Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence?

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341801 · Cited by 2,397

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,345

Vitamin E Consumption and the Risk of Coronary Disease in Women

Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282003 · Cited by 2,085

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial

(2002) · The Lancet · doi:10.1016/s0140-6736(02)09328-5 · Cited by 1,502

Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general Practice

Roncaglioni, M. C. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03539-x · Cited by 993

Basic methods for sensitivity analysis of biases.

Greenland, S. (1996) · International Journal of Epidemiology · doi:10.1093/ije/25.6.1107 · Cited by 605

Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study

Khaw, K., Bingham, S. A., Welch, A. A., Luben, R., Wareham, N. J., Oakes, S., & Day, N. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04128-3 · Cited by 576

Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?

Steinberg, D. H., & Witztum, J. L. (2002) · Circulation · doi:10.1161/01.cir.0000014762.06201.06 · Cited by 473

Developing nurse prescribing in the UK

Avery, A. J., & James, V. (2007) · BMJ · doi:10.1136/bmj.39285.788808.3b · Cited by 31

Strengthening the reporting of genetic risk prediction studies: the GRIPS statement

Janssens, A. C. J. W., Ioannidis, J. P. A., van Duijn, C. M., Little, J., Khoury, M. J., & for the GRIPS Group (2011) · BMJ · doi:10.1136/bmj.d631 · Cited by 29

Obesity as an Avoidable Cause of Cancer (Attributable Risks)

Renehan, A. G., & Soerjomataram, I. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42542-9_13 · Cited by 32

A Future for Observational Epidemiology: Clarity, Credibility, Transparency

Harper, S. B. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy280 · Cited by 31

Oxidative stress and the unfulfilled promises of antioxidant agents

Giorgio, M. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.556 · Cited by 27

Closing Pandora's Box: adapting a systems ergonomics methodology for better understanding the ecological complexity underpinning the development and prevention of running-related injury

Hulme, A., Salmon, P. M., Nielsen, R. O., Read, G. J. M., & Finch, C. F. (2017) · Theoretical Issues in Ergonomics Science · doi:10.1080/1463922x.2016.1274455 · Cited by 30

Mendelian Randomization as Applied to Coronary Heart Disease, Including Recent Advances Incorporating New Technology

Lewis, S. J. (2010) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.880955 · Cited by 29

Genomics of Cancer and a New Era for Cancer Prevention

Brennan, P., & Wild, C. P. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005522 · Cited by 30

CFH Y402H and ARMS2 A69S Polymorphisms and Oral Supplementation with Docosahexaenoic Acid in Neovascular Age-Related Macular Degeneration Patients: The NAT2 Study

Merle, B. M. J., Richard, F., Benlian, P., Puche, N., Delcourt, C., & Souied, E. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130816 · Cited by 29

Association of cord blood vitamin D at delivery with postpartum depression in Australian women

Gould, J. F., Anderson, A. J., Yelland, L. N., Smithers, L. G., Skeaff, C. M., Gibson, R. A., & Makrides, M. (2015) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.12344 · Cited by 27

Cross-sectional association between smoking depictions in films and adolescent tobacco use nested in a British cohort study

Waylen, A. E., Leary, S. D., Ness, A., Tanski, S. E., & Sargent, J. D. (2011) · Thorax · doi:10.1136/thoraxjnl-2011-200053 · Cited by 27

A Novel Dietary Intervention to Optimize Vitamin E Intake of Pregnant Women to 15 mg/Day

Clark, J. S., Craig, L. C. A., McNeill, G., Smith, N. C., Norrie, J. D., & Devereux, G. S. (2011) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jada.2011.08.033 · Cited by 27

Is alcohol consumption related to likelihood of reporting chronic widespread pain in people with stable consumption? Results from UK biobank

Beasley, M., Macfarlane, T. V., & Macfarlane, G. J. (2016) · Pain · doi:10.1097/j.pain.0000000000000675 · Cited by 26

Circulating folate concentrations and risk of coronary artery disease: a prospective cohort study in Chinese adults and a Mendelian randomization analysis

Long, P., Liu, X., Li, J., He, S., Chen, H., Yuan, Y. L., Qiu, G., Yu, K., Liu, K., Jiang, J., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz314 · Cited by 28

Micronutrient malnutrition and the impact of modern plant breeding on public health in India: How cost-effective is biofortification?

