Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study
Abstract
Background The effect of obstructive sleep apnoea-hypopnoea as a cardiovascular risk factor and the potential protective effect of its treatment with continuous positive airway pressure (CPAP) is unclear. We did an observational study to compare incidence of fatal and non-fatal cardiovascular events in simple snorers, patients with untreated obstructive sleep apnoea-hypopnoea, patients treated with CPAP, and healthy men recruited from the general population. Methods We recruited men with obstructive sleep apnoea-hypopnoea or simple snorers from a sleep clinic, and a population-based sample of healthy men, matched for age and body-mass index with the patients with untreated severe obstructive sleep apnoea-hypopnoea. The presence and severity of the disorder was determined with full polysomnography, and the apnoea-hypopnoea index (AHI) was calculated as the average number of apnoeas and hypopnoeas per hour of sleep. Participants were followed-up at least once per year for a mean of 10.1 years (SD 1.6) and CPAP compliance was checked with the built-in meter. Endpoints were fatal cardiovascular events (death from myocardial infarction or stroke) and non-fatal cardiovascular events (non-fatal myocardial infarction, non-fatal stroke, coronary artery bypass surgery, and percutaneous transluminal coronary angiography). Findings 264 healthy men, 377 simple snorers, 403 with untreated mild-moderate obstructive sleep apnoea-hypopnoea, 235 with untreated severe disease, and 372 with the…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is a movement toward using more objective outcomes such as ODI and/or a 50% AHI decrease to under 15 events/h, which correlates with long-term health risk and mortality.
“However, there is a movement toward using more objective outcomes (e.g., ODI) and/or a 50% AHI decrease to under 15 events/h into the mild OSA range, which correlates with long-term health risk and mortality.114,118,433,434,638,642,660,683”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [118]
Obstructive sleep apnea has been linked to an increased risk of job-related and motor vehicle accidents, more frequent health-related missed workdays, and decreased quality of life.
“OSA has been linked to an increased risk of job-related and motor vehicle accidents, more frequent health-related missed workdays, and decreased quality of life.8”
From Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2021) · cites this paper as [8]
Subgroup meta-analyses demonstrated a clinically significant reduction in the risk ratio for mortality of 0.4 (95% CI 0.2 to 0.7) for participants without heart failure.
“meta-analyses demonstrated clinically significant reductions in the risk ratio for mortality of 0.2 (95% CI: 0.1 to 0.5) and 0.4 (95% CI: 0.2 to 0.7) for heart failure 142,146 and no heart failure participants, 137,139,143,144,147 respectively”
OSA increases the rate of new future occurrences of hypertension.
“It has also been substantiated in these studies that OSA increases the rate of new future occurrences of hypertension215).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [215]
Severe OSA is linked to an increased risk of fatal cardiovascular events (OR 2.87; 1.17-7.51) and non-fatal cardiovascular events (OR 3.17, 1.12-7.51) compared to healthy controls.
“severe OSA was linked to an increased risk of fatal cardiovascular events (odds ratio of 2.87; 1.17 – 7.51) as well as non-fatal cardiovascular events (odds ratio of 3.17, 1.12 −7.51) compared to a control of healthy individuals(84).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [84]
OSAS is associated with obesity, short and disrupted sleep, excessive daytime sleepiness, and high rates of morbidity and mortality, predominantly due to cardiovascular disease.
“OSAS is associated with obesity, short and disrupted sleep, excessive daytime sleepiness, and high rates of morbidity and mortality, predominantly due to cardiovascular disease (28).”
From Quantity and Quality of Sleep and Incidence of Type 2 Diabetes (2010) · cites this paper as [28]
Cites
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793 · see citing works
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297 · see citing works
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772 · see citing works
The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults
Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S., & Badr, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304293281704 · Cited by 10,183 · see citing works
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215 · see citing works
Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective
Young, T., Peppard, P. E., & Gottlieb, D. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109080 · Cited by 4,244 · see citing works
Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs
Concato, J., Shah, N., & Horwitz, R. I. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422507 · Cited by 3,563 · see citing works
Nieto, F. J. (2000) · JAMA · doi:10.1001/jama.283.14.1829 · Cited by 3,369 · see citing works
Sleep-disordered Breathing and Cardiovascular Disease
SHAHAR, E., WHITNEY, C. W., REDLINE, S., LEE, E. T., NEWMAN, A. B., JAVIER NIETO, F., O'CONNOR, G. T., BOLAND, L. L., SCHWARTZ, J. E., & SAMET, J. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2001008 · Cited by 2,901 · see citing works
A comparison of observational studies and randomized, controlled trials.
