Cited by 1,735Bone Metabolism and DiseasesBone health and osteoporosis researchRegulation of Appetite and Obesity

The DOI matches its Crossref record; 51 of the 54 references it cites were found in a registry or an index.

Leptin Regulates Bone Formation via the Sympathetic Nervous System

Open access

Takeda, Shu, Elefteriou, Florent, Levasseur, Regis, Liu, Xiuyun, Zhao, Liping, Parker, Keith L., Armstrong, Dawna, Ducy, Patricia, Karsenty, Gerard·2002·Cell

DOI 10.1016/s0092-8674(02)01049-8

Open this paper in CoChat — free account Open PDF

Abstract

We previously showed that leptin inhibits bone formation by an undefined mechanism. Here, we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks differ, and that the peripheral mediators of leptin antiosteogenic function appear to be neuronal. Neuropeptides mediating leptin anorexigenic function do not affect bone formation. Leptin deficiency results in low sympathetic tone, and genetic or pharmacological ablation of adrenergic signaling leads to a leptin-resistant high bone mass. beta-adrenergic receptors on osteoblasts regulate their proliferation, and a beta-adrenergic agonist decreases bone mass in leptin-deficient and wild-type mice while a beta-adrenergic antagonist increases bone mass in wild-type and ovariectomized mice. None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(02)01049-8

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. S. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,715
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Self-citation
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924

Show all 54 references

Research works printed but not linked: 1

Tremollieres, 1993, Vertebral postmenopausal bone loss is reduced in overweight women, J. Clin. Endocrinol. Metab., 77, 683

