Cited by 941Trypanosoma species research and implicationsResearch on Leishmaniasis StudiesVector-borne infectious diseases

The DOI matches its Crossref record; 298 of the 300 references it cites were found in a registry or an index.

Human African trypanosomiasis

Brun, Reto, Blum, Johannes, Chappuis, Francois, Burri, Christian·2010·The Lancet

DOI 10.1016/s0140-6736(09)60829-1

Open this paper in CoChat — free account

Abstract

Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(09)60829-1

Cites

298 of 298 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Polyamine metabolism and function
Pegg, A. E., & McCann, P. P. (1982) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1982.243.5.c212 · Cited by 1,661
The Genome of the African Trypanosome Trypanosoma brucei
Berriman, M., Ghedin, E., Hertz‐Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D. C., Lennard, N. J., Caler, E. V., Hamlin, N. E., Haas, B. J., et al. (2005) · Science · doi:10.1126/science.1112642 · Cited by 1,634
Manson's Tropical Diseases.
(1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-2-324_1 · Cited by 997
Comparative Genomics of Trypanosomatid Parasitic Protozoa
El-Sayed, N. M., Myler, P. J., Blandin, G., Berriman, M., Crabtree, J., Aggarwal, G., Caler, E. V., Renauld, H., Worthey, E. A., Hertz‐Fowler, C., et al. (2005) · Science · doi:10.1126/science.1112181 · Cited by 832
Kinetoplastids: related protozoan pathogens, different diseases
Stuart, K., Brun, R., Croft, S. L., Fairlamb, A. H., Gürtler, R. E., McKerrow, J., Reed, S., & Tarleton, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33945 · Cited by 618
Self-citation
A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences.
Tibayrenc, M., Kjellberg, F., & Ayala, F. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2414 · Cited by 570
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
Priotto, G., Kasparian, S., Mutombo, W., Ngouama, D., Ghorashian, S., Arnold, U., Ghabri, S., Baudin, E., Buard, V., Kazadi-Kyanza, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61117-x · Cited by 544
HOME OR AWAY?
Jb, B., & Gj, R. (1964) · PubMed · Cited by 507
Medical Insects and Arachnids
Lane, R. P., & Crosskey, R. W. (1993) · Springer eBooks · doi:10.1007/978-94-011-1554-4 · Cited by 488
Glossina austeni (Diptera: Glossinidae) Eradicated on the Island of Unguja, Zanzibar, Using the Sterile Insect Technique
Vreysen, M. J. B., Saleh, K. M., Ali, M. Y., Abdulla, A. M., Zhu, Z.-R., Juma, K. G., Dyck, V. A., Msangi, A. R., Mkonyi, P. A., & Feldmann, H. U. (2000) · Journal of Economic Entomology · doi:10.1603/0022-0493-93.1.123 · Cited by 477

Show all 300 references

Research works printed but not linked: 4

Bronner U. Pharmacokinetics of pentamidine. Focus on treatment of Trypanosoma gambiense sleeping sickness. PhD thesis, Karolinska Institute, 1994.
Seixas J. Investigations on the encephalopathic syndrome during melarsoprol treatment of human African trypanosomiasis. PhD thesis, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 2004.
Chappuis, 2004, Eflornithine for the treatment of human African trypanosomiasis: practical perspectives, Dev Sante, 171, 41
African Union. Statement from the Commission of the African union to the AHP/DFID special workshop on: tsetse control—the next 100 years, Sept 9–10, 2002, Edinburgh, UK.

