Cited by 1,363Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSmoking Behavior and Cessation

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Obesity, cigarette smoking, and telomere length in women

Valdes, AM, Andrew, T, Gardner, JP, Kimura, M, Oelsner, E, Cherkas, LF, Aviv, A, Spector, TD·2005·The Lancet

DOI 10.1016/s0140-6736(05)66630-5

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Abstract

Obesity and smoking are important risk factors for many age-related diseases. Both are states of heightened oxidative stress, which increases the rate of telomere erosion per replication, and inflammation, which enhances white blood cell turnover. Together, these processes might accelerate telomere erosion with age. We therefore tested the hypothesis that increased body mass and smoking are associated with shortened telomere length in white blood cells. We investigated 1122 white women aged 18-76 years and found that telomere length decreased steadily with age at a mean rate of 27 bp per year. Telomeres of obese women were 240 bp shorter than those of lean women (p=0.026). A dose-dependent relation with smoking was recorded (p=0.017), and each pack-year smoked was equivalent to an additional 5 bp of telomere length lost (18%) compared with the rate in the overall cohort. Our results emphasise the pro-ageing effects of obesity and cigarette smoking.

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Authors: Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T.
Affiliations: St Thomas' Hospital (GB)
University of Medicine and Dentistry of New Jersey (US)
ORCID: Andrew, T
Kimura, M
Oelsner, E
Aviv, A
Venue: The Lancet
Publisher: Elsevier BV
Published: 2005-08
Volume: 366
Issue: 9486
Pages: 662-664
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(05)66630-5
OpenAlex: W2147991226
Cited by: 1,363
References: 6
Citations by year: 2026: 19 · 2025: 25 · 2024: 46 · 2023: 47 · 2022: 59 · 2021: 63 · 2020: 65 · 2019: 81 · 2018: 62 · 2017: 80 · 2016: 89 · 2015: 75 · 2014: 98 · 2013: 80 · 2012: 100
FWCI: 29.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Healthcare Foundation of New Jersey
Grant Healthcare Foundation
Wellcome Trust
Korea Institute of Machinery and Materials
National Institutes of Health
National Institute on Aging (R01AG021593, AG021593)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: obesity, cigarette smoking, telomere length, leukocytes, oxidative stress, inflammation, aging, pack-years, women, body mass index
MeSH terms: Adolescent, Adult, Aged, Aging, Female, Humans, Middle Aged, Obesity, Risk Factors, Smoking, Telomere

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Obesity, cigarette smoking, and telomere length in women

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