Sorted by citations

Items 201–300 of 1,001

Osteoblastogenesis regulation signals in bone remodeling
Zuo, C., Huang, Y., Bajis, R., Sahih, M., Li, Y., Dai, K., & Zhang, X. (2012) · Osteoporosis International · doi:10.1007/s00198-012-1909-x · Cited by 129
Stem Cell Regulation via Dynamic Interactions of the Nervous and Immune Systems with the Microenvironment
Spiegel, A., Kalinkovich, A., Shivtiel, S., Kollet, Ó., & Lapidot, T. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.10.006 · Cited by 123
Adiponectin regulates BMSC osteogenic differentiation and osteogenesis through the Wnt/β-catenin pathway
Wang, Y., Zhang, X., Shao, J., Liu, H., Liu, X., & Luo, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-03899-z · Cited by 125
Self-citation
The role of leptin in innate and adaptive immune responses.
Bernotienė, E., Palmer, G., & Gabay, C. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2004 · Cited by 134
Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies
Maurel, D. B., Jähn, K., & Lara-Castillo, N. (2017) · Biomedicines · doi:10.3390/biomedicines5040062 · Cited by 127
The Effect of Leptin on Bone - an Evolving Concept of Action
Cirmanová, V., Bayer, M., Stárka, L., & Zajíčková, K. (2008) · Physiological Research · doi:10.33549/physiolres.931499 · Cited by 127
Leptin Modulates both Resorption and Formation while Preventing Disuse-Induced Bone Loss in Tail-Suspended Female Rats
Martin, A., VITTORIS, R. D., David, V., Moraes, R., Bégeot, M., Lafage‐Proust, M., Alexandre, C., Vico, L., & Thomas, T. (2005) · Endocrinology · doi:10.1210/en.2004-1509 · Cited by 123
Bone and Fat: Old Questions, New Insights
Gimble, J. M., & NUTTALL, M. E. (2004) · Endocrine · doi:10.1385/endo:23:2-3:183 · Cited by 125
CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neuronsPreprint
Oury, F., Yadav, V. K., Wang, Y., Zhou, B., Liu, X. S., Guo, X.-D. E., Tecott, L. H., Schütz, G., Means, A. R., & Karsenty, G. (2010) · Genes & Development · doi:10.1101/gad.1977210 · Cited by 122
Self-citation
Transient receptor potential vanilloid 4 deficiency suppresses unloading‐induced bone loss
Mizoguchi, F., Mizuno, A., Hayata, T., Nakashima, K., Heller, S., Ushida, T., Sokabe, M., Miyasaka, N., Suzuki, M., Ezura, Y., et al. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21374 · Cited by 126
Risk of fractures in older adults using antihypertensive medications
Solomon, D. H., Mogun, H., Garneau, K., & Fischer, M. A. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.356 · Cited by 121
Enhanced bone formation in lipodystrophic PPARγhyp/hyp mice relocates haematopoiesis to the spleen
Cock, T., Back, J., Elefteriou, F., Karsenty, G., Kastner, P., Chan, S. H., & Auwerx, J. H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400254 · Cited by 121
Self-citation
The Central Nervous System and Bone Metabolism: An Evolving Story
Dimitri, P., & Rosen, C. J. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0179-6 · Cited by 124
The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens
Mills, E., Yang, L. Y., Nielsen, M. F., Kassem, M. S., Dhillo, W. S., & Comninos, A. N. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab015 · Cited by 136
The complex effects of leptin on bone metabolism through multiple pathways
Thomas, T. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.01.009 · Cited by 121
Antiepileptic drug use and rates of hip bone loss in older men
Ensrud, K. E., Walczak, T. S., BLACKWELL, T. L., Ensrud, E., Barrett-Connor, E. L., & ORWOLL, E. S. (2008) · Neurology · doi:10.1212/01.wnl.0000324919.86696.a9 · Cited by 119
Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification
Kishida, Y., Hirao, M., Tamai, N., Nampei, A., Fujimoto, T., Nakase, T., Shimizu, N., Yoshikawa, H., & Myoui, A. (2005) · Bone · doi:10.1016/j.bone.2005.05.009 · Cited by 118
Deletion of β-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation
Pierroz, D. D., Bonnet, N., Bianchi, E. N., Bouxsein, M., Baldock, P. A. J., Rizzoli, R., & Ferrari, S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1594 · Cited by 118
The effects of static magnetic fields on bone
Zhang, J., Ding, C., Ren, L. M., Zhou, Y., & Shang, P. (2014) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2014.02.001 · Cited by 117
Implications of exercise-induced adipo-myokines in bone metabolism
Lombardi, G., Sanchis‐Gomar, F., Perego, S., Sansoni, V., & Banfi, G. (2015) · Endocrine · doi:10.1007/s12020-015-0834-0 · Cited by 124
Hypothalamic Regulation of Cortical Bone Mass: Opposing Activity of Y2 Receptor and Leptin Pathways
Baldock, P. A. J., Allison, S. J., McDonald, M. M., Sainsbury, A., Enriquez, R. F., Little, D. G., Eisman, J. A., Gardiner, E. M., & Herzog, H. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060705 · Cited by 117
Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
Mutabaruka, M.-S., Aissa, M. A., Delalandre, A., Lavigne, M. J. F., & Lajeunesse, D. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2925 · Cited by 120
AMP-activated protein kinase pathway and bone metabolism
Jeyabalan, J., Shah, M., Viollet, B., & Chenu, C. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0306 · Cited by 120
Bone and brain: a review of neural, hormonal, and musculoskeletal connections.
Jones, K. B., Mollano, A. V., Morcuende, J. A., Cooper, R. R., & Saltzman, C. L. (2004) · Europe PMC (PubMed Central) · Cited by 115
