Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence?

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341801 · Cited by 2,397

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

Rimm, E. B., Stampfer, M. J., Ascherio, A., Giovannucci, E. L., Colditz, G. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282004 · Cited by 2,345

Vitamin E Consumption and the Risk of Coronary Disease in Women

Stampfer, M. J., Hennekens, C. H., Manson, J. E., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282003 · Cited by 2,085

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial

(2002) · The Lancet · doi:10.1016/s0140-6736(02)09328-5 · Cited by 1,502

Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general Practice

Roncaglioni, M. C. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03539-x · Cited by 993

Basic methods for sensitivity analysis of biases.

Greenland, S. (1996) · International Journal of Epidemiology · doi:10.1093/ije/25.6.1107 · Cited by 605

Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study

Khaw, K., Bingham, S. A., Welch, A. A., Luben, R., Wareham, N. J., Oakes, S., & Day, N. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04128-3 · Cited by 576

Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?

Steinberg, D. H., & Witztum, J. L. (2002) · Circulation · doi:10.1161/01.cir.0000014762.06201.06 · Cited by 473

Why Most Published Research Findings Are False

Ioannidis, J. P. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020124 · Cited by 10,505

Untitled work

(2004) · Cited by 5,198

Why Most Published Research Findings Are False

Ioannidis, J. P. A. (2005) · CHANCE · doi:10.1080/09332480.2005.10722754 · Cited by 4,702

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618

Indicators of socioeconomic position (part 1): Figure 1

Galobardes, B., Shaw, M., Lawlor, D. A., Lynch, J. W., & Smith, G. D. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.023531 · Cited by 2,979

Interpretation of the evidence for the efficacy and safety of statin therapy

Collins, R., Reith, C., Emberson, J., Armitage, J., Baigent, C., Blackwell, L., Blumenthal, R., Danesh, J., Smith, G. D., DeMets, D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31357-5 · Cited by 1,857

Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomisation (STROBE-MR): explanation and elaboration.

Skrivankova, V. W., Richmond, R. C., Woolf, B. A. R., Davies, N. M., Swanson, S. A., VanderWeele, T. J., Timpson, N. J., Higgins, J. P. T., Dimou, N., Langenberg, C., et al. (2021) · BMJ · doi:10.1136/bmj.n2233 · Cited by 1,648

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

Rothwell, P. M., Fowkes, F. G. R., Belch, J. F., Ogawa, H., Warlow, C. P., & Meade, T. W. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62110-1 · Cited by 1,497

Oxidative stress and cancer: Have we moved forward?

Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302

Measuring socioeconomic position in health research

Galobardes, B., Lynch, J., & Smith, G. D. (2007) · British Medical Bulletin · doi:10.1093/bmb/ldm001 · Cited by 847

A pragmatic view on pragmatic trials

Patsopoulos, N. A. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.2/npatsopoulos · Cited by 844

Vitamin D and Calcium Intake in Relation to Type 2 Diabetes in Women

Pittas, A. G., Dawson‐Hughes, B., Li, T., van Dam, R. M., Willett, W. C., Manson, J. E., & Hu, F. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-1961 · Cited by 837

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

Algra, A. M., & Rothwell, P. M. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70112-2 · Cited by 833

Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies

Flossmann, E., & Rothwell, P. M. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60747-8 · Cited by 820

Vitamin D Insufficiency

Thacher, T. D., & Clarke, B. L. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0567 · Cited by 775

The Impact of Residual and Unmeasured Confounding in Epidemiologic Studies: A Simulation Study

Fewell, Z., Davey Smith, G., & Sterne, J. A. C. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm165 · Cited by 734

Selenium for preventing cancer

Vinceti, M., Filippini, T., Del Giovane, C., Dennert, G., Zwahlen, M., Brinkman, M., Zeegers, M. P., Horneber, M., D'Amico, R., & Crespi, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub4 · Cited by 649

Indicators of socioeconomic position (part 2)

Galobardes, B., Shaw, M., Lawlor, D. A., Lynch, J. W., & Smith, G. D. (2006) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.028092 · Cited by 649

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

Smith, G. D., Lawlor, D. A., Harbord, R., Timpson, N., Day, I., & Ebrahim, S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040352 · Cited by 569

Dietary polyphenols: Good, bad, or indifferent for your health?

