Cited by 1,761Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

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Association between telomere length in blood and mortality in people aged 60 years or older

Cawthon, Richard M, Smith, Ken R, O'Brien, Elizabeth, Sivatchenko, Anna, Kerber, Richard A·2003·The Lancet

DOI 10.1016/s0140-6736(03)12384-7

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Abstract

During normal ageing, the gradual loss of telomeric DNA in dividing somatic cells can contribute to replicative senescence, apoptosis, or neoplastic transformation. In the genetic disorder dyskeratosis congenita, telomere shortening is accelerated, and patients have premature onset of many age-related diseases and early death. We aimed to assess an association between telomere length and mortality in 143 normal unrelated individuals over the age of 60 years. Those with shorter telomeres in blood DNA had poorer survival, attributable in part to a 3.18-fold higher mortality rate from heart disease (95% CI 1(.)36-7.45, p=0.0079), and an 8.54-fold higher mortality rate from infectious disease (1.52-47.9, p=0.015). These results lend support to the hypothesis that telomere shortening in human beings contributes to mortality in many age-related diseases.

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Authors: Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A.
Affiliations: University of Utah (US)
Corresponding author: Cawthon, Richard M
ORCID: Cawthon, Richard M
Smith, Ken R
Venue: The Lancet
Publisher: Elsevier BV
Published: 2003-02
Volume: 361
Issue: 9355
Pages: 393-395
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(03)12384-7
OpenAlex: W2145859123
Cited by: 1,761
References: 5
Citations by year: 2026: 14 · 2025: 32 · 2024: 52 · 2023: 57 · 2022: 64 · 2021: 68 · 2020: 90 · 2019: 75 · 2018: 101 · 2017: 102 · 2016: 100 · 2015: 91 · 2014: 122 · 2013: 79 · 2012: 87
FWCI: 36.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag013478-04, 5k01ag000767-05)
National Institute on Aging (AG13478, K01 AG00767)
National Cancer Institute (R29CA069421, R29 CA69421)
NIH Clinical Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: telomere length, mortality, aging, replicative senescence, dyskeratosis congenita, heart disease mortality, infectious disease mortality, age-related diseases, blood DNA, older adults
MeSH terms: Aged, Aged, 80 and over, Aging, Blood Donors, Cause of Death, Communicable Diseases, Female, Heart Diseases, Humans, Male, Middle Aged, Mortality, Population Surveillance, Utah, Proportional Hazards Models, Survival Analysis, Telomere, Apoptosis, Age Distribution, Dyskeratosis Congenita

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Association between telomere length in blood and mortality in people aged 60 years or older

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