Sorted by citations

Items 401–500 of 941

Mathematical Modelling of Human African Trypanosomiasis Using Control Measures
Gervas, H. E., Opoku, N. K.-D. O., & Ibrahim, S. (2018) · Computational and Mathematical Methods in Medicine · doi:10.1155/2018/5293568 · Cited by 21
Gambian human African trypanosomiasis in North West Uganda. Are we on course for the 2020 target?
Selby, R., Wamboga, C., Erphas, O., Mugenyi, A., Jamonneau, V., Waiswa, C., Torr, S. J., & Lehane, M. J. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007550 · Cited by 21
Modelling to explore the potential impact of asymptomatic human infections on transmission and dynamics of African sleeping sickness
Aliee, M., Keeling, M. J., & Rock, K. S. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009367 · Cited by 21
Antitrypanosomal screening and cytotoxic effects of selected medicinal plants.
Dyary, H. O., Arifah, A. K., Sharma, R. S., Rasedee, A., Aspollah, M. S. M., Zakaria, Z. A., Zuraini, A., & Somchit, M. N. (2014) · PubMed · Cited by 21
Sleep and Rhythm Changes at the Time ofTrypanosoma bruceiInvasion of the Brain Parenchyma in the Rat
Etet, P. F. S., Palomba, M. L., Colavito, V., Grassi-Zucconi, G., Bentivoglio, M., & Bertini, G. (2012) · Chronobiology International · doi:10.3109/07420528.2012.660713 · Cited by 21
A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis
Burrell‐Saward, H., Rodgers, J., Bradley, B., Croft, S. L., & Ward, T. H. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku393 · Cited by 21
Is SELDI-TOF a valid tool for diagnostic biomarkers?
Ndao, M., Rainczuk, A., Rioux, M.-C., Spithill, T. W., & Ward, B. J. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2010.07.004 · Cited by 21
Human African trypanosomiasis
Brun, R., & Blum, J. A. (2020) · doi:10.1093/med/9780198746690.003.0169 · Cited by 21
Self-citation
Whose Elimination? Frontline Workers’ Perspectives on the Elimination of the Human African Trypanosomiasis and Its Anticipated Consequences
Falisse, J., Miaka, E. M., & Mpanya, A. (2020) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed5010006 · Cited by 20
Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates
García‐Estrada, C., Pérez‐Pertejo, Y., Domínguez-Asenjo, B., Holanda, V. N., Murugesan, S., Valladares, M. M., Balaña‐Fouce, R., & Reguera, R. M. (2023) · Biomolecules · doi:10.3390/biom13040637 · Cited by 20
New Insights in Staging and Chemotherapy of African Trypanosomiasis and Possible Contribution of Medicinal Plants
Etet, P. F. S., & Mahomoodally, M. F. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/343652 · Cited by 20
A Colour Opponent Model That Explains Tsetse Fly Attraction to Visual Baits and Can Be Used to Investigate More Efficacious Bait Materials
Santer, R. D. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003360 · Cited by 20
Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target
Balogun, E. O., Inaoka, D. K., Shiba, T., Kido, Y., Nara, T., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., et al. (2013) · The Journal of Biochemistry · doi:10.1093/jb/mvt037 · Cited by 20
Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target
Ranade, R. M., Gillespie, J. R., Shibata, S., Verlinde, C. L. M. J., Fan, E., Hol, W. G. J., & C, F. S. B. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02578-12 · Cited by 20
Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids
Mathieu, C., Salgado, A. G., Wirdnam, C. D., Meier, S., Grotemeyer, M. S., Inbar, E., Mäser, P., Zilberstein, D., Sigel, E., Bütikofer, P., et al. (2014) · Biochemical Journal · doi:10.1042/bj20140719 · Cited by 20
Lineage-specific proteins essential for endocytosis in trypanosomes
Manna, P. T., Obado, S. O., Boehm, C., Gadelha, C., Šali, A., Chait, B. T., Rout, M. P., & Field, M. C. (2017) · Journal of Cell Science · doi:10.1242/jcs.191478 · Cited by 20
Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents
Moreno-Herrera, A., Cortez-Maya, S., Bocanegra‐García, V., Banik, B. K., & Rivera, G. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200303170000 · Cited by 20
Wild chimpanzees are infected by Trypanosoma brucei
