The DOI matches its Crossref record; 51 of the 54 references it cites were found in a registry or an index.
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Open accessAbstract
We previously showed that leptin inhibits bone formation by an undefined mechanism. Here, we show that hypothalamic leptin-dependent antiosteogenic and anorexigenic networks differ, and that the peripheral mediators of leptin antiosteogenic function appear to be neuronal. Neuropeptides mediating leptin anorexigenic function do not affect bone formation. Leptin deficiency results in low sympathetic tone, and genetic or pharmacological ablation of adrenergic signaling leads to a leptin-resistant high bone mass. beta-adrenergic receptors on osteoblasts regulate their proliferation, and a beta-adrenergic agonist decreases bone mass in leptin-deficient and wild-type mice while a beta-adrenergic antagonist increases bone mass in wild-type and ovariectomized mice. None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“leptin deficiency lowers sympathetic tone, leading to higher bone mass, while β-adrenergic blockade or leptin replacement during disuse mitigates bone loss by boosting osteoblast activity, curbing osteoclast function, and maintaining leptin levels to preserve bone density and formation rates [80,81]”
From Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies (2026) · cites this paper as [80]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. S. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,715
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units
PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · Cited by 3,258
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Self-citationRole of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Research works printed but not linked: 1
- Tremollieres, 1993, Vertebral postmenopausal bone loss is reduced in overweight women, J. Clin. Endocrinol. Metab., 77, 683
Cited by
Sorted by citations
Items 601–700 of 1,001
Evidence from clinical studies of leptin: current and future clinical applications in humans
Perakakis, N., & Mantzoros, C. S. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156053 · Cited by 50
The Genetics of Heterotopic Ossification: Insight Into the Bone Remodeling Pathway
Mitchell, E. J., Canter, J. A., Norris, P. R., Jenkins, J. M., & Morris, J. A. (2010) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0b013e3181ed147b · Cited by 42
Obese Japanese children have low bone mineral density after puberty
Nagasaki, K., Kikuchi, T., Hiura, M., & Uchiyama, M. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0498-y · Cited by 42
Food restriction and simulated microgravity: effects on bone and serum leptin
Baek, K., Barlow, A. A., Allen, M. R., & Bloomfield, S. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01209.2007 · Cited by 42
Maxis, K., Delalandre, A., Martel‐Pelletier, J., Pelletier, J., Duval, N., & Lajeunesse, D. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2092 · Cited by 42
Tanaka, K., Hirai, T., Kodama, D., Kondo, H., Hamamura, K., & Togari, A. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13418 · Cited by 42
The “soft” side of the bone: unveiling its endocrine functions
Cappariello, A., Ponzetti, M., & Rucci, N. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0009 · Cited by 44
Raźny, U., Fedak, D., Kieć‐Wilk, B., Góralska, J., Gruca, A., Zdzienicka, A., Kieć-Klimczak, M., Solnica, B., Hubalewska–Dydejczyk, A., & Malczewska-Malec, M. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2862 · Cited by 42
Devlin, M. J., Robbins, A. E., Cosman, M. N., Moursi, C., Cloutier, A. M., Louis, L. D., Vliet, M. V., Conlon, C., & Bouxsein, M. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.04.003 · Cited by 43
Congenital lipodystrophy induces severe osteosclerosis
Zou, W., Rohatgi, N., Brestoff, J. R., Zhang, Y., Scheller, E. L., Craft, C. S., Brodt, M. D., Migotsky, N., Silva, M. J., Harris, C. A., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008244 · Cited by 41
Ma, H., Karvinen, S. M., Silvennoinen, M., Rinnankoski‐Tuikka, R., Kainulainen, H., Morko, J. P., Peng, Z., Kujala, U. M., Rahkila, P., & Suominen, H. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9346-3 · Cited by 42
