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Cited by 941Trypanosoma species research and implicationsResearch on Leishmaniasis StudiesVector-borne infectious diseases

The DOI matches its Crossref record; 298 of the 300 references it cites were found in a registry or an index.

Human African trypanosomiasis

Brun, Reto, Blum, Johannes, Chappuis, Francois, Burri, Christian·2010·The Lancet
DOI 10.1016/s0140-6736(09)60829-1
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Abstract

Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.

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Crossref · 10.1016/s0140-6736(09)60829-1

Cites

298 of 298 references verified0 citation errors · 0 not checkable

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Citations

Cites

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Research works printed but not linked: 4

  1. Bronner U. Pharmacokinetics of pentamidine. Focus on treatment of Trypanosoma gambiense sleeping sickness. PhD thesis, Karolinska Institute, 1994.
  2. Seixas J. Investigations on the encephalopathic syndrome during melarsoprol treatment of human African trypanosomiasis. PhD thesis, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 2004.
  3. Chappuis, 2004, Eflornithine for the treatment of human African trypanosomiasis: practical perspectives, Dev Sante, 171, 41
  4. African Union. Statement from the Commission of the African union to the AHP/DFID special workshop on: tsetse control—the next 100 years, Sept 9–10, 2002, Edinburgh, UK.

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Metadata

Authors
Brun, R., Blum, J., Chappuis, F., & Burri, C.
Affiliations
Swiss Tropical and Public Health Institute (CH)
Corresponding author
Brun, Reto
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
2010-01
Volume
375
Issue
9709
Pages
148-159
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(09)60829-1
OpenAlex
W2151877638
Cited by
926
References
300
Citations by year
2026: 20 · 2025: 20 · 2024: 35 · 2023: 40 · 2022: 35 · 2021: 47 · 2020: 39 · 2019: 50 · 2018: 49 · 2017: 69 · 2016: 71 · 2015: 78 · 2014: 74 · 2013: 85 · 2012: 85
FWCI
45.64
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Medecins Sans Frontieres Field Research (Medecins Sans Frontieres) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords
sleeping sickness, Trypanosoma brucei gambiense, tsetse flies, neglected tropical diseases, disease resurgence, political instability, vector control, disease elimination, clinical features, diagnosis, treatment, adverse drug reactions, sub-Saharan Africa
MeSH terms
Africa, Eflornithine, Animals, Communicable Disease Control, Humans, Insect Bites and Stings, Insect Vectors, Melarsoprol, Pentamidine, Suramin, Trypanocidal Agents, Trypanosoma brucei gambiense, Trypanosomiasis, African, Tsetse Flies, Variant Surface Glycoproteins, Trypanosoma, Incidence, Endemic Diseases, Biomedical Research

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