Jirků, M., Votýpka, J., Petrželková, K. J., Jirků‐Pomajbíková, K., Kriegová, E., Vodička, R., Lankester, F. J., Leendertz, S. A. J., Wittig, R. M., Boesch, C., et al. (2015) · International Journal for Parasitology Parasites and Wildlife · doi:10.1016/j.ijppaw.2015.05.001 · Cited by 20
A commentary on occupational infectious diseases due to agricultural practices in Sub-Saharan Africa
Anchang, K. Y., Avery, L. M., & Pertiwiningrum, A. (2014) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2014.02.037 · Cited by 20
Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies
Arán, V. J., Kaiser, M., & Dardonville, C. Y. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.06.004 · Cited by 20
African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase
West, R., O'Doherty, O. G., Askwith, T., Atack, J. R., Beswick, P., Laverick, J., Paradowski, M., Pennicott, L. E., Rao, S. P. S., Williams, G., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.067 · Cited by 20
Development of Predictive QSAR Models of 4‐Thiazolidinones Antitrypanosomal Activity Using Modern Machine Learning Algorithms
Kryshchyshyn‐Dylevych, A., Devinyak, O., Kaminskyy, D. V., Grellier, P., & Lesyk, R. (2017) · Molecular Informatics · doi:10.1002/minf.201700078 · Cited by 20
Inhibition of Isoleucyl-tRNA Synthetase as a Potential Treatment for Human African Trypanosomiasis
Cestari, I. D. S., & Stuart, K. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.447441 · Cited by 20
Modes of action
Chopra, I. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-4064-1.00002-6 · Cited by 20
RNA-seq de novo Assembly Reveals Differential Gene Expression in Glossina palpalis gambiensis Infected with Trypanosoma brucei gambiense vs. Non-Infected and Self-Cured Flies
Soumana, I. H., Klopp, C., Ravel, S., Nabihoudine, I., Tchicaya, B., Parrinello, H., Abate, L., Rialle, S., & Geiger, A. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01259 · Cited by 19
Nanotechnological interventions for treatment of trypanosomiasis in humans and animals
Prayag, K. S., Surve, D. H., Paul, A. T., Kumar, S., & Jindal, A. B. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00764-x · Cited by 19
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)
Koester, D. C., Marx, V. M., Williams, S., Jiřiček, J., Dauphinais, M., René, O., Miller, S. L., Zhang, L., Patra, D., Chen, Y., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00791 · Cited by 19
Antitrypanosomal Isothiocyanate and Thiocarbamate Glycosides from Moringa peregrina
Ayyari, M., Salehi, P., Ebrahimi, S. N., Zimmermann, S. Y., Portmann, L., Krauth‐Siegel, R. L., Kaiser, M., Brun, R., Rezadoost, H., Rezazadeh, S., et al. (2013) · Planta Medica · doi:10.1055/s-0033-1351102 · Cited by 19
Self-citation
The Trypanosoma brucei Life Cycle Switch TbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46
Chou, S., Jensen, B. C., Parsons, M., Alber, T., & Grundner, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108860 · Cited by 19
Reviewing Gold(III) complexes as effective biological operators
Patanjali, P. K., Kumar, R., Sourabh, Kumar, A., Chaudhary, P., & Singh, R. P. (2018) · Main Group Chemistry · doi:10.3233/mgc-180247 · Cited by 19
Passive Screening and Diagnosis of Sleeping Sickness with New Tools in Primary Health Services: An Operational Research
Mulenga, P. C., Lutumba, P. T., Coppieters, Y., Mpanya, A., Miaka, E. M., Luboya, O. N., & Chenge, F. M. (2019) · Infectious Diseases and Therapy · doi:10.1007/s40121-019-0253-2 · Cited by 19
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- b ]pyridazines for the Treatment of Human African Trypanosomiasis
Tear, W. F., Bag, S., Díaz-González, R., Ceballos-Pérez, G., Rojas-Barros, D. I., Cordón-Obras, C., Pérez‐Moreno, G., García‐Hernández, R., Martínez, M. S., Ruiz-Pérez, L. M., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01741 · Cited by 19
Prevalence and outcomes of malaria as co-infection among patients with human African trypanosomiasis: a systematic review and meta-analysis
Kotepui, K. U., Masangkay, F. R., Milanez, G. D. J., & Kotepui, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-03295-8 · Cited by 19
