Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study
Open accessAbstract
Leukocyte telomere length (LTL) shortening is a biomarker of cellular aging that can be decelerated by diet. We aimed to investigate the effect of dietary intake of vitamin E on biomarkers of cellular senescence in patients with established cardiovascular disease. To this end, DNA from 1,002 participants of the CORDIOPREV study (NCT00924937) was isolated and LTL was measured by real-time PCR. Dietary information was collected using a 146-item food frequency questionnaire, and several oxidative stress and damage biomarkers were determined. We found that patients with an inadequate intake of vitamin E according to the European Food Safety Authority, U.S. Food and Nutrition Board, and Spanish dietary recommendation had shorter LTL than those with an adequate intake (p = .004, p = .015, and p = .005, respectively). Moreover, we observed a positive correlation between olive oil, fish consumption and LTL (r2 = .083, p = .010; r2 = .090, p = .006, respectively). Subjects who consumed more than 30 mL olive oil/day had longer LTL than subjects with lower consumption (p = .013). Furthermore, we observed higher glutathione peroxidase activity in subjects consuming less vitamin E (p = .031). Our findings support the importance of an adequate consumption of the antioxidant vitamin E, and the value of the diet as a modulating tool of the senescence process.
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Higher consumption of antioxidants such as vitamin E is able to reduce ROS levels, leading to decreased telomere shortening, decelerating cellular senescence, and potentially decreasing the risk of disease development.
“It has been recently observed that a higher consumption of antioxidants such as vitamin E is able to reduce ROS levels, leading to decreased telomere shortening, decelerating the cellular senescence, and potentially decreasing the risk of disease development [132,133].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [133]
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“While previous studies have linked long-term oxidative stress and telomere length to chronic disease outcomes (Corina et al., 2019; Margaritis et al., 2017; Salpea et al., 2010; Sen et al., 2014; Watfa et al., 2011), research in critically ill populations is limited (Duggal et al., 2018; Zribi et…”
Telomeric autophagy in human health, aging, and diseases
Li, X., & Wu, X. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1922188
“…to antioxidant exposure—a Mendelian randomisation analysis of micronutrient levels (Zhu et al., 2026), dietary and supplementation intervention studies (Corina et al., 2019; Nonsa-Ard et al., 2022), and work in a non-mammalian species (Kim and Velando, 2015) — did not report autophagic markers.”
- Authors
- Corina, A., Rangel-Zúñiga, O. A., Jiménez-Lucena, R., Alcalá-Díaz, J. F., Quintana-Navarro, G., Yubero-Serrano, E. M., López-Moreno, J., Delgado-Lista, J., Tinahones, F., Ordovás, J. M., López-Miranda, J., & Pérez-Martínez, P.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Córdoba, Spain
- Tufts University (US)
- ORCID
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-27
- Volume
- 74
- Issue
- 6
- Pages
- 770-777
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2889448719
- Cited by
- 41
- References
- 47
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 3
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Universidad de Córdoba Insitutional Repository (Universidad de Córdoba) (submittedVersion, cc-by-nc-nd)
- Funders
- Fundación Patrimonio Comunal Olivarero, Junta de Andalucía
- Diputaciones de Jaén y Córdoba, Centro de Excelencia en Investigación sobre Aceite de Oliva y Salud
- Ministerio de Medio Ambiente, Medio Rural y Marino, Gobierno de España
- Ministerio de Economía y Competitividad (FIS PI13/00185, AGL2012/39615, PIE14/00005, PIE 14/00031 to J.L.-Mi, AGL2015-67896-P to J.L.-Mi)
- Consejería de Innovación, Ciencia y Empresa, Proyectos de Investigación de Excelencia, Junta de Andalucía (CVI-7450)
- Fondo Europeo de Desarrollo Regional
- U.S. Department of Agriculture—Agricultural Research Service (58-1950-4-003)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- vitamin E, leukocyte telomere length, cellular aging, cellular senescence, cardiovascular disease, dietary intake, oxidative stress, glutathione peroxidase, olive oil consumption, fish consumption, antioxidants, CORDIOPREV study
- MeSH terms
- Olive Oil, Cardiovascular Diseases, Female, Fish Products, Genetic Markers, Glutathione Peroxidase, Humans, Leukocytes, Male, Middle Aged, Prospective Studies, Vitamin E, Cellular Senescence, Oxidative Stress, Diet, Mediterranean, Telomere Shortening, Real-Time Polymerase Chain Reaction, Recommended Dietary Allowances
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