Cited by 2,738Cell death mechanisms and regulationNF-κB Signaling PathwaysImmune Response and Inflammation

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

Open access

Micheau, Olivier, Tschopp, Jürg·2003·Cell

Open this paper in CoChat — free account Open PDF

Abstract

Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to activate the transcription factor NF-kappa B and promote survival. The mechanism by which this decision between cell death and survival is arbitrated is not clear. We report that TNFR1-induced apoptosis involves two sequential signaling complexes. The initial plasma membrane bound complex (complex I) consists of TNFR1, the adaptor TRADD, the kinase RIP1, and TRAF2 and rapidly signals activation of NF-kappa B. In a second step, TRADD and RIP1 associate with FADD and caspase-8, forming a cytoplasmic complex (complex II). When NF-kappa B is activated by complex I, complex II harbors the caspase-8 inhibitor FLIP(L) and the cell survives. Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated.

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(03)00521-x

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.
Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Inhibition of death receptor signals by cellular FLIP
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548
Self-citation
TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways
Hsu, H., Shu, H., Pan, M., & Goeddel, D. V. (1996) · Cell · doi:10.1016/s0092-8674(00)80984-8 · Cited by 1,998
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,987
Self-citation
TNF-R1 Signaling: A Beautiful Pathway
Chen, G., & Goeddel, D. V. (2002) · Science · doi:10.1126/science.1071924 · Cited by 1,930
Signal transduction by tumor necrosis factor and its relatives.
Baud, V., & Karin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02064-5 · Cited by 1,741
CD95's deadly mission in the immune system
Krammer, P. H. (2000) · Nature · doi:10.1038/35037728 · Cited by 1,710
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., et al. (1997) · Nature · doi:10.1038/386517a0 · Cited by 1,316
Self-citation