Brochmann, E. J., Duarte, M. E., Zaidi, H. A., & Murray, S. S. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00194-x · Cited by 42
Adrenergic signalling in osteoarthritis
Sohn, R. E., Rösch, G., Junker, M., Meurer, A., Zaucke, F., & Jenei‐Lanzl, Z. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109948 · Cited by 41
Guo, B., Wang, C., Zhu, Y., Liu, Z., Long, H., Ruan, Z., Lin, Z., Fan, Z., Li, Y., & Zhao, S. (2023) · Bone Research · doi:10.1038/s41413-023-00270-z · Cited by 40
Strategies for promoting neurovascularization in bone regeneration
Li, X.-L., Zhao, Y., Li, M., An, Y.-X., Wu, F., Han, J.-Y., Han, J.-Y., Tay, F. R., 高木, 昭., Jiao, Y., et al. (2025) · Military Medical Research · doi:10.1186/s40779-025-00596-1 · Cited by 50
Pros and cons of fatty acids in bone biology
Wauquier, F., Léotoing, L., Philippe, C., Spilmont, M., Coxam, V., & Wittrant, Y. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.03.001 · Cited by 41
van Kampen, P. J., Martina, J. D., Vos, P. E., Hoedemaekers, C., & Hendricks, H. T. (2011) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181f78a59 · Cited by 41
Li, S., Li, Z., Yang, J., Ha, Y., Zhou, X., & He, C. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200785 · Cited by 43
Zhou (2009) · Molecular Medicine Reports · doi:10.3892/mmr_00000099 · Cited by 41
Wu, Y., Lan, Y., Mao, J., Shen, J., Kang, T., & Xie, Z. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00241-4 · Cited by 40
Crosstalk between Lipid Metabolism and Bone Homeostasis: Exploring Intricate Signaling Relationships
Xiao, H.-X., Li, W., Qin, Y., Lin, Z., Qian, C., Wu, M., Xia, Y., Bai, J., & Geng, D. (2024) · Research · doi:10.34133/research.0447 · Cited by 44
Propranolol Attenuates Risperidone-Induced Trabecular Bone Loss in Female Mice
Motyl, K. J., DeMambro, V., Barlow, D. J., Olshan, D. S., Nagano, K., Baron, R., Rosen, C. J., & Houseknecht, K. L. (2015) · Endocrinology · doi:10.1210/en.2015-1099 · Cited by 39
Hirai, T., Tanaka, K., & Togari, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.546135 · Cited by 40
Bone fractures after menopause
The ESHRE Capri Workshop Group (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq008 · Cited by 47
The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass
Mito, K., Sato, Y., Kobayashi, T., Miyamoto, K., Nitta, E., Iwama, A., Matsumoto, M., Nakamura, M., Sato, K., & Miyamoto, T. K. (2017) · Scientific Reports · doi:10.1038/srep45597 · Cited by 39
Beier, E. E., Sheu, T., Resseguie, E. A., Takahata, M., Awad, H. A., Cory‐Slechta, D. A., & Puzas, J. E. (2017) · Bone Research · doi:10.1038/boneres.2017.13 · Cited by 40
Morinaga, K., Sasaki, H., Park, S., Hokugo, A., Okawa, H., Tahara, Y., Colwell, C. S., & Nishimura, I. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.003 · Cited by 40
Huang, Z., Li, G., Zhang, Z., Gu, R., Wang, W., Lai, X., Cui, Z., Zeng, F., Xu, S., & Deng, F. (2019) · BMC Cancer · doi:10.1186/s12885-019-6301-1 · Cited by 40
RetractedGenetically Modified Animal Models as Tools for Studying Bone and Mineral Metabolism
Davey, R. A., MacLean, H. E., McManus, J. F., Findlay, D. M., & Zajac, J. D. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040206 · Cited by 40
Additive actions of the cannabinoid and neuropeptide Y systems on adiposity and lipid oxidation
Zhang, L., Lee, N. J., Nguyen, A. D., Enriquez, R., Riepler, S. J., Stehrer, B., Yulyaningsih, E., Lin, S., Shi, Y.-C., Baldock, P., et al. (2009) · Diabetes, obesity and metabolism · doi:10.1111/j.1463-1326.2009.01193.x · Cited by 36
Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling
Cohen, M. M. (2006) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31099 · Cited by 42
Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family
Bab, I., Smoum, R., Bradshaw, H. B., & Mechoulam, R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01474.x · Cited by 39
Locher, R. J., Lünnemann, T., Garbe, A., Schaser, K. D., Schmidt-Bleek, K., Duda, G. N., & Tsitsilonis, S. (2015) · Europe PMC (PubMed Central) · Cited by 39