Halliwell, B. B. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.004 · Cited by 558

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

Smith, G. D., & Ebrahim, S. (2005) · BMJ · doi:10.1136/bmj.330.7499.1076 · Cited by 545

Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State

Savini, I., Catani, M. V., Evangelista, D., Gasperi, V., & Avigliano, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510497 · Cited by 527

Relative Citation Impact of Various Study Designs in the Health Sciences

Patsopoulos, N. A. (2005) · JAMA · doi:10.1001/jama.293.19.2362 · Cited by 498

Multiple-bias modelling for analysis of observational data

Greenland, S. (2005) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2004.00349.x · Cited by 497

Why Most Published Research Findings Are False

Ioannidis, J. P. A. (2019) · CHANCE · doi:10.1080/09332480.2019.1579573 · Cited by 474

Is oxidative stress a therapeutic target in cardiovascular disease?

Münzel, T., Gori, T., Bruno, R. M., & Taddei, S. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq396 · Cited by 470

Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?

Ebrahim, S., & Davey Smith, G. (2008) · Human Genetics · doi:10.1007/s00439-007-0448-6 · Cited by 410

Review: Diabetes, Obesity, and Cancer—Pathophysiology and Clinical Implications

Lega, I. C., & Lipscombe, L. L. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz014 · Cited by 381

What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts

Brion, M.-J. A., Lawlor, D. A., Matijasevich, A., Horta, B., Anselmi, L., Araújo, C. L., Menezes, A. M. B., Victora, C. G., & Smith, G. D. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr020 · Cited by 350

A life-course approach to the aetiology of late-onset dementias

Whalley, L. J., Dick, F. D., & McNeill, G. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70286-6 · Cited by 358

Plasma Vitamin C Level, Fruit and Vegetable Consumption, and the Risk of New-Onset Type 2 Diabetes Mellitus The European Prospective Investigation of Cancer–Norfolk Prospective Study

Harding, A.-H. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.14.1493 · Cited by 332

Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis

Wannamethee, S. G., Lowe, G. D. O., Rumley, A., Bruckdorfer, K. R., & Whincup, P. H. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.83.3.567 · Cited by 317

Dietary Fruits and Vegetables and Cardiovascular Diseases Risk

Alissa, E. M., & Ferns, G. A. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1040487 · Cited by 322

Meta-Analysis Comparing Mediterranean to Low-Fat Diets for Modification of Cardiovascular Risk Factors

Nordmann, A. J., Suter, K., Bucher, H. C., Shai, I., Tuttle, K. R., Estruch, R., & Briel, M. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.04.024 · Cited by 322

Invited Commentary: Variable Selection versus Shrinkage in the Control of Multiple Confounders

Greenland, S. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm355 · Cited by 281

Dietary patterns and 15-y risks of major coronary events, diabetes, and mortality

Brunner, E. J., Mosdøl, A., Witte, D. R., Martikainen, P., Stafford, M., Shipley, M. J., & Marmot, M. G. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1414 · Cited by 280

Low Maternal Vitamin E Intake during Pregnancy Is Associated with Asthma in 5-Year-Old Children

Devereux, G. S., Turner, S. W., Craig, L. C. A., McNeill, G., Martindale, S., Harbour, P. J., Helms, P. J. B., & Seaton, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200512-1946oc · Cited by 269

Folic Acid Supplements in Pregnancy and Severe Language Delay in Children

Roth, C., Magnus, P. M., Schjølberg, S., Stoltenberg, C., Surén, P., McKeague, I. W., Smith, G. D., Reichborn‐Kjennerud, T., & Susser, E. (2011) · JAMA · doi:10.1001/jama.2011.1433 · Cited by 273

Fruits, vegetables and coronary heart disease

Dauchet, L., Amouyel, P., & Dallongeville, J. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.131 · Cited by 270

Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study

Weich, S., Pearce, H. L., Croft, P., Singh, S., Crome, I., Bashford, J., & Frisher, M. (2014) · BMJ · doi:10.1136/bmj.g1996 · Cited by 259

Assessing Intrauterine Influences on Offspring Health Outcomes: Can Epidemiological Studies Yield Robust Findings?