Show all 40 references

Sorted by citations

Items 701–800 of 1,008

The effect of TNFα secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT/BMP signaling in osteoprogenitor cells
Lee, S., Sharma, A. R., Choi, B., Jung, J., Chang, J., Park, S., Salvati, E. A., Purdue, P. E., Song, D., & Nam, J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.005 · Cited by 73
Caspase‐8 functions as a key mediator of inflammation and pro‐IL‐1β processing via both canonical and non‐canonical pathways
Monie, T. P., & Bryant, C. E. (2015) · Immunological Reviews · doi:10.1111/imr.12284 · Cited by 74
TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT
Lalaoui, N., Morlé, A., Mérino, D., Jacquemin, G., Iessi, E., Morizot, A., Shirley, S., Robert, B., Solary, É., Garrido, C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019679 · Cited by 73
Self-citation
Divergence from a Dedicated Cellular Suicide Mechanism: Exploring the Evolution of Cell Death
Yuan, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.008 · Cited by 73
Glutathione Depletion Down-regulates Tumor Necrosis Factor α-induced NF-κB Activity via IκB Kinase-dependent and -independent Mechanisms
Lou, H., & Kaplowitz, N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706145200 · Cited by 71
The Interferon Stimulator Mitochondrial Antiviral Signaling Protein Facilitates Cell Death by Disrupting the Mitochondrial Membrane Potential and by Activating Caspases
Yu, C.-Y., Chiang, R.-L., Chang, T.-H., Liao, C., & Lin, Y. (2009) · Journal of Virology · doi:10.1128/jvi.02174-09 · Cited by 76
Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndrome
Kimberley, F. C., Lobito, A. A., Siegel, R. M., & Screaton, G. R. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2197 · Cited by 73
TNF/TNFR: drug target for autoimmune diseases and immune-mediated inflammatory diseases
Doss, C. G. P. (2014) · Frontiers in bioscience · doi:10.2741/4265 · Cited by 73
TNF-α sensitizes chemotherapy and radiotherapy against breast cancer cells
Wu, X., Wu, M., Jiang, M., Zhi, Q., Bian, X., Xu, M., Gong, F.-R., Hou, J., Tao, M., Shou, L., et al. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0382-1 · Cited by 73
Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling
Song, Y., Gao, J. H., Guan, L., Chen, X., Gao, J., & Wang, K. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0735-2 · Cited by 72
Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review
Xu, W., Li, R., & Huang, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.891328 · Cited by 72
Regulatory RNAs and paracrine networks in the heart
Viereck, J., Bang, C., Foinquinos, A., & Thum, T. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu039 · Cited by 71
Exploring death receptor pathways as selective targets in cancer therapy
Russo, M., Mupo, A., Spagnuolo, C., & Russo, G. L. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.03.011 · Cited by 72
Survival and apoptotic pathways initiated by TNF‐α: Modeling and predictions
Rangamani, P., & Sirovich, L. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.21307 · Cited by 72
Redox regulation of hepatocyte apoptosis
García‐Ruiz, C., & Fernández-Checa, J. C. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04644.x · Cited by 71
To fight or die — inhibitor of apoptosis proteins at the crossroad of innate immunity and death
Lopez, J. S., & Meier, P. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.025 · Cited by 71
Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease
Zilberman‐Rudenko, J., Shawver, L., Wessel, A. W., Luo, Y., Pelletier, M., Tsai, W. L., Lee, Y., Vonortas, S., Cheng, L. E., Ashwell, J. D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518163113 · Cited by 75
The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator
Richard, A. C., Ferdinand, J. R., Meylan, F., Hayes, E. T., Gabay, O., & Siegel, R. M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0315-095r · Cited by 72
Necroptosis in cancer: An angel or a demon?
Wang, T., Jin, Y., Yang, W., Zhang, L., Jin, X., Liu, X., He, Y., & Li, X. (2017) · Tumor Biology · doi:10.1177/1010428317711539 · Cited by 72
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth
Ward, G. A., Lewis, E. J., Ahn, J. S., Johnson, C. N., Lyons, J. F., Martins, V., Munck, J. M., Rich, S. J., Smyth, T., Thompson, N. T., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0848 · Cited by 78
Keratins Modulate c-Flip/Extracellular Signal-Regulated Kinase 1 and 2 Antiapoptotic Signaling in Simple Epithelial Cells
Gilbert, S., Loranger, A., & Marceau, N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7072-7081.2004 · Cited by 72
Mediators of necroptosis: from cell death to metabolic regulation
Wu, X., Nagy, L. E., & Gautheron, J. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-023-00011-z · Cited by 78
Mediators of oligodendrocyte differentiation during remyelination
Patel, J. R., & Klein, R. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.037 · Cited by 76
TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathway
Marqués-Fernàndez, F., Planells‐Ferrer, L., Gozzelino, R., Galenkamp, K. M. O., Reix, S., Llecha-Cano, N., López‐Soriano, J., Yuste, V. J., Moubarak, R. S., & Comella, J. X. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.25 · Cited by 70
Vaccinia virus evasion of regulated cell death
Veyer, D. L., Carrara, G., de Motes, C. M., & Smith, G. L. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.03.015 · Cited by 75
The TNF Receptor 1
