Effectiveness and impact of a reduced infant schedule of 4CMenB vaccine against group B meningococcal disease in England: a national observational cohort study
Abstract
Background In September, 2015, the UK became the first country to introduce the multicomponent group B meningococcal (MenB) vaccine (4CMenB, Bexsero) into a publicly funded national immunisation programme. A reduced two-dose priming schedule was offered to infants at 2 months and 4 months, alongside an opportunistic catch-up for 3 month and 4 month olds. 4CMenB was predicted to protect against 73-88% of MenB strains. We aimed to assess the effectiveness and impact of 4CMenB in vaccine-eligible infants in England.Methods Public Health England (PHE) undertakes enhanced surveillance of meningococcal disease through a combination of clinical, public health, and laboratory reporting. Laboratory-confirmed cases of meningococcal disease are followed up with PHE local health protection teams, general practitioners, and hospital clinicians to collect demographic data, vaccination history, clinical presentation, and outcome. For cases diagnosed between Sept 1, 2015, and June 30, 2016, vaccine effectiveness was assessed using the screening method. Impact was assessed by comparing numbers of cases of MenB in vaccine-eligible children to equivalent cohorts in the previous 4 years and to cases in vaccine-ineligible children.Findings Coverage of 4CMenB in infants eligible for routine vaccination was high, achieving 95·5% for one dose and 88·6% for two doses by 6 months of age. Two-dose vaccine effectiveness was 82·9% (95% CI 24·1-95·2) against all MenB cases, equivalent to a vaccine effectiveness of 94·2% against the highest predicted MenB strain coverage of 88%. Compared with the prevaccine period, there was a 50% incidence rate ratio (IRR) reduction in MenB cases in the vaccine-eligible cohort (37 cases vs average 74 cases; IRR 0·50 [95% CI 0·36-0·71]; p=0·0001), irrespective of the infants' vaccination status or predicted MenB strain coverage. Similar reductions were observed even after adjustment for disease trends in vaccine-eligible and vaccine-ineligible children.Interpretation The two-dose 4CMenB priming schedule was highly effective in preventing MenB disease in infants. Cases in vaccine-eligible infants halved in the first 10 months of the programme. While ongoing national surveillance will continue to monitor the longer-term impact of the programme, these findings represent a step forward in the battle against meningococcal disease and will help reassure that the vaccine protects against this deadly infection.Funding Public Health England.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The MenB vaccine is anticipated to protect against 73-88% of invasive strains, but ongoing surveillance will be essential to determine true vaccine effectiveness.
“The vaccine is anticipated to protect against 73-88% of invasive strains, but ongoing surveillance will be essential to determine true vaccine effectiveness.16”
From Community-acquired acute bacterial meningitis in adults: a clinical update (2019) · cites this paper as [16]
Cites
Serruto, D., Bottomley, M. J., Ram, S., Giuliani, M. M., & Rappuoli, R. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.033 · Cited by 405 · see citing works
Donnelly, J., Medini, D., Boccadifuoco, G., Biolchi, A., Ward, J. I., Frasch, C. E., Moxon, E. R., Stella, M., Comanducci, M., Bambini, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013758107 · Cited by 296 · see citing works
Vogel, U. F., Taha, M., Vázquez, J. A., Findlow, J., Claus, H., Stefanelli, P., Caugant, D. A., Kriz, P., Abad, R., Bambini, S., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70006-9 · Cited by 283 · see citing works
Self-citationEstimation of Vaccine Effectiveness Using the Screening Method
Farrington, P. (1993) · International Journal of Epidemiology · doi:10.1093/ije/22.4.742 · Cited by 261 · see citing works
Advances in the Development of Vaccines againstNeisseria meningitidis
Tan, L., Carlone, G. M., & Borrow, R. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0906357 · Cited by 233 · see citing works
Self-citationCartwright, K. A. V., Morris, R., Rümke, H. C., Fox, A., Borrow, R., Begg, N. T., Richmond, P., & POOLMAN, J. T. (1999) · Vaccine · doi:10.1016/s0264-410x(99)00044-4 · Cited by 176 · see citing works
Self-citationMeningococcal C conjugate vaccine: the experience in England and Wales
Campbell, H., Borrow, R., Salisbury, D., & Miller, E. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.04.067 · Cited by 168 · see citing works
Self-citationChristensen, H., Trotter, C. L., Hickman, M., & Edmunds, W. J. (2014) · BMJ · doi:10.1136/bmj.g5725 · Cited by 142 · see citing works
Frosi, G., Biolchi, A., Sapio, M. L., Rigat, F., Gilchrist, S., Lucidarme, J., Findlow, J., Borrow, R., Pizza, M., Giuliani, M. M., et al. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.08.006 · Cited by 137 · see citing works
Self-citationVernikos, G. S., & Medini, D. (2014) · Pathogens and Global Health · doi:10.1179/2047773214y.0000000162 · Cited by 104 · see citing works
Enter B and W: two new meningococcal vaccine programmes launched
Ladhani, S. N., Ramsay, M. E., Borrow, R., Riordan, A. I., Watson, J. M., & Pollard, A. J. (2015) · Archives of Disease in Childhood · doi:10.1136/archdischild-2015-308928 · Cited by 103 · see citing works
Self-citationCampbell, H. J., Saliba, V., Borrow, R., Ramsay, M. E., & Ladhani, S. N. (2015) · Eurosurveillance · doi:10.2807/1560-7917.es2015.20.28.21188 · Cited by 96 · see citing works
Self-citationImmunogenicity of a Meningococcal B Vaccine during a University Outbreak
Basta, N. E., Mahmoud, A. A. F., Wolfson, J. A., Ploß, A., Heller, B. L., Hanna, S., Johnsen, P., Izzo, R., Grenfell, B. T., Findlow, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1514866 · Cited by 73 · see citing works
Self-citationBrunelli, B., Tordello, E. D., Palumbo, E., Biolchi, A., Bambini, S., Comanducci, M., Muzzi, A., Pizza, M., Rappuoli, R., Donnelly, J., et al. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.11.064 · Cited by 51 · see citing works
Tirani, M., Meregaglia, M., & Melegaro, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123383 · Cited by 40 · see citing works
Ladhani, S. N., Waight, P. A., Ribeiro, S., & Ramsay, M. E. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-1247-7 · Cited by 22 · see citing works
Self-citationYamashiro, H., Cutcliffe, N., Dobson, S., Fisman, D. N., & Gold, R. (2015) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2015/963940 · Cited by 8 · see citing works
Flagged first, then by citations
1 of the 18 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Parikh, S. R., Campbell, H. J., Bettinger, J. A., Harrison, L. H., Marshall, H. S., Martinón‐Torres, F., Sáfadi, M. A. P., Shao, Z., Zhu, B., von Gottberg, A., et al. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.05.079 · Cited by 290 · see citing works
Self-citationTechnologies to address antimicrobial resistance
Baker, S. J., Payne, D. J., Rappuoli, R., & Gregorio, E. D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717160115 · Cited by 219 · see citing works
López‐Lacort, M., Muñoz-Quiles, C., Mira‐Iglesias, A., López‐Labrador, F. X., Mengual‐Chuliá, B., Fernández-García, C., Carballido‐Fernández, M., Caplliure, A. P., Mollar‐Maseres, J., Shalabi-Benavent, M. J., et al. (2024) · Eurosurveillance · doi:10.2807/1560-7917.es.2024.29.6.2400046 · Cited by 216 · see citing works
Vaccination of Infants with Meningococcal Group B Vaccine (4CMenB) in England
Ladhani, S. N., Andrews, N. J., Parikh, S. R., Campbell, H. J., White, J. M., Edelstein, M. L., Bai, X., Lucidarme, J., Borrow, R., & Ramsay, M. E. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1901229 · Cited by 215 · see citing works
Self-citationAcevedo, R., Bai, X., Borrow, R., Caugant, D. A., Carlos, J., Ceyhan, M., Christensen, H., Climent, Y., Wals, P. D., Dinleyici, E. Ç., et al. (2018) · Expert Review of Vaccines · doi:10.1080/14760584.2019.1557520 · Cited by 194 · see citing works
Self-citationThe Development of a Vaccine Against Meningococcus B Using Reverse Vaccinology
Masignani, V., Pizza, M., & Moxon, E. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00751 · Cited by 168 · see citing works
Bertran, M., Andrews, N. J., Davison, C., Dugbazah, B., Boateng, J. O., Lunt, R., Hardstaff, J., Green, M., Blomquist, P. B., Turner, C., et al. (2023) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(23)00057-9 · Cited by 155 · see citing works
Self-citationVaccines against Meningococcal Diseases
Pizza, M., Bekkat-Berkani, R., & Rappuoli, R. (2020) · Microorganisms · doi:10.3390/microorganisms8101521 · Cited by 150 · see citing works
Update on community-acquired bacterial meningitis: guidance and challenges
van Ettekoven, C. N., van de Beek, D., & Brouwer, M. C. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.04.019 · Cited by 116 · see citing works
Long, Q., Zheng, P., Zheng, X. W., Li, W., Hua, L., Yang, Z., Huang, W., & Ma, Y. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114321 · Cited by 114 · see citing works
A Vaccine Against Group B Streptococcus: Recent Advances
Carreras‐Abad, C., Ramkhelawon, L., Heath, P. T., & Doaré, K. L. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s203454 · Cited by 112 · see citing works
Wang, B., Giles, L. C., Andraweera, P. H., McMillan, M., Almond, S., Beazley, R., Mitchell, J., Lally, N., Ahoure, M., Denehy, E., et al. (2022) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(21)00754-4 · Cited by 105 · see citing works
Epidemiology of community-acquired bacterial meningitis
Brouwer, M. C., & van de Beek, D. (2017) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000417 · Cited by 99 · see citing works
Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial
Inwald, D. P., Canter, R. R., Woolfall, K., Mouncey, P. R., Zenasni, Z., O’Hara, C., Carter, A., Jones, N., Lyttle, M. D., Nadel, S., et al. (2018) · Archives of Disease in Childhood · doi:10.1136/archdischild-2018-314924 · Cited by 98 · see citing works
Meningococcal B vaccine (4CMenB): the journey from research to real world experience
Rappuoli, R., Pizza, M., Masignani, V., & Vadivelu, K. (2018) · Expert Review of Vaccines · doi:10.1080/14760584.2018.1547637 · Cited by 93 · see citing works
Invasive Meningococcal Disease in the Vaccine Era
Nadel, S., & Ninis, N. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00321 · Cited by 90 · see citing works
Pormohammad, A., Abasi, E., Azimi, T., Hosseini, S. S., Safari, H., Nasiri, M. J., & Fooladi, A. A. I. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.103571 · Cited by 88 · see citing works
Dretler, A. W., Rouphael, N., & Stephens, D. S. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1451810 · Cited by 87 · see citing works
Muzzi, A., Brozzi, A., Serino, L., Bodini, M., Abad, R., Caugant, D. A., Comanducci, M., de Lemos, A. P. S., Gorla, M. C., Křížová, P., et al. (2019) · Vaccine · doi:10.1016/j.vaccine.2018.12.061 · Cited by 87 · see citing works
Self-citationCampbell, H. J., Edelstein, M. L., Andrews, N. J., Borrow, R., Ramsay, M. E., & Ladhani, S. N. (2017) · Emerging infectious diseases · doi:10.3201/eid2307.170236 · Cited by 85 · see citing works
Self-citationAye, A. M. M., Bai, X., Borrow, R., Bory, S., Carlos, J., Caugant, D. A., Chiou, C., Dai, V. T. T., Dinleyici, E. Ç., Ghimire, P., et al. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.07.025 · Cited by 81 · see citing works
Self-citationLadhani, S. N., Campbell, H. J., Andrews, N. J., Parikh, S. R., White, J. M., Edelstein, M. L., Clark, S. A., Lucidarme, J., Borrow, R., & Ramsay, M. E. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1244 · Cited by 80 · see citing works
Self-citationImpact of meningococcal group B OMV vaccines, beyond their brief
Petousis‐Harris, H. (2017) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1381810 · Cited by 80 · see citing works
Meningococcal disease, a clinical and epidemiological review
Siqueira‐Batista, R., Gomes, A. P., Gazineo, J. L. D., Miguel, P. S. B., Santana, L. A., Oliveira, L., & Geller, M. (2017) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2017.10.004 · Cited by 75 · see citing works
Wals, P. D., Deceuninck, G., Lefebvre, B., Tsang, R. S. W., Law, D. K. S., Serres, G. D., Gîlca, V., Gilca, R., & Boulianne, N. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix154 · Cited by 74 · see citing works
Effectiveness of a Meningococcal Group B Vaccine (4CMenB) in Children
Castilla, J., Cenoz, M. G., Abad, R., Sánchez-Cambronero, L., Lorusso, N., Izquierdo, C., Llabrés, S. C., Roig, J., Malvar, A., Carril, F. G., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2206433 · Cited by 71 · see citing works
Borrow, R., Caugant, D. A., Ceyhan, M., Christensen, H., Dinleyici, E. Ç., Findlow, J., Glennie, L., von Gottberg, A., Kechrid, A., Moreno, J. V., et al. (2017) · Journal of Infection · doi:10.1016/j.jinf.2017.04.007 · Cited by 68 · see citing works
Self-citationAzzari, C., Moriondo, M., Nieddu, F., Guarnieri, V., Lodi, L., Canessa, C., Indolfi, G., Giovannini, M., Napoletano, G., Russo, F., et al. (2020) · Vaccines · doi:10.3390/vaccines8030469 · Cited by 68 · see citing works
Serocorrelates of protection against infant group B streptococcus disease
Doaré, K. L., Kampmann, B., Vekemans, J., Heath, P. T., Goldblatt, D., Nahm, M. H., Baker, C. J., Edwards, M. S., Kwatra, G., Andrews, N. J., et al. (2019) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30659-5 · Cited by 68 · see citing works
Self-citationEmerging experience with meningococcal serogroup B protein vaccines
Toneatto, D., Pizza, M., Masignani, V., & Rappuoli, R. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1308828 · Cited by 67 · see citing works
Parikh, S. R., Newbold, L. S., Slater, S., Stella, M., Moschioni, M., Lucidarme, J., Paola, R. D., Giuliani, M., Serino, L., Gray, S. J., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30170-6 · Cited by 66 · see citing works
Self-citationRodrigues, F. M. P., Marlow, R. D., Simões, M. J., Danon, L., Ladhani, S. N., & Finn, A. H. R. (2020) · JAMA · doi:10.1001/jama.2020.20449 · Cited by 63 · see citing works
Self-citationProteome‐minimized outer membrane vesicles from Escherichia coli as a generalized vaccine platform
Zanella, I., König, E., Tomasi, M., Gagliardi, A., Frattini, L. F., Fantappiè, L., Irene, C., Zerbini, F., Caproni, E., Isaac, S. J., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12066 · Cited by 63 · see citing works
Flacco, M. E., Manzoli, L., Rosso, A., Marzuillo, C., Bergamini, M., Stefanati, A., Cultrera, R., Villari, P., Ricciardi, W., Ioannidis, J. P. A., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30048-3 · Cited by 62 · see citing works
Deceuninck, G., Lefebvre, B., Tsang, R. S. W., Betala-Belinga, J.-F., Serres, G. D., & Wals, P. D. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.06.021 · Cited by 62 · see citing works
Bryan, P. T., Seabroke, S., Wong, J., Donegan, K. L., Webb, E., Goldsmith, C., Vipond, C., & Feavers, I. M. (2018) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(18)30103-2 · Cited by 61 · see citing works
Li, J., Shao, Z., Liu, G., Bai, X., Borrow, R., Chen, M., Guo, Q., Han, Y., Li, Y., Taha, M., et al. (2018) · Journal of Infection · doi:10.1016/j.jinf.2018.01.007 · Cited by 59 · see citing works
Self-citationInvasive meningococcal disease in patients with complement deficiencies: a case series (2008–2017)
Ladhani, S. N., Campbell, H. J., Lucidarme, J., Gray, S. J., Parikh, S. R., Willerton, L., Clark, S. A., Lekshmi, A., Walker, A., Patel, S. R., et al. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4146-5 · Cited by 58 · see citing works
Self-citationVillena, R., Sáfadi, M. A. P., Valenzuela, M. T., Torres, J. P., Finn, A. H. R., & O’Ryan, M. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1458175 · Cited by 58 · see citing works
Vekemans, J., Crofts, J., Baker, C. J., Goldblatt, D., Heath, P. T., Madhi, S. A., Doaré, K. L., Andrews, N. J., Pollard, A. J., Saha, S. K., et al. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.04.039 · Cited by 58 · see citing works
Self-citationWang, B., Giles, L. C., Andraweera, P. H., McMillan, M., Almond, S., Beazley, R., Mitchell, J., Ahoure, M., Denehy, E., Flood, L., et al. (2023) · Journal of Infection · doi:10.1016/j.jinf.2023.05.021 · Cited by 57 · see citing works
Yezli, S. (2018) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2018.05.003 · Cited by 57 · see citing works
Nolan, T. M., Santolaya, M. E., de Looze, F. J., Marshall, H. S., Richmond, P., Henein, S., Rheault, P., Heaton, K., Perrett, K. P., Garfield, H., et al. (2019) · Vaccine · doi:10.1016/j.vaccine.2018.12.059 · Cited by 52 · see citing works
Findlow, J., Balmer, P., & Borrow, R. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1593082 · Cited by 51 · see citing works
Self-citationMartinón‐Torres, F., Sáfadi, M. A. P., Martínez, A. C., Marquez, P. I., Torres, J. C. T., Weckx, L. Y., Moreira, E. D., Mensi, I., Calabresi, M., & Toneatto, D. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.05.023 · Cited by 50 · see citing works
Biselli, R., Nisini, R., Lista, F. R., Autore, A., Lastilla, M., Lorenzo, G. D., Peragallo, M. S., Stroffolini, T., & D’Amelio, R. (2022) · Biomedicines · doi:10.3390/biomedicines10082050 · Cited by 48 · see citing works
Parikh, S. R., Campbell, H. J., Gray, S. J., Beebeejaun, K., Ribeiro, S., Borrow, R., Ramsay, M. E., & Ladhani, S. N. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.02.038 · Cited by 47 · see citing works
Self-citationUse of a meningococcal group B vaccine (4CMenB) in populations at high risk of gonorrhoea in the UK
Ladhani, S. N., White, P. J., Campbell, H. J., Mandal, S., Borrow, R., Andrews, N. J., Bhopal, S., Saunders, J., Mohammed, H. P., Drisdale-Gordon, L., et al. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00031-8 · Cited by 46 · see citing works
Self-citationRajam, G., Stella, M., Kim, E., Paulos, S., Boccadifuoco, G., Serino, L., Carlone, G. M., & Medini, D. (2017) · mSphere · doi:10.1128/msphere.00261-17 · Cited by 46 · see citing works
Inhibitors of the Neisseria meningitidis PilF ATPase provoke type IV pilus disassembly
Aubey, F., Corre, J., Kong, Y., Xu, X., Obino, D., Goussard, S., Lapeyrere, C., Souphron, J., Couturier, C., Renard, S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817757116 · Cited by 46 · see citing works
Herd Protection against Meningococcal Disease through Vaccination
Clark, S. A., & Borrow, R. (2020) · Microorganisms · doi:10.3390/microorganisms8111675 · Cited by 45 · see citing works
Self-citationArcher, B. N., Chiu, C. K., Jayasinghe, S. H., Richmond, P., McVernon, J., Lahra, M. M., Andrews, R. M., & McIntyre, P. B. (2017) · The Medical Journal of Australia · doi:10.5694/mja16.01340 · Cited by 44 · see citing works
Recent advances in meningococcal B disease prevention: real-world evidence from 4CMenB vaccination
Martinón‐Torres, F., Banzhoff, A., Azzari, C., Wals, P. D., Marlow, R. D., Marshall, H. S., Pizza, M., Rappuoli, R., & Bekkat-Berkani, R. (2021) · Journal of Infection · doi:10.1016/j.jinf.2021.04.031 · Cited by 42 · see citing works
Vaccination strategies for the prevention of meningococcal disease
Vuocolo, S. C., Balmer, P., Gruber, W. C., Jansen, K. U., Anderson, A. S., Perez, J. L., & York, L. J. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1451287 · Cited by 42 · see citing works
Vaccine Evolution and Its Application to Fight Modern Threats
Andreano, E., D’Oro, U., Rappuoli, R., & Finco, O. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01722 · Cited by 41 · see citing works
Bai, X., Borrow, R., Bukovski, S., Caugant, D. A., Culic, D., Delic, S., Dinleyici, E. Ç., Eloshvili, M., Erdősi, T., Galajeva, J., et al. (2019) · Journal of Infection · doi:10.1016/j.jinf.2019.10.018 · Cited by 41 · see citing works
Self-citationProtection Against Invasive Infections in Children Caused by Encapsulated Bacteria
Sadarangani, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02674 · Cited by 39 · see citing works
Xu, J., Chen, Y., Yue, M., Yu, J., Han, F., Xu, L., & Shao, Z. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2071077 · Cited by 37 · see citing works
Recent Progress in the Prevention of Serogroup B Meningococcal Disease
Feavers, I. M., & Maiden, M. C. J. (2017) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00566-16 · Cited by 36 · see citing works
Human genetics of meningococcal infections
Hodeib, S., Herberg, J. A., Levin, M., & Sancho‐Shimizu, V. (2020) · Human Genetics · doi:10.1007/s00439-020-02128-4 · Cited by 36 · see citing works
Welsch, J. A., Senders, S. D., Essink, B. J., Klein, T., Smolenov, I. V., Pedotti, P., Barbi, S., Verma, B., & Toneatto, D. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.07.016 · Cited by 35 · see citing works
Calle, I. R., Raguindin, P. F., Rial, J. G., Rodrı́guez-Tenreiro, C., & Martinón‐Torres, F. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s159952 · Cited by 34 · see citing works
Success of 4CMenB in preventing meningococcal disease: evidence from real-world experience
Isitt, C. E., Cosgrove, C. A., Ramsay, M. E., & Ladhani, S. N. (2020) · Archives of Disease in Childhood · doi:10.1136/archdischild-2019-318047 · Cited by 34 · see citing works
Self-citationThe Use of Quasi-experimental Designs for Vaccine Evaluation
Bernal, J. L., Andrews, N. J., & Amirthalingam, G. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy906 · Cited by 33 · see citing works
Self-citationValentini, S. B., Santoro, G., Baffetta, F., Franceschi, S., Paludi, M., Brandini, E., Gherardini, L., Serruto, D., & Capecchi, B. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.10.082 · Cited by 33 · see citing works
Tessier, E., Stowe, J., Tsang, C., Rai, Y., Clarke, E., Lakhani, A., Makwana, A., Heard, H., Rickeard, T., Kirsebom, F., et al. (2022) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2022.104974 · Cited by 32 · see citing works
Self-citationMartinón‐Torres, F., Martínez, A. C., Simkó, R., Marquez, P. I., Arimany, J.-L., Giménez‐Sánchez, F., Gianzo, J. A. C., Kovacs, E. M. R., Rojo, P., Wang, H., et al. (2017) · Journal of Infection · doi:10.1016/j.jinf.2017.12.005 · Cited by 31 · see citing works
Engineered Remolding and Application of Bacterial Membrane Vesicles
Li, Q., Rao, Y., Zhu, K., Rao, X., & Zhou, R. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.729369 · Cited by 30 · see citing works
Critical care management of infectious meningitis and encephalitis
Meyfroidt, G., Kurtz, P., & Sonneville, R. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05901-w · Cited by 29 · see citing works
Invasive Meningococcal Disease, 2011–2020, and Impact of the COVID-19 Pandemic, England
Subbarao, S., Campbell, H. J., Ribeiro, S., Clark, S. A., Lucidarme, J., Ramsay, M. E., Borrow, R., & Ladhani, S. N. (2021) · Emerging infectious diseases · doi:10.3201/eid2709.204866 · Cited by 29 · see citing works
