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Association between telomere length in blood and mortality in people aged 60 years or older
Abstract
During normal ageing, the gradual loss of telomeric DNA in dividing somatic cells can contribute to replicative senescence, apoptosis, or neoplastic transformation. In the genetic disorder dyskeratosis congenita, telomere shortening is accelerated, and patients have premature onset of many age-related diseases and early death. We aimed to assess an association between telomere length and mortality in 143 normal unrelated individuals over the age of 60 years. Those with shorter telomeres in blood DNA had poorer survival, attributable in part to a 3.18-fold higher mortality rate from heart disease (95% CI 1(.)36-7.45, p=0.0079), and an 8.54-fold higher mortality rate from infectious disease (1.52-47.9, p=0.015). These results lend support to the hypothesis that telomere shortening in human beings contributes to mortality in many age-related diseases.
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In the citing paper
“telomere length has been shown to predict the replicative capacity of human cells and the appearance of certain age-associated pathologies in humans 54, 55”
From The common biology of cancer and ageing (2007) · cites this paper as [55]
In the citing paper
“In several studies, not only did baseline LTL correlate with medical illnesses cross-sectionally but predicted the subsequent development of cancers, CVD, diabetes or mortality (Cawthon et al., 2003; Willeit et al 2010; Zhao et al., 2014).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Cawthon et al., 2003
In the citing paper
“There are some studies linking shorter LTL with premature mortality (Cawthon et al., 2003; Fitzpatrick et al., 2011; Weischer et al., 2012) and a reduction in years of healthy living (Njajou et al., 2009).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Cawthon et al., 2003
In the citing paper
“Short telomeres have been linked to numerous diseases of aging and in many but not all cases, to all-cause and disease-specific mortality (12–17).”
From Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter (2015) · cites this paper as [17]
Citations
Cites
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,538
Self-citationThe RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960
Construction of linkage maps with DNA markers for human chromosomes
White, R. L., Leppert, M., Bishop, D. T., Barker, D. F., Berkowitz, J., Brown, C. S., Callahan, P. M., Holm, T., & Jerominski, L. (1985) · Nature · doi:10.1038/313101a0 · Cited by 317
Comparison of 2 Methods for Calculating Adjusted Survival Curves From Proportional Hazards Models
Ghali, W. A. (2001) · JAMA · doi:10.1001/jama.286.12.1494 · Cited by 254
Replicative Aging, Telomeres, and Oxidative Stress
Saretzki, G. C., & von Zglinicki, T. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02079.x · Cited by 253
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Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
Self-citationCellular senescence in cancer and aging.
Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,434
Walston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00745.x · Cited by 1,605
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Senescence and aging: Causes, consequences, and therapeutic avenues
McHugh, D., & Gil, J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201708092 · Cited by 1,233
DNA methylation age of blood predicts all-cause mortality in later life
Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0584-6 · Cited by 1,261
Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
The common biology of cancer and ageing
Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Jaskelioff, M., Muller, F. L., Paik, J.-H., Thomas, E., Jiang, S., Adams, A. C., Sahin, E., Kost-Alimova, M., Protopopov, A., Cadiñanos, J., et al. (2011) · Nature · doi:10.1038/nature09603 · Cited by 857
How stem cells age and why this makes us grow old
Sharpless, N. E., & DePinho, R. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2241 · Cited by 743
Cole, J. H., Ritchie, S. J., Bastin, M. E., Hernández, M. C. V., Maniega, S. M., Royle, N. A., Corley, J., Pattie, A., Harris, S. E., Zhang, Q., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.62 · Cited by 848
Regulation of Telomerase by Telomeric Proteins
Smogorzewska, A., & de Lange, T. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.160049 · Cited by 813
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773
Linking functional decline of telomeres, mitochondria and stem cells during ageing
Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759
Telomere length, stem cells and aging
Blasco, M. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.38 · Cited by 747
Brouilette, S., Moore, J. S., McMahon, A. D., Thompson, J. R., Ford, I., Shepherd, J., Packard, C. J., & Samani, N. J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60071-3 · Cited by 747
Telomere length in early life predicts lifespan
Heidinger, B. J., Blount, J. D., Boner, W., Griffiths, K., Metcalfe, N. B., & Monaghan, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113306109 · Cited by 713
Senescence and immortalization: role of telomeres and telomerase
Shay, J. W., & Wright, W. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 747
Health disparities across the lifespan: Meaning, methods, and mechanisms
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Harley, C. B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2275 · Cited by 728
Beyond therapy: biotechnology and the pursuit of happiness
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Black, D. S., & Slavich, G. M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12998 · Cited by 599
Chan, S. R. W. L., & Blackburn, E. H. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2003.1370 · Cited by 595
Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis
Cronkhite, J. T., Xing, C., Raghu, G., Chin, K. M., Torres, F., Rosenblatt, R. L., & Kim Garcia, C. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-550oc · Cited by 573
Marioni, R. E., Shah, S. H., McRae, A. F., Ritchie, S. J., Terrera, G. M., Harris, S. E., Gibson, J., Redmond, P. H., Cox, S. R., Pattie, A., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu277 · Cited by 549
Telomere length assessment: Biomarker of chronic oxidative stress?