Barnhart, B. C., & Peter, M. E. (2003) · Cell · doi:10.1016/s0092-8674(03)00561-0 · Cited by 71
The Cathepsin B Death Pathway Contributes to TNF Plus IFN-γ-Mediated Human Endothelial Injury
Li, J. H., & Pober, J. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1858 · Cited by 71
Linear ubiquitination signals in adaptive immune responses
Ikeda, F. (2015) · Immunological Reviews · doi:10.1111/imr.12300 · Cited by 71
TRAILblazing Strategies for Cancer Treatment
Kretz, A.-L., Trauzold, A., Hillenbrand, A., Knippschild, U., Henne‐Bruns, D., von Karstedt, S., & Lemke, J. (2019) · Cancers · doi:10.3390/cancers11040456 · Cited by 71
The Multiple Roles of the IAP Super-family in cancer
Kumar, S., Fairmichael, C., Longley, D. B., & Turkington, R. C. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107610 · Cited by 72
The ANKK1 Gene Associated with Addictions Is Expressed in Astroglial Cells and Upregulated by Apomorphine
Hoenicka, J., Quiñones‐Lombraña, A., España‐Serrano, L., Alvira, X., Kremer, L., Pérez‐González, R., Rodríguez–Jiménez, R., Jiménez‐Arriero, M. Á., Ponce, G., & Palomo, T. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.012 · Cited by 70
The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation
Song, J., Kang, S. M., Lee, K. M., & Lee, J. E. (2015) · BioMed Research International · doi:10.1155/2015/854359 · Cited by 72
Tumor necrosis factor p55 and p75 receptors are involved in chemical‐induced apoptosis of dentate granule neurons
Harry, G. J., d’Hellencourt, C. L., McPherson, C. A., Funk, J. A., Aoyama, M., & Wine, R. N. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05382.x · Cited by 72
Differential Influence of Normal and Cancer-Associated Fibroblasts on the Growth of Human Epithelial Cells in an In vitro Cocultivation Model of Prostate Cancer
Paland, N., Kamer, I., Kogan-Sakin, I., Madar, S., Goldfinger, N., & Rotter, V. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0073 · Cited by 72
RIPK3 signaling and its role in the pathogenesis of cancers
Liu, S., Joshi, K., Denning, M. F., & Zhang, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03947-y · Cited by 72
Measurement of Apoptosis and Other Forms of Cell Death
Muppidi, J. R., Porter, M. B., & Siegel, R. M. (2004) · Current Protocols in Immunology · doi:10.1002/0471142735.im0317s59 · Cited by 69
Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity
Krajewska, M., You, Z., Rong, J., Kress, C. L., Huang, X., Yang, J., Kyoda, T., Leyva, R., Banares, S., Hu, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024341 · Cited by 74
Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage
Lotocki, G., Vaccari, J. P. D. R., Perez, E. R., Alonso, O. F., Curbelo, K., Keane, R. W., & Dietrich, W. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05123.x · Cited by 69
Necroptotic signaling in adaptive and innate immunity
Lu, J. V., Chen, H. C., & Walsh, C. M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.07.003 · Cited by 71
Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice
Nicolaou, A., Zhao, Z., Northoff, B. H., Sass, K., Herbst, A., Kohlmaier, A., Chalaris, A., Wolfrum, C., Weber, C., Steffens, S., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308682 · Cited by 69
Unleashing TNF cytotoxicity to enhance cancer immunotherapy
Freeman, A. J., Kearney, C. J., Silke, J., & Oliaro, J. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.10.003 · Cited by 69
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
Yan, L., Zhang, T., Wang, K., Chen, Z., Yang, Y., Shan, B., Sun, Q., Zhang, M., Zhang, Y., Zhong, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34993-0 · Cited by 71
Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
Riley, J. S., Hutchinson, R. A., McArt, D. G., Crawford, N., Holohan, C., Paul, I., Schaeybroeck, S. V., Salto‐Tellez, M., Johnston, P. G., Fennell, D. A., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.481 · Cited by 73
Mechanisms regulating neutrophil survival and cell death
Gabelloni, M. L., Trevani, A. S., Sabatté, J., & Geffner, J. R. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0364-x · Cited by 72
Biology and signal transduction pathways of the Lymphotoxin-αβ/LTβR system
Remouchamps, C., Boutaffala, L., Ganeff, C., & Dejardin, E. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.11.007 · Cited by 68
Necroptosis: Biochemical, Physiological and Pathological Aspects
Dunai, Z. A., Bauer, P. I., & Mihalik, R. (2011) · Pathology & Oncology Research · doi:10.1007/s12253-011-9433-4 · Cited by 69
The α1β1 Integrin and TNF Receptor II Protect Airway CD8+ Effector T Cells from Apoptosis during Influenza Infection
Richter, M. V., & Topham, D. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5054 · Cited by 73
Negative Feedback Regulation of NF-κB Action by CITED2 in the Nucleus
Lou, X., Sun, S., Chen, W., Zhou, Y., Huang, Y., Liu, X., Shan, Y., & Wang, C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001650 · Cited by 70
Cisplatin-induced necroptosis in TNFα dependent and independent pathways
Xu, Y., Ma, H., Fang, Y., Zhang, Z., Shao, J., Hong, M., Huang, C., Liu, J., & Chen, R. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.01.004 · Cited by 67
A Novel Caspase-2 Complex Containing TRAF2 and RIP1
Lamkanfi, M., D'Hondt, K., Walle, L. V., van Gurp, M., Denecker, G., Demeulemeester, J., Kalai, M., Declercq, W., Saelens, X., & Vandenabeele, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411180200 · Cited by 68
Ars Moriendi; the art of dying well – new insights into the molecular pathways of necroptotic cell death