Smith, G. D. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00191.x · Cited by 257

Antioxidant Intake in Pregnancy in Relation to Wheeze and Eczema in the First Two Years of Life

Martindale, S., McNeill, G., Devereux, G. S., Campbell, D. M., Russell, G., & Seaton, A. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-220oc · Cited by 250

Volunteering is Associated with Delayed Mortality in Older People: Analysis of the Longitudinal Study of Aging

Harris, A. H. S., & Thoresen, C. E. (2005) · Journal of Health Psychology · doi:10.1177/1359105305057310 · Cited by 243

Persistence of Contradicted Claims in the Literature

Tatsioni, A., Bonitsis, N. G., & Ioannidis, J. P. A. (2007) · JAMA · doi:10.1001/jama.298.21.2517 · Cited by 229

The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials

Gould, J. F., Smithers, L. G., & Makrides, M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.045781 · Cited by 221

The distribution of breeding birds around upland wind farms

Pearce‐Higgins, J. W., Stephen, L., Langston, R. H. W., Bainbridge, I. P., & Bullman, R. (2009) · Journal of Applied Ecology · doi:10.1111/j.1365-2664.2009.01715.x · Cited by 218

Dietary macronutrients and food consumption as determinants of long-term weight change in adult populations: a systematic literature review

Fogelholm, M., Anderssen, S. A., Gunnarsdóttir, I., & Lahti‐Koski, M. (2012) · Food & Nutrition Research · doi:10.3402/fnr.v56i0.19103 · Cited by 234

The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?

Smith, A. D. (2008) · Food and Nutrition Bulletin · doi:10.1177/15648265080292s119 · Cited by 221

Nutrition and the Risk of Alzheimer's Disease

Hu, N., Yu, J., Tan, L., Wang, Y., Sun, L., & Tan, L. (2013) · BioMed Research International · doi:10.1155/2013/524820 · Cited by 228

‘Mendelian randomization’: an approach for exploring causal relations in epidemiology

Gupta, V., Walia, G. K., & SACHDEVA, M. P. (2017) · Public Health · doi:10.1016/j.puhe.2016.12.033 · Cited by 216

Association of C-Reactive Protein With Blood Pressure and Hypertension

Smith, G. D., Lawlor, D. A., Harbord, R. M., Timpson, N. J., Rumley, A., Lowe, G. D. O., Day, I. N. M., & Ebrahim, S. B. J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160351.95181.d0 · Cited by 212

Potential New Risk Factors for Ischemic Stroke

Hankey, G. J. (2006) · Stroke · doi:10.1161/01.str.0000229883.72010.e4 · Cited by 203

Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?

Yarmolinsky, J., Wade, K. H., Richmond, R. C., Langdon, R., Bull, C. J., Tilling, K. M., Relton, C. L., Lewis, S. J., Smith, G. D., & Martin, R. M. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-1177 · Cited by 189

Lower-Energy-Density Diets Are Associated with Higher Monetary Costs per Kilocalorie and Are Consumed by Women of Higher Socioeconomic Status

Monsivais, P., & Drewnowski, A. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2009.02.002 · Cited by 189

Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study

Ebrahim, S. B. J., Sung, J., Song, Y., Ferrer, R. L., Lawlor, D. A., & Smith, G. D. (2006) · BMJ · doi:10.1136/bmj.38855.610324.80 · Cited by 187

Impaired diurnal blood pressure variation and all-cause mortality.

