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Cold feet and prolonged sleep-onset latency in vasospastic syndrome
Abstract
People with vasospastic syndrome have cold hands and feet and abnormal vasoconstriction after local cold exposure. Normally there is a circadian rhythm of distal vasodilation, with onset in the early evening, which directly influences ability to fall asleep. We gave a sleep questionnaire to 32 patients with primary vasospastic syndrome and 31 healthy controls. People with vasospasticity had significantly prolonged sleep-onset latency both at onset of night-time sleep and after nocturnal disturbance. This prolonged latency could be associated with impaired capacity for distal vasodilation.
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“The same association was shown for people with a vasospastic syndrome, who have a lower temperature of their hands and tend to have difficulties falling asleep [64]”
From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [64]
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Metadata
- Authors
- Pache, M., Kräuchi, K., Cajochen, C., Wirz-Justice, A., Dubler, B., Flammer, J., & Kaiser, H. J.
- Affiliations
- Universitäre Psychiatrische Kliniken Basel (CH)
- Corresponding author
- Pache, Mona
- ORCID
- Cajochen, Christian
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 358
- Issue
- 9276
- Pages
- 125-126
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1992460259
- Cited by
- 104
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Keywords
- cold hands and feet, sleep latency, circadian rhythm, vasoconstriction, nocturnal sleep disturbance
- MeSH terms
- Adult, Aged, Constriction, Pathologic, Female, Foot, Humans, Hypothermia, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Predictive Value of Tests, Surveys and Questionnaires, Risk Factors, Syndrome, Vasodilation, Case-Control Studies, Sleep Disorders, Circadian Rhythm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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