Murphy, J. M., & Silke, J. (2014) · EMBO Reports · doi:10.1002/embr.201337970 · Cited by 69
Primidone blocks RIPK1-driven cell death and inflammation
Riebeling, T., Jamal, K., Wilson, R., Kolbrink, B., von Samson‐Himmelstjerna, F. A., Moerke, C., Garcia, L. R., Dahlke, E., Michels, F., Lühder, F., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00690-y · Cited by 65
Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate
Fox, J. L., Hughes, M. A., Meng, X., Sarnowska, N. A., Powley, I. R., Jukes‐Jones, R., Dinsdale, D. D., Ragan, T. J., Fairall, L., Schwabe, J. W. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20806-9 · Cited by 72
Role of necroptosis in traumatic brain and spinal cord injuries
Hu, X., Xu, Y. M., Zhang, H., Li, Y., Wang, X., Xu, C., Ni, W., & Zhou, K. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.12.002 · Cited by 68
Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopenia
Li, X., Li, F., Zhang, X., Zhang, H., Zhao, Q., Li, M., Wu, X., Wang, L., Liu, J., Wu, X., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00938-9 · Cited by 69
Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses
Wood, S. J., Goldufsky, J. W., Seu, M. Y., Dorafshar, A. H., & Shafikhani, S. H. (2023) · Cells · doi:10.3390/cells12010195 · Cited by 79
The mechanism of chronic intracellular infection with Brucella spp.
Guo, X., Zeng, H., Li, M., Xiao, Y., Gu, G., Song, Z., Shuai, X., Guo, J., Huang, Q., Zhou, B., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1129172 · Cited by 69
Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications
Salete-Granado, D., Carbonell, C., Puertas-Miranda, D., Vega-Rodríguez, V.-J., Macia, M. G., Herrero, A. B., & Marcos, M. (2023) · Antioxidants · doi:10.3390/antiox12071425 · Cited by 69
Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases
Chen, Z., Ding, W., Yang, X., Lu, T., & Liu, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117059 · Cited by 71
Sam68 Is Required for Both NF-κB Activation and Apoptosis Signaling by the TNF Receptor
Ramakrishnan, P., & Baltimore, D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.007 · Cited by 68
Paired Box Gene 5 Is a Novel Tumor Suppressor in Hepatocellular Carcinoma Through Interaction With p53 Signaling Pathway §Δ
Liu, W., Li, X., Chu, E. S., Go, M. Y. Y., Xu, L., Zhao, G., Li, L., Dai, N., Si, J., Tao, Q., et al. (2010) · Hepatology · doi:10.1002/hep.24124 · Cited by 67
AMP-activated protein kinase confers protection against TNF-α-induced cardiac cell death
Kewalramani, G., Puthanveetil, P., Wang, F., Kim, M. S., Deppe, S., Abrahani, A., Luciani, D. S., Johnson, J. D., & Rodrigues, B. B. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp166 · Cited by 67
The Ubiquitin System in Immune Regulation
Park, Y., Jin, H., Aki, D., Lee, J., & Liu, Y. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800147-9.00002-9 · Cited by 71
RNAseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation as a Major Abnormality in ALS Spinal Cord
Brohawn, D. G., O’Brien, L. C., & Bennett, J. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160520 · Cited by 65
Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death
Laghlali, G., Lawlor, K. E., & Tate, M. D. (2020) · Viruses · doi:10.3390/v12040401 · Cited by 71
Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases
Liu, J., & Lin, A. (2007) · Oncogene · doi:10.1038/sj.onc.1210417 · Cited by 67
Human Cytomegalovirus Attenuates Interleukin-1β and Tumor Necrosis Factor Alpha Proinflammatory Signaling by Inhibition of NF-κB Activation
Jarvis, M. A., Borton, J. A., Keech, A. M., Wong, J. W., Britt, W. J., Magun, B. E., & Nelson, J. A. (2006) · Journal of Virology · doi:10.1128/jvi.00060-06 · Cited by 67
The CD95/CD95L signaling pathway: A role in carcinogenesis
Fouqué, A., Debure, L., & Legembre, P. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.007 · Cited by 72
Structural analyses of death domains and their interactions
Park, H. H. (2011) · APOPTOSIS · doi:10.1007/s10495-010-0571-z · Cited by 68
Necroptosis in heart disease: Molecular mechanisms and therapeutic implications
Guo, X., Chen, Y., & Liu, Q. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.05.006 · Cited by 70
Tumor necrosis factor (TNF) biology and cell death
Bertazza, L. (2007) · Frontiers in bioscience · doi:10.2741/2881 · Cited by 66
NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells
Singh, K., Poteryakhina, A. V., Zheltukhin, A. O., Bhatelia, K., Prajapati, P., Sripada, L., Tomar, D., Singh, R. K., Singh, A. K., Chumakov, P. M., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.01.016 · Cited by 70
NF-κB Inhibition Reveals Differential Mechanisms of TNF Versus TRAIL-Induced Apoptosis Upstream or at the Level of Caspase-8 Activation Independent of cIAP2
Diessenbacher, P., Hupe, M., Sprick, M. R., Kerstan, A., Geserick, P., Haas, T. L., Wachter, T., Neumann, M., Walczak, H., Silke, J., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701141 · Cited by 68
Activation of Nuclear Factor κB (NF-κB) in Prostate Cancer Is Mediated by Protein Kinase C ϵ (PKCϵ)
Garg, R., Blando, J. M., Pérez, C. J., Wang, H., Benavides, F. J., & Kazanietz, M. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.398925 · Cited by 66
The Adaptor Protein TRADD Is Essential for TNF-Like Ligand 1A/Death Receptor 3 Signaling
Pobezinskaya, E. L., Choksi, S., Morgan, M. J., Cao, X., & Liu, Z.-G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002374 · Cited by 66
Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion
Shirley, S., Morizot, A., & Micheau, O. (2011) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489211796957757 · Cited by 66
Self-citation
Multifunctional murrel caspase 1, 2, 3, 8 and 9: Conservation, uniqueness and their pathogen-induced expression pattern
Kumaresan, V., Ravichandran, G., Nizam, F., Dhayanithi, N. B., Arasu, M. V., Al-Dhabi, N. A., Harikrishnan, R., & Arockiaraj, J. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.01.008 · Cited by 67
TNFR signalling and its clinical implications
Tseng, W.-Y., Huang, Y.-S., Lin, H., Luo, S., McCann, F. E., McNamee, K., Clanchy, F. I. L., & Williams, R. O. (2016) · Cytokine · doi:10.1016/j.cyto.2016.08.027 · Cited by 71
MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity
Lee, I. Y., Lim, J. M., Cho, H., Kim, E., Kim, Y., Oh, H.-K., Yang, W. S., Roh, K.-H., Park, H. W., Mo, J., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.022 · Cited by 68
Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3β Signaling Pathway
Alhusaini, A. M., Fadda, L. M., Hasan, I. H., Zakaria, E. A., Alenazi, A. M., & Mahmoud, A. M. (2019) · Biomolecules · doi:10.3390/biom9110703 · Cited by 72
Role of nitric oxide in liver regeneration
Carnovale, C. E., & Ronco, M. T. (2012) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31436-x · Cited by 65
Tumor Necrosis Factor-α: Life and Death of Hepatocytes During Liver Ischemia/Reperfusion Injury.
Shuh, M., Bohorquez, H. E., Loss, G. E., & Cohen, A. J. (2013) · Europe PMC (PubMed Central) · Cited by 65
Potential role of NF‐κB in adult neural stem cells: the underrated steersman?
Widera, D., Mikenberg, I., Kaltschmidt, B., & Kaltschmidt, C. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.017 · Cited by 65
Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus
Ingaramo, P. I., Ronco, M. T., Francés, D. E., Monti, J. A., Pisani, G. B., Ceballos, M. P., Galleano, M., Carrillo, M. C., & Carnovale, C. E. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.03.015 · Cited by 65
Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo
Yang, T., Shi, R., Chang, L., Tang, K., Chen, K., Gan, Y., Tian, Y., Guo, Y., He, W., Song, X., et al. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0134-9 · Cited by 65
Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity
Krippner‐Heidenreich, A., Grunwald, I., Zimmermann, G., Kühnle, M., Gerspach, J., Sterns, T., Shnyder, S. D., Gill, J. H., Männel, D. N., Pfizenmaier, K., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8176 · Cited by 65
c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis
Chaudhury, H., Zakkar, M., Boyle, J. J., Cuhlmann, S., der Heiden, K. V., Luong, L. A., Davis, J., Platt, A., Mason, J. C., Krams, R., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.201368 · Cited by 65
Necroptosis: Who Knew There were so Many Interesting Ways to Die?
Fayaz, S. M., Kumar, V. S. S., & Rajanikant, G. K. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660189 · Cited by 65
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes
Liang, S., Lv, Z., Zhang, J., Wang, Y., Dong, Y., Wang, Z., Chen, K., Cheng, P., Yang, Q., Guo, F., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01378 · Cited by 66
Gene expression changes in dorsal root ganglia following peripheral nerve injury: roles in inflammation, cell death and nociception
Martin, S. L., Reid, A. J., Verkhratsky, A., Magnaghi, V., & Faroni, A. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.250566 · Cited by 65
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.032 · Cited by 64
Interleukin-1β and TNF-α systems in ovarian follicles and their roles during follicular development, oocyte maturation and ovulation
Silva, J., Lima, F. E. O., Souza, A., & Silva, A. (2020) · Zygote (Cambridge. Print) · doi:10.1017/s0967199420000222 · Cited by 56
Novel role of macrophage TXNIP-mediated CYLD–NRF2–OASL1 axis in stress-induced liver inflammation and cell death
Zhan, Y., Xu, D., Tian, Y., Qu, X., Sheng, M., Lin, Y., Ke, M., Jiang, L., Xia, Q., Kaldas, F. M., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100532 · Cited by 67
Neuroinflammation in neurodegeneration via microbial infections
Tran, V. T. A., Lee, L. P., & Cho, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907804 · Cited by 72
RIP1K and RIP3K provoked by shikonin induce cell cycle arrest in the triple negative breast cancer cell line, MDA-MB-468: necroptosis as a desperate programmed suicide pathway
Shahsavari, Z., Karami‐Tehrani, F., Salami, S., & Ghasemzadeh, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-4258-5 · Cited by 65
Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis
Lavrik, I. N., Golks, A., Baumann, S., & Krammer, P. H. (2006) · Blood · doi:10.1182/blood-2005-07-007096 · Cited by 64
Ubiquitin in NF-κB Signaling
Chiu, Y., Zhao, M., & Chen, Z. J. (2009) · Chemical Reviews · doi:10.1021/cr800554j · Cited by 65
Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth
Baxendale, A. J., Dawson, C., Stewart, S. E., Mudaliar, V., Reynolds, G. M., Gordon, J., Murray, P. G., Young, L. S., & Eliopoulos, A. G. (2005) · Oncogene · doi:10.1038/sj.onc.1208929 · Cited by 64
The Ripoptosome: Death Decision in the Cytosol
Bertrand, M. J. M., & Vandenabeele, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.007 · Cited by 64
Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury
Chavez‐Valdez, R., Martin, L. J., & Northington, F. J. (2012) · Neurology Research International · doi:10.1155/2012/257563 · Cited by 64