Isothermal Nucleic Acid Amplification to Detect Infection Caused by Parasites of the Trypanosomatidae Family: A Literature Review and Opinion on the Laboratory to Field Applicability
Séréno, D., Oury, B., Geiger, A., Vela, A., Karmaoui, A., & Desquesnes, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147543 · Cited by 19
Synthesis and activity of nucleoside-based antiprotozoan compounds
Tran, H.-A., Zheng, Z., Wen, X., Manivannan, S., Pastor, A., Kaiser, M., Brun, R., Snyder, F. F., & Back, T. G. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.02.016 · Cited by 19
Self-citation
New insights in the interactions between African trypanosomes and tsetse flies
Abbeele, J. V. D., & Rotureau, B. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00063 · Cited by 19
Nanomaterials as a Potential Target for Infectious Parasitic Agents
Alsharedeh, R., Rezigue, M. M., Bashatwah, R. M., Amawi, H. A., Aljabali, A. A. A., Obeid, M. A., & Tambuwala, M. M. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230223085403 · Cited by 18
Stoking the drug target pipeline for human A frican trypanosomiasis
Phillips, M. A. (2012) · Molecular Microbiology · doi:10.1111/mmi.12001 · Cited by 18
Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1
Marschner, A., & Klein, C. D. P. (2015) · Biochimie · doi:10.1016/j.biochi.2015.04.012 · Cited by 18
Trypanosoma brucei S-Adenosylmethionine Decarboxylase N Terminus Is Essential for Allosteric Activation by the Regulatory Subunit Prozyme
Velez, N., Brautigam, C. A., & Phillips, M. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442475 · Cited by 18
New discoveries in the transmission biology of sleeping sickness parasites: applying the basics
MacGregor, P., & Matthews, K. R. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0637-y · Cited by 18
A Trk/HKT-Type K + Transporter from Trypanosoma brucei
Mosimann, M., Goshima, S., Wenzler, T., Lüscher, A., Uozumi, N., & Mäser, P. (2010) · Eukaryotic Cell · doi:10.1128/ec.00314-09 · Cited by 18
A systematic review and meta-analysis of trypanosome prevalence in tsetse flies
Abdi, R. D., Agga, G. E., Aregawi, W. G., Bekana, M., Leeuwen, T. V., Delespaux, V., & Duchateau, L. (2017) · BMC Veterinary Research · doi:10.1186/s12917-017-1012-9 · Cited by 19
License to Kill?—Disease Eradication Programs May Not be in Line with the Convention on Biological Diversity
Hochkirch, A., Beninde, J., Fischer, M. L., Krahner, A., Lindemann, C., Matenaar, D., Rohde, K., Wagner, N., Wesch, C., Wirtz, S., et al. (2017) · Conservation Letters · doi:10.1111/conl.12370 · Cited by 18
Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei
Macêdo, J. P., Currier, R. B., Wirdnam, C. D., Horn, D., Alsford, S., & Rentsch, D. (2017) · The FASEB Journal · doi:10.1096/fj.201700311r · Cited by 18
A review of wildlife tourism and meta-analysis of parasitism in Africa’s national parks and game reserves
Odeniran, P. O., Ademola, I. O., & Jegede, H. O. (2018) · Parasitology Research · doi:10.1007/s00436-018-5958-8 · Cited by 18
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2)
de Heuvel, E., Singh, A. K., Boronat, P., Kooistra, A. J., van der Meer, T., Sadek, P., Blaazer, A. R., Shaner, N. C., Bindels, D. S., Caljon, G., et al. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.06.026 · Cited by 18
Identification of sVSG117 as an Immunodiagnostic Antigen and Evaluation of a Dual-Antigen Lateral Flow Test for the Diagnosis of Human African Trypanosomiasis
Sullivan, L., Fleming, J. R., Sastry, L., Mehlert, A., Wall, S. J., & Ferguson, M. A. J. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002976 · Cited by 18
Tsetse fly (Glossina pallidipes) midgut responses to Trypanosoma brucei challenge
Bateta, R., Wang, J., Wu, Y., Weiss, B. L., Warren, W. C., Murilla, G. A., Aksoy, S., & Mireji, P. O. (2017) · Parasites & Vectors · doi:10.1186/s13071-017-2569-7 · Cited by 18
Intravital microscopy: Imaging host–parasite interactions in the brain
Niz, M. D., Nacer, A., & Frischknecht, F. (2019) · Cellular Microbiology · doi:10.1111/cmi.13024 · Cited by 19
Overview of the Effect and Epidemiology of Parasitic Central Nervous System Infections in African Children
Mallewa, M., & Wilmshurst, J. M. (2014) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2014.02.003 · Cited by 18
Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis
Thomas, S. M., Purmal, A. A., Pollastri, M. P., & Mensa‐Wilmot, K. (2017) · Scientific Reports · doi:10.1038/srep40565 · Cited by 18
Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development
Dey, D., Ramakumar, S., & Conn, G. L. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00578 · Cited by 17
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities
Seebacher, W., Wolkinger, V., Faist, J., Kaiser, M., Brun, R., Saf, R., Bučar, F., Gröblacher, B., Brantner, A. H., Merino, V., et al. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.02.044 · Cited by 17
Self-citation
Substrate inhibition and allosteric regulation by heparan sulfate of Trypanosoma brucei cathepsin L
Costa, T. F. R., Reis, F. C. G., & Lima, A. P. C. A. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.12.006 · Cited by 17
Multiorgan Dysfunction Caused by Travel-associated African Trypanosomiasis
Cottle, L. E., Peters, J. R., Hall, A., Bailey, J. W., Noyes, H. A., Rimington, J. E., Beeching, N. J., Squire, S. B., & Beadsworth, M. (2012) · Emerging infectious diseases · doi:10.3201/eid1802.111479 · Cited by 17
Latent Trypanosoma brucei gambiense foci in Uganda: a silent epidemic in children and adults?
Wastling, S. L., Picozzi, K., Wamboga, C., von Wissmann, B., Acup, C. A., Wardrop, N. A., Stothard, J. R., Kakembo, A. S. L., & Welburn, S. C. (2011) · Parasitology · doi:10.1017/s0031182011000230 · Cited by 17
Cyrhetrenylaniline and new organometallic phenylimines derived from 4- and 5-nitrothiophene: Synthesis, characterization, X-Ray structures, electrochemistry and in vitro anti-T. brucei activity
Toro, P. M., Suazo, C., Acuña, A., Fuentealba, M., Artigas, V., Arancibia, R., Olea‐Azar, C., Moncada‐Basualto, M., Wilkinson, S. R., & Klahn, A. H. (2018) · Journal of Organometallic Chemistry · doi:10.1016/j.jorganchem.2018.03.004 · Cited by 17
Encapsulation and delivery of antiparasitic drugs: a review
Sasidharan, S., & Saudagar, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819363-1.00017-x · Cited by 17
Facile Synthesis and Preliminary Structure–Activity Analysis of New Sulfonamides Against Trypanosoma brucei
Rashad, A. A., Jones, A. J., Avery, V. M., Baell, J. B., & Keller, P. A. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400487t · Cited by 17
Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors
Huang, W., Zhang, Z., Ranade, R. M., Gillespie, J. R., Barros-Álvarez, X., Creason, S. A., Shibata, S., Verlinde, C. L. M. J., Hol, W. G. J., C, F. S. B. A., et al. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.04.048 · Cited by 17
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors
de Heuvel, E., Singh, A. K., Edink, E., van der Meer, T., van der Woude, M., Sadek, P., Krell-Jørgensen, M., van den Bergh, T., Veerman, J. J. N., Caljon, G., et al. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.06.027 · Cited by 17
Incorporating Scale Dependence in Disease Burden Estimates: The Case of Human African Trypanosomiasis in Uganda
Hackett, F., Berrang‐Ford, L., Fèvre, E. M., & Simarro, P. P. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002704 · Cited by 16
Zoonotic Parasites of Wildlife in Africa: A Review
Odeniran, P. O., & Ademola, I. O. (2016) · African Journal of Wildlife Research · doi:10.3957/056.046.0001 · Cited by 16
Product feedback regulation implicated in translational control of the T rypanosoma brucei S ‐adenosylmethionine decarboxylase regulatory subunit prozyme
Xiao, Y., Nguyen, S., Kim, S. H., Volkov, O. A., Tu, B. P., & Phillips, M. A. (2013) · Molecular Microbiology · doi:10.1111/mmi.12226 · Cited by 16
Genetic Validation of Trypanosoma brucei Glutathione Synthetase as an Essential Enzyme
Pratt, C., Nguyen, S., & Phillips, M. A. (2014) · Eukaryotic Cell · doi:10.1128/ec.00015-14 · Cited by 16
KHARON Is an Essential Cytoskeletal Protein Involved in the Trafficking of Flagellar Membrane Proteins and Cell Division in African Trypanosomes
