SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS
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PBC is characterised serologically by autoantibodies specific for mitochondrial, nuclear and centromere antigens, some of which are unique to PBC.
“PBC is characterised serologically by autoantibodies specific for mitochondrial, nuclear and centromere antigens, some of which are unique to PBC.66–78”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [67]
They are present in ~95% (mitochondrial) and ~30% (nuclear) of patients.
“They are present in ~95% (mitochondrial) and ~30% (nuclear) of patients.”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [67]
Unlike in many other autoimmune diseases, these autoantibodies are, as a result of their sensitivity and specificity, extremely useful in diagnosis and have contributed significantly to the decline in the need for liver biopsy, at least for the purposes of diagnosis.
“Unlike in many other autoimmune diseases, these autoantibodies are, as a result of their sensitivity and specificity, extremely useful in diagnosis and have contributed significantly to the decline in the need for liver biopsy, at least for the purposes of diagnosis.”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [67]
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- Authors
- WALKER, J.
- Corresponding author
- WALKER, J
- ORCID
- WALKER, J
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1965-04
- Volume
- 285
- Issue
- 7390
- Pages
- 827-831
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1984136449
- Cited by
- 507
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 3 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 9
- FWCI
- 36.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- primary biliary cirrhosis, serological tests, diagnosis, autoantibodies, antimitochondrial antibodies
- MeSH terms
- Anemia, Anemia, Pernicious, Colitis, Colitis, Ulcerative, Complement Fixation Tests, Diagnosis, Differential, Fluorescent Antibody Technique, Hepatitis, Hepatitis A, Humans, Kidney, Latex Fixation Tests, Liver, Liver Cirrhosis, Liver Cirrhosis, Biliary, Stomach, Thyroid Gland, Thyroiditis, Chemical and Drug Induced Liver Injury
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