Authors: Micheau, O., & Tschopp, J.
Affiliations: University of Lausanne (CH)
Corresponding author: Tschopp, Jürg
ORCID: Micheau, Olivier
Venue: Cell
Publisher: Elsevier BV
Published: 2003-07
Volume: 114
Issue: 2
Pages: 181-190
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(03)00521-x
OpenAlex: W2114727688
Cited by: 2,738
References: 40
Citations by year: 2026: 91 · 2025: 103 · 2024: 113 · 2023: 132 · 2022: 152 · 2021: 129 · 2020: 132 · 2019: 107 · 2018: 112 · 2017: 123 · 2016: 132 · 2015: 123 · 2014: 139 · 2013: 125 · 2012: 144
FWCI: 33.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3669 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: TNF receptor 1, apoptosis, TRADD, RIPK1, TRAF2, FADD, caspase-8, FLIP(L), NF-κB activation, cell survival, receptor signaling complex
MeSH terms: Carrier Proteins, Cell Membrane, Cell Survival, Cytoplasm, Humans, Models, Biological, Proteins, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Signal Transduction, Transcriptional Activation, NF-kappa B, RNA-Binding Proteins, Apoptosis, Receptors, Tumor Necrosis Factor, fas Receptor, Jurkat Cells, Caspases, Nuclear Pore Complex Proteins, Intracellular Signaling Peptides and Proteins, TNF Receptor-Associated Factor 1, Adaptor Proteins, Signal Transducing, Caspase 8, Fas-Associated Death Domain Protein, CASP8 and FADD-Like Apoptosis Regulating Protein, Caspase 9, Caspase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks