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RETRACTED: Engineered whole organs and complex tissues
Abstract
End-stage organ failure is a key challenge for the medical community because of the ageing population and the severe shortage of suitable donor organs available. Equally, injuries to or congenital absence of complex tissues such as the trachea, oesophagus, or skeletal muscle have few therapeutic options. A new approach to treatment involves the use of three-dimensional biological scaffolds made of allogeneic or xenogeneic extracellular matrix derived from non-autologous sources. These scaffolds can act as an inductive template for functional tissue and organ reconstruction after recellularisation with autologous stem cells or differentiated cells. Such an approach has been used successfully for the repair and reconstruction of several complex tissues such as trachea, oesophagus, and skeletal muscle in animal models and human beings, and, guided by appropriate scientific and ethical oversight, could serve as a platform for the engineering of whole organs and other tissues.
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“Collagen- or fibrin-based products are the most established ECMs being used clinically to guide regeneration of different tissues, including skin, heart valves, trachea, muscle, and tendon (71, 139).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [139]
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Metadata
- Authors
- Badylak, S. F., Weiss, D. J., Caplan, A., & Macchiarini, P.
- Affiliations
- University of Pittsburgh (US)
- University of Vermont (US)
- University of Pennsylvania (US)
- Corresponding author
- Macchiarini, Paolo
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 379
- Issue
- 9819
- Pages
- 943-952
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2158646376
- Cited by
- 417
- References
- 92
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 14 · 2019: 19 · 2018: 27 · 2017: 52 · 2016: 51 · 2015: 57 · 2014: 65 · 2013: 78 · 2012: 23
- FWCI
- 72.82
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Wallenberg Institute for Regenerative Medicine and Karolinska Institutet/SLL grants (Stockholm, Sweden) and grants from the US National Institutes of Health ((RC4HL106625))
- National Heart, Lung, and Blood Institute ((R21HL094611))
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- tissue engineering, extracellular matrix, stem cells, end-stage organ failure, organ shortage, retraction
- MeSH terms
- Extracellular Matrix, Humans, Bioreactors, Transplants, Tissue Engineering, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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