Sánchez, M. A., Tran, K. D., Valli, J., Hobbs, S., Johnson, E., Gluenz, E., & Landfear, S. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.739235 · Cited by 16
Novel Financing Model for Neglected Tropical Diseases: Development Impact Bonds Applied to Sleeping Sickness and Rabies Control
Welburn, S. C., Bardosh, K., & Coleman, P. G. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005000 · Cited by 16
Ionic Liquid‐Assisted Extraction and Isolation of Cynaropicrin and Cnicin from Artichoke and Blessed thistle
Mizuno, H., & Usuki, T. (2018) · ChemistrySelect · doi:10.1002/slct.201703063 · Cited by 16
Synthesis of proline derived benzenesulfonamides: A potent anti- Trypanosoma brucei gambiense agent
Ugwu, D. I., Okoro, U. C., & Mishra, N. K. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.05.017 · Cited by 16
Trypanosoma brucei infection protects mice against malaria
Sanches‐Vaz, M., Temporão, A., Luís, R., Nunes‐Cabaço, H., Mendes, A. M., Goellner, S., Carvalho, T., Figueiredo, L. M., & Prudêncio, M. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008145 · Cited by 16
Use of herbal remedies in the management of sleeping sickness in four northern provinces of Angola
Vahekeni, N., Neto, P. M., Kayimbo, M. K., Mäser, P., Josenando, T., Costa, E., Falquet, J., & van Eeuwijk, P. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112382 · Cited by 16
Chemotherapy for second-stage human African trypanosomiasis: drugs in use
Lutje, V., Probyn, K., Seixas, J., Bergman, H., & Villanueva, G. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015374 · Cited by 16
Glycolipids are potential targets for protozoan parasite diseases
Debierre-Grockiego, F. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2010.04.006 · Cited by 16
Synthesis, characterization andin vitroantiprotozoal studies of iron(III) complexes of some antimalarial drugs
Ajibade, P. A., & Kolawole, G. A. (2008) · Journal of Coordination Chemistry · doi:10.1080/00958970802072765 · Cited by 16
Depletion of the SR-Related Protein TbRRM1 Leads to Cell Cycle Arrest and Apoptosis-Like Death in Trypanosoma brucei
Levy, G. V., Bañuelos, C. P., Níttolo, A. G., Ortiz, G. E., Mendiondo, N., Moretti, G., Tekiel, V., & Sánchez, D. O. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136070 · Cited by 16
Human African trypanosomiasis in travellers to Kenya
Gobbi, F. G., & Bisoffi, Z. (2012) · Eurosurveillance · doi:10.2807/ese.17.10.20109-en · Cited by 16
Novel quinoline derivatives with broad‐spectrum antiprotozoal activities
Hartman, C. B., Dube, P. S., Legoabe, L. J., Pelt, N. V., Matheeussen, A., Caljon, G., & Beteck, R. M. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202300319 · Cited by 15
Human African Trypanosomiasis: A Highly Neglected Neurological Disease
Buguet, A., Mpanzou, G., & Bentivoglio, M. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8100-3_9 · Cited by 15
Infections of the Developing World
Murthy, S., Keystone, J. S., & Kissoon, N. “. (2013) · Critical Care Clinics · doi:10.1016/j.ccc.2013.03.005 · Cited by 15
Comparative transcriptome analysis of small noncoding RNAs in different stages of Trypanosoma brucei
Zheng, L., Wen, Y., Yang, J., Liao, J., Shao, P., Xu, H. M., Zhou, H., Wen, J.-Z., Lun, Z., Ayala, F. J., et al. (2013) · RNA · doi:10.1261/rna.035683.112 · Cited by 15
Synthesis and evaluation of analogs of 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (MDL 73811, or AbeAdo) – An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity
Brockway, A. J., Volkov, O. A., Cosner, C. C., MacMillan, K. S., Wring, S. A., Richardson, T. E., Peel, M. R., Phillips, M. A., & Brabander, J. K. D. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.07.063 · Cited by 15
A spatial genetics approach to inform vector control of tsetse flies (Glossina fuscipes fuscipes) in Northern Uganda
Saarman, N. P., Burak, M. K., Opiro, R., Hyseni, C., Echodu, R., Dion, K., Opiyo, E. A., Dunn, A. W., Amatulli, G., Aksoy, S., et al. (2018) · Ecology and Evolution · doi:10.1002/ece3.4050 · Cited by 15
Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis
Girard, A., Cooper, A., Mabbott, S. B., Bradley, B., Asiala, S. M., Jamieson, L. E., Clucas, C., Capewell, P., Marchesi, F., Gibbins, M. P., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010060 · Cited by 15
Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease
Truc, P., Lando, A., Penchenier, L., Vatunga, G., & Josenando, T. (2011) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2011.10.002 · Cited by 15
Human African Trypanosomiasis in the Kafue National Park, Zambia
Squarre, D., Kabongo, I., Munyeme, M., Mumba, C., Mwasinga, W., Hachaambwa, L., Sugimoto, C., & Namangala, B. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004567 · Cited by 15
Proteome characterization in various biological fluids of Trypanosoma brucei gambiense-infected subjects
Bonnet, J., Garcia, C., Léger, T., Couquet, M.-P., Vignoles, P., Vatunga, G., Ndung’u, J. M., Boudot, C., Bisser, S., & Courtioux, B. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.11.005 · Cited by 15
From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds
Muthusamy, V., Ariën, K. K., Heeres, J., Joossens, J., Dirié, B., Lyssens, S., Míchiels, J., Cos, P., Lewi, P. J., Vanham, G., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.08.005 · Cited by 15
An Overview of the Effect and Epidemiology of Viral Central Nervous System Infections in African Children
Badoe, Ë., & Wilmshurst, J. M. (2014) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2014.02.002 · Cited by 15
Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei
Quintana, J. F., Bueren‐Calabuig, J. A., Zuccotto, F., de Koning, H. P., Horn, D., & Field, M. C. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008458 · Cited by 15
Structural insights into drug transport by an aquaglyceroporin
Chen, W., Zou, R., Mei, Y., Li, J., Xuan, Y., Cui, B., Zou, J., Wang, J., Lin, S., Zhang, Z., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48445-4 · Cited by 14
Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI–MS and LC/ICP–MS analysis
Baumann, A., Pfeifer, T., Melles, D., & Kärst, U. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6929-7 · Cited by 14
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues
Hu, L., Patel, A. V., Bondada, L., Yang, S., Wang, M. Z., Munde, M. M., Wilson, W. D., Wenzler, T., Brun, R., & Boykin, D. W. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.08.006 · Cited by 14
Self-citation
Genetic and structural study of DNA-directed RNA polymerase II of Trypanosoma brucei , towards the designing of novel antiparasitic agents
Papageorgiou, L., Megalooikonomou, V., & Vlachakis, D. (2017) · PeerJ · doi:10.7717/peerj.3061 · Cited by 14
Molecular identification of trypanosomes in cattle in Malawi using PCR methods and nanopore sequencing: epidemiological implications for the control of human and animal trypanosomiases
Marsela, M., Hayashida, K., Nakao, R., Chatanga, E., Gaithuma, A. K., Kawai, N., Musaya, J., Sugimoto, C., & Yamagishi, J. (2020) · Parasite · doi:10.1051/parasite/2020043 · Cited by 14
The Ecohistory of Tanzania’s Northern Rift Valley – Can One Establish an Objective Baseline as an Endpoint for Ecosystem Restoration?
Prins, H. H. T., & de Jong, J. F. (2022) · Ecological studies · doi:10.1007/978-3-030-93604-4_7 · Cited by 14
Trypanosomatid Aquaporins: Roles in Physiology and Drug Response
Mandal, G., Orta, J., Sharma, M., & Mukhopadhyay, R. (2013) · Diseases · doi:10.3390/diseases2010003 · Cited by 14
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents
Lama, R., Sandhu, R. S., Zhong, B., Li, B., & Su, B. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.07.023 · Cited by 14
Chancres cutanés révélant une trypanosomose africaine à Trypanosoma brucei gambiense chez un résident français au Gabon
Hope-Rapp, E., Coulibaly, O. M., Klement-Frutos, E., Danis, M., Bricaire, F., & Caumes, É. (2009) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/j.annder.2008.09.023 · Cited by 14
TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes
Steinmann, M. E., Schmidt, R. S., Bütikofer, P., Mäser, P., & Sigel, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-00752-1 · Cited by 14