Osteocalcin as a hormone regulating glucose metabolism
Kanazawa, I. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i18.1345 · Cited by 115
Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions
Kelly, R. R., McDonald, L. T., Jensen, N. R., Sidles, S. J., & LaRue, A. C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00200 · Cited by 125
Ghrelin and immunity: A young player in an old field
Dixit, V. D., & Taub, D. D. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.09.003 · Cited by 117
Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease
Diehl, A. M. (2004) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.04.012 · Cited by 117
Functional α1‐ and β2‐adrenergic receptors in human osteoblasts
Huang, H., Brennan‐Speranza, T. C., Muir, M. M., & Mason, R. S. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21761 · Cited by 115
Neural regulation of bone and bone marrow
Maryanovich, M., Takeishi, S., & Frenette, P. S. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031344 · Cited by 114
Roles of leptin in bone metabolism and bone diseases
Chen, X., & Yang, T. (2015) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-014-0569-7 · Cited by 118
Major Depression Is a Risk Factor for Low Bone Mineral Density: A Meta-Analysis
Yirmiya, R., & Bab, I. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.016 · Cited by 117
Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
Iwaniec, U. T., Boghossian, S., Lapke, P. D., Turner, R. T., & Kalra, S. P. (2007) · Peptides · doi:10.1016/j.peptides.2007.02.001 · Cited by 113
Bone: from a reservoir of minerals to a regulator of energy metabolism
Confavreux, C. B. (2011) · Kidney International · doi:10.1038/ki.2011.25 · Cited by 113
Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease
Karthikeyan, B. V., & Pradeep, A. R. (2007) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01078.x · Cited by 114
The crosstalk between bone remodeling and energy metabolism: A translational perspective
Karsenty, G., & Khosla, S. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.010 · Cited by 113
Self-citation
Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models
Reinwald, S., Peterson, R. G., Allen, M. R., & Burr, D. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90937.2008 · Cited by 118
Diabetes Mellitus and Osteoporosis
Sealand, R. O., Razavi, C., & Adler, R. A. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0376-x · Cited by 112
Effects of a β-Blocker on Bone Turnover in Normal Postmenopausal Women: A Randomized Controlled Trial
Reid, I. R., Lucas, J., Wattie, D. J., Horne, A. M., Bolland, M. J., Gamble, G. D., Davidson, J. S., & Grey, A. B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0573 · Cited by 112
TNF‐α Upregulates Sclerostin Expression in Obese Mice Fed a High‐Fat Diet
Baek, K., Hwang, H. R., Park, H., Kwon, A., Qadir, A. S., Ko, S., Woo, K. M., Ryoo, H., Kim, G., & Baek, J. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24487 · Cited by 111
The adverse skeletal effects of selective serotonin reuptake inhibitors
Tsapakis, E.-M., Gamie, Z., Tran, G. T., Adshead, S., Lampard, A. L., Mantalaris, A., & Tsiridis, E. E. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2010.10.006 · Cited by 115
Hallmarks of peripheral nerve function in bone regeneration
Tao, R., Mi, B., Hu, Y., Lin, S., Xiong, Y., Lu, X., Panayi, A. C., Li, G., & Liu, G. (2023) · Bone Research · doi:10.1038/s41413-022-00240-x · Cited by 110
Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats
Chen, J., Lazarenko, O. P., Wu, X., Tong, Y., Blackburn, M. L., Shankar, K., Badger, T. M., & Ronis, M. J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013704 · Cited by 112
Fat fraction mapping using magnetic resonance imaging: insight into pathophysiology
Bray, T., Chouhan, M. D., Punwani, S., Bainbridge, A. P., & Hall-Craggs, M. A. (2017) · British Journal of Radiology · doi:10.1259/bjr.20170344 · Cited by 117
Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y
Zhang, Y., Chen, C., Liu, Y., Rao, S., Tan, Y., Qian, Y., Xia, K., Huang, J., Liu, X., Hong, C., et al. (2021) · Advanced Science · doi:10.1002/advs.202100808 · Cited by 110
Self-citation
Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa
Utz, A. L., Lawson, E. A., Misra, M., Mickley, D. W., Gleysteen, S., Herzog, D. B., Klibanski, A., & Miller, K. K. (2008) · Bone · doi:10.1016/j.bone.2008.03.007 · Cited by 111
Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect
Ortuño, M. J., Robinson, S. T., Subramanyam, P., Paone, R., Huang, Y.-Y., Guo, X.-D. E., Colecraft, H. M., Mann, J. J., & Ducy, P. F. (2016) · Nature Medicine · doi:10.1038/nm.4166 · Cited by 113
Self-citation
Microenvironmental Views on Mesenchymal Stem Cell Differentiation in Aging
Sui, B., Hu, C., Zheng, C., & Jin, Y. (2016) · Journal of Dental Research · doi:10.1177/0022034516653589 · Cited by 109
Potential Adverse Effects of Bronchodilators in the Treatment of Airways Obstruction in Older People
Gupta, P., & O'Mahony, M. S. (2008) · Drugs & Aging · doi:10.2165/00002512-200825050-00005 · Cited by 109
Dose Effects of Propranolol on Cancellous and Cortical Bone in Ovariectomized Adult Rats
Bonnet, N., Laroche, N., Vico, L., Dolleans, E., Benhamou, C. L., & Courteix, D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.105437 · Cited by 109
