Cited by 1,065Celiac Disease Research and ManagementWheat and Barley Genetics and PathologyEosinophilic Esophagitis

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Coeliac disease

Lebwohl, Benjamin, Sanders, David S, Green, Peter H R·2018·The Lancet

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Abstract

Coeliac disease occurs in about 1% of people in most populations. Diagnosis rates are increasing, and this seems to be due to a true rise in incidence rather than increased awareness and detection. Coeliac disease develops in genetically susceptible individuals who, in response to unknown environmental factors, develop an immune response that is subsequently triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe malabsorption to minimally symptomatic or non-symptomatic presentations. Diagnosis requires the presence of duodenal villous atrophy, and most patients have circulating antibodies against tissue transglutaminase; in children, European guidelines allow a diagnosis without a duodenal biopsy provided that strict symptomatic and serological criteria are met. Although a gluten-free diet is an effective treatment in most individuals, a substantial minority develop persistent or recurrent symptoms. Difficulties adhering to a gluten-free diet have led to the development of non-dietary therapies, several of which are undergoing trials in human beings.

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Additional file 1 of Pathologist-trained machine learning classifiers developed to quantitate celiac disease features differentiate endoscopic biopsies according to modified marsh score and dietary intervention response
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Additional file 4 of Pathologist-trained machine learning classifiers developed to quantitate celiac disease features differentiate endoscopic biopsies according to modified marsh score and dietary intervention response
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Additional file 1 of Symptoms and biomarkers associated with undiagnosed celiac seropositivity
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Additional file 3 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease
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Additional file of Is mass screening for coeliac disease a wise use of resources? A health economic evaluation
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Additional file 1 of Is mass screening for coeliac disease a wise use of resources? A health economic evaluation
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Additional file 2 of Pathologist-trained machine learning classifiers developed to quantitate celiac disease features differentiate endoscopic biopsies according to modified marsh score and dietary intervention response
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Additional file 2 of Developing neural network diagnostic models and potential drugs based on novel identified immune-related biomarkers for celiac disease
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Additional file 2 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease
Chen, S., Liu, X., Wang, Z., Zheng, D., Wang, Y., Yan, Y., Peng, X., Ye, Q., & Chen, Y. (2023) · Figshare · doi:10.6084/m9.figshare.23740589
Additional file 3 of Pathologist-trained machine learning classifiers developed to quantitate celiac disease features differentiate endoscopic biopsies according to modified marsh score and dietary intervention response
Gruver, A. M., Lu, H., Zhao, X., Fulford, A. D., Soper, M. D., Ballard, D. W., Hanson, J. C., Schade, A. E., Hsi, E. D., Gottlieb, K. T., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26638569
Additional file 1 of Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease
Chen, S., Liu, X., Wang, Z., Zheng, D., Wang, Y., Yan, Y., Peng, X., Ye, Q., & Chen, Y. (2023) · Figshare · doi:10.6084/m9.figshare.23740586
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Self-citation

Authors: Lebwohl, B., Sanders, D. S., & Green, P. H. R.
Affiliations: Columbia University Irving Medical Center (US)
Royal Hallamshire Hospital (GB)
Corresponding author: Green, Peter H R
ORCID: Lebwohl, Benjamin
Sanders, David S
Green, Peter H R
Venue: The Lancet
Publisher: Elsevier BV
Published: 2018-01
Volume: 391
Issue: 10115
Pages: 70-81
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(17)31796-8
OpenAlex: W4211144941
Cited by: 1,065
References: 143
Citations by year: 2026: 98 · 2025: 101 · 2024: 138 · 2023: 115 · 2022: 142 · 2021: 177 · 2020: 144 · 2019: 90 · 2018: 58
FWCI: 13.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
Keywords: celiac disease, gluten, duodenal villous atrophy, anti-tissue transglutaminase antibodies, serological diagnosis, duodenal biopsy, gluten-free diet, malabsorption, incidence, genetic susceptibility, environmental triggers
MeSH terms: Celiac Disease, Humans

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