The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Obesity, cigarette smoking, and telomere length in women
Abstract
Obesity and smoking are important risk factors for many age-related diseases. Both are states of heightened oxidative stress, which increases the rate of telomere erosion per replication, and inflammation, which enhances white blood cell turnover. Together, these processes might accelerate telomere erosion with age. We therefore tested the hypothesis that increased body mass and smoking are associated with shortened telomere length in white blood cells. We investigated 1122 white women aged 18-76 years and found that telomere length decreased steadily with age at a mean rate of 27 bp per year. Telomeres of obese women were 240 bp shorter than those of lean women (p=0.026). A dose-dependent relation with smoking was recorded (p=0.017), and each pack-year smoked was equivalent to an additional 5 bp of telomere length lost (18%) compared with the rate in the overall cohort. Our results emphasise the pro-ageing effects of obesity and cigarette smoking.
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“Because LTL is also affected by other risk factors for CAD such as oxidative stress27–29, it has been unclear whether the association of shorter LTL with CAD is primary or secondary.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [28]
Citations
Cites
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170
Telomere Length as an Indicator of Biological Aging
Bénétos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.381 · Cited by 627
Self-citationAndrew, T., Hart, D. J., Snieder, H., de Lange, M., Spector, T. D., & MacGregor, A. J. (2001) · Twin Research · doi:10.1375/1369052012803 · Cited by 440
Self-citationOxidative stress and smoking-induced vascular injury
Burke, A., & FitzGerald, G. A. (2003) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(03)00076-8 · Cited by 277
Telomeres and human aging: facts and fibs
Aviv, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.51.pe43 · Cited by 198
Self-citationBełtowski, J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00236-3 · Cited by 168
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Maternal Lifestyle During Pregnancy and Its Influence on Offspring’s Telomere Length
Vakonaki, E., Vitiadou, M. T., Panteris, E., Tzatzarakis, M., Tsatsakis, A., & Hatzidaki, E. (2025) · Life · doi:10.3390/life15081250 · Cited by 6
Metadata
- Authors
- Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T.
- Affiliations
- St Thomas' Hospital (GB)
- University of Medicine and Dentistry of New Jersey (US)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 366
- Issue
- 9486
- Pages
- 662-664
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2147991226
- Cited by
- 1,363
- References
- 6
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 46 · 2023: 47 · 2022: 59 · 2021: 63 · 2020: 65 · 2019: 81 · 2018: 62 · 2017: 80 · 2016: 89 · 2015: 75 · 2014: 98 · 2013: 80 · 2012: 100
- FWCI
- 29.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Healthcare Foundation of New Jersey
- Grant Healthcare Foundation
- Wellcome Trust
- Korea Institute of Machinery and Materials
- National Institutes of Health
- National Institute on Aging (R01AG021593, AG021593)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- obesity, cigarette smoking, telomere length, leukocytes, oxidative stress, inflammation, aging, pack-years, women, body mass index
- MeSH terms
- Adolescent, Adult, Aged, Aging, Female, Humans, Middle Aged, Obesity, Risk Factors, Smoking, Telomere
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