Synergistic Effects of Y2 and Y4 Receptors on Adiposity and Bone Mass Revealed in Double Knockout Mice
Sainsbury, A., Baldock, P. A. J., Schwarzer, C., Ueno, N., Enriquez, R. F., Couzens, M., Inui, A., Herzog, H., & Gardiner, E. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5225-5233.2003 · Cited by 109
Fracture Risk in Perimenopausal Women Treated with Beta-Blockers
Rejnmark, L., Vestergaard, P., Kassem, M. S., Rud, B., Kolthoff, N., Brixen, K., & Mosekilde, L. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0222-x · Cited by 108
New Roles of Carboxypeptidase E in Endocrine and Neural Function and Cancer
Cawley, N. X., Wetsel, W. C., Murthy, S. R. K., Park, J. J., Pacák, K., & Loh, Y. P. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1039 · Cited by 114
Neuronal Activity in Ontogeny and Oncology
Venkatesh, H. S., & Monje, M. (2017) · Trends in cancer · doi:10.1016/j.trecan.2016.12.008 · Cited by 109
Bone Remodeling, Energy Metabolism, and the Molecular Clock
Rosen, C. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.004 · Cited by 107
Leptin reverses the inhibitory effect of caloric restriction on longitudinal growth
Gat-Yablonski, G., Ben-Ari, T., Shtaif, B., Potievsky, O., Moran, O., Eshet, R., Maor, G., Segev, Y., & Phillip, M. (2004) · Endocrinology · doi:10.1210/en.2003-0910 · Cited by 106
Physiological consequences of membrane-initiated estrogen signaling in the brain
Roepke, T., Rønnekleiv, O., & Kelly, M. J. (2011) · Frontiers in Bioscience · doi:10.2741/3805 · Cited by 107
Osteoclast Deficiency Results in Disorganized Matrix, Reduced Mineralization, and Abnormal Osteoblast Behavior in Developing Bone
Dai, X.-M., Zong, X.-H., Akhter, M. P., & Stanley, E. R. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040514 · Cited by 105
A four-season molecule: osteocalcin. Updates in its physiological roles
Lombardi, G., Perego, S., Luzi, L., & Banfi, G. (2014) · Endocrine · doi:10.1007/s12020-014-0401-0 · Cited by 104
Understanding leptin-dependent regulation of skeletal homeostasis
Motyl, K. J., & Rosen, C. J. (2012) · Biochimie · doi:10.1016/j.biochi.2012.04.015 · Cited by 106
Obstructive Sleep Apnea and Metabolic Bone Disease: Insights Into the Relationship Between Bone and Sleep
Swanson, C. M., Shea, S. A., Stone, K. L., Cauley, J. A., Rosen, C. J., Redline, S. S., Karsenty, G., & ORWOLL, E. S. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2446 · Cited by 104
Self-citation
Powerful Bivariate Genome-Wide Association Analyses Suggest the SOX6 Gene Influencing Both Obesity and Osteoporosis Phenotypes in Males
Liu, Y., Pei, Y., Liu, J., Yang, F., Guo, Y., Zhang, L., Liu, X.-G., Yan, H., Wang, L., Zhang, Y., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006827 · Cited by 106
Self-citation
The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise
Aoyama, S., & Shibata, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00063 · Cited by 108
Calcitonin: Physiology or fantasy?
Davey, R. A., & Findlay, D. M. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1869 · Cited by 101
Bone Cell Bioenergetics and Skeletal Energy Homeostasis
Riddle, R. C., & Clemens, T. L. (2017) · Physiological Reviews · doi:10.1152/physrev.00022.2016 · Cited by 108
Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis
Roepke, T. A., Bosch, M. A., Rick, E. A., Lee, B., Wagner, E. J., Seidlova-Wuttke, D., Wuttke, W., Scanlan, T. S., Rønnekleiv, O. K., & Kelly, M. J. (2010) · Endocrinology · doi:10.1210/en.2010-0573 · Cited by 103
Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis.
Bonnet, N., Pierroz, D. D., & Ferrari, S. (2008) · PubMed · Cited by 101
LRP5 mutations in osteoporosis-pseudoglioma syndrome and high-bone-mass disorders
Levasseur, R., Lacombe, D., & de Vernejoul, M. C. (2004) · Joint Bone Spine · doi:10.1016/j.jbspin.2004.10.008 · Cited by 102
Self-citation
MECHANISMS IN ENDOCRINOLOGY: The endocrine role of the skeleton: background and clinical evidence
Theiler‐Schwetz, V., Pieber, T. R., & Obermayer-Pietsch, B. M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0030 · Cited by 104
Repurposing of approved cardiovascular drugs
Ishida, J., Konishi, M., Ebner, N., & Springer, J. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1031-5 · Cited by 103
Cannabinoids and the skeleton: From marijuana to reversal of bone loss
Bab, I., Zimmer, A. D., & Melamed, E. (2009) · Annals of Medicine · doi:10.1080/07853890903121025 · Cited by 103
Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: An analysis by DNA microarray
Onyia, J. E., Helvering, L. M., Gelbert, L. M., Wei, T., Huang, S., Chen, P., Dow, E. R., Maran, A., Zhang, M., Lotinun, S., et al. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20438 · Cited by 101
Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models
Qiao, W., Pan, D., Zheng, Y., Wu, S., Liu, X., Chen, Z., Wan, M., Feng, S., Cheung, K., Yeung, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28203-0 · Cited by 103
Self-citation
Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis
Li, Z., Oben, J. A., Yang, S., Lin, H., Stafford, E. A., Soloski, M. J., THOMAS, S. A., & Diehl, A. M. (2004) · Hepatology · doi:10.1002/hep.20320 · Cited by 100
Leptin Functions Peripherally to Regulate Differentiation of Mesenchymal Progenitor Cells