Houben, J. M. J., Moonen, H. J. J., van Schooten, F., & Hageman, G. J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.10.001 · Cited by 577
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Minamino, T., & Komuro, I. (2007) · Circulation Research · doi:10.1161/01.res.0000256837.40544.4a · Cited by 542
Teixeira, M. T., Arneric, M., Sperisen, P., & Lingner, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00334-4 · Cited by 526
Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?
Sanders, J. L., & Newman, A. B. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs008 · Cited by 556
Mechanism of telomere shortening by oxidative stress
KAWANISHI, S., & OIKAWA, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.047 · Cited by 522
Asghar, M., Hasselquist, D., Hansson, B., Zehtindjiev, P., Westerdahl, H., & Bensch, S. (2015) · Science · doi:10.1126/science.1261121 · Cited by 508
Demissie, S., Levy, D., Benjamin, E. J., Cupples, L. A., Gardner, J. P., Herbert, A., Kimura, M., Larson, M. G., Meigs, J. B., Keaney, J. F., et al. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00224.x · Cited by 508
Gender and telomere length: Systematic review and meta-analysis
Gardner, M. P., Bann, D., Wiley, L., Cooper, R., Hardy, R., Nitsch, D., Martin-Ruiz, C. M., Shiels, P. G., Sayer, A. A., Barbieri, M., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.004 · Cited by 523
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Telomeres, stem cells, senescence, and cancer
Sharpless, N. E., & DePinho, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20761 · Cited by 488
Sharma, R. K., Agarwal, A. K., Rohra, V. K., Assidi, M., Abu-Elmagd, M. M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 486
Cell aging in relation to stress arousal and cardiovascular disease risk factors
Epel, E. S., Lin, J., Wilhelm, F. H., Wolkowitz, O. M., Cawthon, R., Adler, N. E., Dolbier, C., Mendes, W. B., & Blackburn, E. H. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.08.011 · Cited by 450
Self-citationArmanios, M., Chen, J.-L., Chang, Y.-P. C., Brodsky, R. A., Hawkins, A., Griffin, C. A., Eshleman, J. R., Cohen, A. R., Chakravarti, A., Hamosh, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508124102 · Cited by 452
Broer, L., Codd, V., Nyholt, D. R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., de Geus, E. J. C., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.303 · Cited by 450
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Baerlocher, G. M., Vulto, I., de Jong, G., & Lansdorp, P. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.263 · Cited by 449
Geronimus, A. T., Hicken, M. T., Pearson, J. A., Seashols, S. J., Brown, K. L., & Cruz, T. D. (2010) · Human Nature · doi:10.1007/s12110-010-9078-0 · Cited by 447
Lin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.09.012 · Cited by 426
Conway, D. I., Petticrew, M. P., Marlborough, H. S., Berthiller, J., Hashibe, M., & MacPherson, L. M. D. (2008) · International Journal of Cancer · doi:10.1002/ijc.23430 · Cited by 442
Is Telomere Length a Biomarker of Aging? A Review
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Jacobs, T. L., Epel, E. S., Lin, J., Blackburn, E. H., Wolkowitz, O. M., Bridwell, D. A., Zanesco, A. P., Aichele, S. R., Sahdra, B. K., MacLean, K. A., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.010 · Cited by 432
Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820573b6 · Cited by 430
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Lin, S., & Elledge, S. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00430-6 · Cited by 432
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Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421
Collerton, J., Martin-Ruiz, C., Davies, K., Hilkens, C. M., Isaacs, J., Kolenda, C., Parker, C., Dunn, M., Catt, M., Jagger, C., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.005 · Cited by 420
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Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395
Soto‐Pérez‐de‐Celis, E., Li, D., Yuan, Y., Lau, Y. M., & Hurria, A. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30348-6 · Cited by 412
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D’Mello, M. J. J., Ross, S. A., Briel, M., Anand, S. S., Gerstein, H., & Paré, G. (2015) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.113.000485 · Cited by 350
