Cited by 1,065Celiac Disease Research and ManagementWheat and Barley Genetics and PathologyEosinophilic Esophagitis

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Coeliac disease

Lebwohl, Benjamin, Sanders, David S, Green, Peter H R·2018·The Lancet

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Abstract

Coeliac disease occurs in about 1% of people in most populations. Diagnosis rates are increasing, and this seems to be due to a true rise in incidence rather than increased awareness and detection. Coeliac disease develops in genetically susceptible individuals who, in response to unknown environmental factors, develop an immune response that is subsequently triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe malabsorption to minimally symptomatic or non-symptomatic presentations. Diagnosis requires the presence of duodenal villous atrophy, and most patients have circulating antibodies against tissue transglutaminase; in children, European guidelines allow a diagnosis without a duodenal biopsy provided that strict symptomatic and serological criteria are met. Although a gluten-free diet is an effective treatment in most individuals, a substantial minority develop persistent or recurrent symptoms. Difficulties adhering to a gluten-free diet have led to the development of non-dietary therapies, several of which are undergoing trials in human beings.

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Authors: Lebwohl, B., Sanders, D. S., & Green, P. H. R.
Affiliations: Columbia University Irving Medical Center (US)
Royal Hallamshire Hospital (GB)
Corresponding author: Green, Peter H R
ORCID: Lebwohl, Benjamin
Sanders, David S
Green, Peter H R
Venue: The Lancet
Publisher: Elsevier BV
Published: 2018-01
Volume: 391
Issue: 10115
Pages: 70-81
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(17)31796-8
OpenAlex: W4211144941
Cited by: 1,065
References: 143
Citations by year: 2026: 98 · 2025: 101 · 2024: 138 · 2023: 115 · 2022: 142 · 2021: 177 · 2020: 144 · 2019: 90 · 2018: 58
FWCI: 13.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
Keywords: celiac disease, gluten, duodenal villous atrophy, anti-tissue transglutaminase antibodies, serological diagnosis, duodenal biopsy, gluten-free diet, malabsorption, incidence, genetic susceptibility, environmental triggers
MeSH terms: Celiac Disease, Humans

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