Benson, K., & Hartz, A. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006223422506 · Cited by 2,347 · see citing works
(1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410020010002 · Cited by 1,960 · see citing works
Mortality and Apnea Index in Obstructive Sleep Apnea
He, J., Kryger, M. H., Zorick, F. J., Conway, W. A., & Roth, T. G. (1988) · CHEST Journal · doi:10.1378/chest.94.1.9 · Cited by 1,515 · see citing works
DURÁN, J., ESNAOLA, S., RUBIO, R., & IZTUETA, Á. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.3.2005065 · Cited by 1,407 · see citing works
Kaneko, Y., Floras, J. S., Usui, K., Plante, J., Tkacova, R., Kubo, T., Ando, S.-I., & Bradley, T. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022479 · Cited by 1,051 · see citing works
Jenkinson, C., Davies, R. J., Mullins, R., & Stradling, J. R. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10532-9 · Cited by 826 · see citing works
Peker, Y., Hedner, J. A., Norum, J., Kraiczi, H., & Carlson, J. T. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2105124 · Cited by 788 · see citing works
Kato, M., Roberts‐Thomson, P., Phillips, B. G., Haynes, W. G., Winnicki, M., Accurso, V., & Somers, V. K. (2000) · Circulation · doi:10.1161/01.cir.102.21.2607 · Cited by 730 · see citing works
Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model.
Brooks, D., Horner, R. L., KOZAR, L. F., RENDER-TEIXEIRA, C. L., & Phillipson, E. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119120 · Cited by 704 · see citing works
Long-term outcome for obstructive sleep apnea syndrome patients. Mortality.
Partinen, M., Jamieson, A., & Guilleminault, C. (1988) · Chest · doi:10.1378/chest.94.6.1200 · Cited by 675 · see citing works
Time Course of Sleep-related Breathing Disorders in First-Ever Stroke or Transient Ischemic Attack
Parra, O., Arboix, A., Bechich, S., García‐Eroles, L., Montserrat, J. M., LÓPEZ, J. A., Ballester, E., GUERRA, J. M., & Jj, S. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.2.9903139 · Cited by 592 · see citing works
Snoring as a risk factor for ischaemic heart disease and stroke in men.
Koskenvuo, M., Kaprio, J. A., Telakivi, T., Partinen, M., Heikkila, K. V., & Sarna, S. J. (1987) · BMJ · doi:10.1136/bmj.294.6563.16 · Cited by 482 · see citing works
The National Survey of Stroke. Clinical findings.
Walker, A., Robins, M., & Weinfeld, F. D. (1981) · PubMed · Cited by 460 · see citing works
Peker, Y., Hedner, J. A., Kraiczi, H., & Löth, S. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.1.9905035 · Cited by 453 · see citing works
Sleep-disordered Breathing and Coronary Artery Disease
MOOE, T., FRANKLIN, K. A., HOLMSTRÖM, K., RABBEN, T., & WIKLUND, U. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.10.2101072 · Cited by 401 · see citing works
Mortality in Sleep Apnea Patients: A Multivariate Analysis of Risk Factors
Lavie, P., Herer, P., Peled, R., Berger, I., Yoffe, N., Zomer, J., & Rubin, A. E. (1995) · SLEEP · doi:10.1093/sleep/18.3.149 · Cited by 396 · see citing works
Automobile Accidents in Patients with Sleep Apnea Syndrome: An Epidemiological and Mechanistic Study
Barbé, F., Pericas, J., Muñoz, A. M., Findley, L. J., Antó, J. M., Agustí, A. G. N., & JOAN, M. D. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.1.9709135 · Cited by 372 · see citing works
Self-citationMilleron, O. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.02.008 · Cited by 370 · see citing works
SNORING AND CEREBRAL INFARCTION
Partinen, M., & Palomäki, H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92625-x · Cited by 365 · see citing works
Indications for Positive Airway Pressure Treatment of Adult Obstructive Sleep Apnea Patients
Loube, D. I., Gay, P. C., Strohl, K. P., Pack, A. I., White, D. P., & Collop, N. A. (1999) · Chest · doi:10.1378/chest.115.3.863 · Cited by 363 · see citing works
Ballester, E., Badia, J. R., Hernández, L., CARRASCO, E., de PABLO, J., FORNAS, C., Rodriguez‐Roisin, R., & Montserrat, J. M. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.2.9804061 · Cited by 349 · see citing works
Effectiveness of CPAP Treatment in Daytime Function in Sleep Apnea Syndrome
MONTSERRAT, J. M., FERRER, M., HERNANDEZ, L., FARRÉ, R., VILAGUT, G., NAVAJAS, D., BADIA, J. R., CARRASCO, E., DE PABLO, J., BALLESTER, E., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.4.2006034 · Cited by 349 · see citing works
Bokinsky, G. E., Miller, M. J., Ault, K. A., Husband, P., & Mitchell, J. (1995) · CHEST Journal · doi:10.1378/chest.108.3.625 · Cited by 284 · see citing works
Snoring and the risk of ischemic brain infarction.