Farzaneh‐Far, R. (2010) · JAMA · doi:10.1001/jama.2009.2008 · Cited by 362
Bekaert, S., De Meyer, T., Rietzschel, E. R., De Buyzere, M. L., De Bacquer, D., Langlois, M., Segers, P., Cooman, L., Van Damme, P., Cassiman, P., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00321.x · Cited by 348
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Jeyapalan, J. C., & Sedivy, J. M. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.001 · Cited by 351
Aubert, G., Hills, M., & Lansdorp, P. M. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.04.003 · Cited by 342
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Monocyte Telomere Shortening and Oxidative DNA Damage in Type 2 Diabetes
Sampson, M., Winterbone, M. S., Hughes, J. C., Dozio, N., & Hughes, D. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1715 · Cited by 343
O’Donovan, A., Pantell, M. S., Puterman, E. M., Dhabhar, F. S., Blackburn, E. H., Yaffe, K. S., Cawthon, R., Opresko, P. L., Hsueh, W.-C., Satterfield, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019687 · Cited by 338
Self-citationThe Cambridge Handbook of Age and Ageing
Bengtson, V. L., Coleman, P. G., & Kirkwood, T. B. L. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511610714 · Cited by 347
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Puterman, E., Lin, J., Blackburn, E., O'Donovan, A., Adler, N., & Epel, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010837 · Cited by 339
Telomeres and early-life stress: an overview
Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339
Telomerase: A target for cancer therapeutics
Shay, J. W., & Wright, W. E. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00159-9 · Cited by 334
Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., & von Zglinicki, T. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.029 · Cited by 333
The role of CD8+ T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336
Canela, A., Vera, E., Klatt, P., & Blasco, M. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609367104 · Cited by 347
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de Magalhães, J. P., & Passos, J. F. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.07.001 · Cited by 316
Loss of cardioprotection with ageing
Boengler, K., Schulz, R., & Heusch, G. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp033 · Cited by 328
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Entringer, S., Buss, C., & Wadhwa, P. D. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.019 · Cited by 324
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T Cell Replicative Senescence in Human Aging
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Needham, B. L., Adler, N. E., Gregorich, S. E., Rehkopf, D. H., Lin, J., Blackburn, E. H., & Epel, E. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.023 · Cited by 332
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Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 341
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Metadata
- Authors
- Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A.
- Affiliations
- University of Utah (US)
- Corresponding author
- Cawthon, Richard M
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 361
- Issue
- 9355
- Pages
- 393-395
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2145859123
- Cited by
- 1,761
- References
- 5
- Citations by year
- 2026: 14 · 2025: 32 · 2024: 52 · 2023: 57 · 2022: 64 · 2021: 68 · 2020: 90 · 2019: 75 · 2018: 101 · 2017: 102 · 2016: 100 · 2015: 91 · 2014: 122 · 2013: 79 · 2012: 87
- FWCI
- 36.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag013478-04, 5k01ag000767-05)
- National Institute on Aging (AG13478, K01 AG00767)
- National Cancer Institute (R29CA069421, R29 CA69421)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- telomere length, mortality, aging, replicative senescence, dyskeratosis congenita, heart disease mortality, infectious disease mortality, age-related diseases, blood DNA, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Blood Donors, Cause of Death, Communicable Diseases, Female, Heart Diseases, Humans, Male, Middle Aged, Mortality, Population Surveillance, Utah, Proportional Hazards Models, Survival Analysis, Telomere, Apoptosis, Age Distribution, Dyskeratosis Congenita
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