Authors: Brun, R., Blum, J., Chappuis, F., & Burri, C.
Affiliations: Swiss Tropical and Public Health Institute (CH)
Corresponding author: Brun, Reto
ORCID: Blum, Johannes
Burri, Christian
Venue: The Lancet
Publisher: Elsevier BV
Published: 2010-01
Volume: 375
Issue: 9709
Pages: 148-159
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(09)60829-1
OpenAlex: W2151877638
Cited by: 926
References: 300
Citations by year: 2026: 20 · 2025: 20 · 2024: 35 · 2023: 40 · 2022: 35 · 2021: 47 · 2020: 39 · 2019: 50 · 2018: 49 · 2017: 69 · 2016: 71 · 2015: 78 · 2014: 74 · 2013: 85 · 2012: 85
FWCI: 45.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Medecins Sans Frontieres Field Research (Medecins Sans Frontieres) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords: sleeping sickness, Trypanosoma brucei gambiense, tsetse flies, neglected tropical diseases, disease resurgence, political instability, vector control, disease elimination, clinical features, diagnosis, treatment, adverse drug reactions, sub-Saharan Africa
MeSH terms: Africa, Eflornithine, Animals, Communicable Disease Control, Humans, Insect Bites and Stings, Insect Vectors, Melarsoprol, Pentamidine, Suramin, Trypanocidal Agents, Trypanosoma brucei gambiense, Trypanosomiasis, African, Tsetse Flies, Variant Surface Glycoproteins, Trypanosoma, Incidence, Endemic Diseases, Biomedical Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human African trypanosomiasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks