The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Association between telomere length in blood and mortality in people aged 60 years or older
Abstract
During normal ageing, the gradual loss of telomeric DNA in dividing somatic cells can contribute to replicative senescence, apoptosis, or neoplastic transformation. In the genetic disorder dyskeratosis congenita, telomere shortening is accelerated, and patients have premature onset of many age-related diseases and early death. We aimed to assess an association between telomere length and mortality in 143 normal unrelated individuals over the age of 60 years. Those with shorter telomeres in blood DNA had poorer survival, attributable in part to a 3.18-fold higher mortality rate from heart disease (95% CI 1(.)36-7.45, p=0.0079), and an 8.54-fold higher mortality rate from infectious disease (1.52-47.9, p=0.015). These results lend support to the hypothesis that telomere shortening in human beings contributes to mortality in many age-related diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“telomere length has been shown to predict the replicative capacity of human cells and the appearance of certain age-associated pathologies in humans 54, 55”
From The common biology of cancer and ageing (2007) · cites this paper as [55]
In the citing paper
“In several studies, not only did baseline LTL correlate with medical illnesses cross-sectionally but predicted the subsequent development of cancers, CVD, diabetes or mortality (Cawthon et al., 2003; Willeit et al 2010; Zhao et al., 2014).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Cawthon et al., 2003
In the citing paper
“There are some studies linking shorter LTL with premature mortality (Cawthon et al., 2003; Fitzpatrick et al., 2011; Weischer et al., 2012) and a reduction in years of healthy living (Njajou et al., 2009).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Cawthon et al., 2003
In the citing paper
“Short telomeres have been linked to numerous diseases of aging and in many but not all cases, to all-cause and disease-specific mortality (12–17).”
From Determinants of telomere attrition over 1 year in healthy older women: stress and health behaviors matter (2015) · cites this paper as [17]
Citations
Cites
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,538
Self-citationThe RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960
Construction of linkage maps with DNA markers for human chromosomes
White, R. L., Leppert, M., Bishop, D. T., Barker, D. F., Berkowitz, J., Brown, C. S., Callahan, P. M., Holm, T., & Jerominski, L. (1985) · Nature · doi:10.1038/313101a0 · Cited by 317
Comparison of 2 Methods for Calculating Adjusted Survival Curves From Proportional Hazards Models
Ghali, W. A. (2001) · JAMA · doi:10.1001/jama.286.12.1494 · Cited by 254
Replicative Aging, Telomeres, and Oxidative Stress
Saretzki, G. C., & von Zglinicki, T. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02079.x · Cited by 253
Cited by
Sorted by citations
Items 501–600 of 1,002
Maternal Folate Concentration in Early Pregnancy and Newborn Telomere Length
Entringer, S., Epel, E. S., Lin, J., Blackburn, E. H., Buß, C., Shahbaba, B., Gillen, D. L., Venkataramanan, R., Simhan, H. N., & Wadhwa, P. D. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000381925 · Cited by 68
Kozlitina, J., & Garcia, C. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051046 · Cited by 69
Tying it all together: telomeres, sexual size dimorphism and the gender gap in life expectancy
Stindl, R. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00316-5 · Cited by 68
Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts
Westin, E. R., Chavez, E. A., Lee, K. M., Gourronc, F. A., Riley, S., Lansdorp, P. M., Goldman, F. D., & Klingelhutz, A. J. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00288.x · Cited by 68
Role of telomere dysfunction in aging and its detection by biomarkers
von Figura, G., Hartmann, D., Song, Z., & Rudolph, K. L. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0509-5 · Cited by 70
Voillemot, M., Hine, K., Zahn, S., Criscuolo, F., Gustafsson, L., Doligez, B., & Bize, P. (2012) · BMC Ecology · doi:10.1186/1472-6785-12-17 · Cited by 67