Palomäki, H. (1991) · Stroke · doi:10.1161/01.str.22.8.1021 · Cited by 270 · see citing works
Sleep apnea in patients with transient ischemic attack and stroke
Bassetti, C. L., Aldrich, M. S., Chervin, R. D., & Quint, D. J. (1996) · Neurology · doi:10.1212/wnl.47.5.1167 · Cited by 254 · see citing works
Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction
Iranzo, Á., Santamaría, J., Berenguer, J., Sánchez, M., & Chamorro, A. (2002) · Neurology · doi:10.1212/wnl.58.6.911 · Cited by 230 · see citing works
Snoring and risk of cardiovascular disease in women
Hu, F. B., Willett, W. C., Manson, J. E., Colditz, G. A., Rimm, E. B., Speizer, F. E., Hennekens, C. H., & Stampfer, M. J. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00540-9 · Cited by 227 · see citing works
Morbidity, Mortality and Sleep-Disordered Breathing in Community Dwelling Elderly
Ancoli‐Israel, S., Kripke, D. F., Klauber, M. R., Fell, R. L., Stepnowsky, C. J., Estline, E., Khazeni, N., & Chinn, A. (1996) · SLEEP · doi:10.1093/sleep/19.4.277 · Cited by 226 · see citing works
CROSS-REACTION OF HUMAN SERUM-PROTEINS WITH HBsAg
Goudeau, A., Houwen, B., & Dankert, J. R. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90192-5 · Cited by 210 · see citing works
Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction
Wessendorf, T., Dahm, C., & Teschler, H. (2003) · Neurology · doi:10.1212/wnl.60.6.1053 · Cited by 209 · see citing works
Wilcox, I., Grunstein, R. R., Hedner, J. A., Doyle, J. M., Collins, F. L., Fletcher, P., Kelly, D. T., & Sullivan, C. E. (1993) · SLEEP · doi:10.1093/sleep/16.6.539 · Cited by 204 · see citing works
Platelet function in patients with obstructivesleep apnoea syndrome
Sanner, B. M., KONERMANN, M., Tepel, M., Groetz, J., Mummenhoff, C., & Zidek, W. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.16d14.x · Cited by 180 · see citing works
A Specific and Potent Pressor Effect of Hypoxia in Patients with Sleep Apnea
Hedner, J. A., Wilcox, I., LAKS, L., et al. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.5_pt_1.1240 · Cited by 167 · see citing works
Increased mortality among sleepy snorers: a prospective population based study
Lindberg, E., Janson, C., Svärdsudd, K., Gislason, T., Hetta, J. E., & Boman, G. (1998) · Thorax · doi:10.1136/thx.53.8.631 · Cited by 163 · see citing works
Neck manipulation as a cause of stroke.
Robertson, J. T. (1981) · Stroke · doi:10.1161/01.str.12.1.1 · Cited by 141 · see citing works
Imadojemu, V. A., Gleeson, K., Quraishi, S. A., Kunselman, A. R., Sinoway, L. I., & Leuenberger, U. A. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.7.2102003 · Cited by 139 · see citing works
Snoring in a Hispanic-American Population
Schmidt-Nowara, W. W. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.1990.00390150089017 · Cited by 131 · see citing works
Do Patients with Sleep Apnea Die in Their Sleep?
