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PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE
Abstract
The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins. This finding supports existing evidence that H.D.L. facilitates the uptake of cholesterol from peripheral tissues and its transport to the liver for catabolism and excretion. Plasma-H.D.L., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease (I.H.D.), namely hypercholesterolaemia, hypertriglyceridaimia, male sex, obesity, and diabetes mellitus, while subjects with existing clinical I.H.D. have lower levels of H.D.L. than healthy subjects within the same community. It is proposed that a reduction of plasma-H.D.L. concentration may accelerate the development of atherosclerosis, and hence I.H.D., by impairing the clearance of cholesterol from the arterial wall.
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“there is an inverse relationship between serum HDL levels and the risk of coronary heart disease49,50.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [49]
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“For many decades, a low level of HDL-C has been viewed as a robust and independent CVD risk factor1-4.”
From Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?: New Insights From the Framingham Offspring Study (2016) · cites this paper as [1]
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Metadata
- Authors
- Miller, G. J., & Miller, N. E.
- Affiliations
- University Hospital Llandough (GB)
- Edinburgh Royal Infirmary (GB)
- ORCID
- Miller, G.J
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1975-01
- Volume
- 305
- Issue
- 7897
- Pages
- 16-19
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1994967652
- Cited by
- 2,621
- References
- 59
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 9 · 2023: 7 · 2022: 15 · 2021: 17 · 2020: 24 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 29 · 2015: 29 · 2014: 22 · 2013: 32 · 2012: 26
- FWCI
- 157.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- high-density lipoprotein, ischemic heart disease, atherosclerosis, cholesterol metabolism, hypercholesterolemia, hypertriglyceridemia, obesity, diabetes mellitus, sex differences, cardiovascular risk factors
- MeSH terms
- Arteries, Arteriosclerosis, Cholesterol, Coronary Disease, Denmark, Inuit, Female, Finland, Humans, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Liver, Male, Middle Aged, Sex Factors, Sweden, Triglycerides, United States
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