Employment and work schedule are related to telomere length in women
Parks, C. G., DeRoo, L. A., Miller, D. B., McCanlies, E. C., Cawthon, R., & Sandler, D. P. (2011) · Occupational and Environmental Medicine · doi:10.1136/oem.2010.063214 · Cited by 69
Self-citationReplicative senescence and the art of counting
von Zglinicki, T. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.015 · Cited by 69
Spyridopoulos, I., Erben, Y., Brümmendorf, T. H., Haendeler, J., Dietz, K., Seeger, F. H., Kissel, C. K., Martin, H., Hoffmann, J., Aßmus, B., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160846 · Cited by 68
Telomere shortening and immune activity in war veterans with posttraumatic stress disorder
Jergović, M., Tomičević, M., Vidović, A., Bendelja, K., Savić, A., Vojvoda, V., Rac, D., Lovrić-Čavar, D., Rabatić, S., Jovanovic, T., et al. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.06.010 · Cited by 67
Growth, telomere dynamics and successful and unsuccessful human aging
Aviv, A., Levy, D. A., & Mangel, M. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00143-x · Cited by 66
Telomere Length and Mortality in Elderly Men: The Zutphen Elderly Study
Houben, J. M. J., Giltay, E. J., Ottenheim, N. R., Hageman, G. J., & Kromhout, D. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq164 · Cited by 67
Anxiety disorders and accelerated cellular ageing
Verhoeven, J. E., Révész, D., van Oppen, P., Epel, E. S., Wolkowitz, O. M., & Penninx, B. W. J. H. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.151027 · Cited by 72
Father Loss and Child Telomere Length
Mitchell, C. M., McLanahan, S., Schneper, L. M., Garfinkel, I., Jeanne Brooks-gunn, B., & Notterman, D. A. (2017) · PEDIATRICS · doi:10.1542/peds.2016-3245 · Cited by 72
RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
Safdar, A., Khrapko, K., Flynn, J. M., Saleem, A., Lisio, M. D., Johnston, A. P. W., Kratysberg, Y., Samjoo, I. A., Kitaoka, Y., Ogborn, D. I., et al. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0075-9 · Cited by 68
RetractedGoglin, S. E., Farzaneh‐Far, R., Epel, E. S., Lin, J., Blackburn, E. H., & Whooley, M. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160748 · Cited by 68
The role of telomeres and vitamin D in cellular aging and age-related diseases
Pusceddu, I., Farrell, C.-J. L., Pierro, A. M. D., Jani, E., Herrmann, W., & Herrmann, M. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-1184 · Cited by 68
Caruso, C. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s72 · Cited by 68
Is the aging process accelerated in chronic obstructive pulmonary disease?
Lee, J., Sandford, A. J., Man, P., & Sin, D. D. (2010) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328341cead · Cited by 65
McKnight, T. D., & Shippen, D. E. (2004) · The Plant Cell · doi:10.1105/tpc.160470 · Cited by 68
A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans
Mangino, M., Brouilette, S., Braund, P. S., Tirmizi, N., Vasa‐Nicotera, M., Thompson, J. R., & Samani, N. J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn152 · Cited by 66
Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis
Machado-Oliveira, G., Ramos, C., Marques, A. R. A., & Vieira, O. V. (2020) · Cells · doi:10.3390/cells9102146 · Cited by 70
Short telomeres increase the risk of severe COVID-19
Froidure, A., Mahieu, M., Hoton, D., Laterre, P., Yombi, J. C., Koenig, S., Ghaye, B., Defour, J., & Decottignies, A. (2020) · Aging · doi:10.18632/aging.104097 · Cited by 69
Sletten, S., Bourgeon, S., Bårdsen, B., Herzke, D., Criscuolo, F., Massemin, S., Zahn, S., Johnsen, T. V., & Bustnes, J. O. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.08.123 · Cited by 65
Barbieri, M., Paolisso, G., Kimura, M., Gardner, J. P., Boccardi, V., Papa, M., Hjelmborg, J., Christensen, K., Brimacombe, M. B., Nawrot, T. S., et al. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.002 · Cited by 66
Krauss, J., Farzaneh‐Far, R., Puterman, E. M., Na, B., Lin, J., Epel, E. S., Blackburn, E. H., & Whooley, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026983 · Cited by 66
The (pro)renin receptor in health and disease
Nguyen, G. (2010) · Annals of Medicine · doi:10.3109/07853890903321567 · Cited by 65