Gonzalez‐Rothi, R. J., Foresman, G. E., & Block, A. J. (1988) · CHEST Journal · doi:10.1378/chest.94.3.531 · Cited by 123 · see citing works
A Community Study of Snoring and Sleep-Disordered Breathing. Health Outcomes
Olson, L. G., King, M. T., Hensley, M. J., & Saunders, N. A. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7633732 · Cited by 114 · see citing works
Prevalence of sleep apnoea syndrome in the Spanish adult population
Marín, J. M., Gascón, J., Carrizo, S. J., et al. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.2.381 · Cited by 103 · see citing works
Self-citationTratamiento del síndrome de las apneas-hipoapneas durante el sueño
Montserrat, J. M., Amilibia, J., Barbé, F., Capote, F., Duran, J., Mangado, N. G., Jiménez, A., Marín, J. M., Masa, F., & Terán, J. (1998) · Archivos de Bronconeumología · doi:10.1016/s0300-2896(15)30454-3 · Cited by 92 · see citing works
Self-citationSham continuous positive airway pressure for placebo-controlled studies in sleep apnoea
Farré, R., Hernández, L., Montserrat, J. M., Rotger, M., Ballester, E., & Navajas, D. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01056-9 · Cited by 91 · see citing works
Risk of Ischemic Heart Disease in Self-reported Snorers
Jennum, P., Hein, H. O., Suadicani, P., & Gyntelberg, F. (1995) · CHEST Journal · doi:10.1378/chest.108.1.138 · Cited by 39 · see citing works
Sleep apnoea and its impact on public health
Wright, J., & Sheldon, T. (1998) · Thorax · doi:10.1136/thx.53.5.410 · Cited by 26 · see citing works
Addressing the Ethical Problems of Randomized and Placebo-Controlled Trials of CPAP
Karlawish, J. H., & Pack, A. I. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.4.ed0201d · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391 · see citing works
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616 · see citing works
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893 · see citing works
Kapur, V. K., Auckley, D. H., Chowdhuri, S., Kuhlmann, D. C., Mehra, R., Ramar, K., & Harrod, C. G. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6506 · Cited by 3,253 · see citing works
Obstructive Sleep Apnea as a Risk Factor for Stroke and Death
Yaggi, H. K., Concato, J., Kernan, W. N., Lichtman, J. H., Brass, L. M., & Mohsenin, V. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043104 · Cited by 3,004 · see citing works
Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., et al. (2014) · Stroke · doi:10.1161/str.0000000000000046 · Cited by 2,650 · see citing works
Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study
Heinzer, R., Vat, S., Marques-Vidal, P., Marti-Soler, H., Andries, D., Tobback, N., Mooser, V, Preisig, M., Malhotra, A., Waeber, G., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00043-0 · Cited by 2,481 · see citing works
The epidemiology of adult obstructive sleep apnea
Punjabi, N. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200709-155mg · Cited by 2,361 · see citing works
Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Sleep · doi:10.1093/sleep/33.5.585 · Cited by 2,224 · see citing works
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243 · see citing works
Cappuccio, F. P., Cooper, D., D'Elia, L., Strazzullo, P., & Miller, M. A. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr007 · Cited by 2,146 · see citing works
CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea
McEvoy, R. D., Antic, N. A., Heeley, E., Luo, Y., Ou, Q., Zhang, X., Mediano, O., Chen, R., Drager, L. F., Liu, Z., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606599 · Cited by 2,101 · see citing works
Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort
(2008) · Sleep · doi:10.5665/sleep/31.8.1071 · Cited by 1,853 · see citing works
Adult obstructive sleep apnoea
Jordan, A. S., McSharry, D. G., & Malhotra, A. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60734-5 · Cited by 1,735 · see citing works
Quantity and Quality of Sleep and Incidence of Type 2 Diabetes
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Diabetes Care · doi:10.2337/dc09-1124 · Cited by 1,670 · see citing works
Gottlieb, D. J., Yenokyan, G., Newman, A. B., O'Connor, G. T., Punjabi, N. M., Quan, S. F., Redline, S., Resnick, H. E., Tong, E. K., Diener-West, M., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.901801 · Cited by 1,551 · see citing works
Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study
Punjabi, N. M., Caffo, B. S., Goodwin, J. L., Gottlieb, D. J., Newman, A. B., O'Connor, G. T., Rapoport, D. M., Redline, S., Resnick, H. E., Robbins, J. A., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000132 · Cited by 1,482 · see citing works
“Perhaps the most persuasive evidence is that treatment with positive airway pressure improves blood pressure [30,31] and may decrease cardiovascular events [18].”
BackgroundSleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.002 · Cited by 1,510 · see citing works
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450 · see citing works
Javaheri, S., Barbe, F., Campos-Rodriguez, F., Dempsey, J. A., Khayat, R., Javaheri, S., Malhotra, A., Martinez-Garcia, M. A., Mehra, R., Pack, A. I., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.069 · Cited by 1,434 · see citing works
Yeghiazarians, Y., Jneid, H., Tietjens, J. R., Redline, S., Brown, D. L., El-Sherif, N., Mehra, R., Bozkurt, B., Ndumele, C. E., Somers, V. K., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000988 · Cited by 1,431 · see citing works
Obstructive sleep apnoea and its cardiovascular consequences
Bradley, T. D., & Floras, J. S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61622-0 · Cited by 1,385 · see citing works
Primary Prevention of Ischemic Stroke
Goldstein, L. B., Adams, R. J., Alberts, M. J., Appel, L. J., Brass, L. M., Bushnell, C., Culebras, A., DeGraba, T. J., Gorelick, P. B., Guyton, J. R., et al. (2006) · Stroke · doi:10.1161/01.str.0000223048.70103.f1 · Cited by 1,359 · see citing works
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,301 · see citing works
Upper-Airway Stimulation for Obstructive Sleep Apnea
Strollo, P. J., Soose, R. J., Maurer, J. T., de Vries, N., Cornelius, J., Froymovich, O., Hanson, R. D., Padhya, T. A., Steward, D. L., Gillespie, M. B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308659 · Cited by 1,299 · see citing works
Obstructive Sleep Apnea–Hypopnea and Incident Stroke: The Sleep Heart Health Study
Redline, S., Yenokyan, G., Gottlieb, D. J., Shahar, E., O'Connor, G. T., Resnick, H. E., Diener-West, M., Sanders, M. H., Wolf, P. A., Geraghty, E. M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200911-1746oc · Cited by 1,269 · see citing works
Association of Nocturnal Arrhythmias with Sleep-disordered Breathing
Mehra, R., Benjamin, E. J., Shahar, E., Gottlieb, D. J., Nawabit, R., Kirchner, H. L., Sahadevan, J., & Redline, S. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1442oc · Cited by 1,262 · see citing works
Obstructive sleep apnoea syndrome
Lévy, P., Kohler, M., McNicholas, W. T., Barbé, F., McEvoy, R. D., Somers, V. K., Lavie, L., & Pépin, J.-L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.15 · Cited by 1,235 · see citing works
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000596 · Cited by 1,127 · see citing works
St-Onge, M.-P., Grandner, M. A., Brown, D., Conroy, M. B., Jean-Louis, G., Coons, M., & Bhatt, D. L. (2016) · Circulation · doi:10.1161/cir.0000000000000444 · Cited by 1,044 · see citing works
Ryan, S., Taylor, C. T., & McNicholas, W. T. (2005) · Circulation · doi:10.1161/circulationaha.105.556746 · Cited by 970 · see citing works
Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort
Jones, S. (2009) · Yearbook of Pulmonary Disease · doi:10.1016/s8756-3452(08)79181-3 · Cited by 958 · see citing works
McNicholas, W. T., Bonsignore, M. R., & the Management Committee of EU COST ACTION B26 (2007) · European Respiratory Journal · doi:10.1183/09031936.00027406 · Cited by 911 · see citing works
Drager, L. F., Togeiro, S. M., Polotsky, V. Y., & Lorenzi-Filho, G. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.045 · Cited by 886 · see citing works
Sleep Apnea as an Independent Risk Factor for All-Cause Mortality: The Busselton Health Study
(2008) · Sleep · doi:10.5665/sleep/31.8.1079 · Cited by 889 · see citing works
Azarbarzin, A., Sands, S. A., Stone, K. L., Taranto-Montemurro, L., Messineo, L., Terrill, P. I., Ancoli-Israel, S., Ensrud, K., Purcell, S., White, D. P., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy624 · Cited by 893 · see citing works
Lackland, D. T., Roccella, E. J., Deutsch, A. F., Fornage, M., George, M. G., Howard, G., Kissela, B. M., Kittner, S. J., Lichtman, J. H., Lisabeth, L. D., et al. (2014) · Stroke · doi:10.1161/01.str.0000437068.30550.cf · Cited by 815 · see citing works
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Barbé, F., Durán-Cantolla, J., Sánchez-de-la-Torre, M., Martínez-Alonso, M., Carmona, C., Barceló, A., Chiner, E., Masa, J. F., Gonzalez, M., Marín, J. M., et al. (2012) · JAMA · doi:10.1001/jama.2012.4366 · Cited by 792 · see citing works
Self-citationAssociation Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension
Marin, J. M., Agusti, A., Villar, I., Forner, M., Nieto, D., Carrizo, S. J., Barbé, F., Vicente, E., Wei, Y., Nieto, F. J., et al. (2012) · JAMA · doi:10.1001/jama.2012.3418 · Cited by 781 · see citing works
Self-citationInteractions Between Obesity and Obstructive Sleep Apnea
Romero‐Corral, A., Caples, S. M., López-Jiménez, F. A., & Somers, V. K. (2010) · CHEST Journal · doi:10.1378/chest.09-0360 · Cited by 788 · see citing works
Peker, Y., Glantz, H., Eulenburg, C., Wegscheider, K., Herlitz, J., & Thunström, E. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201601-0088oc · Cited by 756 · see citing works
Oldenburg, O., Lamp, B., Faber, L., Teschler, H., Horstkotte, D., & Töpfer, V. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.08.003 · Cited by 756 · see citing works
Comprehensive Overview of Nursing and Interdisciplinary Rehabilitation Care of the Stroke Patient
Miller, E., Murray, L., Richards, L. G., Zorowitz, R. D., Bakas, T., Clark, P. C., & Billinger, S. A. (2010) · Stroke · doi:10.1161/str.0b013e3181e7512b · Cited by 761 · see citing works
Patil, S. P., Ayappa, I. A., Caples, S. M., Kimoff, R. J., Patel, S. R., & Harrod, C. G. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7638 · Cited by 721 · see citing works
Tsutsui, H., Isobe, M., Ito, H., Ito, H., Okumura, K., Ōno, M., Kitakaze, M., Kinugawa, K., Kihara, Y., Goto, Y., et al. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0342 · Cited by 708 · see citing works
Marin, J. M., Soriano, J. B., Carrizo, S. J., Boldova, A., & Celli, B. R. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1869oc · Cited by 699 · see citing works
Self-citationSleep, sleep deprivation, autonomic nervous system and cardiovascular diseases
Tobaldini, E., Costantino, G., Solbiati, M., Cogliati, C. B., Kára, T., Nobili, L., & Montano, N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.004 · Cited by 671 · see citing works
Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure
Wang, H., Parker, J. D., Newton, G. E., Floras, J. S., Mak, S., Chiu, K.-L., Ruttanaumpawan, P., Tomlinson, G., & Bradley, T. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.12.046 · Cited by 616 · see citing works
Jelić, S., Padeletti, M., Kawut, S. M., Higgins, C., Canfield, S. M., Onat, D., Colombo, P. C., Basner, R. C., Factor, P. H., & LeJemtel, T. H. (2008) · Circulation · doi:10.1161/circulationaha.107.741512 · Cited by 621 · see citing works
JBS3 Board (2014) · Heart · doi:10.1136/heartjnl-2014-305693 · Cited by 608 · see citing works
Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction
Mentz, R. J., Kelly, J. P., von Lueder, T. G., Voors, A. A., Lam, C. S. P., Cowie, M. R., Kjeldsen, K., Jankowska, E. A., Atar, D., Butler, J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.08.036 · Cited by 546 · see citing works
Sánchez-de-la-Torre, M., Sánchez-de-la-Torre, A., Bertran, S., Abad, J., Duran-Cantolla, J., Cabriada, V., Mediano, O., Masdeu, M. J., Alonso, M. L., Masa, J. F., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30271-1 · Cited by 522 · see citing works
Foster, G. D. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.266 · Cited by 538 · see citing works
Oral Appliance Treatment for Obstructive Sleep Apnea: An Update
Sutherland, K., Vanderveken, O. M., Tsuda, H., Marklund, M., Gagnadoux, F., Kushida, C. A., Cistulli, P. A., & on behalf of the ORANGE-Registry (Oral Appliance Network on Global Effectiveness) (2014) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3460 · Cited by 515 · see citing works
Frequency of Sleep Apnea in Stroke and TIA Patients: A Meta-analysis
Johnson, K. G., & Johnson, D. C. (2010) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27760 · Cited by 523 · see citing works
Epidemiology of obstructive sleep apnea: a population-based perspective
Lee, W. J., Nagubadi, S., Kryger, M. H., & Mokhlesi, B. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.3.349 · Cited by 517 · see citing works
Marshall, N. S., Wong, K. K. H., Cullen, S. R. J., Knuiman, M. W., & Grunstein, R. R. (2014) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3600 · Cited by 513 · see citing works
Mechanisms of vascular damage in obstructive sleep apnea
Kohler, M., & Stradling, J. R. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.145 · Cited by 512 · see citing works
Sleep, Cognition, and Normal Aging
Scullin, M. K., & Bliwise, D. L. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691614556680 · Cited by 504 · see citing works
Achondroplasia: a comprehensive clinical review
Pauli, R. M. (2019) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-018-0972-6 · Cited by 496 · see citing works
Obstructive sleep apnoea and cardiovascular disease
Sánchez‐de‐la‐Torre, M., Campos‐Rodríguez, F., & Barbé, F. (2012) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(12)70051-6 · Cited by 492 · see citing works
Metrics of sleep apnea severity: beyond the apnea-hypopnea index
Malhotra, A., Ayappa, I., Ayas, N., Collop, N., Kirsch, D., Mcardle, N., Mehra, R., Pack, A. I., Punjabi, N., White, D. P., et al. (2021) · SLEEP · doi:10.1093/sleep/zsab030 · Cited by 489 · see citing works
Sleep Apnea and Cardiovascular Disease: Lessons From Recent Trials and Need for Team Science
Drager, L. F., McEvoy, R. D., Barbe, F., Lorenzi-Filho, G., & Redline, S. (2017) · Circulation · doi:10.1161/circulationaha.117.029400 · Cited by 465 · see citing works
Long-term Effect of Continuous Positive Airway Pressure in Hypertensive Patients with Sleep Apnea
Barbé, F., Durán-Cantolla, J., Capote, F., de la Peña, M., Chiner, E., Masa, J. F., Gonzalez, M., Marín, J. M., Garcia-Rio, F., de Atauri, J. D., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200901-0050oc · Cited by 460 · see citing works
Witkowski, A., Prejbisz, A., Florczak, E., Kądziela, J., Śliwiński, P., Bieleń, P., Michałowska, I., Kabat, M., Warchoł, E., Januszewicz, M., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173799 · Cited by 460 · see citing works
Prevalence of Symptoms and Risk of Sleep Apnea in the US Population
Hiestand, D. M., Britz, P., Goldman, M., & Phillips, B. A. (2006) · CHEST Journal · doi:10.1378/chest.130.3.780 · Cited by 450 · see citing works
Javaheri, S., Shukla, R., Zeigler, H., & WEXLER, L. F. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.084 · Cited by 443 · see citing works
Sleep-disordered Breathing and Cancer Mortality: Results from the Wisconsin Sleep Cohort Study
Nieto, F. J., Peppard, P. E., Young, T., Finn, L., Hla, K. M., & Farré, R. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0130oc · Cited by 443 · see citing works
Sleep-Disordered Breathing and Acute Ischemic Stroke
Bassetti, C. L., Миланова, М., & Gugger, M. (2006) · Stroke · doi:10.1161/01.str.0000208215.49243.c3 · Cited by 438 · see citing works
Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology - 2019
Précoma, D. B., de Oliveira, G. M. M., Simão, A. F. L., Dutra, Ó. P., Coelho-Filho, O. R., Izar, M. C. D. O., Póvoa, R., Giuliano, I. D. C. B., Filho, A. C. D. A., Machado, C. A., et al. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190204 · Cited by 469 · see citing works
Kendzerska, T., Gershon, A. S., HAWKER, G. A., Leung, R. S. T., & TOMLINSON, G. A. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001599 · Cited by 434 · see citing works
Severe Sleep Apnea and Risk of Ischemic Stroke in the Elderly
Muñóz, R., Durán‐Cantolla, J., Martínez‐Vila, E., Gállego, J., Rubio, R., Aizpuru, F., & Torre, G. D. L. (2006) · Stroke · doi:10.1161/01.str.0000236560.15735.0f · Cited by 415 · see citing works
The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies
Poulain, M. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051299 · Cited by 413 · see citing works
Tongue Fat and its Relationship to Obstructive Sleep Apnea
Kim, A. M., Keenan, B. T., Jackson, N., Chan, E. L., Staley, B., Poptani, H., Torigian, D. A., Pack, A. I., & Schwab, R. J. (2014) · Sleep · doi:10.5665/sleep.4072 · Cited by 394 · see citing works
Sleep as a Potential Fundamental Contributor to Disparities in Cardiovascular Health
Jackson, C. L., Redline, S., & Emmons, K. M. (2015) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031914-122838 · Cited by 388 · see citing works
Martínez-García, M. A., Soler-Cataluña, J. J., Ejarque-Martínez, L., Soriano, Y., Román-Sánchez, P., Illa, F. B., Canal, J. M. M., & Durán-Cantolla, J. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200808-1341oc · Cited by 390 · see citing works
Campos-Rodriguez, F., Martinez-Garcia, M. A., Martinez, M., Duran-Cantolla, J., Peña, M. D. L., Masdeu, M. J., Gonzalez, M., Campo, F. D., Gallego, I., Marin, J. M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1671oc · Cited by 386 · see citing works
Self-citationShort sleep duration and incident coronary artery calcification
(2008) · JAMA · doi:10.1001/jama.2008.867 · Cited by 389 · see citing works
Non-CPAP therapies in obstructive sleep apnoea
Randerath, W. J., Verbraecken, J., Andreas, S., Bettega, G., Boudewyns, A., Hamans, E., Jalbert, F., Paoli, J. R., Sanner, B., Smith, I., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00099710 · Cited by 388 · see citing works
Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes
Botros, N., Concato, J., Mohsenin, V., Selim, B., Doctor, K., & Yaggi, H. K. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.04.026 · Cited by 384 · see citing works
Sleep Apnea and Cardiovascular Disease
Kasai, T., Floras, J. S., & Bradley, T. D. (2012) · Circulation · doi:10.1161/circulationaha.111.070813 · Cited by 383 · see citing works
Campos-Rodriguez, F., Martinez-Garcia, M. A., de la Cruz-Moron, I., Almeida-Gonzalez, C., Catalan-Serra, P., & Montserrat, J. M. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-2-201201170-00006 · Cited by 379 · see citing works
Wozniak, D. R., Lasserson, T. J., & Smith, I. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007736.pub2 · Cited by 380 · see citing works
Aurora, R. N., Chowdhuri, S., Ramar, K., Bista, S. R., Casey, K. R., Lamm, C. I., Kristo, D. A., Mallea, J. M., Rowley, J. A., Zak, R. S., et al. (2012) · Sleep · doi:10.5665/sleep.1580 · Cited by 369 · see citing works
Obstructive Sleep Apnea and Type 2 Diabetes
Tasali, E., Mokhlesi, B., & Van Cauter, E. (2008) · Chest · doi:10.1378/chest.07-0828 · Cited by 371 · see citing works
Aurora, R. N., Casey, K. R., Kristo, D. A., Auerbach, S. H., Bista, S. R., Chowdhuri, S., Karippot, A., Lamm, C. I., Ramar, K., Zak, R., et al. (2010) · SLEEP · doi:10.1093/sleep/33.10.1408 · Cited by 369 · see citing works
Loke, Y. K., Brown, J. W. L., Kwok, C. S., Niruban, A., & Myint, P. K. (2012) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.111.964783 · Cited by 367 · see citing works
CPAP versus Oxygen in Obstructive Sleep Apnea
Gottlieb, D. J., Punjabi, N. M., Mehra, R., Patel, S. R., Quan, S. F., Babineau, D. C., Tracy, R. P., Rueschman, M., Blumenthal, R. S., Lewis, E. F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1306766 · Cited by 366 · see citing works
Pathogenesis of obstructive sleep apnea
Ryan, C. M., & Bradley, T. D. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00772.2005 · Cited by 365 · see citing works
Chung, F., Memtsoudis, S. G., Ramachandran, S. K., Nagappa, M., Opperer, M., Cozowicz, C., Patrawala, S., Lam, D., Kumar, A., Joshi, G. P., et al. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001416 · Cited by 360 · see citing works
“Further work is needed to answer questions such as: (1) How do we better stratify risk among these patients? Are there phenotypic characteristics among OSA patients that identify those at particular risk? Are there better sleep study metrics than AHI to identify perioperative risk? (2) Which surgical patients with dia…”
BackgroundInfluentialObesity hypoventilation syndrome
Masa, J. F., Pépin, J.-L., Borel, J.-C., Mokhlesi, B., Murphy, P. B., & Sánchez-Quiroga, M. Á. (2019) · European Respiratory Review · doi:10.1183/16000617.0097-2018 · Cited by 360 · see citing works
International Consensus Statement on Obstructive Sleep Apnea
Chang, J. L., Goldberg, A. N., Alt, J. A., Mohammed, A., Ashbrook, L., Auckley, D., Ayappa, I., Bakhtiar, H., Barrera, J. E., Bartley, B. L., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23079 · Cited by 350 · see citing works
Pratt-Ubunama, M. N., Nishizaka, M. K., Boedefeld, R. L., Cofield, S. S., Harding, S. M., & Calhoun, D. A. (2007) · Chest · doi:10.1378/chest.06-1442 · Cited by 331 · see citing works
The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study
Marti-Soler, H., Hirotsu, C., Marques-Vidal, P., Vollenweider, P., Waeber, G., Preisig, M., Tafti, M., Tufik, S. B., Bittencourt, L., Tufik, S., et al. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)30075-3 · Cited by 317 · see citing works
Wang, X., Ouyang, Y., Wang, Z., Zhao, G., Liu, L., & Bi, Y. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.088 · Cited by 324 · see citing works
Drager, L. F., Polotsky, V. Y., & Lorenzi-Filho, G. (2011) · Chest · doi:10.1378/chest.10-2223 · Cited by 322 · see citing works
Obstructive sleep apnea syndrome
Mannarino, M. R., Filippo, F. D., & Pirro, M. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.05.013 · Cited by 327 · see citing works
Tamisier, R., Pépin, J. L., Rémy, J., Baguet, J. P., Taylor, J. A., Weiss, J. W., & Lévy, P. (2011) · European Respiratory Journal · doi:10.1183/09031936.00204209 · Cited by 323 · see citing works
Pulmonary hypertension in obstructive sleep apnoea: effects of continuous positive airway pressure
Arias, M. A., García-Río, F., Alonso-Fernández, A., Martínez, I., & Villamor, J. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi807 · Cited by 319 · see citing works
- Authors
- Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G.
- Affiliations
- Hospital Universitario Miguel Servet (ES)
- ORCID
- Vicente, Eugenio
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 365
- Issue
- 9464
- Pages
- 1046-1053
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2034556696
- Cited by
- 4,678
- References
- 54
- Citations by year
- 2026: 119 · 2025: 122 · 2024: 152 · 2023: 163 · 2022: 192 · 2021: 205 · 2020: 246 · 2019: 217 · 2018: 264 · 2017: 260 · 2016: 286 · 2015: 331 · 2014: 317 · 2013: 301 · 2012: 235
- FWCI
- 110.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- continuous positive airway pressure, cardiovascular outcomes, cardiovascular risk, simple snoring, CPAP therapy, apnea-hypopnea index, myocardial infarction, stroke, coronary artery bypass grafting, CPAP adherence, men, long-term follow-up, cardiovascular mortality
- MeSH terms
- Cardiovascular Diseases, Humans, Male, Middle Aged, Risk Factors, Snoring, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
