Cited by 2,621Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

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PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE

Miller, G.J, Miller, N.E·1975·The Lancet

DOI 10.1016/s0140-6736(75)92376-4

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Abstract

The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins. This finding supports existing evidence that H.D.L. facilitates the uptake of cholesterol from peripheral tissues and its transport to the liver for catabolism and excretion. Plasma-H.D.L., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease (I.H.D.), namely hypercholesterolaemia, hypertriglyceridaimia, male sex, obesity, and diabetes mellitus, while subjects with existing clinical I.H.D. have lower levels of H.D.L. than healthy subjects within the same community. It is proposed that a reduction of plasma-H.D.L. concentration may accelerate the development of atherosclerosis, and hence I.H.D., by impairing the clearance of cholesterol from the arterial wall.

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Authors: Miller, G. J., & Miller, N. E.
Affiliations: University Hospital Llandough (GB)
Edinburgh Royal Infirmary (GB)
ORCID: Miller, G.J
Venue: The Lancet
Publisher: Elsevier BV
Published: 1975-01
Volume: 305
Issue: 7897
Pages: 16-19
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(75)92376-4
OpenAlex: W1994967652
Cited by: 2,621
References: 59
Citations by year: 2026: 5 · 2025: 11 · 2024: 9 · 2023: 7 · 2022: 15 · 2021: 17 · 2020: 24 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 29 · 2015: 29 · 2014: 22 · 2013: 32 · 2012: 26
FWCI: 157.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, ischemic heart disease, atherosclerosis, cholesterol metabolism, hypercholesterolemia, hypertriglyceridemia, obesity, diabetes mellitus, sex differences, cardiovascular risk factors
MeSH terms: Arteries, Arteriosclerosis, Cholesterol, Coronary Disease, Denmark, Inuit, Female, Finland, Humans, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Liver, Male, Middle Aged, Sex Factors, Sweden, Triglycerides, United States

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PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE

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