Self-citationMarshall, H. S., McMillan, M., Koehler, A. P., Lawrence, A. J., MacLennan, J. M., Maiden, M. C. J., Ramsay, M. E., Ladhani, S. N., Trotter, C. L., Borrow, R., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020988 · Cited by 28 · see citing works
Self-citationMartinón‐Torres, F., Nolan, T. M., Toneatto, D., & Banzhoff, A. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1627159 · Cited by 28 · see citing works
The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae
Rubin, D. H. F., Ross, J. D. C., & Grad, Y. H. (2020) · Translational research · doi:10.1016/j.trsl.2020.02.002 · Cited by 27 · see citing works
Vaccine Candidates for the Control and Prevention of the Sexually Transmitted Disease Gonorrhea
Haese, E. C., Thai, V. C., & Kahler, C. M. (2021) · Vaccines · doi:10.3390/vaccines9070804 · Cited by 27 · see citing works
Cost Effectiveness of Meningococcal Serogroup B Vaccination in College-Aged Young Adults
Leeds, I. L., Namasivayam, V., Bamogo, A., Sankhla, P., & Thayer, W. M. (2018) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2018.09.020 · Cited by 27 · see citing works
Correlates of protection for meningococcal surface protein vaccines: lessons from the past
Findlow, J., Lucidarme, J., Taha, M., Burman, C., & Balmer, P. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1940144 · Cited by 25 · see citing works
Marshall, H. S., Lally, N., Flood, L., & Phillips, P. A. (2020) · The Medical Journal of Australia · doi:10.5694/mja2.50481 · Cited by 25 · see citing works
Lujan, E., Partridge, E., Giuntini, S., Ram, S., & Granoff, D. M. (2017) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00121-17 · Cited by 24 · see citing works
Ladhani, S. N., Andrews, N. J., & Ramsay, M. E. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30492-8 · Cited by 24 · see citing works
Self-citationMarshall, G. S., Abbing‐Karahagopian, V., Marshall, H. S., Cenci, S., Conway, J. H., Occhipinti, E., Bekkat-Berkani, R., Banzhoff, A., & Sohn, W.-Y. (2023) · Expert Review of Vaccines · doi:10.1080/14760584.2023.2222015 · Cited by 24 · see citing works
Lujan, E., Winter, K., Rovaris, J., Liu, Q., & Granoff, D. M. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix519 · Cited by 24 · see citing works
Rodrigues, C. M. C., Lucidarme, J., Borrow, R., Smith, A. H., Cameron, J. C., Moxon, E. R., & Maiden, M. C. J. (2018) · Emerging infectious diseases · doi:10.3201/eid2404.171480 · Cited by 24 · see citing works
Self-citationNeisseria meningitidis and meningococcal disease: recent discoveries and innovations
Read, R. C. (2019) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000606 · Cited by 24 · see citing works
Stejskal, L., Thistlethwaite, A., Bencomo, F. R., Rashmi, S., Harrison, O. B., Feavers, I. M., Maiden, M. C. J., Jerse, A. E., Barnes, G., Chirro, O., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51053-x · Cited by 23 · see citing works
Sohn, W.-Y., Tahrat, H., Novy, P., & Bekkat-Berkani, R. (2022) · Expert Review of Vaccines · doi:10.1080/14760584.2022.2021881 · Cited by 23 · see citing works
Psychological interventions as vaccine adjuvants: A systematic review
Vedhara, K., Ayling, K., Sunger, K., Caldwell, D. M., Halliday, V., Fairclough, L. C., Avery, A. J., Robles, L. A., Garibaldi, J. M., Welton, N. J., et al. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.04.091 · Cited by 23 · see citing works
Bonanni, P., Villani, A., Scotti, S., Biasci, P., Russo, R., Maio, T., Rosati, G. V., Moscadelli, A., Conforti, G., Azzari, C., et al. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.01.019 · Cited by 23 · see citing works
López‐Sagaseta, J., Beernink, P. T., Bianchi, F., Santini, L., Frigimelica, E., Lucas, A. H., Pizza, M., & Bottomley, M. J. (2018) · Nature Communications · doi:10.1038/s41467-018-02827-7 · Cited by 23 · see citing works
Challenges and opportunities for meningococcal vaccination in the developing world
Shaker, R., Fayad, D., & Dbaibo, G. S. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1434463 · Cited by 22 · see citing works
Subbarao, S., Ribeiro, S., Campbell, H. J., Okike, I. O., Ramsay, M. E., & Ladhani, S. N. (2023) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2023.100692 · Cited by 22 · see citing works
Self-citationProteomics, Bioinformatics and Structure-Function Antigen Mining For Gonorrhea Vaccines
Baarda, B. I., Martinez, F. G., & Sikora, A. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02793 · Cited by 22 · see citing works
Zafack, J. G., Bureau, A., Skowronski, D. M., & Serres, G. D. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026953 · Cited by 22 · see citing works
Martinón‐Torres, F., Bosch, X. F., Rappuoli, R., Ladhani, S. N., Redondo, E., Vesikari, T., García‐Sastre, A., Calle, I. R., Rial, J. G., Salas, A., et al. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1609823 · Cited by 21 · see citing works
Self-citationLiguori, A., Iacono, L. D., Maruggi, G., Benucci, B., Merola, M., Surdo, P. L., López‐Sagaseta, J., Pizza, M., Malito, E., & Bottomley, M. J. (2018) · mBio · doi:10.1128/mbio.01914-18 · Cited by 21 · see citing works
Evaluating the Effectiveness of Vaccines Using a Regression Discontinuity Design
Basta, N. E., & Halloran, M. E. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz043 · Cited by 21 · see citing works
Martín-Galiano, A. J., & McConnell, M. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02841 · Cited by 21 · see citing works
Pneumococcal Choline-Binding Proteins Involved in Virulence as Vaccine Candidates
Sempere, J., Llamosí, M., Menéndez, I. D. R., Ruiz, B. L., Domenech, M., & González‐Camacho, F. (2021) · Vaccines · doi:10.3390/vaccines9020181 · Cited by 21 · see citing works
Doaré, K. L., Benassi, V., Cavaleri, M., Enwere, G., Giersing, B. K., Goldblatt, D., Heath, P. T., Hombach, J., Isbrucker, R. A., Karampatsas, K., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127131 · Cited by 20 · see citing works
Wang, B., Giles, L. C., Andraweera, P. H., McMillan, M., Beazley, R., Almond, S., Lally, N., Bell, C., Flood, L., Ward, J. S., et al. (2025) · Clinical Infectious Diseases · doi:10.1093/cid/ciaf372 · Cited by 20 · see citing works
Lodi, L., Barbati, F., Amicizia, D., Baldo, V., Barbui, A. M., Bondi, A., Costantino, C., Dalt, L. D., Ferrara, L., Fortunato, F., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.29678 · Cited by 20 · see citing works
Self-citation
- Authors
- Parikh, S. R., Andrews, N. J., Beebeejaun, K., Campbell, H., Ribeiro, S., Ward, C., White, J. M., Borrow, R., Ramsay, M. E., & Ladhani, S. N.
- Affiliations
- Public Health England (GB)
- Corresponding author
- Ladhani, Shamez N
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 388
- Issue
- 10061
- Pages
- 2775-2782
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2540474236
- Cited by
- 275
- References
- 18
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 15 · 2021: 20 · 2020: 38 · 2019: 63 · 2018: 53 · 2017: 35 · 2016: 1
- FWCI
- 51.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- Funders
- Public Health England
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- 4CMenB, infant vaccination schedule, catch-up vaccination, meningococcal disease incidence, vaccination coverage, meningococcal serogroups, national vaccination program, disease surveillance, vaccine impact, meningococcal serogroup B
- MeSH terms
- United Kingdom, Humans, Immunization Schedule, Infant, Meningococcal Infections, Public Health, Treatment Outcome, Immunization Programs, Meningococcal Vaccines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review