Evolutionary ecology of telomeres: a review
Olsson, M. M., Wapstra, E., & Friesen, C. R. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13443 · Cited by 64
Siegl-Cachedenier, I., Flores, I., Klatt, P., & Blasco, M. A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704141 · Cited by 64
Telomerase as a Therapeutic Target in Cardiovascular Disease
Hoffmann, J., Richardson, G. D., Haendeler, J., Altschmied, J., Andrés, V., & Spyridopoulos, I. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315695 · Cited by 67
Habitual physical exercise has beneficial effects on telomere length in postmenopausal women
Kim, J., Ko, J., Lee, D., Lim, I., & Bang, H. (2012) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182503e97 · Cited by 64
The natural history of telomeres: tools for aging animals and exploring the aging process
Vleck, C. M., Haussmann, M. F., & Vleck, D. B. V. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00110-4 · Cited by 69
Smith, K. R., Hanson, H. A., Norton, M. C., Hollingshaus, M., & Mineau, G. P. (2014) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.11.054 · Cited by 69
Self-citationA Prospective Study of Leukocyte Telomere Length and Risk of Type 2 Diabetes in Postmenopausal Women
You, N. Y., Chen, B. H., Song, Y., Lu, X., Chen, Y., Manson, J. E., Kang, M., Howard, B. V., Margolis, K. L., Curb, J. D., et al. (2012) · Diabetes · doi:10.2337/db12-0241 · Cited by 64
Senescence in the wild: Insights from a long-term study on Seychelles warblers
Hammers, M., Kingma, S. A., Bebbington, K., van de Crommenacker, J., Spurgin, L. G., Richardson, D. S., Burke, T. A., Dugdale, H. L., & Komdeur, J. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.08.019 · Cited by 66
Leukocyte telomere length in mild cognitive impairment and Alzheimer's disease patients
Scarabino, D., Broggio, E., Gambina, G., & Corbo, R. M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.025 · Cited by 64
Novel roles for telomerase in aging
Geserick, C., & Blasco, M. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.017 · Cited by 65
The Long and Short of Telomere Length and Diabetes
Elks, C. E., & Scott, R. A. (2013) · Diabetes · doi:10.2337/db13-1469 · Cited by 63
Nakamura, K., Takubo, K., Izumiyama‐Shimomura, N., Sawabe, M., Arai, T., Kishimoto, H., Fujiwara, M., Kato, M., Oshimura, M., Ishii, A., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.003 · Cited by 66
Inflammation, Telomere Length, and Grip Strength: A 10-year Longitudinal Study
Baylis, D., Ntani, G., Edwards, M. H., Syddall, H. E., Bartlett, D. B., Dennison, E. M., Martin-Ruiz, C. M., von Zglinicki, T., Kuh, D. J., Lord, J. M., et al. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9862-7 · Cited by 63
Duraimani, S., Schneider, R. H., Randall, O. S., Nidich, S. I., Xu, S., Ketete, M., Rainforth, M. A., Gaylord‐King, C., Salerno, J. W., & Fagan, J. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142689 · Cited by 65
Verhoeven, J. E., van Oppen, P., Révész, D., Wolkowitz, O. M., & Penninx, B. W. J. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15070887 · Cited by 65
Allele-specific relative telomere lengths are inherited
Graakjær, J., Der‐Sarkissian, H., Schmitz, A., Bayer, J. A., Thomas, G. D., Kølvraa, S., & Londoño‐Vallejo, A. (2006) · Human Genetics · doi:10.1007/s00439-006-0137-x · Cited by 67
Lanna, A., Coutavas, E., Levati, L., Seidel, J., Rustin, M. H. A., Henson, S. M., Akbar, A. N., & Franzese, O. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301409 · Cited by 62
No association between mean telomere length and life stress observed in a 30 year birth cohort
Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097102 · Cited by 62
Fyhrquist, F., Silventoinen, K., Saijonmaa, O., KONTULA, K. K., Devereux, R. B., Fairé, U. D., Os, I., & Dahlöf, B. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.57 · Cited by 62
Telomere shortening with aging in the human pancreas
Ishii, A., Nakamura, K., Kishimoto, H., Honma, N., Aida, J., Sawabe, M., Arai, T., Fujiwara, M., Takeuchi, F., Kato, M., et al. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.036 · Cited by 62
DNA damage in non-communicable diseases: A clinical and epidemiological perspective
Milić, M., Frustaci, A., Bufalo, A. D., Sánchez-Alarcón, J., Quintana, R. V., Russo, P., & Bonassi, S. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.11.009 · Cited by 62
Laimer, M. W., Melmer, A., Lamina, C., Raschenberger, J., Adamovski, P., Engl, J., Ress, C., Tschoner, A., Gelsinger, C., Mair, L., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.238 · Cited by 62
Number of Children and Telomere Length in Women: A Prospective, Longitudinal Evaluation
Barha, C. K., Hanna, C. W., Salvante, K. G., Wilson, S. L., Robinson, W. P., Altman, R. M., & Nepomnaschy, P. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146424 · Cited by 59
Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease
Deems, N. P., & Leuner, B. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100820 · Cited by 67
Riddell, N. E., Griffiths, S. J., Rivino, L., King, D. C. B., Teo, G. H., Henson, S. M., Cantisan, S., Solana, R., Kemeny, D. M., MacAry, P. A., et al. (2015) · Immunology · doi:10.1111/imm.12409 · Cited by 60
Marasco, V., Boner, W., Griffiths, K., Heidinger, B. J., & Monaghan, P. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.1845 · Cited by 61
Telomere length in blood cells and breast cancer risk: investigations in two case–control studies
Zheng, Y., Ambrosone, C. B., Byrne, C., Davis, W., Nesline, M., & McCann, S. E. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0440-z · Cited by 59
Vaziri, H., Chapman, K., Guigova, A., Teichroeb, J. H., Lacher, M. D., Sternberg, H., Singeç, I., Briggs, L., Wheeler, J., Sampathkumar, J., et al. (2010) · Regenerative Medicine · doi:10.2217/rme.10.21 · Cited by 62
Warner, H. R. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.7.b692 · Cited by 60
Park, M., Verhoeven, J. E., Cuijpers, P., Reynolds III, C. F., & Penninx, B. W. J. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128460 · Cited by 59
Accelerated Cell Aging in Female APOE-ε4 Carriers: Implications for Hormone Therapy Use
Jacobs, E. G., Kroenke, C. H., Lin, J., Epel, E. S., Kenna, H. A., Blackburn, E. H., & Rasgon, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054713 · Cited by 63
Avian senescence: underlying mechanisms
Vleck, C. M., Haussmann, M. F., & Vleck, D. B. V. (2007) · Journal für Ornithologie · doi:10.1007/s10336-007-0186-5 · Cited by 65
Immediate and delayed effects of growth conditions on ageing parameters in nestling zebra finches
Reichert, S., Criscuolo, F., Zahn, S., Arrivé, M., Bize, P., & Massemin, S. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.109942 · Cited by 60
Relative telomere length and cognitive decline in the Nurses’ Health Study
Devore, E. E., Prescott, J., Vivo, I. D., & Grodstein, F. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.01.041 · Cited by 63
Biological ageing and frailty markers in breast cancer patients
Brouwers, B. A. H., Dalmasso, B., Hatse, S., Laenen, A., Kenis, C., Swerts, E., Neven, P., Smeets, A., Schöffski, P., & Wildiers, H. P. M. W. (2015) · Aging · doi:10.18632/aging.100745 · Cited by 59
Circadian desynchronization triggers premature cellular aging in a diurnal rodent
Grosbellet, E., Zahn, S., Arrivé, M., Dumont, S., Gourmelen, S., Pévet, P., Challet, É., & Criscuolo, F. (2015) · The FASEB Journal · doi:10.1096/fj.14-266817 · Cited by 61
Hostility and Cellular Aging in Men from the Whitehall II Cohort
Brydon, L., Lin, J., Butcher, L., Hamer, M., Erusalimsky, J. D., Blackburn, E. H., & Steptoe, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.020 · Cited by 60
Impact of nutrition on ageing and disease
Bengmark, S. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000171129.29278.26 · Cited by 59
Kleemeier Award Lecture 2008 – the canary in the coal mine: telomeres and human healthspan
Effros, R. B. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp001 · Cited by 58
Obesity is associated with shorter telomeres in 8 year-old children
Clemente, D. B. P., Maître, L., Bustamante, M., Chatzi, L., Roumeliotaki, T., Fossati, S., Gražulevičienė, R., Gützkow, K. B., Lepeule, J., Martens, D. S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55283-8 · Cited by 59
Nordfjäll, K., Eliasson, M., Stegmayr, B. G., Lundin, S., Roos, G., & Nilsson, P. M. (2008) · Scandinavian Journal of Public Health · doi:10.1177/1403494808090634 · Cited by 58
Cordero, A., Masiá, M. D., & Galve, E. (2014) · Revista Española de Cardiología · doi:10.1016/j.recesp.2014.04.007 · Cited by 73
Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study: Table 1
Batty, G. D., Wang, Y., Brouilette, S., Shiels, P. G., Packard, C., Moore, J., Samani, N. J., & Ford, I. (2009) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2009.088427 · Cited by 58
Telomere Length and Physical Performance at Older Ages: An Individual Participant Meta-Analysis
Gardner, M. P., Martin-Ruiz, C. M., Cooper, R., Hardy, R., Sayer, A. A., Cooper, C. C., Deary, I. J., Gallacher, J., Harris, S. E., Shiels, P. G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069526 · Cited by 58
Telomere Attrition in White Blood Cell Correlating with Cardiovascular Damage
NAKASHIMA, H., Ozono, R., SUYAMA, C., Sueda, T., Kambe, M., & Oshima, T. (2004) · Hypertension Research · doi:10.1291/hypres.27.319 · Cited by 58
CNS Ageing in Health and Neurodegenerative Disorders
Kesidou, E., Theotokis, P., Damianidou, O., Boziki, M. K., Konstantinidou, N., Taloumtzis, C., Sintila, S.-A., Grigoriadis, P., Evangelopoulos, M., Bakirtzis, C., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062255 · Cited by 64
Telomeres, cellular senescence, and aging: past and future
Eppard, M., Passos, J. F., & Victorelli, S. G. (2023) · Biogerontology · doi:10.1007/s10522-023-10085-4 · Cited by 67
Caini, S., Raimondi, S., Johansson, H. A., GIORGI, V. D., Zanna, I., Palli, D., & Gandini, S. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.08.003 · Cited by 56
Short Leukocyte Telomere Length is Associated with Abdominal Aortic Aneurysm (AAA)
Atturu, G., Brouilette, S., Samani, N. J., London, N. J. M., Sayers, R. D., & Bown, M. J. (2010) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2010.01.013 · Cited by 57
Telomere, aging and age-related diseases
Huang, X., Li, C., Ren, F., Zhang, H., & Zhang, L. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0021-1 · Cited by 60
Maternal Effects Underlie Ageing Costs of Growth in the Zebra Finch (Taeniopygia guttata)
Tissier, M. L., Williams, T. D., & Criscuolo, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097705 · Cited by 57
Leukocytes of exceptionally old persons display ultra-short telomeres
Kimura, M., Barbieri, M., Gardner, J. P., Skurnick, J., Cao, X., van Riel, N. A. W., Rizzo, M. R., Paoliso, G., & Aviv, A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00615.2007 · Cited by 57
Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
Barbé‐Tuana, F. M., Parisi, M. M., Panizzutti, B., Fries, G. R., Grün, L. K., Guma, F. T. C. R., Kapczinski, F. P., Berk, M., Gama, C. S., & Rosa, A. R. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2016-1910 · Cited by 61
Impact of prenatal heavy metal exposure on newborn leucocyte telomere length: A birth-cohort study
Wai, K. M., Umezaki, M., Kosaka, S., Mar, O., Umemura, M., Fillman, T. J., & Watanabe, C. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.090 · Cited by 56
Panickar, K. S., & Jewell, D. E. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0017 · Cited by 58
Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT
Röth, A., Baerlocher, G. M., Schertzer, M., Chavez, E. A., Dührsen, U., & Lansdorp, P. M. (2005) · Blood · doi:10.1182/blood-2004-10-4144 · Cited by 57
Hoare, M., Gelson, W. T. H., Das, A., Fletcher, J. M., Davies, S. E., Curran, M. D., Vowler, S. L., Maini, M. K., Akbar, A. N., & Alexander, G. J. M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.005 · Cited by 53
Unlocking longevity: the role of telomeres and its targeting interventions
Schellnegger, M., Hofmann, E., Carnieletto, M., & Kamolz, L. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1339317 · Cited by 65
Possibility of mixed progenitor cells in sea star arm regeneration
Hernroth, B. E., Farahani, F., Brunborg, G., Dupont, S., Dejmek, A., & Sköld, H. N. (2010) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21352 · Cited by 55
Shaffer, J. A., Epel, E. S., Kang, M. S., Ye, S., Schwartz, J. E., Davidson, K. W., Kirkland, S., Honig, L. S., & Shimbo, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048318 · Cited by 56