Scheller, E. L., Song, J., Dishowitz, M. I., Soki, F. N., Hankenson, K. D., & Krebsbach, P. H. (2010) · Stem Cells · doi:10.1002/stem.432 · Cited by 106
Leptin: cutting the fat off the bone
Cock, T., & Auwerx, J. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14747-2 · Cited by 100
Low dose beta‐blocker prevents ovariectomy‐induced bone loss in rats without affecting heart functions
Bonnet, N., Benhamou, C. L., Malaval, L., Gonçalves, C., Vico, L., Eder, V., Pichon, C., & Courteix, D. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21564 · Cited by 99
Obesity and alcoholic liver disease
Diehl, A. M. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.07.010 · Cited by 99
It takes nerve to fight back: The significance of neural innervation of the bone marrow and spleen for immune function
Jung, W., Lévesque, J.-P., & Ruitenberg, M. J. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.010 · Cited by 102
Drugs and fracture repair
Aspenberg, P. (2005) · Acta Orthopaedica · doi:10.1080/17453670510045318 · Cited by 97
The Impact of Childhood Obesity on Skeletal Health and Development
Dimitri, P. (2019) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2019.28.1.4 · Cited by 97
Leptin Is a Negative Independent Predictor of Areal BMD and Cortical Bone Size in Young Adult Swedish Men
Lorentzon, M., Landin‐Wilhelmsen, K., Mellström, D., & Ohlsson, C. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060814 · Cited by 97
β2-Adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms
Aitken, S. J., Landao‐Bassonga, E., Ralston, S. H., & Idris, A. I. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.11.012 · Cited by 99
Increased Bone Formation in Mice Lacking Apolipoprotein E
Schilling, A. F., Schinke, T., Münch, C., Gebauer, M., Niemeier, A., Priemel, M., Streichert, T., Rueger, J. M., & Amling, M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041101 · Cited by 98
Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications
Yadav, V. K., Oury, F., Tanaka, K. F., Thomas, T., Wang, Y., Cremers, S., Hen, R., Krust, A., Chambon, P., & Karsenty, G. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101940 · Cited by 96
Self-citation
Osteoblast specific Y1 receptor deletion enhances bone mass
Lee, N. J., Nguyen, A., Enriquez, R. F., Doyle, K. L., Sainsbury, A., Baldock, P. A. J., & Herzog, H. (2010) · Bone · doi:10.1016/j.bone.2010.10.174 · Cited by 96
Extreme Obesity Reduces Bone Mineral Density: Complementary Evidence from Mice and Women
Núñez, N. P., Carpenter, C. L., Perkins, S. N., Berrigan, D. A., Jaque, S. V., Ingles, S. A., Bernstein, L., Forman, M. R., Barrett, J. C., & Hursting, S. D. (2007) · Obesity · doi:10.1038/oby.2007.236 · Cited by 96
Human brain evolution and the “Neuroevolutionary Time-depth Principle:” Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder
Bracha, H. S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.01.008 · Cited by 100
Osteotropic effects by the neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal peptide.
Lerner, U. H., & Persson, E. (2008) · PubMed · Cited by 94
Skeletal interoception in bone homeostasis and pain
Lv, X., Gao, F., & Cao, X. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.025 · Cited by 94
β2-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone
Ma, Y., Nyman, J. S., Tao, H., Moss, H. H., Yang, X., & Elefteriou, F. (2011) · Endocrinology · doi:10.1210/en.2010-0881 · Cited by 92
Self-citation
Inhibition of titanium-particle-induced inflammatory osteolysis after local administration of dopamine and suppression of osteoclastogenesis via D2-like receptor signaling pathway
Yang, H., Xu, Y., Zhu, M., Gu, Y., Zhang, W., Shao, H., Wang, Y., Ping, Z., Hu, X., Wang, L., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.046 · Cited by 92
Interactions between central nervous system and peripheral metabolic organs
Zeng, W., Yang, F., Shen, W. L., Zhan, C., Zheng, P., & Hu, J. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2103-5 · Cited by 103
Osteocalcin: A Multifaceted Bone-Derived Hormone
Karsenty, G. (2023) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061121-091348 · Cited by 97
Self-citation
Hematopoietic Stem Cell Trafficking
Méndez‐Ferrer, S., & Frenette, P. S. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.086 · Cited by 92
Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver
Musso, G., Paschetta, E., Gambino, R., Cassader, M., & Molinaro, F. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.006 · Cited by 98
Severe osteopenia in CFTR-null mice
Dif, F., Marty, C., Baudoin, C., de Vernejoul, M. C., & Levi, G. (2004) · Bone · doi:10.1016/j.bone.2004.05.021 · Cited by 92
Calcitonin and bone formation: a knockout full of surprises
Zaidi, M., Moonga, B. S., & Abe, E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci17425 · Cited by 91
Expression of Semaphorin‐3A and its receptors in endochondral ossification: Potential role in skeletal development and innervation
Gomez, C. G., Burt‐Pichat, B., Mallein‐Gérin, F., Merle, B., Delmas, P. D., Skerry, T. M., Vico, L., Malaval, L., & Chenu, C. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20512 · Cited by 94
Adipokines, bone-derived factors and bone turnover in obese children; evidence for altered fat-bone signalling resulting in reduced bone mass
Dimitri, P., Wales, J. K., & Bishop, N. J. (2010) · Bone · doi:10.1016/j.bone.2010.09.034 · Cited by 91