Yokomoto‐Umakoshi, M., Kanazawa, I., Kondo, S., & Sugimoto, T. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej17-0011 · Cited by 39
Chronic Mild Stress Causes Bone Loss via an Osteoblast-Specific Glucocorticoid-Dependent Mechanism
Henneicke, H., Li, J., Kim, S., Gasparini, S. J., Seibel, M. J., & Zhou, H. (2017) · Endocrinology · doi:10.1210/en.2016-1658 · Cited by 43
Kim, B., Kwak, M. K., Ahn, S. H., Kim, H., Lee, S. H., Song, K., Suh, S., Kim, J. H., & Koh, J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00169 · Cited by 39
Wu, H., Song, Y., Li, J., Lei, X., Zhang, S., Gao, Y., Cheng, P., Liu, B., Miao, S., Bi, L., et al. (2019) · Cell Proliferation · doi:10.1111/cpr.12725 · Cited by 39
Hu, S., Shao, Z., Zhang, C., Chen, L., Mamun, A. A., Zhao, N., Cai, J., Lou, Z., Wang, X., & Chen, J. (2020) · Aging · doi:10.18632/aging.103339 · Cited by 39
Effect of leptin on differentiation of human dental stem cells
Um, S., Choi, J., Lee, J., Zhang, Q., & Seo, B. (2011) · Oral Diseases · doi:10.1111/j.1601-0825.2011.01820.x · Cited by 39
Interaction of bone and brain: osteocalcin and cognition
Nakamura, M., Imaoka, M., & Takeda, M. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1770247 · Cited by 42
Niwczyk, O., Grymowicz, M., Szczęsnowicz, A., Hajbos, M., Kostrzak, A., Budzik, M. P., Maciejewska-Jeske, M., Bala, G., Smolarczyk, R., & Męczekalski, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076840 · Cited by 39
Sheng, Z., Xu, K., Ou, Y., Dai, R.-C., Luo, X., Liu, S., Su, X. Y., Wu, X., Xie, H., Yuan, L., et al. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03941.x · Cited by 38
Albert, J. S., Bhattacharyya, N., Wolfe, L. A., Bone, W. P., Maduro, V. V. B., Accardi, J., Adams, D. R., Schwartz, C. E., Norris, J. W., Wood, T. C., et al. (2015) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-015-0235-8 · Cited by 38
Evolution of the Marrow Adipose Tissue Microenvironment
Craft, C. S., & Scheller, E. L. (2016) · Calcified Tissue International · doi:10.1007/s00223-016-0168-9 · Cited by 38
Lian, X., & Gollasch, M. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0692-z · Cited by 39
The Effects of Bariatric Surgery on Bone Metabolism
Gregory, N. S. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.09.011 · Cited by 38
Zhang, C., Chiu, P., Chan, B. P. M., Li, T., Wen, C., Xu, A., & Yan, C. H. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.03.002 · Cited by 38
Interaction between the nervous and skeletal systems
Xu, J., Zhang, Z., Zhao, J., Meyers, C. A., Lee, S., Qin, Q., & James, A. W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.976736 · Cited by 39
Dionyssiotis, Y. (2011) · PubMed · Cited by 38
Central and peripheral nervous systems: master controllers in cancer metastasis
Shi, M., Liu, D., Yang, Z., & Guo, N. (2013) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9440-x · Cited by 39
Bone Health and Associated Metabolic Complications in Neuromuscular Diseases
Joyce, N. C., Hache, L. P., & Clemens, P. R. (2012) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2012.08.005 · Cited by 41
Chen, J., Zhang, J., Lazarenko, O. P., Cao, J., Blackburn, M. L., Badger, T. M., & Ronis, M. J. J. (2013) · The FASEB Journal · doi:10.1096/fj.12-226464 · Cited by 40
Doping and musculoskeletal system: short‐term and long‐lasting effects of doping agents
Nikolopoulos, D., Spiliopoulou, C., & Theocharis, S. E. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00881.x · Cited by 41
Jahn, D., Knapstein, P. R., Otto, E., Köhli, P., Sevecke, J., Graef, F., Graffmann, C., Fuchs, M., Jiang, S., Rickert, M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk9129 · Cited by 38
Chamouni, A., Schreiweis, C., & Oury, F. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-015-9312-5 · Cited by 38
Kelly, M. J., & Rønnekleiv, O. (2012) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2012.07.002 · Cited by 40
Furuzawa, M., Chen, H., Fujiwara, S., Yamada, K., & Kubo, K. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.003 · Cited by 37
Glutamate Signaling in Healthy and Diseased Bone
Cowan, R. W., Seidlitz, E. P., & Singh, G. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00089 · Cited by 37
Bone endocrine regulation of energy metabolism and male reproduction
