Cited by 1,761Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

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Association between telomere length in blood and mortality in people aged 60 years or older

Cawthon, Richard M, Smith, Ken R, O'Brien, Elizabeth, Sivatchenko, Anna, Kerber, Richard A·2003·The Lancet

DOI 10.1016/s0140-6736(03)12384-7

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Abstract

During normal ageing, the gradual loss of telomeric DNA in dividing somatic cells can contribute to replicative senescence, apoptosis, or neoplastic transformation. In the genetic disorder dyskeratosis congenita, telomere shortening is accelerated, and patients have premature onset of many age-related diseases and early death. We aimed to assess an association between telomere length and mortality in 143 normal unrelated individuals over the age of 60 years. Those with shorter telomeres in blood DNA had poorer survival, attributable in part to a 3.18-fold higher mortality rate from heart disease (95% CI 1(.)36-7.45, p=0.0079), and an 8.54-fold higher mortality rate from infectious disease (1.52-47.9, p=0.015). These results lend support to the hypothesis that telomere shortening in human beings contributes to mortality in many age-related diseases.

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Construction of linkage maps with DNA markers for human chromosomes
White, R. L., Leppert, M., Bishop, D. T., Barker, D. F., Berkowitz, J., Brown, C. S., Callahan, P. M., Holm, T., & Jerominski, L. (1985) · Nature · doi:10.1038/313101a0 · Cited by 317
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Bonfigli, A. R., Spazzafumo, L., Prattichizzo, F., Bonafè, M., Mensa’, E., Micolucci, L., Giuliani, A., Fabbietti, P., Testa, R., Boemi, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10615 · Cited by 74
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Khaltourina, D. A., Matveyev, Y., Alekseev, A., Cortese, F., & Ioviţă, A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111230 · Cited by 78
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Stier, A., Metcalfe, N. B., & Monaghan, P. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2020.1378 · Cited by 85
Targeting the molecular & cellular pillars of human aging with exercise
Goh, J., Wong, E. S. P., Soh, J., Maier, A. B., & Kennedy, B. K. (2021) · FEBS Journal · doi:10.1111/febs.16337 · Cited by 73
Extent and variability of interstitial telomeric sequences and their effects on estimates of telomere length
Foote, C. G., Vleck, D. B. V., & Vleck, C. M. (2013) · Molecular Ecology Resources · doi:10.1111/1755-0998.12079 · Cited by 71
Weight Loss in Obese Men Is Associated with Increased Telomere Length and Decreased Abasic Sites in Rectal Mucosa
O’Callaghan, N. J., Clifton, P. M., Noakes, M., & Fenech, M. F. (2009) · Rejuvenation Research · doi:10.1089/rej.2008.0819 · Cited by 72
Reduced telomere length variation in healthy oldest old
Halaschek-Wiener, J., Vulto, I. M., Fornika, D., Collins, J. A., Connors, J. M., Le, N. D., Lansdorp, P. M., & Brooks-Wilson, A. R. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.07.004 · Cited by 70
In vivo regulation of telomerase activity and telomere length
Hathcock, K. S., Chiang, Y. J., & Hodes, R. J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00267.x · Cited by 71
Genome maintenance and transcription integrity in aging and disease
Wolters, S., & Schumacher, B. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00019 · Cited by 73
High lead exposure is associated with telomere length shortening in Chinese battery manufacturing plant workers
Wu, Y., Liu, Y., Ni, N., Bao, B., Zhang, C., & Lu, L. (2012) · Occupational and Environmental Medicine · doi:10.1136/oemed-2011-100478 · Cited by 71
The Longevity Gender Gap: Are Telomeres the Explanation?
Aviv, A., Shay, J. W., Christensen, K., & Wright, W. E. (2005) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2005.23.pe16 · Cited by 71
Pain is associated with short leukocyte telomere length in women with fibromyalgia
Hassett, A. L., Epel, E., Clauw, D. J., Harris, R. E., Harte, S. E., Kairys, A., Buyske, S., & Williams, D. A. (2012) · The Journal of Pain · doi:10.1016/j.jpain.2012.07.003 · Cited by 70
Ageing and reproduction: antioxidant supplementation alleviates telomere loss in wild birds
Badás, E. P., Martínez, J., de Aguilar, J. R., Miranda, F. I., Figuerola, J., & Merino, S. (2015) · Journal of Evolutionary Biology · doi:10.1111/jeb.12615 · Cited by 75
Knee Osteoarthritis, Potential Mediators, and Risk of All‐Cause Mortality: Data From the Osteoarthritis Initiative
Wang, Y., Nguyen, U., Lane, N. E., Lu, N., Wei, J., Lei, G., Zeng, C., & Zhang, Y. (2020) · Arthritis Care & Research · doi:10.1002/acr.24151 · Cited by 71
Gene expression profiles associated with aging and mortality in humans
Kerber, R. A., O’Brien, E., & Cawthon, R. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00467.x · Cited by 74
Self-citation
Change in Peripheral Blood Leukocyte Telomere Length and Mortality in Breast Cancer Survivors
Duggan, C. R., Risques, R. A., Alfano, C. M., Prunkard, D. E., Imayama, I., Holte, S., Baumgartner, K. B., Baumgartner, R., Bernstein, L., Ballard-Barbash, R. R., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju035 · Cited by 70
Shared Phenotypes Among Segmental Progeroid Syndromes Suggest Underlying Pathways of Aging
Höfer, A., Tran, R. T., Aziz, O. Z., Wright, W. E., Novelli, G., Shay, J. W., & Lewis, M. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.1.10 · Cited by 71
Telomerase activation: A potential key modulator for human healthspan and longevity
Boccardi, V., & Paolisso, G. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2013.12.006 · Cited by 70
Sex differences in telomere length, lifespan, and embryonic dyskerin levels
Lansdorp, P. M. (2022) · Aging Cell · doi:10.1111/acel.13614 · Cited by 68
Telomere length and its associations with oxidized-LDL carotid artery distensibility and smoking
Staessen, J. A. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e176 · Cited by 69
Comprehensive geriatric assessment in the older cancer patient: coming of age in clinical cancer care
Owusu, C., & Berger, N. A. (2014) · Clinical Practice · doi:10.2217/cpr.14.72 · Cited by 70
Mother–offspring and nest-mate resemblance but no heritability in early-life telomere length in white-throated dippers
Becker, P. J. J., Reichert, S., Zahn, S., Hegelbach, J., Massemin, S., Keller, L. F., Postma, E., & Criscuolo, F. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2924 · Cited by 68