Authors: Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G.
Affiliations: The University of Texas Southwestern Medical Center (US)
Baylor College of Medicine (US)
ORCID: Elefteriou, Florent
Liu, Xiuyun
Zhao, Liping
Ducy, Patricia
Venue: Cell
Publisher: Elsevier BV
Published: 2002-11
Volume: 111
Issue: 3
Pages: 305-317
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(02)01049-8
OpenAlex: W2147510409
Cited by: 1,735
References: 54
Citations by year: 2026: 50 · 2025: 58 · 2024: 61 · 2023: 49 · 2022: 55 · 2021: 57 · 2020: 69 · 2019: 70 · 2018: 66 · 2017: 68 · 2016: 66 · 2015: 81 · 2014: 86 · 2013: 71 · 2012: 105
FWCI: 23.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3911 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-54480, R01DK058883, R01DK054480, DK58883)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24054)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: leptin, bone formation, sympathetic nervous system, beta-adrenergic receptors, osteoblast proliferation, leptin resistance, leptin deficiency, hypothalamic neurons, osteoporosis, bone mass, ovariectomy
MeSH terms: Adrenergic beta-Antagonists, Animals, Cells, Cultured, Hypothalamus, Mice, Inbred C57BL, Neuropeptides, Obesity, Oligopeptides, Osteoblasts, Osteogenesis, Pyrrolidonecarboxylic Acid, Receptors, Adrenergic, beta, Sympathetic Nervous System, Receptors, Corticotropin, Leptin, Receptor, Melanocortin, Type 4, Mice, Receptors, Leptin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Leptin Regulates Bone Formation via the Sympathetic Nervous System

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks