., Hashimoto, J. G., Wiren, K. M., & Chenu, C. (2006) · Bone · doi:10.1016/j.bone.2006.06.009 · Cited by 131
Changes in Skeletal Integrity and Marrow Adiposity during High-Fat Diet and after Weight Loss
Scheller, E. L., Khoury, B. M., Moller, K. L., Wee, N. K. Y., Khandaker, S., Kozloff, K. M., Abrishami, S., Zamarron, B. F., & Singer, K. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00102 · Cited by 137
Osteocrin, a Novel Bone-specific Secreted Protein That Modulates the Osteoblast Phenotype
Thomas, G. P., Moffatt, P., Salois, P., Gaumond, M.-H., Gingras, R., Godin, É., Miao, D., Goltzman, D., & Lanctôt, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307310200 · Cited by 130
Angiotensin II Type 2 Receptor Blockade Increases Bone Mass
Izu, Y., Mizoguchi, F., Kawamata, A., Hayata, T., Nakamoto, T., Nakashima, K., Inagami, T., Ezura, Y., & Noda, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807610200 · Cited by 128
Long Bone Defect Models for Tissue Engineering Applications: Criteria for Choice
Horner, E. A., Kirkham, J., Wood, D. J., Curran, S., Smith, M. D., Thomson, B. M., & Yang, X. (2009) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0224 · Cited by 124
Bonnet, N., Benhamou, C. L., Brunet-Imbault, B., Arlettaz, A., Horcajada, M.-N., Richard, O., Vico, L., Collomp, K., & Courteix, D. (2005) · Bone · doi:10.1016/j.bone.2005.07.012 · Cited by 128
Shi, Y., Oury, F., Yadav, V. K., Wess, J., Liu, X. S., Guo, X. E., Murshed, M., & Karsenty, G. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.01.005 · Cited by 126
Self-citationNeuronal signaling and the regulation of bone remodeling
Elefteriou, F. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5175-3 · Cited by 131
Self-citationOsteocytes Regulate Primary Lymphoid Organs and Fat Metabolism
Sato, M., Asada, N., Kawano, Y., Wakahashi, K., Minagawa, K., Kawano, H., Sada, A., Ikeda, K., Matsui, T., & Katayama, Y. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.014 · Cited by 126
Novel insights into the relationship between diabetes and osteoporosis
de Paula, F. J. A., Horowitz, M. C., & Rosen, C. J. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1135 · Cited by 125
Burwell, R. G., Aujla, R. K., Grevitt, M. P., Dangerfield, P., Moulton, A., Randell, T. L., & Anderson, S. (2009) · Scoliosis · doi:10.1186/1748-7161-4-24 · Cited by 130
Metadata
- Authors
- Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Baylor College of Medicine (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 111
- Issue
- 3
- Pages
- 305-317
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2147510409
- Cited by
- 1,735
- References
- 54
- Citations by year
- 2026: 50 · 2025: 58 · 2024: 61 · 2023: 49 · 2022: 55 · 2021: 57 · 2020: 69 · 2019: 70 · 2018: 66 · 2017: 68 · 2016: 66 · 2015: 81 · 2014: 86 · 2013: 71 · 2012: 105
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-54480, R01DK058883, R01DK054480, DK58883)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24054)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- leptin, bone formation, sympathetic nervous system, beta-adrenergic receptors, osteoblast proliferation, leptin resistance, leptin deficiency, hypothalamic neurons, osteoporosis, bone mass, ovariectomy
- MeSH terms
- Adrenergic beta-Antagonists, Animals, Cells, Cultured, Hypothalamus, Mice, Inbred C57BL, Neuropeptides, Obesity, Oligopeptides, Osteoblasts, Osteogenesis, Pyrrolidonecarboxylic Acid, Receptors, Adrenergic, beta, Sympathetic Nervous System, Receptors, Corticotropin, Leptin, Receptor, Melanocortin, Type 4, Mice, Receptors, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review