Karsenty, G. (2011) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2011.07.007 · Cited by 36
Self-citationBonnet, N., Benhamou, C. L., Beaupied, H., Laroche, N., Vico, L., Dolleans, E., & Courteix, D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00815.2006 · Cited by 37
Donepezil regulates energy metabolism and favors bone mass accrual
Eimar, H. A., Alebrahim, S., Manickam, G., Alsubaie, A., Nada, L. A., Murshed, M., & Tamimi, F. (2015) · Bone · doi:10.1016/j.bone.2015.12.009 · Cited by 37
Kuriyama, N., Inaba, M., Ozaki, E., Yoneda, Y., Matsui, D., Hashiguchi, K., Koyama, T., Iwai, K., Watanabe, I., Tanaka, R., et al. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.02.005 · Cited by 39
Nakamura, Y., Nakano, M., Suzuki, T., Sato, J., Kato, H., Takahashi, J. A., & Shiraki, M. (2019) · Bone · doi:10.1016/j.bone.2020.115404 · Cited by 39
(2019) · PubMed Central · Cited by 37
Ueland, T., Fougner, S. L., Godang, K., Lekva, T., Schurgers, L. J., Scholz, H., Halvorsen, B. L., Schreiner, T., Aukrust, P., & Bollerslev, J. (2009) · Endocrine Reviews · doi:10.1210/edrv.30.7.9997 · Cited by 37
Mpalaris, V., Anagnostis, P. G., Anastasilakis, A. D., Goulis, D. G., Doumas, A., & Iakovou, I. P. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.03.004 · Cited by 37
Wang, L., Hinoi, E., Takemori, A., Takarada, T., & Yoneda, Y. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706358 · Cited by 36
Vasoactive Intestinal Peptide Promotes Fracture Healing in Sympathectomized Mice
Shi, L., Liu, Y., Yang, Z., Wu, T., Lo, H. T. J., Xu, J., Zhang, J., Lin, W., Zhang, J., Lu, F., et al. (2021) · Calcified Tissue International · doi:10.1007/s00223-021-00820-9 · Cited by 36
Elevated leptin expression in rat model of traumatic spinal cord injury and femoral fracture
Wang, L., Tang, X., Zhang, H., Yuan, J., Ding, H., & Wei, Y. (2011) · Journal of Spinal Cord Medicine · doi:10.1179/2045772311y.0000000034 · Cited by 38
Shimizu, Y., Hosomichi, J., Kaneko, S., Shibutani, N., & Ono, T. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.05.004 · Cited by 36
Du, Z.-J., Wang, L., Zhao, L., Cao, J., Wang, T., Liu, P., Zhang, Y., Yang, X., Cheng, X., Liu, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105976 · Cited by 36
Self-citationBlair, H. C., Zaidi, M., Huang, C. L.-H., & Sun, L. (2008) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2008.00048.x · Cited by 37
Possover, M. (2013) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2013.10.030 · Cited by 36
Nervous Activity in a Stem Cell Niche
Larsson, J. T., & Scadden, D. T. (2006) · Cell · doi:10.1016/j.cell.2006.01.006 · Cited by 36
Calcium Kinetics Are Altered in Clinically Stable Girls with Cystic Fibrosis
Schulze, K. J., O'Brien, K. O., Germain‐Lee, E. L., Booth, S. L., Leonard, A., & Rosenstein, B. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031879 · Cited by 36
The COMT val158met Polymorphism Is Associated With Peak BMD in Men
Lorentzon, M., Eriksson, A., Mellström, D., & Ohlsson, C. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040909 · Cited by 36
Zhang, Z., Jiang, L., Jiang, S., & Dai, L. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20846 · Cited by 36
Investigational anabolic therapies for osteoporosis
Trivedi, R., Goswami, R., & Chattopadhyay, N. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.501077 · Cited by 35
Howard, J. T., Walick, K. S., & Rivera, J. C. (2015) · Journal of Pediatric Orthopaedics · doi:10.1097/bpo.0000000000000651 · Cited by 35
Neuronal Control of Bone Remodeling
Corr, A. P., Smith, J. T., & Baldock, P. A. J. (2017) · Toxicologic Pathology · doi:10.1177/0192623317738708 · Cited by 38
Doherty, A., Battaglino, R. A., Donovan, J. M., GAGNON, D. R., Lazzari, A. A., Garshick, E., ZAFONTE, R. D., & Morse, L. R. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2020 · Cited by 35
Bone and Metabolism: A Complex Crosstalk
Lieben, L., Callewaert, F., & Bouillon, R. (2009) · Hormone Research in Paediatrics · doi:10.1159/000178056 · Cited by 36
Wen, Z., Chang, Y., & Jean, Y. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.03.017 · Cited by 35