Stein, A. J. (2006) · University writing server of the University of Hohenheim (Universität Hohenheim) · Cited by 27

Vitamin D and chronic disease prevention

Welsh, P. I., & Sattar, N. A. (2014) · BMJ · doi:10.1136/bmj.g2280 · Cited by 27

Pharmacogenetics and ethnically targeted therapies

Rahemtulla, T., & Bhopal, R. S. (2005) · BMJ · doi:10.1136/bmj.330.7499.1036 · Cited by 26

Results of Observational Studies: Analysis of Findings from the Nurses’ Health Study

Tai, V., Grey, A. B., & Bolland, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110403 · Cited by 28

Sociodemographic, health and lifestyle characteristics reported by discrete groups of adult dietary supplement users in Alberta, Canada: findings from The Tomorrow Project

Robson, P. J., Siou, G. L., Ullman, R., & Bryant, H. E. (2008) · Public Health Nutrition · doi:10.1017/s136898000800219x · Cited by 26

Analysing the effect of area of residence over the life course in multilevel epidemiology

Næss, Ø., & Leyland, A. H. (2010) · Scandinavian Journal of Public Health · doi:10.1177/1403494810384646 · Cited by 26

Is plasma homocysteine a modifiable risk factor for stroke?

Hankey, G. J. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0093 · Cited by 26

Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis

Dooley, A., Low, S. Y., Holmes, A. M., Kidane, A. G., Abraham, D., Black, C. M., & Bruckdorfer, K. R. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem303 · Cited by 26

Observational versus randomised trial evidence

Khaw, K., Day, N. E., Bingham, S. A., & Wareham, N. J. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16924-9 · Cited by 26

Epidemiology of Moderate Alcohol Consumption and Breast Cancer: Association or Causation?

Zakhari, S., & Hoek, J. B. (2018) · Cancers · doi:10.3390/cancers10100349 · Cited by 28

Be(ing) prepared: Guide and Scout participation, childhood social position and mental health at age 50—a prospective birth cohort study

Dibben, C. J. L., Playford, C., & Mitchell, R. (2016) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2016-207898 · Cited by 29

The polypill and cardiovascular disease

Fahey, T. P., Brindle, P. M., & Ebrahim, S. B. J. (2005) · BMJ · doi:10.1136/bmj.330.7499.1035 · Cited by 24

Introduction to Mendelian randomization

Yeung, S. L. A., Luo, S., Iwagami, M., & Goto, A. (2024) · Annals of Clinical Epidemiology · doi:10.37737/ace.25004 · Cited by 26

Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross‐sectional associations with insulin resistance and glycaemia in 9–10 year‐old children

Donin, A. S., Dent, J. E., Nightingale, C. M., Sattar, N. A., Owen, C. G., Rudnicka, A. R., Perkin, M. R., Stephen, A. M., Jebb, S. A., Cook, D. G., et al. (2015) · Diabetic Medicine · doi:10.1111/dme.13006 · Cited by 24

Weight history from birth through childhood and youth in relation to adult lung function, in Danish juvenile obese and non-obese men

Bua, J., Prescott, E., Schack‐Nielsen, L., Petersen, L. V., Godtfredsen, N. S., Sørensen, T. I. A., & Osler, M. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802998 · Cited by 24

Real world effects of COPD medications: a cohort study with validation against results from randomised controlled trials

Wing, K., Williamson, E., Carpenter, J. R., Wise, L., Schneeweiß, S., Smeeth, L. L., Quint, J. K., & Douglas, I. (2020) · European Respiratory Journal · doi:10.1183/13993003.01586-2020 · Cited by 24

Instrumented Difference-in-Differences

Ye, T., Ertefaie, A., Flory, J., Hennessy, S., & Small, D. S. (2022) · Biometrics · doi:10.1111/biom.13783 · Cited by 23

Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial

Gould, J. F., Treyvaud, K., Yelland, L. N., Anderson, P. J., Smithers, L. G., Gibson, R. A., McPhee, A. J., & Makrides, M. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011465 · Cited by 23

Birth weight and prematurity with lung function at ~17.5 years: “Children of 1997” birth cohort

He, B., Kwok, M. K., Yeung, S. L. A., Lin, S. L., Leung, J. Y. Y., Hui, L. L., Li, A. M., Leung, G. M., & Schooling, C. M. (2020) · Scientific Reports · doi:10.1038/s41598-019-56086-7 · Cited by 23

Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis

Zhao, M., Wei, F., Li, H., Wang, Z., Wang, S., Liu, Y., Fei, G., Ge, Y., & Wei, P. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03062-2 · Cited by 22

Association between the plasma proteome and serum ascorbic acid concentrations in humans

Costa, L. A. D., García‐Bailo, B., Borchers, C. H., Badawi, A. F., & El‐Sohemy, A. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.05.002 · Cited by 22

Beyond the Single SNP: Emerging Developments in Mendelian Randomization in the “Omics” Era

Brion, M., Benyamin, B., Visscher, P. M., & Smith, G. D. (2014) · Current Epidemiology Reports · doi:10.1007/s40471-014-0024-2 · Cited by 22

The triumph of the null hypothesis: epidemiology in an age of change

Maziak, W. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn268 · Cited by 23

Commentary: Strengths and limitations of the discordant twin-pair design in social epidemiology. Where do we go from here?

Madsen, M. F., & Osler, M. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp264 · Cited by 22

DMRdb: a disease-centric Mendelian randomization database for systematically assessing causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases

Zheng, X., Tian, Z., Che, X., Zhang, X., Xiang, Y., Ge, Z., Zhai, Z., Ma, Q., & Pan, J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae853 · Cited by 22

Lack of correlation between school mask mandates and paediatric COVID-19 cases in a large cohort

Chandra, A., & Høeg, T. B. (2022) · Journal of Infection · doi:10.1016/j.jinf.2022.09.019 · Cited by 21

Association between intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid (n-3 PUFA DHA) and reduced risk of ovarian cancer: A systematic Mendelian Randomization study

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Folic acid supplements and risk for oral clefts in the newborn: a population-based study

Gildestad, T., Bjørge, T., Vollset, S. E., Klungsøyr, K., Nilsen, R. M., Haaland, Ø. A., & Øyen, N. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003013 · Cited by 21

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Yassa, Ö. Y., Domaç, S. F. M., & Kenangıl, G. (2019) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000539 · Cited by 21

An Introduction to Instrumental Variables Analysis: Part 1

Bennett, D. (2010) · Neuroepidemiology · doi:10.1159/000319455 · Cited by 20

Commentary: Assessing the impact of breastfeeding on child health: where conventional methods alone fall short for reliably establishing causal inference

Brion, M. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp318 · Cited by 20

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Yeung, S. L. A., Lin, S. L., Lam, H. S., & Schooling, C. M. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.07.021 · Cited by 19

Nutrition challenges for the twenty-first century

Dangour, A. D., & Uauy, R. D. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061689 · Cited by 19

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Mika Kivimaki, B., Virtanen, M., Nyberg, S. T., & Batty, G. D. (2020) · Environment International · doi:10.1016/j.envint.2020.106048 · Cited by 18

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Zizzo, D. J., Parravano, M., Nakamura, R., Forwood, S., & Suhrcke, M. (2021) · Experimental Economics · doi:10.1007/s10683-020-09698-0 · Cited by 18

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Wassall, H. J., Devereux, G. S., Seaton, A., & Barker, R. N. (2013) · Nutrients · doi:10.3390/nu5093337 · Cited by 17

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Gawlik, N. R., Anderson, A. J., Makrides, M., Kettler, L. J., & Gould, J. F. (2020) · Nutrients · doi:10.3390/nu12103106 · Cited by 17

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Gould, J. F., Best, K. P., & Makrides, M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.014 · Cited by 20

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Zou, Y., Wang, Q., & Cheng, X. (2023) · Neurology and Therapy · doi:10.1007/s40120-023-00458-9 · Cited by 16

Vitamin Supplementation and Stroke Prevention

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Doctors should be able to prescribe exercise like a drug

Nunan, D. (2016) · BMJ · doi:10.1136/bmj.i2468 · Cited by 16

Unge på Kanten - Om inkludering av utsatte ungdommer

Publikation, N. (2012) · doi:10.6027/nord2012-005 · Cited by 16

Is Vitamin D the Fountain of Youth?

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The Search for Modifiable Risk Factors for Schizophrenia

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Commentary: Can maternal-paternal comparisons contribute to our understanding of maternal pre-pregnancy obesity and its association with offspring cognitive outcomes?

Brion, M. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt041 · Cited by 15

Using negative controls to adjust for unmeasured confounding bias in time series studies

Hu, J. K., Tchetgen, E. J. T., & Dominici, F. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00249-4 · Cited by 16

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Kaur, K., Kaur, R., & Kaur, M. (2016) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 14

Excess Weight as a Risk Factor Common to Many Cancer Sites: Words of Caution when Interpreting Meta-analytic Evidence

Arnold, M., Renehan, A. G., & Colditz, G. A. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0940 · Cited by 15

No Casual Relationship Between T2DM and the Risk of Infectious Diseases: A Two-Sample Mendelian Randomization Study

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Which Circulating Antioxidant Vitamins Are Confounded by Socioeconomic Deprivation? The MIDSPAN Family Study

Talwar, D. K., McConnachie, A., Welsh, P. I., Upton, M. N., O’Reilly, D. S. J., Smith, G. D., Watt, G. C. M., & Sattar, N. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011312 · Cited by 14

Effects of air pollution on health

Hales, S., & Howden‐Chapman, P. (2007) · BMJ · doi:10.1136/bmj.39304.389433.ad · Cited by 14

A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke

Soremekun, O. S., Musanabaganwa, C., Uwineza, A., Ardissino, M., Rajasundaram, S., Wani, A. H., Jansen, S., Mutabaruka, J., Rutembesa, E., Soremekun, C., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02542-y · Cited by 12

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Wang, L., Zhou, L., ZhangBao, J., Huang, W., Tan, H., Fan, Y., Lü, C., Yu, J. Y., Wang, M., Lu, J., et al. (2023) · European Journal of Neurology · doi:10.1111/ene.16014 · Cited by 14

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Welsh, P. I., Packard, C. J., & Sattar, N. A. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32831551e0 · Cited by 14

Family history of premature myocardial infarction, life course socioeconomic position and coronary heart disease mortality — A Cohort of Norway (CONOR) study

Fiskå, B. S., Ariansen, I., Graff‐Iversen, S., Tell, G. S., Egeland, G. M., & Næss, Ø. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.160 · Cited by 13

Reducing sickness absence in occupational settings

Vahtera, J., & Mika Kivimaki, B. (2008) · Occupational and Environmental Medicine · doi:10.1136/oem.2007.036061 · Cited by 13

Going From Zero to 100 in Remote Dementia Research: A Practical Guide.

O'Connell, M. E., Vellani, S., Robertson, S., O'Rourke, H. M., & McGilton, K. S. (2021) · Journal of Medical Internet Research · doi:10.2196/24098 · Cited by 12

Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1

Manolis, A. S., Manolis, T. A., Melita, H., & Manolis, A. S. (2023) · Current Vascular Pharmacology · doi:10.2174/1570161121666230912155548 · Cited by 12

Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses

Papadimitriou, N., Qu, C., Harrison, T. A., Bever, A. M., Martin, R. M., Tsilidis, K. K., Newcomb, P. A., Thibodeau, S. N., Newton, C. C., Um, C. Y., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105010 · Cited by 13

A causal relationship between educational attainment and risk of infectious diseases: A Mendelian randomisation study

Liu, J., Ren, J., Gao, X.-M., Zhang, C., Deng, G., Li, J., Li, R., Wang, X., & Wang, G. (2024) · Journal of Global Health · doi:10.7189/jogh.14.04089 · Cited by 13

Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with l-ascorbic acid

Wade, K. H., Forouhi, N. G., Cook, D. G., Johnson, P., McConnachie, A., Morris, R. W., Rodriguez, S., Ye, Z., Ebrahim, S., Padmanabhan, S., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092981 · Cited by 12

Exploring the relationship between maternal iron status and offspring’s blood pressure and adiposity: a Mendelian randomization study

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TRIALSCOPE — A Framework for Clinical Trial Simulation from Real-World Data

Hernández, J. G., Ueno, R., Wong, C., Gero, Z., Bagga, J., Chien, I., Oravkin, E., Kıcıman, E., Nori, A. V., Weerasinghe, R. K., et al. (2025) · NEJM AI · doi:10.1056/aioa2400859 · Cited by 12

The future of epidemiology: methods or matter?

Ebrahim, S. B. J., Ferrie, J. E., & Smith, G. D. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyx032 · Cited by 13

Evaluating the risk of sepsis attributing to obesity: a two-sample Mendelian randomization study

Hu, J., Gan, Q., Zhou, D., Xia, X., Wei, X., Xiao, R., Tang, J. P., & Li, J. (2023) · Postgraduate Medical Journal · doi:10.1093/postmj/qgad072 · Cited by 10

Using Observational Data to Estimate the Effect of Hand Washing and Clean Delivery Kit Use by Birth Attendants on Maternal Deaths after Home Deliveries in Rural Bangladesh, India and Nepal

Seward, N., Prost, A., Copas, A. J., Corbin, M., Li, L., Colbourn, T., Osrin, D., Neuman, M., Azad, K., Kuddus, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136152 · Cited by 11

Insight into the causality between basal metabolic rate and endometrial and ovarian cancers: Analysis utilizing systematic Mendelian randomization and genetic association data from over 331,000 UK biobank participants

Zhang, H., Qiu, J., Meng, F., & Shu, X. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.13971 · Cited by 9

The relationship of fatty acids to ischaemic heart disease and lifespan in men and women using Mendelian randomization

Schooling, C. M., Kwok, M. K., & Zhao, J. V. (2023) · International Journal of Epidemiology · doi:10.1093/ije/dyad108 · Cited by 10

Using Feedlot Operational Data to Make Valid Conclusions for Improving Health Management

Theurer, M. E., Renter, D. G., & White, B. J. (2015) · Veterinary Clinics of North America Food Animal Practice · doi:10.1016/j.cvfa.2015.05.004 · Cited by 10

Conducting cost-effectiveness analyses of type 2 diabetes in low- and middle-income countries: can locally generated observational study data overcome methodological limitations?

Baik, S.-H., Chacra, A. R., Li, Y., White, J. R., Güler, S., & Latif, Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(10)70004-8 · Cited by 10

A comparison of the association between socioeconomic position and cardiovascular disease risk factors in three age cohorts of Australian women: findings from the Australian Longitudinal Study on Women's Health

Lawlor, D. A., Tooth, L. R., Lee, C., & Dobson, A. J. (2005) · Journal of Public Health · doi:10.1093/pubmed/fdi052 · Cited by 10

Body Mass Index and Cancer Risk: The Evidence for Causal Association~!2009-04-22~!2009-06-16~!2010-07-13~!

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Smith, G. D., & Lynch, J. W. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198525738.003.0034 · Cited by 10

Antioxidants and respiratory disease: the uric acid paradox

Shaheen, S. O. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205751 · Cited by 10

Comment: The Need for Syncretism in Applied StatisticsPreprint

Greenland, S. (2016) · Cited by 10

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