Authors: Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A.
Affiliations: University of Utah (US)
Corresponding author: Cawthon, Richard M
ORCID: Cawthon, Richard M
Smith, Ken R
Venue: The Lancet
Publisher: Elsevier BV
Published: 2003-02
Volume: 361
Issue: 9355
Pages: 393-395
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(03)12384-7
OpenAlex: W2145859123
Cited by: 1,761
References: 5
Citations by year: 2026: 14 · 2025: 32 · 2024: 52 · 2023: 57 · 2022: 64 · 2021: 68 · 2020: 90 · 2019: 75 · 2018: 101 · 2017: 102 · 2016: 100 · 2015: 91 · 2014: 122 · 2013: 79 · 2012: 87
FWCI: 36.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag013478-04, 5k01ag000767-05)
National Institute on Aging (AG13478, K01 AG00767)
National Cancer Institute (R29CA069421, R29 CA69421)
NIH Clinical Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: telomere length, mortality, aging, replicative senescence, dyskeratosis congenita, heart disease mortality, infectious disease mortality, age-related diseases, blood DNA, older adults
MeSH terms: Aged, Aged, 80 and over, Aging, Blood Donors, Cause of Death, Communicable Diseases, Female, Heart Diseases, Humans, Male, Middle Aged, Mortality, Population Surveillance, Utah, Proportional Hazards Models, Survival Analysis, Telomere, Apoptosis, Age Distribution, Dyskeratosis Congenita

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Association between telomere length in blood and mortality in people aged 60 years or older

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