Tsirpanlis, G. I. (2008) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.07.035 · Cited by 55
The zebrafish as a gerontology model in nervous system aging, disease, and repair
houcke, J. V., Groef, L. D., Dekeyster, E., & Moons, L. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.10.004 · Cited by 59
Telomerase levels in schizophrenia: A preliminary study
Porton, B., DeLisi, L. E., Bertisch, H. C., Ji, F., Gordon, D., LI, P., Benedict, M. M., Greenberg, W. M., & Kao, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.08.028 · Cited by 59
Parental age influences offspring telomere loss
Heidinger, B. J., Herborn, K. A., Granroth‐Wilding, H. M. V., Boner, W., Burthe, S. J., Newell, M. A., Wanless, S., Daunt, F., & Monaghan, P. (2015) · Functional Ecology · doi:10.1111/1365-2435.12630 · Cited by 56
Persistent Herpesvirus Infections and Telomere Attrition Over 3 Years in the Whitehall II Cohort
Dowd, J. B., Bosch, J. A., Steptoe, A., Jayabalasingham, B., Lin, J., Yolken, R. H., & Aiello, A. E. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix255 · Cited by 56
The aging lung: tissue telomere shortening in health and disease
Everaerts, S., Lammertyn, E. J., Martens, D. S., Sadeleer, L. D., Maes, K., van Batenburg, A. A., Goldschmeding, R., van Moorsel, C. H. M., Dupont, L., Wuyts, W. A., et al. (2018) · Respiratory Research · doi:10.1186/s12931-018-0794-z · Cited by 57
Teo, J. X., Dávila, S., Yang, C., Hii, A. A., Pua, C. J., Yap, J. J. L., Tan, S. Y., Sahlén, A., Chin, C. W.-L., Teh, B. T., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0605-1 · Cited by 57
Scarabino, D., Peconi, M., Broggio, E., Gambina, G., Maggi, E., Armeli, F., Mantuano, E., Morello, M., Corbo, R. M., & Businaro, R. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110945 · Cited by 59
Telomere length inheritance and aging
Kappei, D., & Londoño‐Vallejo, A. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.009 · Cited by 57
RETRACTED: New intranasal and injectable gene therapy for healthy life extension
Jaijyan, D. K., Selariu, A., Cruz-Cosme, R., Tong, M., Yang, S., Stefa, A., Kekich, D., Sadoshima, J., Herbig, U., Tang, Q., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121499119 · Cited by 57
RetractedRegulation of Senescence in Cancer and Aging
Kong, Y., Cui, H., Ramkumar, C., & Zhang, H. (2011) · Journal of Aging Research · doi:10.4061/2011/963172 · Cited by 61
Premature aging disorders: A clinical and genetic compendium
Schnabel, F., Kornak, U., & Wollnik, B. (2020) · Clinical Genetics · doi:10.1111/cge.13837 · Cited by 60
Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
Banerjee, P., Kotla, S., Velatooru, L. R., Abe, R. J., Olmsted‐Davis, E. A., Cooke, J. P., Schadler, K., Deswal, A. M., Herrmann, J., Lin, S. H., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.763930 · Cited by 55
Metadata
- Authors
- Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A.
- Affiliations
- University of Utah (US)
- Corresponding author
- Cawthon, Richard M
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 361
- Issue
- 9355
- Pages
- 393-395
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2145859123
- Cited by
- 1,761
- References
- 5
- Citations by year
- 2026: 14 · 2025: 32 · 2024: 52 · 2023: 57 · 2022: 64 · 2021: 68 · 2020: 90 · 2019: 75 · 2018: 101 · 2017: 102 · 2016: 100 · 2015: 91 · 2014: 122 · 2013: 79 · 2012: 87
- FWCI
- 36.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag013478-04, 5k01ag000767-05)
- National Institute on Aging (AG13478, K01 AG00767)
- National Cancer Institute (R29CA069421, R29 CA69421)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- telomere length, mortality, aging, replicative senescence, dyskeratosis congenita, heart disease mortality, infectious disease mortality, age-related diseases, blood DNA, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Blood Donors, Cause of Death, Communicable Diseases, Female, Heart Diseases, Humans, Male, Middle Aged, Mortality, Population Surveillance, Utah, Proportional Hazards Models, Survival Analysis, Telomere, Apoptosis, Age Distribution, Dyskeratosis Congenita
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