Leptin deficiency—Lessons in regional differences in the regulation of bone mass
Reid, I. R. (2003) · Bone · doi:10.1016/j.bone.2003.11.007 · Cited by 35
Structure and Function of Bone Marrow Adipocytes
de Paula, F. J. A., & Rosen, C. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170010 · Cited by 39
Brain, lifestyle and environmental pathways linking physical and mental health
Tian, Y., Cole, J. H., Bullmore, E. T., & Zalesky, A. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00303-4 · Cited by 39
Gordeladze, J. O., Djouad, F., Brondello, J., Noël, D., Duroux-Richard, I., Apparailly, F., & Jørgensen, C. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.143 · Cited by 36
Neuroimmune interactions in cardiovascular diseases
Carnevale, D., & Lembo, G. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa151 · Cited by 34
Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications
Piccinin, M. A., & Khan, Z. A. (2014) · Adipocyte · doi:10.4161/adip.32215 · Cited by 39
Hypothalamic control of bone metabolism
Sharan, K., & Yadav, V. K. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.04.003 · Cited by 34
Lee, S. W., Rho, J. H., Lee, S. Y., Kim, J., Cheong, J.-H., Kim, H. Y., Jeong, N. Y., Chung, W. T., & Yoo, Y. H. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.06.005 · Cited by 34
The control of bone remodeling by neuropeptide Y receptors
Allison, S. J., Baldock, P. A. J., & Herzog, H. (2006) · Peptides · doi:10.1016/j.peptides.2006.05.029 · Cited by 34
Ye, J., Huang, B., & Gong, P. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-02177-5 · Cited by 37
Schurman, C. A., Burton, J. B., Rose, J., Ellerby, L., Alliston, T. N., & Schilling, B. (2023) · Journal of Bone Metabolism · doi:10.11005/jbm.2023.30.1.1 · Cited by 33
β-adrenergic receptor signaling regulates Ptgs2 by driving circadian gene expression in osteoblasts
Hirai, T., Tanaka, K., & Togari, A. (2014) · Journal of Cell Science · doi:10.1242/jcs.148148 · Cited by 33
Muscle–bone interactions: movement in the field of mechano–humoral coupling of muscle and bone
Cardozo, C. P., & Graham, Z. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13411 · Cited by 32
Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice
Zhu, Y., Ma, Y., & Elefteriou, F. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.11.002 · Cited by 34
Self-citationBiomarkers of Osteoporosis: An Update
Parveen, B., Parveen, A., & Vohora, D. (2019) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666190204165207 · Cited by 33
Rösch, G., Bagdadi, K. E., Muschter, D., Taheri, S., Dorn, C., Meurer, A., Straub, R. H., Zaucke, F., Schilling, A. F., Grässel, S., et al. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.11.016 · Cited by 33
Jarecki, J., Malecka-Massalska, T. J., Kosior‐Jarecka, E., Widuchowski, W., Krasowski, P., Gutbier, M., Dobrzyński, M., & Blicharski, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063530 · Cited by 33
Metadata
- Authors
- Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Baylor College of Medicine (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 111
- Issue
- 3
- Pages
- 305-317
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2147510409
- Cited by
- 1,735
- References
- 54
- Citations by year
- 2026: 50 · 2025: 58 · 2024: 61 · 2023: 49 · 2022: 55 · 2021: 57 · 2020: 69 · 2019: 70 · 2018: 66 · 2017: 68 · 2016: 66 · 2015: 81 · 2014: 86 · 2013: 71 · 2012: 105
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-54480, R01DK058883, R01DK054480, DK58883)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24054)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- leptin, bone formation, sympathetic nervous system, beta-adrenergic receptors, osteoblast proliferation, leptin resistance, leptin deficiency, hypothalamic neurons, osteoporosis, bone mass, ovariectomy
- MeSH terms
- Adrenergic beta-Antagonists, Animals, Cells, Cultured, Hypothalamus, Mice, Inbred C57BL, Neuropeptides, Obesity, Oligopeptides, Osteoblasts, Osteogenesis, Pyrrolidonecarboxylic Acid, Receptors, Adrenergic, beta, Sympathetic Nervous System, Receptors, Corticotropin, Leptin, Receptor, Melanocortin, Type 4, Mice, Receptors, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
