The DOI matches its Crossref record; 91 of the 92 references it cites were found in a registry or an index.
RETRACTED: Engineered whole organs and complex tissues
Abstract
End-stage organ failure is a key challenge for the medical community because of the ageing population and the severe shortage of suitable donor organs available. Equally, injuries to or congenital absence of complex tissues such as the trachea, oesophagus, or skeletal muscle have few therapeutic options. A new approach to treatment involves the use of three-dimensional biological scaffolds made of allogeneic or xenogeneic extracellular matrix derived from non-autologous sources. These scaffolds can act as an inductive template for functional tissue and organ reconstruction after recellularisation with autologous stem cells or differentiated cells. Such an approach has been used successfully for the repair and reconstruction of several complex tissues such as trachea, oesophagus, and skeletal muscle in animal models and human beings, and, guided by appropriate scientific and ethical oversight, could serve as a platform for the engineering of whole organs and other tissues.
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“Collagen- or fibrin-based products are the most established ECMs being used clinically to guide regeneration of different tissues, including skin, heart valves, trachea, muscle, and tendon (71, 139).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [139]
Citations
Cites
2 retracted
RETRACTED: Clinical transplantation of a tissue-engineered airway
Macchiarini, P., Jungebluth, P., Go, T., Asnaghi, M. A., Rees, L., Cogan, T. A., Dodson, A., Martorell, J., Bellini, S., Parnigotto, P. P., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61598-6 · Cited by 1,431
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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
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Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
An overview of tissue and whole organ decellularization processes
Crapo, P. M., Gilbert, T. W., & Badylak, S. F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.057 · Cited by 3,591
Self-citationPerfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650
Self-organizing optic-cup morphogenesis in three-dimensional culture
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Tissue-engineered autologous bladders for patients needing cystoplasty
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Murry, C. E., & Keller, G. M. (2008) · Cell · doi:10.1016/j.cell.2008.02.008 · Cited by 1,760
Research works printed but not linked: 2
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- Ott, 2005, A novel population of adult derived cardiac progenitor cells is capable of functional myocardial repair, Circulation, 112, II
Cited by
Sorted by citations
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Injectable hydrogels for cartilage and bone tissue engineering
Liu, M., Zeng, X., Ma, C., Yi, H., Ali, Z., Mou, X., Li, S., Deng, Y., & He, N. (2017) · Bone Research · doi:10.1038/boneres.2017.14 · Cited by 1,236
The extracellular matrix: tools and insights for the "omics" era
Naba, A., Clauser, K. R., Ding, H., Whittaker, C. A., Carr, S. A., & Hynes, R. O. (2016) · Matrix Biology · doi:10.1016/j.matbio.2015.06.003 · Cited by 1,037
“Tissue engineers have exploited, to varying degrees, aspects of ECM biology, in particular its biomechanical properties (not discussed here), to design novel scaffolds to support tissue regeneration [92].”
Advancing biomaterials of human origin for tissue engineering
Chen, F.-M., & Liu, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.004 · Cited by 1,158
Role of the extracellular matrix in regulating stem cell fate
Watt, F. M., & Huck, W. T. S. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3620 · Cited by 861
Metadata
- Authors
- Badylak, S. F., Weiss, D. J., Caplan, A., & Macchiarini, P.
- Affiliations
- University of Pittsburgh (US)
- University of Vermont (US)
- University of Pennsylvania (US)
- Corresponding author
- Macchiarini, Paolo
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 379
- Issue
- 9819
- Pages
- 943-952
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2158646376
- Cited by
- 417
- References
- 92
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 14 · 2019: 19 · 2018: 27 · 2017: 52 · 2016: 51 · 2015: 57 · 2014: 65 · 2013: 78 · 2012: 23
- FWCI
- 72.82
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Wallenberg Institute for Regenerative Medicine and Karolinska Institutet/SLL grants (Stockholm, Sweden) and grants from the US National Institutes of Health ((RC4HL106625))
- National Heart, Lung, and Blood Institute ((R21HL094611))
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- tissue engineering, extracellular matrix, stem cells, end-stage organ failure, organ shortage, retraction
- MeSH terms
- Extracellular Matrix, Humans, Bioreactors, Transplants, Tissue Engineering, Tissue Scaffolds
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