Brotman, D., Davidson, M. B., Boumitri, M., & Vidt, D. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2007.7 · Cited by 197

Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials

Stevens, R. J., Ali, R., Bankhead, C. R., Bethel, M. A., Cairns, B. J., Camisasca, R. P., Crowe, F. L., Farmer, A. J., Harrison, S., Hirst, J. A., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2653-7 · Cited by 161

Diet and Asthma: Nutrition Implications from Prevention to Treatment

Allan, K., & Devereux, G. S. (2011) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.10.048 · Cited by 180

Fruit and Vegetables Consumption and Gastric Cancer: A Systematic Review and Meta-Analysis of Cohort Studies

Lunet, N., Lacerda-Vieira, A., & Barros, H. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5301_1 · Cited by 166

Common Methods for Performing Mendelian Randomization

Teumer, A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00051 · Cited by 163

The relationship of dietary patterns with adult lung function and COPD

Shaheen, S. O., Jameson, K. A., Syddall, H. E., Sayer, A. A., Dennison, E. M., Cooper, C. C., Robinson, S. M., & The Hertfordshire Cohort Study Group (2010) · European Respiratory Journal · doi:10.1183/09031936.00114709 · Cited by 164

Dietary Intake of Fruits and Vegetables Improves Microvascular Function in Hypertensive Subjects in a Dose-Dependent Manner

McCall, D. O., McGartland, C. P., McKinley, M. C., Patterson, C. C., Sharpe, P., McCance, D. R., Young, I. S., & Woodside, J. V. (2009) · Circulation · doi:10.1161/circulationaha.108.831297 · Cited by 161

The quality and monetary value of diets consumed by adults in the United States

Rehm, C. D., Monsivais, P., & Drewnowski, A. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.015560 · Cited by 158

Life Course Perspectives on the Epidemiology of Depression

Colman, I., & Ataullahjan, A. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005501002 · Cited by 163

Pooling fMRI data: meta-analysis, mega-analysis and multi-center studies

Costafreda, S. G. (2009) · Frontiers in Neuroinformatics · doi:10.3389/neuro.11.033.2009 · Cited by 166

Ultraprocessed Foods and Obesity Risk: A Critical Review of Reported Mechanisms

Valicente, V. M., Peng, C.-H., Pacheco, K., Lin, L., Kielb, E., Dawoodani, E., Abdollahi, A., & Mattes, R. D. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.006 · Cited by 166

Selenium for preventing cancer

Vinceti, M., Dennert, G., Crespi, C. M., Zwahlen, M., Brinkman, M. T., Zeegers, M. P., Horneber, M., D’Amico, R., & Giovane, C. D. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub3 · Cited by 151

Challenges in Systematic Reviews That Assess Treatment Harms

Chou, R., & Helfand, M. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-12_part_2-200506211-00009 · Cited by 145

‘Junk food’ diet and childhood behavioural problems: results from the ALSPAC cohort

Wiles, N., Northstone, K., Emmett, P. M., & Lewis, G. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602967 · Cited by 146

Accuracy of adults’ recall of childhood social class: findings from the Aberdeen children of the 1950s study

Batty, G. D., Lawlor, D. A., Macintyre, S., Clark, H., & Leon, D. A. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.030932 · Cited by 148

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

Zheng, J., Luan, J., Sofianopoulou, E., Imamura, F., Stewart, I. D., Day, F. R., Pietzner, M., Wheeler, E., Lotta, L. A., Gundersen, T. E., et al. (2020) · Diabetes Care · doi:10.2337/dc20-1328 · Cited by 142

In Search of Fewer Independent Risk Factors

Brotman, D. J. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.2.138 · Cited by 138

Synthetic or food-derived vitamin C—Are they equally bioavailable?

Carr, A., & Vissers, M. (2013) · Nutrients · doi:10.3390/nu5114284 · Cited by 137

Dietary antioxidants, circulating antioxidant concentrations, total antioxidant capacity, and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective observational studies

Jayedi, A., Rashidy-Pour, A., Parohan, M., Zargar, M. S., & Shab-Bidar, S. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy040 · Cited by 137

Approaches for drawing causal inferences from epidemiological birth cohorts: A review

Richmond, R. C., Al-Amin, A., Smith, G. D., & Relton, C. L. (2014) · Early Human Development · doi:10.1016/j.earlhumdev.2014.08.023 · Cited by 138

Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health

Davey Smith, G. (2011) · Genes & Nutrition · doi:10.1007/s12263-010-0181-y · Cited by 134

Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies

Ye, Z., & Song, H. (2008) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282f11f95 · Cited by 131

The scandal of poor epidemiological research: ***

von Elm, E. B., & Egger, M. (2004) · BMJ · doi:10.1136/bmj.329.7471.868 · Cited by 134

Evolution and Translation of Research Findings: From Bench to Where

Ioannidis, J. P. A. (2006) · PLoS Clinical Trials · doi:10.1371/journal.pctr.0010036 · Cited by 129

Free Radicals, Antioxidants and Eye Diseases: Evidence from Epidemiological Studies on Cataract and Age-Related Macular Degeneration

Fletcher, A. (2010) · Ophthalmic Research · doi:10.1159/000316476 · Cited by 129

TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women’s Heart and Health Study

Timpson, N. J., Christensen, M. B., Lawlor, D. A., Gaunt, T. R., Day, I. N. M., Ebrahim, S. B. J., & Smith, G. D. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1005 · Cited by 125

Long-term effects of neighbourhood deprivation on diabetes risk: quasi-experimental evidence from a refugee dispersal policy in Sweden

White, J. S., Hamad, R., Li, X., Basu, S., Ohlsson, H., Sundquist, J., & Sundquist, K. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30009-2 · Cited by 120

B-Vitamins and Fatty Acids in the Prevention and Treatment of Alzheimer's Disease and Dementia: A Systematic Review

Dangour, A. D., Whitehouse, P. J., Rafferty, K., Mitchell, S., Smith, L. A., Hawkesworth, S., & Vellas, B. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-090940 · Cited by 122

Effect of iodine supplementation in pregnancy on child development and other clinical outcomes: a systematic review of randomized controlled trials

Zhou, S. J., Anderson, A. J., Gibson, R. A., & Makrides, M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.065854 · Cited by 123

Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer–Norfolk prospective population study

Myint, P. K., Luben, R., Welch, A. A., Bingham, S. A., Wareham, N. J., & Khaw, K. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.64 · Cited by 117

Maternal smoking and child psychological problems: disentangling causal and noncausal effects

Brion, M.-J., Victora, C., Matijasevich, A., Horta, B., Anselmi, L., Steer, C., Menezes, A. M. B., Lawlor, D. A., & Davey Smith, G. (2010) · PEDIATRICS · doi:10.1542/peds.2009-2754 · Cited by 117

Genetics: Implications for Prevention and Management of Coronary Artery Disease

Assimes, T. L., & Roberts, R. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.10.039 · Cited by 118

Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization

Smith, G. D., Timpson, N. J., & Ebrahim, S. B. J. (2008) · Annals of Medicine · doi:10.1080/07853890802010709 · Cited by 112

Plasma carotene and α-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the Survey in Europe on Nutrition and the Elderly, a Concerted Action (SENECA)

Buijsse, B., Feskens, E. J. M., Schlettwein-Gsell, D., Ferry, M., Kok, F. J., Kromhout, D., & de Groot, C. P. G. M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.879 · Cited by 115

Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study

Bingham, S. A., Luben, R., Welch, A. A., Low, Y. L., Khaw, K., Wareham, N. J., & Day, N. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn111 · Cited by 113

Commentary: The hormone replacement-coronary heart disease conundrum: is this the death of observational epidemiology?

Lawlor, D. A. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh124 · Cited by 109

Nutrition and the risk of stroke

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